PDLIM7: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
imported>Citation bot
m (Removed parameters. You can use this bot yourself. Report bugs here. | User-activated.)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''PDZ and LIM domain protein 7''' is a [[protein]] that in humans is encoded by the ''PDLIM7'' [[gene]].<ref name="pmid11874232">{{cite journal |vauthors=Liu Y, Hair GA, Boden SD, Viggeswarapu M, Titus L | title = Overexpressed LIM mineralization proteins do not require LIM domains to induce bone | journal = J Bone Miner Res | volume = 17 | issue = 3 | pages = 406–14 |date=Mar 2002 | pmid = 11874232 | pmc =  | doi =10.1359/jbmr.2002.17.3.406  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDLIM7 PDZ and LIM domain 7 (enigma)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9260| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = PDZ and LIM domain 7 (enigma)
| HGNCid = 22958
| Symbol = PDLIM7
| AltSymbols =;
| OMIM = 605903
| ECnumber = 
| Homologene = 3980
| MGIid = 
| GeneAtlas_image1 = PBB_GE_PDLIM7_203370_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PDLIM7_203369_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PDLIM7_214266_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0001725 |text = stress fiber}} {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9260
    | Hs_Ensembl = ENSG00000196923
    | Hs_RefseqProtein = NP_005442
    | Hs_RefseqmRNA = NM_005451
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 176843001
    | Hs_GenLoc_end = 176857208
    | Hs_Uniprot = Q9NR12
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''PDZ and LIM domain 7 (enigma)''', also known as '''PDLIM7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDLIM7 PDZ and LIM domain 7 (enigma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9260| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: PDLIM7 PDZ and LIM domain 7 (enigma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9260| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein–protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.<ref name="entrez" />
}}
}}
==Interactions==
PDLIM7 has been shown to [[Protein–protein interaction|interact]] with [[TPM2]].<ref name=pmid10359609>{{cite journal |last=Guy |first=P M |authorlink= |author2=Kenny D A |author3=Gill G N  |date=Jun 1999 |title=The PDZ domain of the LIM protein enigma binds to beta-tropomyosin |journal=Mol. Biol. Cell |volume=10 |issue=6 |pages=1973–84 | issn = 1059-1524| pmid = 10359609 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=25398 | doi=10.1091/mbc.10.6.1973}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bach I |title=The LIM domain: regulation by association. |journal=Mech. Dev. |volume=91 |issue= 1-2 |pages= 5-17 |year= 2000 |pmid= 10704826 |doi=  }}
*{{cite journal  | author=Bach I |title=The LIM domain: regulation by association |journal=Mech. Dev. |volume=91 |issue= 1–2 |pages= 5–17 |year= 2000 |pmid= 10704826 |doi=10.1016/S0925-4773(99)00314-7 }}
*{{cite journal  | author=Wu RY, Gill GN |title=LIM domain recognition of a tyrosine-containing tight turn. |journal=J. Biol. Chem. |volume=269 |issue= 40 |pages= 25085-90 |year= 1994 |pmid= 7929196 |doi=  }}
*{{cite journal  |vauthors=Wu RY, Gill GN |title=LIM domain recognition of a tyrosine-containing tight turn |journal=J. Biol. Chem. |volume=269 |issue= 40 |pages= 25085–90 |year= 1994 |pmid= 7929196 |doi=  }}
*{{cite journal | author=Kuroda S, Tokunaga C, Kiyohara Y, ''et al.'' |title=Protein-protein interaction of zinc finger LIM domains with protein kinase C. |journal=J. Biol. Chem. |volume=271 |issue= 49 |pages= 31029-32 |year= 1997 |pmid= 8940095 |doi=  }}
*{{cite journal   |vauthors=Kuroda S, Tokunaga C, Kiyohara Y, etal |title=Protein-protein interaction of zinc finger LIM domains with protein kinase C |journal=J. Biol. Chem. |volume=271 |issue= 49 |pages= 31029–32 |year= 1997 |pmid= 8940095 |doi=10.1074/jbc.271.49.31029 }}
*{{cite journal  | author=Durick K, Gill GN, Taylor SS |title=Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. |journal=Mol. Cell. Biol. |volume=18 |issue= 4 |pages= 2298-308 |year= 1998 |pmid= 9528800 |doi=  }}
*{{cite journal  |vauthors=Durick K, Gill GN, Taylor SS |title=Shc and Enigma are both required for mitogenic signaling by Ret/ptc2 |journal=Mol. Cell. Biol. |volume=18 |issue= 4 |pages= 2298–308 |year= 1998 |pmid= 9528800 |doi= | pmc=121481 }}
*{{cite journal  | author=Guy PM, Kenny DA, Gill GN |title=The PDZ domain of the LIM protein enigma binds to beta-tropomyosin. |journal=Mol. Biol. Cell |volume=10 |issue= 6 |pages= 1973-84 |year= 1999 |pmid= 10359609 |doi=  }}
*{{cite journal  |vauthors=Guy PM, Kenny DA, Gill GN |title=The PDZ domain of the LIM protein enigma binds to beta-tropomyosin |journal=Mol. Biol. Cell |volume=10 |issue= 6 |pages= 1973–84 |year= 1999 |pmid= 10359609 |doi=  10.1091/mbc.10.6.1973| pmc=25398 }}
*{{cite journal  | author=Liu Y, Hair GA, Boden SD, ''et al.'' |title=Overexpressed LIM mineralization proteins do not require LIM domains to induce bone. |journal=J. Bone Miner. Res. |volume=17 |issue= 3 |pages= 406-14 |year= 2002 |pmid= 11874232 |doi=  }}
*{{cite journal   |vauthors=Borrello MG, Mercalli E, Perego C, etal |title=Differential interaction of Enigma protein with the two RET isoforms |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 3 |pages= 515–22 |year= 2002 |pmid= 12176011 |doi=10.1016/S0006-291X(02)00886-0 }}
*{{cite journal | author=Borrello MG, Mercalli E, Perego C, ''et al.'' |title=Differential interaction of Enigma protein with the two RET isoforms. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 3 |pages= 515-22 |year= 2002 |pmid= 12176011 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |bibcode=2005Natur.433...77A }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Sangadala S, Boden SD, Viggeswarapu M, etal |title=LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads |journal=J. Biol. Chem. |volume=281 |issue= 25 |pages= 17212–9 |year= 2006 |pmid= 16611643 |doi= 10.1074/jbc.M511013200 }}
*{{cite journal | author=Sangadala S, Boden SD, Viggeswarapu M, ''et al.'' |title=LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads. |journal=J. Biol. Chem. |volume=281 |issue= 25 |pages= 17212-9 |year= 2006 |pmid= 16611643 |doi= 10.1074/jbc.M511013200 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal   |vauthors=Barrès R, Grémeaux T, Gual P, etal |title=Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation |journal=Mol. Endocrinol. |volume=20 |issue= 11 |pages= 2864–75 |year= 2007 |pmid= 16803868 |doi= 10.1210/me.2005-0455 | pmc=1892539 }}
*{{cite journal | author=Barrès R, Grémeaux T, Gual P, ''et al.'' |title=Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation. |journal=Mol. Endocrinol. |volume=20 |issue= 11 |pages= 2864-75 |year= 2007 |pmid= 16803868 |doi= 10.1210/me.2005-0455 }}
*{{cite journal  |vauthors=Zhang DW, Li LW, Hu YY |title=A novel TAT fusion protein with osteoinductive activity |journal=Med. Hypotheses |volume=68 |issue= 5 |pages= 1009–11 |year= 2007 |pmid= 17126496 |doi= 10.1016/j.mehy.2006.09.057 }}
*{{cite journal  | author=Zhang DW, Li LW, Hu YY |title=A novel TAT fusion protein with osteoinductive activity. |journal=Med. Hypotheses |volume=68 |issue= 5 |pages= 1009-11 |year= 2007 |pmid= 17126496 |doi= 10.1016/j.mehy.2006.09.057 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{WikiDoc Sources}}
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-5-stub}}

Latest revision as of 13:36, 7 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

PDZ and LIM domain protein 7 is a protein that in humans is encoded by the PDLIM7 gene.[1][2]

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein–protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.[2]

Interactions

PDLIM7 has been shown to interact with TPM2.[3]

References

  1. ↑ Liu Y, Hair GA, Boden SD, Viggeswarapu M, Titus L (Mar 2002). "Overexpressed LIM mineralization proteins do not require LIM domains to induce bone". J Bone Miner Res. 17 (3): 406–14. doi:10.1359/jbmr.2002.17.3.406. PMID 11874232.
  2. ↑ 2.0 2.1 "Entrez Gene: PDLIM7 PDZ and LIM domain 7 (enigma)".
  3. ↑ Guy, P M; Kenny D A; Gill G N (Jun 1999). "The PDZ domain of the LIM protein enigma binds to beta-tropomyosin". Mol. Biol. Cell. 10 (6): 1973–84. doi:10.1091/mbc.10.6.1973. ISSN 1059-1524. PMC 25398. PMID 10359609.

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=PDLIM7&oldid=1532910"