UBE1L: Difference between revisions

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Latest revision as of 18:44, 15 February 2018

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.^[1]^[2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.^[2]

References

↑ Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.
↑ ^2.0 ^2.1 "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

Carritt B, Kok K, van den Berg A, et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer". Cancer Res. 52 (6): 1536–41. PMID 1311632.
Kok K, Van den Berg A, Veldhuis PM, et al. (1995). "The genomic structure of the human UBE1L gene". Gene Expr. 4 (3): 163–75. PMID 7734949.
McLaughlin PM, Helfrich W, Kok K, et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines". Int. J. Cancer. 85 (6): 871–6. doi:10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O. PMID 10709110.
Yuan W, Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein". EMBO J. 20 (3): 362–71. doi:10.1093/emboj/20.3.362. PMC 133459. PMID 11157743.
Kitareewan S, Pitha-Rowe I, Sekula D, et al. (2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3806–11. doi:10.1073/pnas.052011299. PMC 122605. PMID 11891284.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Pitha-Rowe I, Hassel BA, Dmitrovsky E (2004). "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia". J. Biol. Chem. 279 (18): 18178–87. doi:10.1074/jbc.M309259200. PMID 14976209.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lenschow DJ, Giannakopoulos NV, Gunn LJ, et al. (2006). "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo". J. Virol. 79 (22): 13974–83. doi:10.1128/JVI.79.22.13974-13983.2005. PMC 1280211. PMID 16254333.
Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid8327486-1] Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.

[entrez-2] 2.0 ^2.1 "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

[1]

[2]

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+{{Infobox_gene}}
-{{GNF_Protein_box
+'''Ubiquitin-like modifier-activating enzyme 7''' is a [[protein]] that in humans is encoded by the ''UBA7'' [[gene]].<ref name="pmid8327486">{{cite journal | vauthors = Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B | title = A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 13 | pages = 6071–5 |date=Aug 1993 | pmid = 8327486 | pmc = 46869 | doi =10.1073/pnas.90.13.6071  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7318| accessdate = }}</ref>
- | image =
- | image_source =
- | PDB =
- | Name = Ubiquitin-activating enzyme E1-like
- | HGNCid = 12471
- | Symbol = UBE1L
- | AltSymbols =; D8; MGC12713; UBE2
- | OMIM = 191325
- | ECnumber =
- | Homologene = 2502
- | MGIid = 1349462
- | GeneAtlas_image1 = PBB_GE_UBE1L_1294_at_tn.png
- | GeneAtlas_image2 = PBB_GE_UBE1L_203281_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004839 |text = ubiquitin activating enzyme activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0019782 |text = ISG15 activating enzyme activity}}
-  | Component =
- | Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 7318
-    | Hs_Ensembl = ENSG00000182179
-    | Hs_RefseqProtein = NP_003326
-    | Hs_RefseqmRNA = NM_003335
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 49817643
-    | Hs_GenLoc_end = 49826395
-    | Hs_Uniprot = P41226
-    | Mm_EntrezGene = 74153
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA = NM_023738
-    | Mm_RefseqProtein = NP_076227
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Ubiquitin-activating enzyme E1-like''', also known as '''UBE1L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7318| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.<ref name="entrez">{{cite web | title = Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7318| accessdate = }}</ref>
+| summary_text = The modification of proteins with [[ubiquitin]] is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. [[Ubiquitination]] involves at least three classes of [[enzymes]]: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and [[ubiquitin-protein ligases]], or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a [[retinoid]] target that triggers [[promyelocytic leukemia]] (PML)/[[retinoic acid receptor alpha]] (RARalpha) degradation and [[apoptosis]] in acute promyelocytic leukemia.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Carritt B, Kok K, van den Berg A, ''et al.'' |title=A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. |journal=Cancer Res. |volume=52 |issue= 6 |pages= 1536-41 |year= 1992 |pmid= 1311632 |doi=  }}
+*{{cite journal   |vauthors=Carritt B, Kok K, van den Berg A, etal |title=A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. |journal=Cancer Res. |volume=52 |issue= 6 |pages= 1536–41 |year= 1992 |pmid= 1311632 |doi=  }}
-*{{cite journal  | author=Kok K, Van den Berg A, Veldhuis PM, ''et al.'' |title=The genomic structure of the human UBE1L gene. |journal=Gene Expr. |volume=4 |issue= 3 |pages= 163-75 |year= 1995 |pmid= 7734949 |doi=  }}
+*{{cite journal   |vauthors=Kok K, Van den Berg A, Veldhuis PM, etal |title=The genomic structure of the human UBE1L gene. |journal=Gene Expr. |volume=4 |issue= 3 |pages= 163–75 |year= 1995 |pmid= 7734949 |doi=  }}
-*{{cite journal  | author=Kok K, Hofstra R, Pilz A, ''et al.'' |title=A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 13 |pages= 6071-5 |year= 1993 |pmid= 8327486 |doi=  }}
+*{{cite journal   |vauthors=McLaughlin PM, Helfrich W, Kok K, etal |title=The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines. |journal=Int. J. Cancer |volume=85 |issue= 6 |pages= 871–6 |year= 2000 |pmid= 10709110 |doi=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O  }}
-*{{cite journal  | author=McLaughlin PM, Helfrich W, Kok K, ''et al.'' |title=The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines. |journal=Int. J. Cancer |volume=85 |issue= 6 |pages= 871-6 |year= 2000 |pmid= 10709110 |doi=  }}
+*{{cite journal  | vauthors=Yuan W, Krug RM |title=Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. |journal=EMBO J. |volume=20 |issue= 3 |pages= 362–71 |year= 2001 |pmid= 11157743 |doi= 10.1093/emboj/20.3.362  | pmc=133459 }}
-*{{cite journal  | author=Yuan W, Krug RM |title=Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. |journal=EMBO J. |volume=20 |issue= 3 |pages= 362-71 |year= 2001 |pmid= 11157743 |doi= 10.1093/emboj/20.3.362 }}
+*{{cite journal   |vauthors=Kitareewan S, Pitha-Rowe I, Sekula D, etal |title=UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3806–11 |year= 2002 |pmid= 11891284 |doi= 10.1073/pnas.052011299  | pmc=122605 }}
-*{{cite journal  | author=Kitareewan S, Pitha-Rowe I, Sekula D, ''et al.'' |title=UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3806-11 |year= 2002 |pmid= 11891284 |doi= 10.1073/pnas.052011299 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
-*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
+*{{cite journal  | vauthors=Pitha-Rowe I, Hassel BA, Dmitrovsky E |title=Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18178–87 |year= 2004 |pmid= 14976209 |doi= 10.1074/jbc.M309259200 }}
-*{{cite journal  | author=Pitha-Rowe I, Hassel BA, Dmitrovsky E |title=Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18178-87 |year= 2004 |pmid= 14976209 |doi= 10.1074/jbc.M309259200 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal   |vauthors=Lenschow DJ, Giannakopoulos NV, Gunn LJ, etal |title=Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. |journal=J. Virol. |volume=79 |issue= 22 |pages= 13974–83 |year= 2006 |pmid= 16254333 |doi= 10.1128/JVI.79.22.13974-13983.2005  | pmc=1280211 }}
-*{{cite journal  | author=Lenschow DJ, Giannakopoulos NV, Gunn LJ, ''et al.'' |title=Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. |journal=J. Virol. |volume=79 |issue= 22 |pages= 13974-83 |year= 2006 |pmid= 16254333 |doi= 10.1128/JVI.79.22.13974-13983.2005 }}
+*{{cite journal   |vauthors=Takeuchi T, Iwahara S, Saeki Y, etal |title=Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme. |journal=J. Biochem. |volume=138 |issue= 6 |pages= 711–9 |year=  2005|pmid= 16428300 |doi= 10.1093/jb/mvi172 }}
-*{{cite journal  | author=Takeuchi T, Iwahara S, Saeki Y, ''et al.'' |title=Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme. |journal=J. Biochem. |volume=138 |issue= 6 |pages= 711-9 |year=  |pmid= 16428300 |doi= 10.1093/jb/mvi172 }}
 }}
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UBE1L: Difference between revisions

Latest revision as of 18:44, 15 February 2018

References

Further reading

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