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{{Infobox_gene}}
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'''Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1''' is an [[enzyme]].  In [[human]]s, it is encoded by the '''''NDST1''''' [[gene]].<ref name="pmid7601448">{{cite journal | vauthors = Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ | title = Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1 | journal = Genomics | volume = 26 | issue = 2 | pages = 239–44 |date=Aug 1995 | pmid = 7601448 | pmc =  | doi =10.1016/0888-7543(95)80206-2 }}</ref><ref name="pmid9230113">{{cite journal | vauthors = Humphries DE, Sullivan BM, Aleixo MD, Stow JL | title = Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network | series = 325 | journal = Biochem J | volume = ( Pt 2) | issue =  | pages = 351–7 |date=Aug 1997 | pmid = 9230113 | pmc = 1218567 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3340| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_NDST1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nst.
| PDB = {{PDB2|1nst}}
| Name = N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
| HGNCid = 7680
| Symbol = NDST1
| AltSymbols =; HSST; NST1
| OMIM = 600853
| ECnumber =
| Homologene = 20386
| MGIid = 104719
  | GeneAtlas_image1 = PBB_GE_NDST1_202608_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0015016 |text = [heparan sulfate]-glucosamine N-sulfotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006476 |text = protein amino acid deacetylation}} {{GNF_GO|id=GO:0006477 |text = protein amino acid sulfation}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0015012 |text = heparan sulfate proteoglycan biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3340
    | Hs_Ensembl = ENSG00000070614
    | Hs_RefseqProtein = NP_001534
    | Hs_RefseqmRNA = NM_001543
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 149867947
    | Hs_GenLoc_end = 149913642
    | Hs_Uniprot = P52848
    | Mm_EntrezGene = 15531
    | Mm_Ensembl = ENSMUSG00000054008
    | Mm_RefseqmRNA = NM_008306
    | Mm_RefseqProtein = NP_032332
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 60811332
    | Mm_GenLoc_end = 60838758
    | Mm_Uniprot = Q3UHN9
  }}
}}
'''N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1''', also known as '''NDST1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3340| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal | author=Dixon J, Loftus SK, Gladwin AJ, ''et al.'' |title=Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1. |journal=Genomics |volume=26 |issue= 2 |pages= 239-44 |year= 1995 |pmid= 7601448 |doi=  }}
*{{cite journal   |vauthors=Sueyoshi T, Kakuta Y, Pedersen LC, etal |title=A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase. |journal=FEBS Lett. |volume=433 |issue= 3 |pages= 211–4 |year= 1998 |pmid= 9744796 |doi=10.1016/S0014-5793(98)00913-2 }}
*{{cite journal  | author=Humphries DE, Sullivan BM, Aleixo MD, Stow JL |title=Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network. |journal=Biochem. J. |volume=325 ( Pt 2) |issue=  |pages= 351-7 |year= 1997 |pmid= 9230113 |doi=  }}
*{{cite journal  | vauthors=Aikawa J, Esko JD |title=Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 2690–5 |year= 1999 |pmid= 9915799 |doi=10.1074/jbc.274.5.2690 }}
*{{cite journal  | author=Sueyoshi T, Kakuta Y, Pedersen LC, ''et al.'' |title=A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase. |journal=FEBS Lett. |volume=433 |issue= 3 |pages= 211-4 |year= 1998 |pmid= 9744796 |doi=  }}
*{{cite journal  | vauthors=Kakuta Y, Sueyoshi T, Negishi M, Pedersen LC |title=Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 10673–6 |year= 1999 |pmid= 10196134 |doi=10.1074/jbc.274.16.10673 }}
*{{cite journal  | author=Aikawa J, Esko JD |title=Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 2690-5 |year= 1999 |pmid= 9915799 |doi=  }}
*{{cite journal  | vauthors=Pikas DS, Eriksson I, Kjellén L |title=Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns. |journal=Biochemistry |volume=39 |issue= 15 |pages= 4552–8 |year= 2000 |pmid= 10758005 |doi=10.1021/bi992524l }}
*{{cite journal  | author=Kakuta Y, Sueyoshi T, Negishi M, Pedersen LC |title=Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 10673-6 |year= 1999 |pmid= 10196134 |doi=  }}
*{{cite journal  | vauthors=Mura CV, Becker MI, Orellana A, Wolff D |title=Immunopurification of Golgi vesicles by magnetic sorting. |journal=J. Immunol. Methods |volume=260 |issue= 1-2 |pages= 263–71 |year= 2002 |pmid= 11792394 |doi=10.1016/S0022-1759(01)00546-4 }}
*{{cite journal  | author=Pikas DS, Eriksson I, Kjellén L |title=Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns. |journal=Biochemistry |volume=39 |issue= 15 |pages= 4552-8 |year= 2000 |pmid= 10758005 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Mura CV, Becker MI, Orellana A, Wolff D |title=Immunopurification of Golgi vesicles by magnetic sorting. |journal=J. Immunol. Methods |volume=260 |issue= 1-2 |pages= 263-71 |year= 2002 |pmid= 11792394 |doi=  }}
*{{cite journal  | vauthors=Bengtsson J, Eriksson I, Kjellén L |title=Distinct effects on heparan sulfate structure by different active site mutations in NDST-1. |journal=Biochemistry |volume=42 |issue= 7 |pages= 2110–5 |year= 2003 |pmid= 12590599 |doi= 10.1021/bi026928g }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=van den Born J, Pikas DS, Pisa BJ, etal |title=Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2. |journal=Glycobiology |volume=13 |issue= 1 |pages= 1–10 |year= 2003 |pmid= 12634318 |doi= 10.1093/glycob/cwg011 }}
*{{cite journal  | author=Bengtsson J, Eriksson I, Kjellén L |title=Distinct effects on heparan sulfate structure by different active site mutations in NDST-1. |journal=Biochemistry |volume=42 |issue= 7 |pages= 2110-5 |year= 2003 |pmid= 12590599 |doi= 10.1021/bi026928g }}
*{{cite journal   |vauthors=Nakayama K, Natori Y, Sato T, etal |title=Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis. |journal=J. Lab. Clin. Med. |volume=143 |issue= 2 |pages= 106–14 |year= 2004 |pmid= 14966466 |doi= 10.1016/j.lab.2003.10.012 }}
*{{cite journal | author=van den Born J, Pikas DS, Pisa BJ, ''et al.'' |title=Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2. |journal=Glycobiology |volume=13 |issue= 1 |pages= 1-10 |year= 2003 |pmid= 12634318 |doi= 10.1093/glycob/cwg011 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Nakayama K, Natori Y, Sato T, ''et al.'' |title=Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis. |journal=J. Lab. Clin. Med. |volume=143 |issue= 2 |pages= 106-14 |year= 2004 |pmid= 14966466 |doi= 10.1016/j.lab.2003.10.012 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3340}}
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[[Category:Human proteins]]


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Latest revision as of 00:54, 6 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.[1][2][3]


References

  1. ↑ Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ (Aug 1995). "Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1". Genomics. 26 (2): 239–44. doi:10.1016/0888-7543(95)80206-2. PMID 7601448.
  2. ↑ Humphries DE, Sullivan BM, Aleixo MD, Stow JL (Aug 1997). "Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network". Biochem J. 325. ( Pt 2): 351–7. PMC 1218567. PMID 9230113.
  3. ↑ "Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1".

Further reading


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