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{{Infobox_gene}}
{{Infobox_gene}}
'''Translin''' is a DNA-binding [[protein]] that in humans is encoded by the ''TSN'' [[gene]].<ref name="pmid7947454">{{cite journal | vauthors = Kasai M, Aoki K, Matsuo Y, Minowada J, Maziarz RT, Strominger JL | title = Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11) | journal = International Immunology | volume = 6 | issue = 7 | pages = 1017–25 | date = Jul 1994 | pmid = 7947454 | pmc =  | doi = 10.1093/intimm/6.7.1017 }}</ref><ref name="pmid9244443">{{cite journal | vauthors = Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M | title = Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein | journal = Genomics | volume = 43 | issue = 2 | pages = 237–41 | date = Jul 1997 | pmid = 9244443 | pmc =  | doi = 10.1006/geno.1997.4796 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TSN translin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7247| accessdate = }}</ref> Together with [[translin-associated factor X]], translin forms the '''component 3 of promoter of RISC''' ('''C3PO''') complex which facilitates endonucleolytic cleavage of the passenger strand during [[microRNA]] loading into the RNA-induced silencing complex (RISC).<ref>{{cite journal | vauthors = Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch LN, Grishin NV, Liu Q | title = C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation | journal = Science | volume = 325 | issue = 5941 | pages = 750–3 | date = Aug 2009 | pmid = 19661431 | doi = 10.1126/science.1176325 | pmc=2855623}}</ref><ref>{{cite journal | vauthors = Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H | title = Structure of C3PO and mechanism of human RISC activation | journal = Nature Structural & Molecular Biology | volume = 18 | issue = 6 | pages = 650–7 | date = Jun 2011 | pmid = 21552258 | doi = 10.1038/nsmb.2032 | pmc=3109212}}</ref><ref>{{cite journal | vauthors = Ha M, Kim VN | title = Regulation of microRNA biogenesis | journal = Nature Reviews Molecular Cell Biology | volume = 15 | issue = 8 | pages = 509–24 | date = Aug 2014 | pmid = 25027649 | doi = 10.1038/nrm3838 }}</ref>
'''Translin''' is a DNA-binding [[protein]] that in humans is encoded by the ''TSN'' [[gene]].<ref name="pmid7947454">{{cite journal | vauthors = Kasai M, Aoki K, Matsuo Y, Minowada J, Maziarz RT, Strominger JL | title = Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11) | journal = [[International Immunology]] | volume = 6 | issue = 7 | pages = 1017–25 | date = Jul 1994 | pmid = 7947454 | pmc =  | doi = 10.1093/intimm/6.7.1017 }}</ref><ref name="pmid9244443">{{cite journal | vauthors = Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M | title = Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein | journal = Genomics | volume = 43 | issue = 2 | pages = 237–41 | date = Jul 1997 | pmid = 9244443 | pmc =  | doi = 10.1006/geno.1997.4796 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TSN translin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7247| accessdate = }}</ref> Together with [[translin-associated factor X]], translin forms the '''component 3 of promoter of RISC''' ('''C3PO''') complex which facilitates endonucleolytic cleavage of the passenger strand during [[microRNA]] loading into the RNA-induced silencing complex (RISC).<ref>{{cite journal | vauthors = Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch LN, Grishin NV, Liu Q | title = C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation | journal = Science | volume = 325 | issue = 5941 | pages = 750–3 | date = Aug 2009 | pmid = 19661431 | doi = 10.1126/science.1176325 | pmc=2855623}}</ref><ref>{{cite journal | vauthors = Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H | title = Structure of C3PO and mechanism of human RISC activation | journal = Nature Structural & Molecular Biology | volume = 18 | issue = 6 | pages = 650–7 | date = Jun 2011 | pmid = 21552258 | doi = 10.1038/nsmb.2032 | pmc=3109212}}</ref><ref>{{cite journal | vauthors = Ha M, Kim VN | title = Regulation of microRNA biogenesis | journal = Nature Reviews Molecular Cell Biology | volume = 15 | issue = 8 | pages = 509–24 | date = Aug 2014 | pmid = 25027649 | doi = 10.1038/nrm3838 }}</ref>


== Function ==
== Function ==

Latest revision as of 05:23, 15 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Translin is a DNA-binding protein that in humans is encoded by the TSN gene.[1][2][3] Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).[4][5][6]

Function

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.[3]

Interactions

Translin has been shown to interact with PPP1R15A.[7]

References

  1. ↑ Kasai M, Aoki K, Matsuo Y, Minowada J, Maziarz RT, Strominger JL (Jul 1994). "Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11)". International Immunology. 6 (7): 1017–25. doi:10.1093/intimm/6.7.1017. PMID 7947454.
  2. ↑ Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M (Jul 1997). "Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein". Genomics. 43 (2): 237–41. doi:10.1006/geno.1997.4796. PMID 9244443.
  3. ↑ 3.0 3.1 "Entrez Gene: TSN translin".
  4. ↑ Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch LN, Grishin NV, Liu Q (Aug 2009). "C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation". Science. 325 (5941): 750–3. doi:10.1126/science.1176325. PMC 2855623. PMID 19661431.
  5. ↑ Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H (Jun 2011). "Structure of C3PO and mechanism of human RISC activation". Nature Structural & Molecular Biology. 18 (6): 650–7. doi:10.1038/nsmb.2032. PMC 3109212. PMID 21552258.
  6. ↑ Ha M, Kim VN (Aug 2014). "Regulation of microRNA biogenesis". Nature Reviews Molecular Cell Biology. 15 (8): 509–24. doi:10.1038/nrm3838. PMID 25027649.
  7. ↑ Hasegawa T, Isobe K (Aug 1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochimica et Biophysica Acta. 1428 (2–3): 161–8. doi:10.1016/s0304-4165(99)00060-4. PMID 10434033.

Further reading

  • Aoki K, Suzuki K, Sugano T, Tasaka T, Nakahara K, Kuge O, Omori A, Kasai M (Jun 1995). "A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations". Nature Genetics. 10 (2): 167–74. doi:10.1038/ng0695-167. PMID 7663511.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Aoki K, Nakahara K, Ikegawa C, Seto M, Takahashi T, Minowada J, Strominger JL, Maziarz RT, Kasai M (Apr 1994). "Nuclear proteins binding to a novel target sequence within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH gene family". Oncogene. 9 (4): 1109–15. PMID 8134113.
  • Aoki K, Ishida R, Kasai M (Jan 1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX". FEBS Letters. 401 (2–3): 109–12. doi:10.1016/S0014-5793(96)01444-5. PMID 9013868.
  • Kasai M, Matsuzaki T, Katayanagi K, Omori A, Maziarz RT, Strominger JL, Aoki K, Suzuki K (Apr 1997). "The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome". The Journal of Biological Chemistry. 272 (17): 11402–7. doi:10.1074/jbc.272.17.11402. PMID 9111049.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hasegawa T, Isobe K (Aug 1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochimica et Biophysica Acta. 1428 (2–3): 161–8. doi:10.1016/s0304-4165(99)00060-4. PMID 10434033.
  • Badge RM, Yardley J, Jeffreys AJ, Armour JA (May 2000). "Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination". Human Molecular Genetics. 9 (8): 1239–44. doi:10.1093/hmg/9.8.1239. PMID 10767349.
  • Hosaka T, Kanoe H, Nakayama T, Murakami H, Yamamoto H, Nakamata T, Tsuboyama T, Oka M, Kasai M, Sasaki MS, Nakamura T, Toguchida J (Nov 2000). "Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6)". Oncogene. 19 (50): 5821–5. doi:10.1038/sj.onc.1203943. PMID 11126370.
  • Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB (Apr 2001). "Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA". The Journal of Biological Chemistry. 276 (16): 13256–63. doi:10.1074/jbc.M009707200. PMID 11278549.
  • Lee SP, Fuior E, Lewis MS, Han MK (Nov 2001). "Analytical ultracentrifugation studies of translin: analysis of protein-DNA interactions using a single-stranded fluorogenic oligonucleotide". Biochemistry. 40 (46): 14081–8. doi:10.1021/bi010302t. PMID 11705401.
  • Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". Journal of Cell Science. 115 (Pt 1): 207–16. PMID 11801738.
  • Han MK, Lin P, Paek D, Harvey JJ, Fuior E, Knutson JR (Mar 2002). "Fluorescence studies of pyrene maleimide-labeled translin: excimer fluorescence indicates subunits associate in a tail-to-tail configuration to form octamer". Biochemistry. 41 (10): 3468–76. doi:10.1021/bi015901e. PMID 11876655.
  • Sengupta K, Rao BJ (Dec 2002). "Translin binding to DNA: recruitment through DNA ends and consequent conformational transitions". Biochemistry. 41 (51): 15315–26. doi:10.1021/bi026378m. PMID 12484770.
  • Li K, Wang L, Cheng J, Lu YY, Zhang LX, Mu JS, Hong Y, Liu Y, Duan HJ, Wang G, Li L, Chen JM (Feb 2003). "Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus". World Journal of Gastroenterology. 9 (2): 300–3. doi:10.3748/wjg.v9.i2.300. PMID 12532453.
  • Yang S, Cho YS, Chennathukuzhi VM, Underkoffler LA, Loomes K, Hecht NB (Mar 2004). "Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation". The Journal of Biological Chemistry. 279 (13): 12605–14. doi:10.1074/jbc.M313133200. PMID 14711818.


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