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{{Infobox_gene}}
{{PBB_Controls
'''T-complex protein 1 subunit epsilon''' is a [[protein]] that in humans is encoded by the ''CCT5'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCT5 chaperonin containing TCP1, subunit 5 (epsilon)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22948| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chaperonin containing TCP1, subunit 5 (epsilon)
| HGNCid = 1618
| Symbol = CCT5
| AltSymbols =; CCT-epsilon; CCTE; KIAA0098; TCP-1-epsilon
| OMIM = 610150
| ECnumber = 
| Homologene = 6287
| MGIid = 107185
| GeneAtlas_image1 = PBB_GE_CCT5_208696_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005832 |text = chaperonin-containing T-complex}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22948
    | Hs_Ensembl = ENSG00000150753
    | Hs_RefseqProtein = NP_036205
    | Hs_RefseqmRNA = NM_012073
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 10303282
    | Hs_GenLoc_end = 10319501
    | Hs_Uniprot = P48643
    | Mm_EntrezGene = 12465
    | Mm_Ensembl = ENSMUSG00000022234
    | Mm_RefseqmRNA = NM_007637
    | Mm_RefseqProtein = NP_031663
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 31535404
    | Mm_GenLoc_end = 31546350
    | Mm_Uniprot = Q3TIE0
  }}
}}
'''Chaperonin containing TCP1, subunit 5 (epsilon)''', also known as '''CCT5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCT5 chaperonin containing TCP1, subunit 5 (epsilon)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22948| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez">{{cite web | title = Entrez Gene: CCT5 chaperonin containing TCP1, subunit 5 (epsilon)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22948| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CCT5 (gene) has been shown to [[Protein-protein interaction|interact]] with [[PPP4C]].<ref name=pmid18715871>{{cite journal | vauthors = Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC | title = PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 43 | pages = 29273–84 | date = Oct 2008 | pmid = 18715871 | pmc = 2662017 | doi = 10.1074/jbc.M803443200 }}</ref><ref name=pmid16085932>{{cite journal | vauthors = Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R | title = A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 11 | pages = 1725–40 | date = Nov 2005 | pmid = 16085932 | doi = 10.1074/mcp.M500231-MCP200 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
==External links==
* {{UCSC gene info|CCT5}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Roobol A, Holmes FE, Hayes NV, Baines AJ, Carden MJ | title = Cytoplasmic chaperonin complexes enter neurites developing in vitro and differ in subunit composition within single cells | journal = Journal of Cell Science | volume = 108 | issue = 4 | pages = 1477–88  | date = Apr 1995 | pmid = 7615668 | doi =  }}
| citations =
* {{cite journal | vauthors = Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H | title = Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 1 | pages = 37–43 | year = 1995 | pmid = 7788527 | doi = 10.1093/dnares/2.1.37 }}
*{{cite journal | author=Roobol A, Holmes FE, Hayes NV, ''et al.'' |title=Cytoplasmic chaperonin complexes enter neurites developing in vitro and differ in subunit composition within single cells. |journal=J. Cell. Sci. |volume=108 ( Pt 4) |issue= |pages= 1477-88 |year= 1995 |pmid= 7615668 |doi=  }}
* {{cite journal | vauthors = Kubota H, Hynes G, Carne A, Ashworth A, Willison K | title = Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin | journal = Current Biology | volume = 4 | issue = 2 | pages = 89–99  | date = Feb 1994 | pmid = 7953530 | doi = 10.1016/S0960-9822(94)00024-2 }}
*{{cite journal | author=Nagase T, Miyajima N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 1 |pages= 37-43 |year= 1995 |pmid= 7788527 |doi= }}
* {{cite journal | vauthors = Liou AK, Willison KR | title = Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes | journal = The EMBO Journal | volume = 16 | issue = 14 | pages = 4311–6  | date = Jul 1997 | pmid = 9250675 | pmc = 1170057 | doi = 10.1093/emboj/16.14.4311 }}
*{{cite journal | author=Kubota H, Hynes G, Carne A, ''et al.'' |title=Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. |journal=Curr. Biol. |volume=4 |issue= 2 |pages= 89-99 |year= 1994 |pmid= 7953530 |doi= }}
* {{cite journal | vauthors = Roperch JP, Lethrone F, Prieur S, Piouffre L, Israeli D, Tuynder M, Nemani M, Pasturaud P, Gendron MC, Dausset J, Oren M, Amson RB, Telerman A | title = SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 14 | pages = 8070–3  | date = Jul 1999 | pmid = 10393949 | pmc = 22189 | doi = 10.1073/pnas.96.14.8070 }}
*{{cite journal | author=Liou AK, Willison KR |title=Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes. |journal=EMBO J. |volume=16 |issue= 14 |pages= 4311-6 |year= 1997 |pmid= 9250675 |doi= }}
* {{cite journal | vauthors = Yanaka N, Kobayashi K, Wakimoto K, Yamada E, Imahie H, Imai Y, Mori C | title = Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis | journal = The Journal of Biological Chemistry | volume = 275 | issue = 20 | pages = 14791–4  | date = May 2000 | pmid = 10747865 | doi = 10.1074/jbc.C901047199 }}
*{{cite journal | author=Roperch JP, Lethrone F, Prieur S, ''et al.'' |title=SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 14 |pages= 8070-3 |year= 1999 |pmid= 10393949 |doi= }}
* {{cite journal | vauthors = Yoo BC, Kim SH, Cairns N, Fountoulakis M, Lubec G | title = Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease | journal = Biochemical and Biophysical Research Communications | volume = 280 | issue = 1 | pages = 249–58  | date = Jan 2001 | pmid = 11162507 | doi = 10.1006/bbrc.2000.4109 }}
*{{cite journal | author=Yanaka N, Kobayashi K, Wakimoto K, ''et al.'' |title=Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 14791-4 |year= 2000 |pmid= 10747865 |doi= 10.1074/jbc.C901047199 }}
* {{cite journal | vauthors = Yoo BC, Vlkolinsky R, Engidawork E, Cairns N, Fountoulakis M, Lubec G | title = Differential expression of molecular chaperones in brain of patients with Down syndrome | journal = Electrophoresis | volume = 22 | issue = 6 | pages = 1233–41  | date = Apr 2001 | pmid = 11358150 | doi = 10.1002/1522-2683()22:6<1233::AID-ELPS1233>3.0.CO;2-M }}
*{{cite journal | author=Yoo BC, Kim SH, Cairns N, ''et al.'' |title=Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 1 |pages= 249-58 |year= 2001 |pmid= 11162507 |doi= 10.1006/bbrc.2000.4109 }}
* {{cite journal | vauthors = Yokota S, Yanagi H, Yura T, Kubota H | title = Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle | journal = European Journal of Biochemistry / FEBS | volume = 268 | issue = 17 | pages = 4664–73  | date = Sep 2001 | pmid = 11532003 | doi = 10.1046/j.1432-1327.2001.02393.x }}
*{{cite journal | author=Yoo BC, Vlkolinsky R, Engidawork E, ''et al.'' |title=Differential expression of molecular chaperones in brain of patients with Down syndrome. |journal=Electrophoresis |volume=22 |issue= 6 |pages= 1233-41 |year= 2001 |pmid= 11358150 |doi= 10.1002/1522-2683()22:6<1233::AID-ELPS1233>3.0.CO;2-M }}
* {{cite journal | vauthors = McCormack EA, Llorca O, Carrascosa JL, Valpuesta JM, Willison KR | title = Point mutations in a hinge linking the small and large domains of beta-actin result in trapped folding intermediates bound to cytosolic chaperonin CCT | journal = Journal of Structural Biology | volume = 135 | issue = 2 | pages = 198–204 | year = 2002 | date = Aug 2001 | pmid = 11580269 | doi = 10.1006/jsbi.2001.4385 }}
*{{cite journal | author=Yokota S, Yanagi H, Yura T, Kubota H |title=Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. |journal=Eur. J. Biochem. |volume=268 |issue= 17 |pages= 4664-73 |year= 2001 |pmid= 11532003 |doi= }}
* {{cite journal | vauthors = Llorca O, Martín-Benito J, Gómez-Puertas P, Ritco-Vonsovici M, Willison KR, Carrascosa JL, Valpuesta JM | title = Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin | journal = Journal of Structural Biology | volume = 135 | issue = 2 | pages = 205–18 | year = 2002 | date = Aug 2001 | pmid = 11580270 | doi = 10.1006/jsbi.2001.4359 }}
*{{cite journal | author=McCormack EA, Llorca O, Carrascosa JL, ''et al.'' |title=Point mutations in a hinge linking the small and large domains of beta-actin result in trapped folding intermediates bound to cytosolic chaperonin CCT. |journal=J. Struct. Biol. |volume=135 |issue= 2 |pages= 198-204 |year= 2002 |pmid= 11580269 |doi= 10.1006/jsbi.2001.4385 }}
* {{cite journal | vauthors = Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA | title = Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex | journal = Genes & Development | volume = 16 | issue = 24 | pages = 3130–5 | year = 2003 | date = Dec 2002 | pmid = 12502735 | pmc = 187500 | doi = 10.1101/gad.1037502 }}
*{{cite journal | author=Llorca O, Martín-Benito J, Gómez-Puertas P, ''et al.'' |title=Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin. |journal=J. Struct. Biol. |volume=135 |issue= 2 |pages= 205-18 |year= 2002 |pmid= 11580270 |doi= 10.1006/jsbi.2001.4359 }}
* {{cite journal | vauthors = Ludwig A, Dietel M, Lage H | title = Identification of differentially expressed genes in classical and atypical multidrug-resistant gastric carcinoma cells | journal = Anticancer Research | volume = 22 | issue = 6A | pages = 3213–21 | year = 2003 | pmid = 12530067 | doi = }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R | title = A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51901–10 | year = 2004 | date = Dec 2003 | pmid = 14532270 | doi = 10.1074/jbc.M309655200 }}
*{{cite journal | author=Guenther MG, Yu J, Kao GD, ''et al.'' |title=Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. |journal=Genes Dev. |volume=16 |issue= 24 |pages= 3130-5 |year= 2003 |pmid= 12502735 |doi= 10.1101/gad.1037502 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23  | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
*{{cite journal | author=Ludwig A, Dietel M, Lage H |title=Identification of differentially expressed genes in classical and atypical multidrug-resistant gastric carcinoma cells. |journal=Anticancer Res. |volume=22 |issue= 6A |pages= 3213-21 |year= 2003 |pmid= 12530067 |doi= }}
* {{cite journal | vauthors = Lukov GL, Hu T, McLaughlin JN, Hamm HE, Willardson BM | title = Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly | journal = The EMBO Journal | volume = 24 | issue = 11 | pages = 1965–75  | date = Jun 2005 | pmid = 15889144 | pmc = 1142607 | doi = 10.1038/sj.emboj.7600673 }}
*{{cite journal | author=Imai Y, Soda M, Murakami T, ''et al.'' |title=A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51901-10 |year= 2004 |pmid= 14532270 |doi= 10.1074/jbc.M309655200 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68  | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Lukov GL, Hu T, McLaughlin JN, ''et al.'' |title=Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly. |journal=EMBO J. |volume=24 |issue= 11 |pages= 1965-75 |year= 2005 |pmid= 15889144 |doi= 10.1038/sj.emboj.7600673 }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:17, 25 April 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

T-complex protein 1 subunit epsilon is a protein that in humans is encoded by the CCT5 gene.[1]

Function

This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[1]

Interactions

CCT5 (gene) has been shown to interact with PPP4C.[2][3]

References

  1. ↑ 1.0 1.1 "Entrez Gene: CCT5 chaperonin containing TCP1, subunit 5 (epsilon)".
  2. ↑ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  3. ↑ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

External links

Further reading


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