SEMA5A: Difference between revisions
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'''Semaphorin-5A''' is a [[protein]] that in humans is encoded by the ''SEMA5A'' [[gene]].<ref name="pmid8817451">{{cite journal | vauthors = Adams RH, Betz H, Puschel AW | title = A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis | journal = Mech Dev | volume = 57 | issue = 1 | pages = 33–45 |date=Feb 1997 | pmid = 8817451 | pmc = | doi =10.1016/0925-4773(96)00525-4 }}</ref><ref name="pmid9464278">{{cite journal | vauthors = Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M | title = Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval | journal = Biochem Biophys Res Commun | volume = 242 | issue = 3 | pages = 685–91 |date=Mar 1998 | pmid = 9464278 | pmc = | doi = 10.1006/bbrc.1997.8027 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9037| accessdate = }}</ref> | '''Semaphorin-5A''' is a [[protein]] that in humans is encoded by the ''SEMA5A'' [[gene]].<ref name="pmid8817451">{{cite journal | vauthors = Adams RH, Betz H, Puschel AW | title = A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis | journal = Mech Dev | volume = 57 | issue = 1 | pages = 33–45 |date=Feb 1997 | pmid = 8817451 | pmc = | doi =10.1016/0925-4773(96)00525-4 }}</ref><ref name="pmid9464278">{{cite journal | vauthors = Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M | title = Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval | journal = Biochem Biophys Res Commun | volume = 242 | issue = 3 | pages = 685–91 |date=Mar 1998 | pmid = 9464278 | pmc = | doi = 10.1006/bbrc.1997.8027 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9037| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9037| accessdate = }}</ref> | | summary_text = Members of the semaphorin protein family, such as SEMA5A, are involved in [[axonal guidance]] during [[neural development]] (Adams et al., 1996).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9037| accessdate = }}</ref> | ||
}} | }} | ||
Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016). | Semaphorine 5A also plays a role in [[autism]], reducing the ability of [[neurons]] to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016). | ||
==References== | ==References== | ||
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*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} | *{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} | ||
*{{cite journal |vauthors=Melin M, Carlsson B, Anckarsater H, etal |title=Constitutional downregulation of SEMA5A expression in autism. |journal=Neuropsychobiology |volume=54 |issue= 1 |pages= 64–9 |year= 2007 |pmid= 17028446 |doi= 10.1159/000096040 | pmc=2553518 }} | *{{cite journal |vauthors=Melin M, Carlsson B, Anckarsater H, etal |title=Constitutional downregulation of SEMA5A expression in autism. |journal=Neuropsychobiology |volume=54 |issue= 1 |pages= 64–9 |year= 2007 |pmid= 17028446 |doi= 10.1159/000096040 | pmc=2553518 |url=http://www.hal.inserm.fr/inserm-00124743/document }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
Latest revision as of 13:24, 4 November 2018
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Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.[1][2][3]
Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM][3]
Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016).
References
- ↑ Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev. 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451.
- ↑ Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
- ↑ 3.0 3.1 "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Simmons AD, Overhauser J, Lovett M (1997). "Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library". Genome Res. 7 (2): 118–27. doi:10.1101/gr.7.2.118. PMID 9049630.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Artigiani S, Conrotto P, Fazzari P, et al. (2005). "Plexin-B3 is a functional receptor for semaphorin 5A". EMBO Rep. 5 (7): 710–4. doi:10.1038/sj.embor.7400189. PMC 1299100. PMID 15218527.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Melin M, Carlsson B, Anckarsater H, et al. (2007). "Constitutional downregulation of SEMA5A expression in autism". Neuropsychobiology. 54 (1): 64–9. doi:10.1159/000096040. PMC 2553518. PMID 17028446.
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