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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Serine/threonine-protein kinase OSR1''' is an [[enzyme]] that in humans is encoded by the ''OXSR1'' [[gene]].<ref name="pmid10083736">{{cite journal | vauthors = Tamari M, Daigo Y, Nakamura Y | title = Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3 | journal = J Hum Genet | volume = 44 | issue = 2 | pages = 116–20 |date=Apr 1999 | pmid = 10083736 | pmc =  | doi = 10.1007/s100380050121 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OXSR1 oxidative-stress responsive 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9943| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Oxidative-stress responsive 1
| HGNCid = 8508
| Symbol = OXSR1
| AltSymbols =; KIAA1101; OSR1
| OMIM = 604046
| ECnumber = 
| Homologene = 31288
| MGIid = 1917378
| GeneAtlas_image1 = PBB_GE_OXSR1_202696_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9943
    | Hs_Ensembl = ENSG00000172939
    | Hs_RefseqProtein = NP_005100
    | Hs_RefseqmRNA = NM_005109
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 38182030
    | Hs_GenLoc_end = 38271983
    | Hs_Uniprot = O95747
    | Mm_EntrezGene = 108737
    | Mm_Ensembl = ENSMUSG00000036737
    | Mm_RefseqmRNA = XM_135264
    | Mm_RefseqProtein = XP_135264
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 119087139
    | Mm_GenLoc_end = 119171108
    | Mm_Uniprot = Q6ZPX7
  }}
}}
'''Oxidative-stress responsive 1''', also known as '''OXSR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OXSR1 oxidative-stress responsive 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9943| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.<ref name="entrez">{{cite web | title = Entrez Gene: OXSR1 oxidative-stress responsive 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9943| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the Ser/Thr protein kinase family of [[proteins]]. It regulates downstream [[kinases]] in response to environmental stress, and may play a role in regulating the [[actin cytoskeleton]].<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Tamari M, Daigo Y, Nakamura Y |title=Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. |journal=J. Hum. Genet. |volume=44 |issue= 2 |pages= 116-20 |year= 1999 |pmid= 10083736 |doi=  }}
*{{cite journal   |vauthors=Daigo Y, Isomura M, Nishiwaki T, etal |title=Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3. |journal=DNA Res. |volume=6 |issue= 1 |pages= 37–44 |year= 1999 |pmid= 10231028 |doi=10.1093/dnares/6.1.37 }}
*{{cite journal  | author=Daigo Y, Isomura M, Nishiwaki T, ''et al.'' |title=Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3. |journal=DNA Res. |volume=6 |issue= 1 |pages= 37-44 |year= 1999 |pmid= 10231028 |doi=  }}
*{{cite journal   |vauthors=Kikuno R, Nagase T, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 }}
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi=  }}
*{{cite journal  | vauthors=Piechotta K, Lu J, Delpire E |title=Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50812–9 |year= 2003 |pmid= 12386165 |doi= 10.1074/jbc.M208108200 }}
*{{cite journal  | author=Piechotta K, Lu J, Delpire E |title=Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50812-9 |year= 2003 |pmid= 12386165 |doi= 10.1074/jbc.M208108200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Chen W, Yazicioglu M, Cobb MH |title=Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11129–36 |year= 2004 |pmid= 14707132 |doi= 10.1074/jbc.M313562200 }}
*{{cite journal  | author=Chen W, Yazicioglu M, Cobb MH |title=Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11129-36 |year= 2004 |pmid= 14707132 |doi= 10.1074/jbc.M313562200 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Ballif BA, Villén J, Beausoleil SA, etal |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal   |vauthors=Moriguchi T, Urushiyama S, Hisamoto N, etal |title=WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42685–93 |year= 2006 |pmid= 16263722 |doi= 10.1074/jbc.M510042200 }}
*{{cite journal | author=Moriguchi T, Urushiyama S, Hisamoto N, ''et al.'' |title=WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42685-93 |year= 2006 |pmid= 16263722 |doi= 10.1074/jbc.M510042200 }}
*{{cite journal   |vauthors=Cusick JK, Xu LG, Bin LH, etal |title=Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. |journal=Biochem. Biophys. Res. Commun. |volume=340 |issue= 2 |pages= 535–43 |year= 2006 |pmid= 16389068 |doi= 10.1016/j.bbrc.2005.12.033 }}
*{{cite journal | author=Cusick JK, Xu LG, Bin LH, ''et al.'' |title=Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. |journal=Biochem. Biophys. Res. Commun. |volume=340 |issue= 2 |pages= 535-43 |year= 2006 |pmid= 16389068 |doi= 10.1016/j.bbrc.2005.12.033 }}
*{{cite journal   |vauthors=Vitari AC, Thastrup J, Rafiqi FH, etal |title=Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. |journal=Biochem. J. |volume=397 |issue= 1 |pages= 223–31 |year= 2006 |pmid= 16669787 |doi= 10.1042/BJ20060220 | pmc=1479760 }}
*{{cite journal | author=Vitari AC, Thastrup J, Rafiqi FH, ''et al.'' |title=Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. |journal=Biochem. J. |volume=397 |issue= 1 |pages= 223-31 |year= 2006 |pmid= 16669787 |doi= 10.1042/BJ20060220 }}
*{{cite journal   |vauthors=Anselmo AN, Earnest S, Chen W, etal |title=WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 29 |pages= 10883–8 |year= 2006 |pmid= 16832045 |doi= 10.1073/pnas.0604607103 | pmc=1544143 }}
*{{cite journal | author=Anselmo AN, Earnest S, Chen W, ''et al.'' |title=WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 29 |pages= 10883-8 |year= 2006 |pmid= 16832045 |doi= 10.1073/pnas.0604607103 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal   |vauthors=Villa F, Goebel J, Rafiqi FH, etal |title=Structural insights into the recognition of substrates and activators by the OSR1 kinase. |journal=EMBO Rep. |volume=8 |issue= 9 |pages= 839–45 |year= 2007 |pmid= 17721439 |doi= 10.1038/sj.embor.7401048 | pmc=1973955 }}
*{{cite journal | author=Villa F, Goebel J, Rafiqi FH, ''et al.'' |title=Structural insights into the recognition of substrates and activators by the OSR1 kinase. |journal=EMBO Rep. |volume=8 |issue= 9 |pages= 839-45 |year= 2007 |pmid= 17721439 |doi= 10.1038/sj.embor.7401048 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-3-stub}}

Latest revision as of 14:29, 14 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the OXSR1 gene.[1][2]

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.[2]

References

  1. ↑ Tamari M, Daigo Y, Nakamura Y (Apr 1999). "Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3". J Hum Genet. 44 (2): 116–20. doi:10.1007/s100380050121. PMID 10083736.
  2. ↑ 2.0 2.1 "Entrez Gene: OXSR1 oxidative-stress responsive 1".

Further reading



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