TFB1M: Difference between revisions
Jump to navigation
Jump to search
m Bot: HTTP→HTTPS |
Humans |
||
| Line 1: | Line 1: | ||
{{Infobox_gene}} | {{Infobox_gene}} | ||
''' Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial''' is a mitochondrial [[enzyme]] that in | ''' Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial''' is a mitochondrial [[enzyme]] that in 12-Eiael mag ingay is encoded by the ''TFB1M'' [[gene]].<ref name="pmid10810093">{{cite journal |vauthors=Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Res | volume = 10 | issue = 5 | pages = 703–13 |date=Aug 2000 | pmid = 10810093 | pmc = 310876 | doi =10.1101/gr.10.5.703 }}</ref><ref name="pmid11809803">{{cite journal |vauthors=McCulloch V, Seidel-Rogol BL, Shadel GS | title = A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine | journal = Mol Cell Biol | volume = 22 | issue = 4 | pages = 1116–25 |date=Jan 2002 | pmid = 11809803 | pmc = 134642 | doi =10.1128/MCB.22.4.1116-1125.2002 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TFB1M transcription factor B1, mitochondrial| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51106| accessdate = }}</ref> | ||
TFB1M is a mitochondrial methyltransferase, which uses [[S-adenosyl methionine]] to dimethylate two highly conserved [[adenosine]] residues at the 3'-end of the mitochondrial [[12S rRNA]] thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.<ref name="pmid11809803"/><ref name="pmid12068295">{{cite journal |vauthors=Falkenberg M, Gaspari M, Rantanen A, etal |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 }}</ref><ref name="pmid19356719">{{cite journal |author1=Metodiev MD |author2=Lesko N |author3=Park CB |author4=Camara Y. |author5=Shi Y. |author6=Wibom R. |author7=Hultenby K. |author8=Gustafsson CM |author9=Larsson NG. | title = Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome | journal = Cell Metab. | volume = 9 | issue = 4 | pages = 386–97 |date=Apr 2009 | pmid = 19356719 | doi =10.1016/j.cmet.2009.03.001}}</ref> | TFB1M is a mitochondrial methyltransferase, which uses [[S-adenosyl methionine]] to dimethylate two highly conserved [[adenosine]] residues at the 3'-end of the mitochondrial [[12S rRNA]] thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.<ref name="pmid11809803"/><ref name="pmid12068295">{{cite journal |vauthors=Falkenberg M, Gaspari M, Rantanen A, etal |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 }}</ref><ref name="pmid19356719">{{cite journal |author1=Metodiev MD |author2=Lesko N |author3=Park CB |author4=Camara Y. |author5=Shi Y. |author6=Wibom R. |author7=Hultenby K. |author8=Gustafsson CM |author9=Larsson NG. | title = Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome | journal = Cell Metab. | volume = 9 | issue = 4 | pages = 386–97 |date=Apr 2009 | pmid = 19356719 | doi =10.1016/j.cmet.2009.03.001}}</ref> | ||
| Line 16: | Line 16: | ||
| citations = | | citations = | ||
*{{cite journal |vauthors=Falkenberg M, Gaspari M, Rantanen A, etal |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 }} | *{{cite journal |vauthors=Falkenberg M, Gaspari M, Rantanen A, etal |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Seidel-Rogol BL, McCulloch V, Shadel GS |title=Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. |journal=Nat. Genet. |volume=33 |issue= 1 |pages= 23–4 |year= 2003 |pmid= 12496758 |doi= 10.1038/ng1064 }} | *{{cite journal |vauthors=Seidel-Rogol BL, McCulloch V, Shadel GS |title=Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. |journal=Nat. Genet. |volume=33 |issue= 1 |pages= 23–4 |year= 2003 |pmid= 12496758 |doi= 10.1038/ng1064 }} | ||
*{{cite journal |vauthors=Rantanen A, Gaspari M, Falkenberg M, etal |title=Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. |journal=Mamm. Genome |volume=14 |issue= 1 |pages= 1–6 |year= 2003 |pmid= 12532263 |doi= 10.1007/s00335-002-2218-z }} | *{{cite journal |vauthors=Rantanen A, Gaspari M, Falkenberg M, etal |title=Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. |journal=Mamm. Genome |volume=14 |issue= 1 |pages= 1–6 |year= 2003 |pmid= 12532263 |doi= 10.1007/s00335-002-2218-z }} | ||
Latest revision as of 12:57, 21 October 2018
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial enzyme that in 12-Eiael mag ingay is encoded by the TFB1M gene.[1][2][3] TFB1M is a mitochondrial methyltransferase, which uses S-adenosyl methionine to dimethylate two highly conserved adenosine residues at the 3'-end of the mitochondrial 12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.[2][4][5]
Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an in vitro system containing recombinant mitochondrial RNA polymerase and TFAM.[6] There are no experimental data demonstrating that this function occurs in vivo.
Interactions
TFB1M has been shown to interact with TFAM.[7]
References
- ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
- ↑ 2.0 2.1 McCulloch V, Seidel-Rogol BL, Shadel GS (Jan 2002). "A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine". Mol Cell Biol. 22 (4): 1116–25. doi:10.1128/MCB.22.4.1116-1125.2002. PMC 134642. PMID 11809803.
- ↑ "Entrez Gene: TFB1M transcription factor B1, mitochondrial".
- ↑ Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295.
- ↑ Metodiev MD; Lesko N; Park CB; Camara Y.; Shi Y.; Wibom R.; Hultenby K.; Gustafsson CM; Larsson NG. (Apr 2009). "Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome". Cell Metab. 9 (4): 386–97. doi:10.1016/j.cmet.2009.03.001. PMID 19356719.
- ↑ Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295.
- ↑ McCulloch, Vicki; Shadel Gerald S (Aug 2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. United States. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. ISSN 0270-7306. PMC 166325. PMID 12897151.
Further reading
- Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Seidel-Rogol BL, McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop". Nat. Genet. 33 (1): 23–4. doi:10.1038/ng1064. PMID 12496758.
- Rantanen A, Gaspari M, Falkenberg M, et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2". Mamm. Genome. 14 (1): 1–6. doi:10.1007/s00335-002-2218-z. PMID 12532263.
- McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. PMC 166325. PMID 12897151.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Bykhovskaya Y, Mengesha E, Wang D, et al. (2004). "Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation". Mol. Genet. Metab. 82 (1): 27–32. doi:10.1016/j.ymgme.2004.01.020. PMID 15110318.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators". Mol. Cell. Biol. 25 (4): 1354–66. doi:10.1128/MCB.25.4.1354-1366.2005. PMC 548005. PMID 15684387.
- Cotney J, Wang Z, Shadel GS (2007). "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression". Nucleic Acids Res. 35 (12): 4042–54. doi:10.1093/nar/gkm424. PMC 1919481. PMID 17557812.
 | This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it. |