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{{Infobox_gene}}
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'''Sodium- and chloride-dependent taurine transporter''' is a [[protein]] that in humans is encoded by the ''SLC6A6'' [[gene]].<ref name="pmid8010975">{{cite journal | vauthors = Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V | title = Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta | journal = Biochem J | volume = 300 | issue =  3| pages = 893–900 |date=Jul 1994 | pmid = 8010975 | pmc = 1138249 | doi =  }}</ref><ref name="pmid8382624">{{cite journal | vauthors = Jhiang SM, Fithian L, Smanik P, McGill J, Tong Q, Mazzaferri EL | title = Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells | journal = FEBS Lett | volume = 318 | issue = 2 | pages = 139–44 |date=Mar 1993 | pmid = 8382624 | pmc =  | doi =10.1016/0014-5793(93)80008-I }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6533| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Solute carrier family 6 (neurotransmitter transporter, taurine), member 6
| HGNCid = 11052
| Symbol = SLC6A6
| AltSymbols =; MGC10619; MGC131729; TAUT
| OMIM = 186854
  | ECnumber =
| Homologene = 2291
| MGIid = 98488
| GeneAtlas_image1 = PBB_GE_SLC6A6_205921_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC6A6_205920_at_tn.png
  | Function = {{GNF_GO|id=GO:0005369 |text = taurine:sodium symporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006520 |text = amino acid metabolic process}} {{GNF_GO|id=GO:0006836 |text = neurotransmitter transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6533
    | Hs_Ensembl = ENSG00000131389
    | Hs_RefseqProtein = NP_003034
    | Hs_RefseqmRNA = NM_003043
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 14419110
    | Hs_GenLoc_end = 14505859
    | Hs_Uniprot = P31641
    | Mm_EntrezGene = 21366
    | Mm_Ensembl = ENSMUSG00000030096
    | Mm_RefseqmRNA = NM_009320
    | Mm_RefseqProtein = NP_033346
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 91649599
    | Mm_GenLoc_end = 91724570
    | Mm_Uniprot = Q3UPI8
  }}
}}
'''Solute carrier family 6 (neurotransmitter transporter, taurine), member 6''', also known as '''SLC6A6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6533| accessdate = }}</ref>
 
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==References==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Uchida S, Kwon HM, Yamauchi A, ''et al.'' |title=Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 17 |pages= 8230-4 |year= 1992 |pmid= 1518851 |doi= }}
*{{cite journal   |vauthors=Uchida S, Kwon HM, Yamauchi A, etal |title=Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(−)-dependent taurine transporter that is regulated by hypertonicity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 17 |pages= 8230–4 |year= 1992 |pmid= 1518851 |doi=10.1073/pnas.89.17.8230 | pmc=49891 }}
*{{cite journal  | author=Ramamoorthy S, Leibach FH, Mahesh VB, ''et al.'' |title=Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. |journal=Biochem. J. |volume=300 ( Pt 3) |issue= |pages= 893-900 |year= 1994 |pmid= 8010975 |doi=  }}
*{{cite journal  | vauthors=Miyamoto Y, Liou GI, Sprinkle TJ |title=Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium. |journal=Curr. Eye Res. |volume=15 |issue= 3 |pages= 345–9 |year= 1996 |pmid= 8654117 |doi=10.3109/02713689609007631 }}
*{{cite journal  | author=Jhiang SM, Fithian L, Smanik P, ''et al.'' |title=Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells. |journal=FEBS Lett. |volume=318 |issue= 2 |pages= 139-44 |year= 1993 |pmid= 8382624 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Miyamoto Y, Liou GI, Sprinkle TJ |title=Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium. |journal=Curr. Eye Res. |volume=15 |issue= 3 |pages= 345-9 |year= 1996 |pmid= 8654117 |doi=  }}
*{{cite journal  | vauthors=Mochizuki T, Satsu H, Shimizu M |title=Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells. |journal=FEBS Lett. |volume=517 |issue= 1–3 |pages= 92–6 |year= 2002 |pmid= 12062416 |doi=10.1016/S0014-5793(02)02584-X }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Han X, Patters AB, Chesney RW |title=Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39266–73 |year= 2002 |pmid= 12163498 |doi= 10.1074/jbc.M205939200 }}
*{{cite journal  | author=Mochizuki T, Satsu H, Shimizu M |title=Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 92-6 |year= 2002 |pmid= 12062416 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Han X, Patters AB, Chesney RW |title=Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39266-73 |year= 2002 |pmid= 12163498 |doi= 10.1074/jbc.M205939200 }}
*{{cite journal  | vauthors=Han X, Chesney RW |title=Regulation of taurine transporter gene (TauT) by WT1 |journal=FEBS Lett. |volume=540 |issue= 1–3 |pages= 71–6 |year= 2003 |pmid= 12681485 |doi=10.1016/S0014-5793(03)00227-8 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Roos S, Powell TL, Jansson T |title=Human placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression, and regulation |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=287 |issue= 4 |pages= R886–93 |year= 2004 |pmid= 15166008 |doi= 10.1152/ajpregu.00232.2004 }}
*{{cite journal  | author=Han X, Chesney RW |title=Regulation of taurine transporter gene (TauT) by WT1. |journal=FEBS Lett. |volume=540 |issue= 1-3 |pages= 71-6 |year= 2003 |pmid= 12681485 |doi=  }}
*{{cite journal  | vauthors=Satsu H, Manabe M, Shimizu M |title=Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter |journal=FEBS Lett. |volume=569 |issue= 1–3 |pages= 123–8 |year= 2004 |pmid= 15225620 |doi= 10.1016/j.febslet.2004.05.062 }}
*{{cite journal  | author=Roos S, Powell TL, Jansson T |title=Human placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression, and regulation. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=287 |issue= 4 |pages= R886-93 |year= 2004 |pmid= 15166008 |doi= 10.1152/ajpregu.00232.2004 }}
*{{cite journal  | vauthors=Mochizuki T, Satsu H, Nakano T, Shimizu M |title=Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells |journal=BioFactors |volume=21 |issue= 1–4 |pages= 141–4 |year= 2005 |pmid= 15630186 |doi=10.1002/biof.552210128 }}
*{{cite journal  | author=Satsu H, Manabe M, Shimizu M |title=Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter. |journal=FEBS Lett. |volume=569 |issue= 1-3 |pages= 123-8 |year= 2004 |pmid= 15225620 |doi= 10.1016/j.febslet.2004.05.062 }}
*{{cite journal  | vauthors=Mochizuki T, Satsu H, Shimizu M |title=Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells |journal=FEBS Lett. |volume=579 |issue= 14 |pages= 3069–74 |year= 2005 |pmid= 15907840 |doi= 10.1016/j.febslet.2005.04.063 }}
*{{cite journal  | author=Mochizuki T, Satsu H, Nakano T, Shimizu M |title=Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells. |journal=Biofactors |volume=21 |issue= 1-4 |pages= 141-4 |year= 2005 |pmid= 15630186 |doi=  }}
*{{cite journal   |vauthors=Nakashima E, Pop-Busui R, Towns R, etal |title=Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase |journal=Antioxid. Redox Signal. |volume=7 |issue= 11–12 |pages= 1530–42 |year= 2006 |pmid= 16356117 |doi= 10.1089/ars.2005.7.1530 }}
*{{cite journal  | author=Mochizuki T, Satsu H, Shimizu M |title=Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells. |journal=FEBS Lett. |volume=579 |issue= 14 |pages= 3069-74 |year= 2005 |pmid= 15907840 |doi= 10.1016/j.febslet.2005.04.063 }}
*{{cite journal   |vauthors=Iruloh CG, D'Souza SW, Speake PF, etal |title=Taurine transporter in fetal T lymphocytes and platelets: differential expression and functional activity |journal=Am. J. Physiol., Cell Physiol. |volume=292 |issue= 1 |pages= C332–41 |year= 2007 |pmid= 16956961 |doi= 10.1152/ajpcell.00634.2005 }}
*{{cite journal | author=Nakashima E, Pop-Busui R, Towns R, ''et al.'' |title=Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase. |journal=Antioxid. Redox Signal. |volume=7 |issue= 11-12 |pages= 1530-42 |year= 2006 |pmid= 16356117 |doi= 10.1089/ars.2005.7.1530 }}
*{{cite journal | author=Iruloh CG, D'Souza SW, Speake PF, ''et al.'' |title=Taurine transporter in fetal T lymphocytes and platelets: differential expression and functional activity. |journal=Am. J. Physiol., Cell Physiol. |volume=292 |issue= 1 |pages= C332-41 |year= 2007 |pmid= 16956961 |doi= 10.1152/ajpcell.00634.2005 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 11:09, 7 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.[1][2][3]

References

  1. ↑ Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V (Jul 1994). "Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta". Biochem J. 300 (3): 893–900. PMC 1138249. PMID 8010975.
  2. ↑ Jhiang SM, Fithian L, Smanik P, McGill J, Tong Q, Mazzaferri EL (Mar 1993). "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells". FEBS Lett. 318 (2): 139–44. doi:10.1016/0014-5793(93)80008-I. PMID 8382624.
  3. ↑ "Entrez Gene: SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=SLC6A6&oldid=1532228"