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{{Infobox_gene}}
{{PBB_Controls
'''Claudin 3''', also known as '''CLDN3''', is a [[protein]] which in humans is encoded by the ''CLDN3'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLDN3 claudin 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1365| accessdate = }}</ref> It is a member of the [[claudin]] protein family.
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Tight junction]]s represent one mode of cell-to-cell [[cell adhesion|adhesion]] in [[epithelium|epithelial]] or [[endothelium|endothelial]] cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the [[paracellular transport|paracellular]] space. These junctions are composed of sets of continuous networking strands in the outwardly facing [[cytoplasm]]ic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this [[intron]]-less gene, a member of the [[claudin]] family, is an [[integral membrane protein]] and a component of [[tight junction]] strands. It is also a low-affinity receptor for [[Clostridium perfringens enterotoxin]], and shares [[peptide sequence|amino acid sequence]] similarity with a putative apoptosis-related protein found in rat.<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Claudin 3
| HGNCid = 2045
| Symbol = CLDN3
| AltSymbols =; C7orf1; CPE-R2; CPETR2; HRVP1; RVP1
| OMIM = 602910
| ECnumber = 
| Homologene = 1001
| MGIid = 1329044
| GeneAtlas_image1 = PBB_GE_CLDN3_203953_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CLDN3_203954_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005923 |text = tight junction}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0016338 |text = calcium-independent cell-cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1365
    | Hs_Ensembl = ENSG00000165215
    | Hs_RefseqProtein = NP_001297
    | Hs_RefseqmRNA = NM_001306
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 72821653
    | Hs_GenLoc_end = 72822315
    | Hs_Uniprot = O15551
    | Mm_EntrezGene = 12739
    | Mm_Ensembl = ENSMUSG00000070473
    | Mm_RefseqmRNA = NM_009902
    | Mm_RefseqProtein = NP_034032
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 135270841
    | Mm_GenLoc_end = 135272099
    | Mm_Uniprot = Q3TMQ3
  }}
}}
'''Claudin 3''', also known as '''CLDN3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLDN3 claudin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1365| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text = Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.<ref name="entrez">{{cite web | title = Entrez Gene: CLDN3 claudin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1365| accessdate = }}</ref>
}}


==References==
CLDN3 has been shown to [[Protein-protein interaction|interact]] with [[CLDN1]]<ref name=pmid12909588>{{cite journal | vauthors = Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG | title = Role of claudin interactions in airway tight junctional permeability | journal = Am. J. Physiol. Lung Cell Mol. Physiol. | volume = 285 | issue = 5 | pages = L1166-78  | date = Nov 2003 | pmid = 12909588 | doi = 10.1152/ajplung.00182.2003 }}</ref> and [[CLDN5]].<ref name=pmid12909588/>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CLDN3}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kniesel U, Wolburg H | title = Tight junctions of the blood-brain barrier | journal = Cell. Mol. Neurobiol. | volume = 20 | issue = 1 | pages = 57–76 | year = 2000 | pmid = 10690502 | doi = 10.1023/A:1006995910836 }}
| citations =
* {{cite journal | vauthors = Heiskala M, Peterson PA, Yang Y | title = The roles of claudin superfamily proteins in paracellular transport | journal = Traffic | volume = 2 | issue = 2 | pages = 93–8 | year = 2001 | pmid = 11247307 | doi = 10.1034/j.1600-0854.2001.020203.x }}
*{{cite journal | author=Kniesel U, Wolburg H |title=Tight junctions of the blood-brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57-76 |year= 2000 |pmid= 10690502 |doi= }}
* {{cite journal | vauthors = Tsukita S, Furuse M, Itoh M | title = Multifunctional strands in tight junctions | journal = Nat. Rev. Mol. Cell Biol. | volume = 2 | issue = 4 | pages = 285–93 | year = 2001 | pmid = 11283726 | doi = 10.1038/35067088 }}
*{{cite journal | author=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93-8 |year= 2001 |pmid= 11247307 |doi= }}
* {{cite journal | vauthors = Tsukita S, Furuse M | title = Claudin-based barrier in simple and stratified cellular sheets | journal = Curr. Opin. Cell Biol. | volume = 14 | issue = 5 | pages = 531–6 | year = 2002 | pmid = 12231346 | doi = 10.1016/S0955-0674(02)00362-9 }}
*{{cite journal | author=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285-93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 }}
* {{cite journal | vauthors = González-Mariscal L, Betanzos A, Nava P, Jaramillo BE | title = Tight junction proteins | journal = Prog. Biophys. Mol. Biol. | volume = 81 | issue = 1 | pages = 1–44 | year = 2003 | pmid = 12475568 | doi = 10.1016/S0079-6107(02)00037-8 }}
*{{cite journal | author=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531-6 |year= 2003 |pmid= 12231346 |doi= }}
* {{cite journal | vauthors = Katahira J, Sugiyama H, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N | title = Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo | journal = J. Biol. Chem. | volume = 272 | issue = 42 | pages = 26652–8 | year = 1997 | pmid = 9334247 | doi = 10.1074/jbc.272.42.26652 }}
*{{cite journal | author=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1-44 |year= 2003 |pmid= 12475568 |doi= }}
* {{cite journal | vauthors = Peacock RE, Keen TJ, Inglehearn CF | title = Analysis of a human gene homologous to rat ventral prostate.1 protein | journal = Genomics | volume = 46 | issue = 3 | pages = 443–9 | year = 1997 | pmid = 9441748 | doi = 10.1006/geno.1997.5033 }}
*{{cite journal | author=Katahira J, Sugiyama H, Inoue N, ''et al.'' |title=Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26652-8 |year= 1997 |pmid= 9334247 |doi= }}
* {{cite journal | vauthors = Morita K, Furuse M, Fujimoto K, Tsukita S | title = Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 2 | pages = 511–6 | year = 1999 | pmid = 9892664 | pmc = 15167 | doi = 10.1073/pnas.96.2.511 }}
*{{cite journal | author=Peacock RE, Keen TJ, Inglehearn CF |title=Analysis of a human gene homologous to rat ventral prostate.1 protein. |journal=Genomics |volume=46 |issue= 3 |pages= 443-9 |year= 1998 |pmid= 9441748 |doi= 10.1006/geno.1997.5033 }}
* {{cite journal | vauthors = Furuse M, Sasaki H, Tsukita S | title = Manner of interaction of heterogeneous claudin species within and between tight junction strands | journal = J. Cell Biol. | volume = 147 | issue = 4 | pages = 891–903 | year = 1999 | pmid = 10562289 | pmc = 2156154 | doi = 10.1083/jcb.147.4.891 }}
*{{cite journal | author=Morita K, Furuse M, Fujimoto K, Tsukita S |title=Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 511-6 |year= 1999 |pmid= 9892664 |doi= }}
* {{cite journal | vauthors = Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S | title = Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1351–63 | year = 1999 | pmid = 10601346 | pmc = 2168087 | doi = 10.1083/jcb.147.6.1351 }}
*{{cite journal | author=Furuse M, Sasaki H, Tsukita S |title=Manner of interaction of heterogeneous claudin species within and between tight junction strands. |journal=J. Cell Biol. |volume=147 |issue= 4 |pages= 891-903 |year= 1999 |pmid= 10562289 |doi= }}
* {{cite journal | vauthors = Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H | title = Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 28204–11 | year = 2001 | pmid = 11382769 | doi = 10.1074/jbc.M103083200 }}
*{{cite journal | author=Itoh M, Furuse M, Morita K, ''et al.'' |title=Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351-63 |year= 2000 |pmid= 10601346 |doi= }}
* {{cite journal | vauthors = Long H, Crean CD, Lee WH, Cummings OW, Gabig TG | title = Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium | journal = Cancer Res. | volume = 61 | issue = 21 | pages = 7878–81 | year = 2001 | pmid = 11691807 | doi =  }}
*{{cite journal | author=Miyamori H, Takino T, Kobayashi Y, ''et al.'' |title=Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28204-11 |year= 2001 |pmid= 11382769 |doi= 10.1074/jbc.M103083200 }}
* {{cite journal | vauthors = Katoh M, Katoh M | title = CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family | journal = Int. J. Mol. Med. | volume = 11 | issue = 6 | pages = 683–9 | year = 2003 | pmid = 12736707 | doi = 10.3892/ijmm.11.6.683 }}
*{{cite journal | author=Long H, Crean CD, Lee WH, ''et al.'' |title=Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium. |journal=Cancer Res. |volume=61 |issue= 21 |pages= 7878-81 |year= 2001 |pmid= 11691807 |doi=  }}
* {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Katoh M, Katoh M |title=CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 683-9 |year= 2004 |pmid= 12736707 |doi= }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 12:42, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene.[1] It is a member of the claudin protein family.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat.[1]

Interactions

CLDN3 has been shown to interact with CLDN1[2] and CLDN5.[2]

References

  1. ↑ 1.0 1.1 "Entrez Gene: CLDN3 claudin 3".
  2. ↑ 2.0 2.1 Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5): L1166–78. doi:10.1152/ajplung.00182.2003. PMID 12909588.

External links

Further reading


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