ACTL6A: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Actin-like protein 6A''' is a [[protein]] that in humans is encoded by the ''ACTL6A'' [[gene]].<ref name="pmid9845365">{{cite journal | vauthors = Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR | title = Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling | journal = Cell | volume = 95 | issue = 5 | pages = 625–36 | date = December 1998 | pmid = 9845365 | pmc =  | doi = 10.1016/S0092-8674(00)81633-5 }}</ref><ref name="pmid10380635">{{cite journal | vauthors = Harata M, Mochizuki R, Mizuno S | title = Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues | journal = Biosci Biotechnol Biochem | volume = 63 | issue = 5 | pages = 917–23 | date = July 1999 | pmid = 10380635 | pmc = | doi = 10.1271/bbb.63.917 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ACTL6A actin-like 6A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=86| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Actin-like 6A
| HGNCid = 24124
| Symbol = ACTL6A
| AltSymbols =; ACTL6; BAF53A; MGC5382
| OMIM = 604958
| ECnumber = 
| Homologene = 55811
| MGIid = 1861453
| GeneAtlas_image1 = PBB_GE_ACTL6A_202666_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016585 |text = chromatin remodeling complex}} {{GNF_GO|id=GO:0035267 |text = NuA4 histone acetyltransferase complex}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 86
    | Hs_Ensembl = ENSG00000136518
    | Hs_RefseqProtein = NP_004292
    | Hs_RefseqmRNA = NM_004301
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 180763575
    | Hs_GenLoc_end = 180788886
    | Hs_Uniprot = O96019
    | Mm_EntrezGene = 56456
    | Mm_Ensembl = ENSMUSG00000027671
    | Mm_RefseqmRNA = NM_019673
    | Mm_RefseqProtein = NP_062647
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 32900277
    | Mm_GenLoc_end = 32918517
    | Mm_Uniprot = Q3TF62
  }}
}}
'''Actin-like 6A''', also known as '''ACTL6A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ACTL6A actin-like 6A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=86| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the [[BAF complex|BAF (BRG1/brm-associated factor) complex]] in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: ACTL6A actin-like 6A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=86| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
 
==Further reading==
ACTL6A is amplified in head and squamous cancers and confers poor prognosis in patients.<ref name="pmid28041841">{{cite journal | vauthors = Saladi SV, Ross K, Karaayvaz M, Tata PR, Mou H, Rajagopal J, Ramaswamy S, Ellisen LW | title = ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis | journal = Cancer Cell | volume = 31 | issue = 1 | pages = 35–49 | year = 2017 | pmid = 28041841 | doi = 10.1016/j.ccell.2016.12.001 | pmc=5225026}}</ref> In hepatocellular carcinomas, it promotes metastasis.<ref name="pmid26698646">{{cite journal | vauthors = Xiao S, Chang RM, Yang MY, Lei X, Liu X, Gao WB, Xiao JL, Yang LY | title = Actin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition | journal = Hepatology | volume = 63 | issue = 4 | pages = 1256–71 | year = 2016 | pmid = 26698646 | pmc = 4834727 | doi = 10.1002/hep.28417 }}</ref>
 
== Interactions ==
 
ACTL6A has been shown to [[Protein-protein interaction|interact]] with [[SMARCA2]],<ref name=pmid8895581>{{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = EMBO J. | volume = 15 | issue = 19 | pages = 5370–82 | date = October 1996 | pmid = 8895581 | pmc = 452280 }}</ref><ref name=pmid11839798>{{cite journal | vauthors = Park J, Wood MA, Cole MD | title = BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation | journal = Mol. Cell. Biol. | volume = 22 | issue = 5 | pages = 1307–16 | date = March 2002 | pmid = 11839798 | pmc = 134713 | doi = 10.1128/MCB.22.5.1307-1316.2002 }}</ref><ref name=pmid12437990>{{cite journal | vauthors = Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M | title = Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex | journal = Biochem. Biophys. Res. Commun. | volume = 299 | issue = 2 | pages = 328–34 | date = November 2002 | pmid = 12437990 | doi = 10.1016/S0006-291X(02)02637-2 }}</ref> [[Myc]],<ref name=pmid11839798/> [[Transformation/transcription domain-associated protein]],<ref name=pmid11839798/> [[RuvB-like 1]]<ref name=pmid11839798/> and [[SMARCA4]].<ref name=pmid9845365 /><ref name=pmid8895581/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Schafer DA, Schroer TA | title = Actin-related proteins. | journal = Annu. Rev. Cell Dev. Biol. | volume = 15 | issue =  | pages = 341–63 | year = 2000 | pmid = 10611965 | doi = 10.1146/annurev.cellbio.15.1.341 }}
| citations =
* {{cite journal | vauthors = Doyon Y, Côté J | title = The highly conserved and multifunctional NuA4 HAT complex. | journal = Curr. Opin. Genet. Dev. | volume = 14 | issue = 2 | pages = 147–54 | year = 2004 | pmid = 15196461 | doi = 10.1016/j.gde.2004.02.009 }}
*{{cite journal | author=Schafer DA, Schroer TA |title=Actin-related proteins. |journal=Annu. Rev. Cell Dev. Biol. |volume=15 |issue=  |pages= 341-63 |year= 2000 |pmid= 10611965 |doi= 10.1146/annurev.cellbio.15.1.341 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex. |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147-54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A human RNA polymerase II complex containing factors that modify chromatin structure | journal = Mol. Cell. Biol. | volume = 18 | issue = 9 | pages = 5355–63 | year = 1998 | pmid = 9710619 | pmc = 109120 | doi =  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Phelan ML, Sif S, Narlikar GJ, Kingston RE | title = Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits | journal = Mol. Cell | volume = 3 | issue = 2 | pages = 247–53 | year = 1999 | pmid = 10078207 | doi = 10.1016/S1097-2765(00)80315-9 }}
*{{cite journal | author=Cho H, Orphanides G, Sun X, ''et al.'' |title=A human RNA polymerase II complex containing factors that modify chromatin structure. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5355-63 |year= 1998 |pmid= 9710619 |doi=  }}
* {{cite journal | vauthors = Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y | title = Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis | journal = Cell | volume = 102 | issue = 4 | pages = 463–73 | year = 2000 | pmid = 10966108 | doi = 10.1016/S0092-8674(00)00051-9 }}
*{{cite journal | author=Zhao K, Wang W, Rando OJ, ''et al.'' |title=Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. |journal=Cell |volume=95 |issue= 5 |pages= 625-36 |year= 1998 |pmid= 9845365 |doi= }}
* {{cite journal | vauthors = Xue Y, Canman JC, Lee CS, Nie Z, Yang D, Moreno GT, Young MK, Salmon ED, Wang W | title = The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 24 | pages = 13015–20 | year = 2001 | pmid = 11078522 | pmc = 27170 | doi = 10.1073/pnas.240208597 }}
*{{cite journal | author=Phelan ML, Sif S, Narlikar GJ, Kingston RE |title=Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. |journal=Mol. Cell |volume=3 |issue= 2 |pages= 247-53 |year= 1999 |pmid= 10078207 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Harata M, Mochizuki R, Mizuno S |title=Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues. |journal=Biosci. Biotechnol. Biochem. |volume=63 |issue= 5 |pages= 917-23 |year= 1999 |pmid= 10380635 |doi= }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Rep. | volume = 1 | issue = 3 | pages = 287–92 | year = 2001 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Ikura T, Ogryzko VV, Grigoriev M, ''et al.'' |title=Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. |journal=Cell |volume=102 |issue= 4 |pages= 463-73 |year= 2000 |pmid= 10966108 |doi= }}
* {{cite journal | vauthors = Sung YH, Choi EY, Kwon H | title = Identification of a nuclear protein ArpN as a component of human SWI/SNF complex and its selective association with a subset of active genes | journal = Mol. Cells | volume = 11 | issue = 1 | pages = 75–81 | year = 2001 | pmid = 11266125 | doi = }}
*{{cite journal | author=Xue Y, Canman JC, Lee CS, ''et al.'' |title=The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 24 |pages= 13015-20 |year= 2001 |pmid= 11078522 |doi= 10.1073/pnas.240208597 }}
* {{cite journal | vauthors = Lai CH, Chiu JY, Lin W | title = Identification of the human crooked neck gene by comparative gene identification | journal = Biochim. Biophys. Acta | volume = 1517 | issue = 3 | pages = 449–54 | year = 2001 | pmid = 11342225 | doi = 10.1016/s0167-4781(00)00295-5 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM | title = The p400 complex is an essential E1A transformation target | journal = Cell | volume = 106 | issue = 3 | pages = 297–307 | year = 2001 | pmid = 11509179 | doi = 10.1016/S0092-8674(01)00450-0 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG | title = SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones | journal = J. Biol. Chem. | volume = 277 | issue = 7 | pages = 5498–505 | year = 2002 | pmid = 11734557 | doi = 10.1074/jbc.M108702200 }}
*{{cite journal | author=Sung YH, Choi EY, Kwon H |title=Identification of a nuclear protein ArpN as a component of human SWI/SNF complex and its selective association with a subset of active genes. |journal=Mol. Cells |volume=11 |issue= 1 |pages= 75-81 |year= 2001 |pmid= 11266125 |doi= }}
* {{cite journal | vauthors = Park J, Wood MA, Cole MD | title = BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation | journal = Mol. Cell. Biol. | volume = 22 | issue = 5 | pages = 1307–16 | year = 2002 | pmid = 11839798 | pmc = 134713 | doi = 10.1128/MCB.22.5.1307-1316.2002 }}
*{{cite journal | author=Lai CH, Chiu JY, Lin W |title=Identification of the human crooked neck gene by comparative gene identification. |journal=Biochim. Biophys. Acta |volume=1517 |issue= 3 |pages= 449-54 |year= 2001 |pmid= 11342225 |doi= }}
* {{cite journal | vauthors = Ohfuchi E, Nishimori K, Harata M | title = Alternative splicing products of the gene for a human nuclear actin-related protein, hArpNbeta/Baf53, that encode a protein isoform, hArpNbetaS, in the cytoplasm | journal = Biosci. Biotechnol. Biochem. | volume = 66 | issue = 8 | pages = 1740–3 | year = 2003 | pmid = 12353638 | doi = 10.1271/bbb.66.1740 }}
*{{cite journal | author=Fuchs M, Gerber J, Drapkin R, ''et al.'' |title=The p400 complex is an essential E1A transformation target. |journal=Cell |volume=106 |issue= 3 |pages= 297-307 |year= 2001 |pmid= 11509179 |doi= }}
* {{cite journal | vauthors = Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M | title = Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex | journal = Biochem. Biophys. Res. Commun. | volume = 299 | issue = 2 | pages = 328–34 | year = 2003 | pmid = 12437990 | doi = 10.1016/S0006-291X(02)02637-2 }}
*{{cite journal | author=Kato H, Tjernberg A, Zhang W, ''et al.'' |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498-505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200 }}
*{{cite journal | author=Park J, Wood MA, Cole MD |title=BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. |journal=Mol. Cell. Biol. |volume=22 |issue= 5 |pages= 1307-16 |year= 2002 |pmid= 11839798 |doi= }}
*{{cite journal  | author=Ohfuchi E, Nishimori K, Harata M |title=Alternative splicing products of the gene for a human nuclear actin-related protein, hArpNbeta/Baf53, that encode a protein isoform, hArpNbetaS, in the cytoplasm. |journal=Biosci. Biotechnol. Biochem. |volume=66 |issue= 8 |pages= 1740-3 |year= 2003 |pmid= 12353638 |doi=  }}
*{{cite journal  | author=Kuroda Y, Oma Y, Nishimori K, ''et al.'' |title=Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 2 |pages= 328-34 |year= 2003 |pmid= 12437990 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Human proteins]]
{{WikiDoc Sources}}

Latest revision as of 12:13, 4 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Actin-like protein 6A is a protein that in humans is encoded by the ACTL6A gene.[1][2][3]

Function

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.[3]

Clinical significance

ACTL6A is amplified in head and squamous cancers and confers poor prognosis in patients.[4] In hepatocellular carcinomas, it promotes metastasis.[5]

Interactions

ACTL6A has been shown to interact with SMARCA2,[6][7][8] Myc,[7] Transformation/transcription domain-associated protein,[7] RuvB-like 1[7] and SMARCA4.[1][6]

References

  1. ↑ 1.0 1.1 Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR (December 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell. 95 (5): 625–36. doi:10.1016/S0092-8674(00)81633-5. PMID 9845365.
  2. ↑ Harata M, Mochizuki R, Mizuno S (July 1999). "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues". Biosci Biotechnol Biochem. 63 (5): 917–23. doi:10.1271/bbb.63.917. PMID 10380635.
  3. ↑ 3.0 3.1 "Entrez Gene: ACTL6A actin-like 6A".
  4. ↑ Saladi SV, Ross K, Karaayvaz M, Tata PR, Mou H, Rajagopal J, Ramaswamy S, Ellisen LW (2017). "ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis". Cancer Cell. 31 (1): 35–49. doi:10.1016/j.ccell.2016.12.001. PMC 5225026. PMID 28041841.
  5. ↑ Xiao S, Chang RM, Yang MY, Lei X, Liu X, Gao WB, Xiao JL, Yang LY (2016). "Actin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition". Hepatology. 63 (4): 1256–71. doi:10.1002/hep.28417. PMC 4834727. PMID 26698646.
  6. ↑ 6.0 6.1 Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (October 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. PMC 452280. PMID 8895581.
  7. ↑ 7.0 7.1 7.2 7.3 Park J, Wood MA, Cole MD (March 2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Mol. Cell. Biol. 22 (5): 1307–16. doi:10.1128/MCB.22.5.1307-1316.2002. PMC 134713. PMID 11839798.
  8. ↑ Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M (November 2002). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex". Biochem. Biophys. Res. Commun. 299 (2): 328–34. doi:10.1016/S0006-291X(02)02637-2. PMID 12437990.

Further reading

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