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'''Nucleotide-binding oligomerization domain-containing protein 1''' is a [[protein]] receptor that in humans is encoded by the ''NOD1'' [[gene]].<ref name="pmid10224040">{{cite journal | vauthors = Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS | title = Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB | journal = J Biol Chem | volume = 274 | issue = 19 | pages = 12955–8 |date=Jun 1999 | pmid = 10224040 | pmc =  | doi =10.1074/jbc.274.19.12955 }}</ref><ref name="pmid10329646">{{cite journal | vauthors = Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Nunez G | title = Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB | journal = J Biol Chem | volume = 274 | issue = 21 | pages = 14560–7 |date=Jul 1999 | pmid = 10329646 | pmc =  | doi =10.1074/jbc.274.21.14560 }}</ref> It recognizes bacterial molecules and stimulates an immune reaction.
'''Nucleotide-binding oligomerization domain-containing protein 1''' ('''NOD1''') is a [[protein]] receptor that in humans is encoded by the ''NOD1'' [[gene]].<ref name="pmid10224040">{{cite journal | vauthors = Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS | title = Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB | journal = The Journal of Biological Chemistry | volume = 274 | issue = 19 | pages = 12955–8 | date = May 1999 | pmid = 10224040 | pmc =  | doi = 10.1074/jbc.274.19.12955 }}</ref><ref name="pmid10329646">{{cite journal | vauthors = Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G | title = Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB | journal = The Journal of Biological Chemistry | volume = 274 | issue = 21 | pages = 14560–7 | date = May 1999 | pmid = 10329646 | pmc =  | doi = 10.1074/jbc.274.21.14560 }}</ref> It recognizes bacterial molecules and stimulates an immune reaction .<ref>{{cite journal | vauthors = Mahla RS, Reddy MC, Prasad DV, Kumar H | title = Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology | journal = Frontiers in Immunology | volume = 4 | pages = 248 | date = September 2013 | pmid = 24032031 | pmc = 3759294 | doi = 10.3389/fimmu.2013.00248 }}</ref>.


NOD1 protein contains a [[caspase recruitment domain]] (CARD). NOD1 is a member of [[NOD-like receptor]] protein family and is a close relative of [[NOD2]]. NOD1 is an intracellular [[pattern recognition receptor]], which is similar in structure to resistant proteins of plants, and mediates [[Innate immune system|innate]] and [[Adaptive immune system|acquired immunity]] by recognizing bacterial molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety. Nod1 interacts with [[RIPK2]] through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor [[NF-κB]].
NOD1 protein contains a [[caspase recruitment domain]] (CARD). NOD1 is a member of [[NOD-like receptor]] protein family and is a close relative of [[NOD2]]. NOD1 is an intracellular [[pattern recognition receptor]], which is similar in structure to resistant proteins of plants, and mediates [[Innate immune system|innate]] and [[Adaptive immune system|acquired immunity]] by recognizing bacterial molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety. Nod1 interacts with [[RIPK2]] through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor [[NF-κB]].


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== References ==
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==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Martinon F, Tschopp J | title = NLRs join TLRs as innate sensors of pathogens | journal = Trends in Immunology | volume = 26 | issue = 8 | pages = 447–54 | date = August 2005 | pmid = 15967716 | doi = 10.1016/j.it.2005.06.004 }}
| citations =
* {{cite journal | vauthors = Strober W, Murray PJ, Kitani A, Watanabe T | title = Signalling pathways and molecular interactions of NOD1 and NOD2 | journal = Nature Reviews. Immunology | volume = 6 | issue = 1 | pages = 9–20 | date = January 2006 | pmid = 16493424 | doi = 10.1038/nri1747 }}
*{{cite journal | vauthors=Martinon F, Tschopp J |title=NLRs join TLRs as innate sensors of pathogens. |journal=Trends Immunol. |volume=26 |issue= 8 |pages= 447–54 |year= 2006 |pmid= 15967716 |doi= 10.1016/j.it.2005.06.004 }}
* {{cite journal | vauthors = Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Núñez G | title = An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways | journal = The Journal of Biological Chemistry | volume = 275 | issue = 36 | pages = 27823–31 | date = September 2000 | pmid = 10880512 | doi = 10.1074/jbc.M003415200 }}
*{{cite journal | vauthors=Strober W, Murray PJ, Kitani A, Watanabe T |title=Signalling pathways and molecular interactions of NOD1 and NOD2. |journal=Nat. Rev. Immunol. |volume=6 |issue= 1 |pages= 9–20 |year= 2006 |pmid= 16493424 |doi= 10.1038/nri1747 }}
* {{cite journal | vauthors = Inohara N, Ogura Y, Chen FF, Muto A, Nuñez G | title = Human Nod1 confers responsiveness to bacterial lipopolysaccharides | journal = The Journal of Biological Chemistry | volume = 276 | issue = 4 | pages = 2551–4 | date = January 2001 | pmid = 11058605 | doi = 10.1074/jbc.M009728200 }}
*{{cite journal   |vauthors=Inohara N, Koseki T, Lin J, etal |title=An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27823–31 |year= 2000 |pmid= 10880512 |doi= 10.1074/jbc.M003415200 }}
* {{cite journal | vauthors = Chu ZL, Pio F, Xie Z, Welsh K, Krajewska M, Krajewski S, Godzik A, Reed JC | title = A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis | journal = The Journal of Biological Chemistry | volume = 276 | issue = 12 | pages = 9239–45 | date = March 2001 | pmid = 11113115 | doi = 10.1074/jbc.M006309200 }}
*{{cite journal   |vauthors=Inohara N, Ogura Y, Chen FF, etal |title=Human Nod1 confers responsiveness to bacterial lipopolysaccharides. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2551–4 |year= 2001 |pmid= 11058605 |doi= 10.1074/jbc.M009728200 }}
* {{cite journal | vauthors = Yoo NJ, Park WS, Kim SY, Reed JC, Son SG, Lee JY, Lee SH | title = Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1 | journal = Biochemical and Biophysical Research Communications | volume = 299 | issue = 4 | pages = 652–8 | date = December 2002 | pmid = 12459189 | doi = 10.1016/S0006-291X(02)02714-6 }}
*{{cite journal   |vauthors=Chu ZL, Pio F, Xie Z, etal |title=A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 9239–45 |year= 2001 |pmid= 11113115 |doi= 10.1074/jbc.M006309200 }}
* {{cite journal | vauthors = Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S | title = Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways | journal = Oncogene | volume = 22 | issue = 21 | pages = 3307–18 | date = May 2003 | pmid = 12761501 | doi = 10.1038/sj.onc.1206406 }}
*{{cite journal   |vauthors=Yoo NJ, Park WS, Kim SY, etal |title=Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 4 |pages= 652–8 |year= 2003 |pmid= 12459189 |doi=10.1016/S0006-291X(02)02714-6 }}
* {{cite journal | vauthors = Stehlik C, Hayashi H, Pio F, Godzik A, Reed JC | title = CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways | journal = The Journal of Biological Chemistry | volume = 278 | issue = 34 | pages = 31941–9 | date = August 2003 | pmid = 12775719 | doi = 10.1074/jbc.M300009200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
* {{cite journal | vauthors = Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jéhanno M, Viala J, Tedin K, Taha MK, Labigne A, Zähringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ | title = Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan | journal = Science | volume = 300 | issue = 5625 | pages = 1584–7 | date = June 2003 | pmid = 12791997 | doi = 10.1126/science.1084677 }}
*{{cite journal  |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423  | pmc=2882961 }}
* {{cite journal | vauthors = Hisamatsu T, Suzuki M, Podolsky DK | title = Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 35 | pages = 32962–8 | date = August 2003 | pmid = 12813035 | doi = 10.1074/jbc.M304355200 }}
*{{cite journal  |vauthors=Matsuda A, Suzuki Y, Honda G, etal |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 }}
* {{cite journal | vauthors = Girardin SE, Travassos LH, Hervé M, Blanot D, Boneca IG, Philpott DJ, Sansonetti PJ, Mengin-Lecreulx D | title = Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 43 | pages = 41702–8 | date = October 2003 | pmid = 12871942 | doi = 10.1074/jbc.M307198200 }}
*{{cite journal   |vauthors=Stehlik C, Hayashi H, Pio F, etal |title=CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 31941–9 |year= 2003 |pmid= 12775719 |doi= 10.1074/jbc.M300009200 }}
* {{cite journal | vauthors = Kim JG, Lee SJ, Kagnoff MF | title = Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors | journal = Infection and Immunity | volume = 72 | issue = 3 | pages = 1487–95 | date = March 2004 | pmid = 14977954 | pmc = 356064 | doi = 10.1128/IAI.72.3.1487-1495.2004 }}
*{{cite journal   |vauthors=Girardin SE, Boneca IG, Carneiro LA, etal |title=Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan |journal=Science |volume=300 |issue= 5625 |pages= 1584–7 |year= 2003 |pmid= 12791997 |doi= 10.1126/science.1084677 }}
* {{cite journal | vauthors = Damiano JS, Oliveira V, Welsh K, Reed JC | title = Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses | journal = The Biochemical Journal | volume = 381 | issue = Pt 1 | pages = 213–9 | date = July 2004 | pmid = 15107016 | pmc = 1133779 | doi = 10.1042/BJ20031506 }}
*{{cite journal | vauthors=Hisamatsu T, Suzuki M, Podolsky DK |title=Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 32962–8 |year= 2003 |pmid= 12813035 |doi= 10.1074/jbc.M304355200 }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  |vauthors=Girardin SE, Travassos LH, Hervé M, etal |title=Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2 |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 41702–8 |year= 2004 |pmid= 12871942 |doi= 10.1074/jbc.M307198200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Kim JG, Lee SJ, Kagnoff MF |title=Nod1 Is an Essential Signal Transducer in Intestinal Epithelial Cells Infected with Bacteria That Avoid Recognition by Toll-Like Receptors |journal=Infect. Immun. |volume=72 |issue= 3 |pages= 1487–95 |year= 2004 |pmid= 14977954 |doi=10.1128/IAI.72.3.1487-1495.2004 | pmc=356064  }}
*{{cite journal | vauthors=Damiano JS, Oliveira V, Welsh K, Reed JC |title=Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses |journal=Biochem. J. |volume=381 |issue= Pt 1 |pages= 213–9 |year= 2004 |pmid= 15107016 |doi= 10.1042/BJ20031506  | pmc=1133779 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
}}
 
==References==
{{Reflist}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{UCSC genome browser|NOD1}}
* {{UCSC genome browser|NOD1}}
* {{UCSC gene details|NOD1}}
* {{UCSC gene details|NOD1}}


{{PDB Gallery|geneid=10392}}
{{PDB Gallery|geneid=10392}}
{{NOD-like receptors}}
{{NOD-like receptors}}
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{{DEFAULTSORT:Nod1}}
{{DEFAULTSORT:Nod1}}
[[Category:LRR proteins]]
[[Category:LRR proteins]]
[[Category:NOD-like receptors]]
[[Category:NOD-like receptors]]


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Latest revision as of 18:30, 24 June 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a protein receptor that in humans is encoded by the NOD1 gene.[1][2] It recognizes bacterial molecules and stimulates an immune reaction .[3].

NOD1 protein contains a caspase recruitment domain (CARD). NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing bacterial molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety. Nod1 interacts with RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor NF-κB.

References

  1. ↑ Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS (May 1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". The Journal of Biological Chemistry. 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.
  2. ↑ Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G (May 1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". The Journal of Biological Chemistry. 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.
  3. ↑ Mahla RS, Reddy MC, Prasad DV, Kumar H (September 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC 3759294. PMID 24032031.

Further reading

External links

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