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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Semaphorin-3B''' is a [[protein]] that in humans is encoded by the ''SEMA3B'' [[gene]].<ref name="pmid7748561">{{cite journal | vauthors = Püschel AW, Adams RH, Betz H | title = Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension | journal = Neuron | volume = 14 | issue = 5 | pages = 941–8 | date = May 1995 | pmid = 7748561 | pmc =  | doi = 10.1016/0896-6273(95)90332-1 }}</ref><ref name="pmid8633026">{{cite journal | vauthors = Sekido Y, Bader S, Latif F, Chen JY, Duh FM, Wei MH, Albanesi JP, Lee CC, Lerman MI, Minna JD | title = Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 9 | pages = 4120–5 | date = April 1996 | pmid = 8633026 | pmc = 39497 | doi = 10.1073/pnas.93.9.4120 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7869| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
| HGNCid = 10724
| Symbol = SEMA3B
| AltSymbols =; FLJ34863; LUCA-1; SEMA5; SEMAA; SemA; semaV
| OMIM = 601281
| ECnumber = 
| Homologene = 20972
| MGIid = 107561
| GeneAtlas_image1 = PBB_GE_SEMA3B_203071_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007411 |text = axon guidance}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7869
    | Hs_Ensembl = ENSG00000012171
    | Hs_RefseqProtein = NP_001005914
    | Hs_RefseqmRNA = NM_001005914
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 50280044
    | Hs_GenLoc_end = 50289574
    | Hs_Uniprot = Q13214
    | Mm_EntrezGene = 20347
    | Mm_Ensembl = ENSMUSG00000057969
    | Mm_RefseqmRNA = NM_001042779
    | Mm_RefseqProtein = NP_001036244
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 107456218
    | Mm_GenLoc_end = 107467330
    | Mm_Uniprot = Q62177
  }}
}}
'''Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B''', also known as '''SEMA3B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7869| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.<ref name="entrez">{{cite web | title = Entrez Gene: SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7869| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wei MH, Latif F, Bader S, Kashuba V, Chen JY, Duh FM, Sekido Y, Lee CC, Geil L, Kuzmin I, Zabarovsky E, Klein G, Zbar B, Minna JD, Lerman MI | title = Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG | journal = Cancer Research | volume = 56 | issue = 7 | pages = 1487–92 | date = April 1996 | pmid = 8603390 | doi =  }}
| citations =
* {{cite journal | vauthors = Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM | title = Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors | journal = Nature Neuroscience | volume = 1 | issue = 6 | pages = 487–93 | date = October 1998 | pmid = 10196546 | doi = 10.1038/2203 }}
*{{cite journal  | author=Püschel AW, Adams RH, Betz H |title=Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. |journal=Neuron |volume=14 |issue= 5 |pages= 941-8 |year= 1995 |pmid= 7748561 |doi=  }}
* {{cite journal | vauthors = Lerman MI, Minna JD | title = The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium | journal = Cancer Research | volume = 60 | issue = 21 | pages = 6116–33 | date = November 2000 | pmid = 11085536 | doi =  }}
*{{cite journal | author=Wei MH, Latif F, Bader S, ''et al.'' |title=Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG. |journal=Cancer Res. |volume=56 |issue= 7 |pages= 1487-92 |year= 1996 |pmid= 8603390 |doi=  }}
* {{cite journal | vauthors = Tomizawa Y, Sekido Y, Kondo M, Gao B, Yokota J, Roche J, Drabkin H, Lerman MI, Gazdar AF, Minna JD | title = Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 24 | pages = 13954–9 | date = November 2001 | pmid = 11717452 | pmc = 61148 | doi = 10.1073/pnas.231490898 }}
*{{cite journal | author=Sekido Y, Bader S, Latif F, ''et al.'' |title=Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 9 |pages= 4120-5 |year= 1996 |pmid= 8633026 |doi=  }}
* {{cite journal | vauthors = Tse C, Xiang RH, Bracht T, Naylor SL | title = Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line | journal = Cancer Research | volume = 62 | issue = 2 | pages = 542–6 | date = January 2002 | pmid = 11809707 | doi =  }}
*{{cite journal  | author=Takahashi T, Nakamura F, Jin Z, ''et al.'' |title=Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. |journal=Nat. Neurosci. |volume=1 |issue= 6 |pages= 487-93 |year= 1999 |pmid= 10196546 |doi= 10.1038/2203 }}
* {{cite journal | vauthors = Ochi K, Mori T, Toyama Y, Nakamura Y, Arakawa H | title = Identification of semaphorin3B as a direct target of p53 | journal = Neoplasia | volume = 4 | issue = 1 | pages = 82–7 | year = 2002 | pmid = 11922394 | pmc = 1503310 | doi = 10.1038/sj.neo.7900211}}
*{{cite journal | author=Lerman MI, Minna JD |title=The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. |journal=Cancer Res. |volume=60 |issue= 21 |pages= 6116-33 |year= 2000 |pmid= 11085536 |doi=  }}
* {{cite journal | vauthors = Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Williams NN, Kaiser LR, Croce CM | title = Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer | journal = Cancer Research | volume = 63 | issue = 12 | pages = 3352–5 | date = June 2003 | pmid = 12810670 | doi =  }}
*{{cite journal | author=Tomizawa Y, Sekido Y, Kondo M, ''et al.'' |title=Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 24 |pages= 13954-9 |year= 2002 |pmid= 11717452 |doi= 10.1073/pnas.231490898 }}
* {{cite journal | vauthors = Castro-Rivera E, Ran S, Thorpe P, Minna JD | title = Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 31 | pages = 11432–7 | date = August 2004 | pmid = 15273288 | pmc = 509218 | doi = 10.1073/pnas.0403969101 }}
*{{cite journal | author=Tse C, Xiang RH, Bracht T, Naylor SL |title=Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. |journal=Cancer Res. |volume=62 |issue= 2 |pages= 542-6 |year= 2002 |pmid= 11809707 |doi=  }}
* {{cite journal | vauthors = Marsit CJ, Wiencke JK, Liu M, Kelsey KT | title = The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans | journal = Carcinogenesis | volume = 26 | issue = 8 | pages = 1446–9 | date = August 2005 | pmid = 15831529 | doi = 10.1093/carcin/bgi098 }}
*{{cite journal | author=Ochi K, Mori T, Toyama Y, ''et al.'' |title=Identification of semaphorin3B as a direct target of p53. |journal=Neoplasia |volume=4 |issue= 1 |pages= 82-7 |year= 2002 |pmid= 11922394 |doi= 10.1038/sj/neo/7900211 }}
* {{cite journal | vauthors = Nair PN, McArdle L, Cornell J, Cohn SL, Stallings RL | title = High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene | journal = Cancer Genetics and Cytogenetics | volume = 174 | issue = 2 | pages = 100–10 | date = April 2007 | pmid = 17452250 | doi = 10.1016/j.cancergencyto.2006.11.017 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Kuroki T, Trapasso F, Yendamuri S, ''et al.'' |title=Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer. |journal=Cancer Res. |volume=63 |issue= 12 |pages= 3352-5 |year= 2003 |pmid= 12810670 |doi=  }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Castro-Rivera E, Ran S, Thorpe P, Minna JD |title=Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 31 |pages= 11432-7 |year= 2004 |pmid= 15273288 |doi= 10.1073/pnas.0403969101 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Marsit CJ, Wiencke JK, Liu M, Kelsey KT |title=The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans. |journal=Carcinogenesis |volume=26 |issue= 8 |pages= 1446-9 |year= 2005 |pmid= 15831529 |doi= 10.1093/carcin/bgi098 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Nair PN, McArdle L, Cornell J, ''et al.'' |title=High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene. |journal=Cancer Genet. Cytogenet. |volume=174 |issue= 2 |pages= 100-10 |year= 2007 |pmid= 17452250 |doi= 10.1016/j.cancergencyto.2006.11.017 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
 
{{gene-3-stub}}

Latest revision as of 16:18, 16 February 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Semaphorin-3B is a protein that in humans is encoded by the SEMA3B gene.[1][2][3]

Function

The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.[3]

References

  1. ↑ Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
  2. ↑ Sekido Y, Bader S, Latif F, Chen JY, Duh FM, Wei MH, Albanesi JP, Lee CC, Lerman MI, Minna JD (April 1996). "Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns". Proceedings of the National Academy of Sciences of the United States of America. 93 (9): 4120–5. doi:10.1073/pnas.93.9.4120. PMC 39497. PMID 8633026.
  3. ↑ 3.0 3.1 "Entrez Gene: SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B".

Further reading

  • Wei MH, Latif F, Bader S, Kashuba V, Chen JY, Duh FM, Sekido Y, Lee CC, Geil L, Kuzmin I, Zabarovsky E, Klein G, Zbar B, Minna JD, Lerman MI (April 1996). "Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG". Cancer Research. 56 (7): 1487–92. PMID 8603390.
  • Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM (October 1998). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nature Neuroscience. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.
  • Lerman MI, Minna JD (November 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–33. PMID 11085536.
  • Tomizawa Y, Sekido Y, Kondo M, Gao B, Yokota J, Roche J, Drabkin H, Lerman MI, Gazdar AF, Minna JD (November 2001). "Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B". Proceedings of the National Academy of Sciences of the United States of America. 98 (24): 13954–9. doi:10.1073/pnas.231490898. PMC 61148. PMID 11717452.
  • Tse C, Xiang RH, Bracht T, Naylor SL (January 2002). "Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line". Cancer Research. 62 (2): 542–6. PMID 11809707.
  • Ochi K, Mori T, Toyama Y, Nakamura Y, Arakawa H (2002). "Identification of semaphorin3B as a direct target of p53". Neoplasia. 4 (1): 82–7. doi:10.1038/sj.neo.7900211. PMC 1503310. PMID 11922394.
  • Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Williams NN, Kaiser LR, Croce CM (June 2003). "Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer". Cancer Research. 63 (12): 3352–5. PMID 12810670.
  • Castro-Rivera E, Ran S, Thorpe P, Minna JD (August 2004). "Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect". Proceedings of the National Academy of Sciences of the United States of America. 101 (31): 11432–7. doi:10.1073/pnas.0403969101. PMC 509218. PMID 15273288.
  • Marsit CJ, Wiencke JK, Liu M, Kelsey KT (August 2005). "The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans". Carcinogenesis. 26 (8): 1446–9. doi:10.1093/carcin/bgi098. PMID 15831529.
  • Nair PN, McArdle L, Cornell J, Cohn SL, Stallings RL (April 2007). "High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene". Cancer Genetics and Cytogenetics. 174 (2): 100–10. doi:10.1016/j.cancergencyto.2006.11.017. PMID 17452250.


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