UNC93A: Difference between revisions
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'''Unc-93 homolog A (C. elegans)''' is a [[protein]] that in humans is encoded by the UNC93A [[gene]].<ref name="entrez"> | |||
{{cite web | title = Entrez Gene: Unc-93 homolog A (C. elegans) | url = https://www.ncbi.nlm.nih.gov/gene/54346 }}</ref> | |||
Unc93A is a [[major facilitator superfamily]] (MFS), and a putative [[Solute carrier family|solute carrier]] in humans.<ref name="Perland_2017a">{{cite journal | vauthors = Perland E, Fredriksson R | title = Classification Systems of Secondary Active Transporters | journal = Trends in Pharmacological Sciences | volume = 38 | issue = 3 | pages = 305–315 | date = March 2017 | pmid = 27939446 | doi = 10.1016/j.tips.2016.11.008 }}</ref><ref name="Perland_2017b">{{cite journal | vauthors = Perland E, Bagchi S, Klaesson A, Fredriksson R | title = Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression | journal = Open Biology | volume = 7 | issue = 9 | date = September 2017 | pmid = 28878041 | pmc = 5627054 | doi = 10.1098/rsob.170142 | page=170142}}</ref> It belongs to the [[atypical SLCs]]<nowiki/> that was recently listed.<ref name="Perland_2017a" /> It is therefore presumed that UNC93A is a transporter protein. | |||
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UNC93A is closely related to Unc93B1 and [[Mfsd11|MFSD11]].<ref name="Ceder_2017">{{cite journal | vauthors = Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R | title = The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice | language = English | journal = Frontiers in Molecular Neuroscience | volume = 10 | pages = 351 | date = 2017 | pmid = 29163028 | doi = 10.3389/fnmol.2017.00351 | url = https://www.frontiersin.org/articles/10.3389/fnmol.2017.00351/full | pmc=5671512}}</ref><ref>{{cite journal | vauthors = Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R | title = The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis | journal = PLOS One | volume = 11 | issue = 6 | pages = e0156912 | date = 2016 | pmid = 27272503 | pmc = 4896477 | doi = 10.1371/journal.pone.0156912 }}</ref> | |||
UNC93A is | UNC93A is affected by amino acid deprivation in cell cortex cultures<ref name="Perland_2017b" /><ref name="Ceder_2017" /> and starvation in ''in vivo'' samples.<ref name="Ceder_2017" /> | ||
It is expressed in neurons, with staining close to the plasma membrane.<ref name="Ceder_2017" /> | |||
Read also <ref>{{cite journal | vauthors = Levin JZ, Horvitz HR | title = The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction | journal = The Journal of Cell Biology | volume = 117 | issue = 1 | pages = 143–55 | date = April 1992 | pmid = 1313436 | pmc = 2289394 | doi=10.1083/jcb.117.1.143}}</ref><ref>{{cite journal | vauthors = de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR | title = sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans | journal = The Journal of Neuroscience | volume = 23 | issue = 27 | pages = 9133–45 | date = October 2003 | pmid = 14534247 }}</ref> for functional studies in C.elegans. | |||
Read also <ref>{{ | |||
== References == | == References == | ||
{{reflist}} | {{reflist}} | ||
== Further reading == | == Further reading == | ||
{{refbegin}} | |||
{{refbegin | * {{cite journal | vauthors = Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS | title = The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer | journal = BMC Genetics | volume = 3 | pages = 20 | date = October 2002 | pmid = 12381271 | pmc = 134458 | doi = 10.1186/1471-2156-3-20 }} | ||
*{{ | |||
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| title = The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer | |||
| journal = BMC Genetics | |||
| volume = 3 | |||
| pages = 20 | |||
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{{refend}} | {{refend}} | ||
Latest revision as of 14:02, 10 July 2018
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Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.[1]
Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.[2][3] It belongs to the atypical SLCs that was recently listed.[2] It is therefore presumed that UNC93A is a transporter protein.
UNC93A is closely related to Unc93B1 and MFSD11.[4][5]
UNC93A is affected by amino acid deprivation in cell cortex cultures[3][4] and starvation in in vivo samples.[4]
It is expressed in neurons, with staining close to the plasma membrane.[4]
Read also [6][7] for functional studies in C.elegans.
References
- ↑ "Entrez Gene: Unc-93 homolog A (C. elegans)".
- ↑ 2.0 2.1 Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
- ↑ 3.0 3.1 Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
- ↑ 4.0 4.1 4.2 4.3 Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
- ↑ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS One. 11 (6): e0156912. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
- ↑ Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
- ↑ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. PMID 14534247.
Further reading
- Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (October 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.
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