AKAP12: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''A-kinase anchor protein 12''' is an [[enzyme]] that in humans is encoded by the ''AKAP12'' [[gene]].<ref name="pmid9000000">{{cite journal | vauthors = Nauert JB, Klauck TM, Langeberg LK, Scott JD | title = Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein | journal = Curr. Biol. | volume = 7 | issue = 1 | pages = 52–62  | date = Mar 1997 | pmid = 9000000 | pmc =  | doi = 10.1016/S0960-9822(06)00027-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKAP12 A kinase (PRKA) anchor protein (gravin) 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9590| accessdate = }}</ref>
'''A-kinase anchor protein 12, aka AKAP250,''' is an [[enzyme]] that in humans is encoded by the ''AKAP12'' [[gene]].<ref name="pmid9000000">{{cite journal | vauthors = Nauert JB, Klauck TM, Langeberg LK, Scott JD | title = Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein | journal = Curr. Biol. | volume = 7 | issue = 1 | pages = 52–62  | date = Mar 1997 | pmid = 9000000 | pmc =  | doi = 10.1016/S0960-9822(06)00027-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKAP12 A kinase (PRKA) anchor protein (gravin) 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9590| accessdate = }}</ref>


== Function ==
== Function ==

Latest revision as of 15:56, 24 December 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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Wikidata
View/Edit Human

A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene.[1][2]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinase A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[2]

Interactions

AKAP12 has been shown to interact with Beta-2 adrenergic receptor.[3][4]

References

  1. ↑ Nauert JB, Klauck TM, Langeberg LK, Scott JD (Mar 1997). "Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein". Curr. Biol. 7 (1): 52–62. doi:10.1016/S0960-9822(06)00027-3. PMID 9000000.
  2. ↑ 2.0 2.1 "Entrez Gene: AKAP12 A kinase (PRKA) anchor protein (gravin) 12".
  3. ↑ Fan G, Shumay E, Wang H, Malbon CC (Jun 2001). "The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization". J. Biol. Chem. 276 (26): 24005–14. doi:10.1074/jbc.M011199200. PMID 11309381.
  4. ↑ Shih M, Lin F, Scott JD, Wang HY, Malbon CC (Jan 1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin". J. Biol. Chem. 274 (3): 1588–95. doi:10.1074/jbc.274.3.1588. PMID 9880537.

External links

Further reading


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