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{{Infobox_gene}}
{{PBB_Controls
'''NEDD9-interacting protein with calponin homology and LIM domains''' is a [[protein]] that in humans is encoded by the ''MICAL1'' [[gene]].<ref name="pmid11827972">{{cite journal |vauthors=Suzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana K, Morimoto C, Hirai H | title = MICAL, a novel CasL interacting molecule, associates with vimentin | journal = J Biol Chem | volume = 277 | issue = 17 | pages = 14933–41 |date=Apr 2002 | pmid = 11827972 | pmc =  | doi = 10.1074/jbc.M111842200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MICAL1 microtubule associated monoxygenase, calponin and LIM domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64780| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_MICAL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wyl.
| PDB = {{PDB2|1wyl}}, {{PDB2|2bra}}, {{PDB2|2bry}}, {{PDB2|2c4c}}, {{PDB2|2co8}}, {{PDB2|2dk9}}
| Name = Microtubule associated monoxygenase, calponin and LIM domain containing 1
| HGNCid = 20619
| Symbol = MICAL1
| AltSymbols =; DKFZp434B1517; FLJ11937; FLJ21739; MICAL; MICAL-1; NICAL
| OMIM = 607129
| ECnumber = 
| Homologene = 11246
| MGIid = 2385847
| GeneAtlas_image1 = PBB_GE_MICAL1_218376_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0017124 |text = SH3 domain binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005882 |text = intermediate filament}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006725 |text = aromatic compound metabolic process}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64780
    | Hs_Ensembl = ENSG00000135596
    | Hs_RefseqProtein = NP_073602
    | Hs_RefseqmRNA = NM_022765
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 109871958
    | Hs_GenLoc_end = 109883883
    | Hs_Uniprot = Q8TDZ2
    | Mm_EntrezGene = 171580
    | Mm_Ensembl = ENSMUSG00000019823
    | Mm_RefseqmRNA = NM_138315
    | Mm_RefseqProtein = NP_612188
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 41164792
    | Mm_GenLoc_end = 41175447
    | Mm_Uniprot = Q3TB77
  }}
}}
'''Microtubule associated monoxygenase, calponin and LIM domain containing 1''', also known as '''MICAL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MICAL1 microtubule associated monoxygenase, calponin and LIM domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64780| accessdate = }}</ref>


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| summary_text =  
}}
}}
==Interactions==
MICAL1 has been shown to [[Protein-protein interaction|interact]] with [[NEDD9]]<ref name=pmid11827972 /> and [[RAB1A]].<ref name=pmid12788069>{{cite journal |last=Weide |first=Thomas |authorlink= |author2=Teuber Julia |author3=Bayer Michael |author4=Barnekow Angelika  |date=Jun 2003 |title=MICAL-1 isoforms, novel rab1 interacting proteins |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue=1 |pages=79–86 |publisher= |location = United States| issn = 0006-291X| pmid = 12788069 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0006-291X(03)00918-5 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Iwata S, Ohashi Y, Kamiguchi K, Morimoto C |title=Beta 1-integrin-mediated cell signaling in T lymphocytes. |journal=J. Dermatol. Sci. |volume=23 |issue= 2 |pages= 75-86 |year= 2000 |pmid= 10808124 |doi=  }}
*{{cite journal  |vauthors=Iwata S, Ohashi Y, Kamiguchi K, Morimoto C |title=Beta 1-integrin-mediated cell signaling in T lymphocytes. |journal=J. Dermatol. Sci. |volume=23 |issue= 2 |pages= 75–86 |year= 2000 |pmid= 10808124 |doi=10.1016/S0923-1811(99)00096-1 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Hattori A, Okumura K, Nagase T, ''et al.'' |title=Characterization of long cDNA clones from human adult spleen. |journal=DNA Res. |volume=7 |issue= 6 |pages= 357-66 |year= 2001 |pmid= 11214971 |doi=  }}
*{{cite journal   |vauthors=Hattori A, Okumura K, Nagase T, etal |title=Characterization of long cDNA clones from human adult spleen |journal=DNA Res. |volume=7 |issue= 6 |pages= 357–66 |year= 2001 |pmid= 11214971 |doi=10.1093/dnares/7.6.357  }}
*{{cite journal  | author=Suzuki T, Nakamoto T, Ogawa S, ''et al.'' |title=MICAL, a novel CasL interacting molecule, associates with vimentin. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14933-41 |year= 2002 |pmid= 11827972 |doi= 10.1074/jbc.M111842200 }}
*{{cite journal   |vauthors=Terman JR, Mao T, Pasterkamp RJ, etal |title=MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion |journal=Cell |volume=109 |issue= 7 |pages= 887–900 |year= 2002 |pmid= 12110185 |doi=10.1016/S0092-8674(02)00794-8 }}
*{{cite journal | author=Terman JR, Mao T, Pasterkamp RJ, ''et al.'' |title=MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. |journal=Cell |volume=109 |issue= 7 |pages= 887-900 |year= 2002 |pmid= 12110185 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Weide T, Teuber J, Bayer M, Barnekow A |title=MICAL-1 isoforms, novel rab1 interacting proteins |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 1 |pages= 79–86 |year= 2003 |pmid= 12788069 |doi=10.1016/S0006-291X(03)00918-5 }}
*{{cite journal  | author=Weide T, Teuber J, Bayer M, Barnekow A |title=MICAL-1 isoforms, novel rab1 interacting proteins. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 1 |pages= 79-86 |year= 2003 |pmid= 12788069 |doi=  }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Fischer J, Weide T, Barnekow A |title=The MICAL proteins and rab1: a possible link to the cytoskeleton? |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 415–23 |year= 2005 |pmid= 15694364 |doi= 10.1016/j.bbrc.2004.12.182 }}
*{{cite journal  | author=Fischer J, Weide T, Barnekow A |title=The MICAL proteins and rab1: a possible link to the cytoskeleton? |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 415-23 |year= 2005 |pmid= 15694364 |doi= 10.1016/j.bbrc.2004.12.182 }}
*{{cite journal   |vauthors=Bayer M, Fischer J, Kremerskothen J, etal |title=Identification and characterization of Iporin as a novel interaction partner for rab1 |journal=BMC Cell Biol. |volume=6 |pages= 15 |year= 2006 |pmid= 15796781 |doi= 10.1186/1471-2121-6-15 | pmc=1079803 }}
*{{cite journal | author=Bayer M, Fischer J, Kremerskothen J, ''et al.'' |title=Identification and characterization of Iporin as a novel interaction partner for rab1. |journal=BMC Cell Biol. |volume=6 |issue= 1 |pages= 15 |year= 2006 |pmid= 15796781 |doi= 10.1186/1471-2121-6-15 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Jin X, Zhang J, Dai H, etal |title=Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain |journal=Biophys. Chem. |volume=129 |issue= 2–3 |pages= 269–78 |year= 2007 |pmid= 17662518 |doi= 10.1016/j.bpc.2007.06.008 }}
*{{cite journal | author=Jin X, Zhang J, Dai H, ''et al.'' |title=Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain. |journal=Biophys. Chem. |volume=129 |issue= 2-3 |pages= 269-78 |year= 2007 |pmid= 17662518 |doi= 10.1016/j.bpc.2007.06.008 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=64780}}
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Latest revision as of 03:41, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1 gene.[1][2]


Interactions

MICAL1 has been shown to interact with NEDD9[1] and RAB1A.[3]

References

  1. ↑ 1.0 1.1 Suzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana K, Morimoto C, Hirai H (Apr 2002). "MICAL, a novel CasL interacting molecule, associates with vimentin". J Biol Chem. 277 (17): 14933–41. doi:10.1074/jbc.M111842200. PMID 11827972.
  2. ↑ "Entrez Gene: MICAL1 microtubule associated monoxygenase, calponin and LIM domain containing 1".
  3. ↑ Weide, Thomas; Teuber Julia; Bayer Michael; Barnekow Angelika (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. Commun. United States. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. ISSN 0006-291X. PMID 12788069.

Further reading



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