EIF2A: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Eukaryotic translation initiation factor 2A''' is a [[protein]] that in humans is encoded by the ''EIF2A'' [[gene]].<ref name="pmid12133843">{{cite journal | vauthors = Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC | title = Characterization of mammalian eIF2A and identification of the yeast homolog | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37079–87 | date = Oct 2002 | pmid = 12133843 | pmc =  | doi = 10.1074/jbc.M207109200 }}</ref><ref name="pmid1620067">{{cite journal | vauthors = Merrick WC | title = Mechanism and regulation of eukaryotic protein synthesis | journal = Microbiological Reviews | volume = 56 | issue = 2 | pages = 291–315 | date = Jun 1992 | pmid = 1620067 | pmc = 372869 | doi =  }}</ref><ref name="entrez"/>
'''Eukaryotic translation initiation factor 2A''' ('''eIF2A''') is a [[protein]] that in humans is encoded by the ''EIF2A'' [[gene]].<ref name="pmid12133843">{{cite journal | vauthors = Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC | title = Characterization of mammalian eIF2A and identification of the yeast homolog | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37079–87 | date = Oct 2002 | pmid = 12133843 | pmc =  | doi = 10.1074/jbc.M207109200 }}</ref><ref name="pmid1620067">{{cite journal | vauthors = Merrick WC | title = Mechanism and regulation of eukaryotic protein synthesis | journal = Microbiological Reviews | volume = 56 | issue = 2 | pages = 291–315 | date = Jun 1992 | pmid = 1620067 | pmc = 372869 | doi =  }}</ref><ref name="entrez"/> The eIF2A protein is not to be confused with [[EIF2S1|eIF2α]], a subunit of the heterotrimeric [[eIF2]] complex. Instead, eIF2A functions by a separate mechanism in [[eukaryotic translation]].


== Function ==
== Function ==


EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83939| accessdate = }}</ref> It has been shown to be important for translation initiation mediated by the [[HCV IRES]] under stress conditions by binding to the IRES domain IIId and Met-tRNA<sub>i</sub><sup>Met</sup>.<ref name="pmid21556050">{{cite journal | vauthors = Kim JH, Park SM, Park JH, Keum SJ, Jang SK | title = eIF2A mediates translation of hepatitis C viral mRNA under stress conditions | journal = The EMBO Journal | volume = 30 | issue = 12 | pages = 2454–64 | date = Jun 2011 | pmid = 21556050 | pmc =  3116280| doi = 10.1038/emboj.2011.146 }}</ref>
eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83939| accessdate = }}</ref> It may be important for translation initiation mediated by the [[HCV IRES]] under stress conditions, but this result has been debated.<ref name="pmid21556050">{{cite journal | vauthors = Kim JH, Park SM, Park JH, Keum SJ, Jang SK | title = eIF2A mediates translation of hepatitis C viral mRNA under stress conditions | journal = The EMBO Journal | volume = 30 | issue = 12 | pages = 2454–64 | date = Jun 2011 | pmid = 21556050 | pmc =  3116280| doi = 10.1038/emboj.2011.146 }}</ref><ref name="Jaafar Oguro Nakamura Kieft p. ">{{cite journal | vauthors = Jaafar ZA, Oguro A, Nakamura Y, Kieft JS | title = Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling | journal = eLife | volume = 5 | pages = e21198 | date = December 2016 | pmid = 28009256 | doi = 10.7554/elife.21198 }}</ref>  


== See also ==
== See also ==

Latest revision as of 09:13, 3 January 2018

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SpeciesHumanMouse
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Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene.[1][2][3] The eIF2A protein is not to be confused with eIF2α, a subunit of the heterotrimeric eIF2 complex. Instead, eIF2A functions by a separate mechanism in eukaryotic translation.

Function

eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM][3] It may be important for translation initiation mediated by the HCV IRES under stress conditions, but this result has been debated.[4][5]

See also

References

  1. ↑ Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC (Oct 2002). "Characterization of mammalian eIF2A and identification of the yeast homolog". The Journal of Biological Chemistry. 277 (40): 37079–87. doi:10.1074/jbc.M207109200. PMID 12133843.
  2. ↑ Merrick WC (Jun 1992). "Mechanism and regulation of eukaryotic protein synthesis". Microbiological Reviews. 56 (2): 291–315. PMC 372869. PMID 1620067.
  3. ↑ 3.0 3.1 "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa".
  4. ↑ Kim JH, Park SM, Park JH, Keum SJ, Jang SK (Jun 2011). "eIF2A mediates translation of hepatitis C viral mRNA under stress conditions". The EMBO Journal. 30 (12): 2454–64. doi:10.1038/emboj.2011.146. PMC 3116280. PMID 21556050.
  5. ↑ Jaafar ZA, Oguro A, Nakamura Y, Kieft JS (December 2016). "Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling". eLife. 5: e21198. doi:10.7554/elife.21198. PMID 28009256.

Further reading


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