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{{Infobox_gene}}
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'''Staphylococcal nuclease domain-containing protein 1''' also known as '''100 kDa coactivator''' or '''Tudor domain-containing protein 11''' (TDRD11) is a [[protein]] that in humans is encoded by the ''SND1'' [[gene]].<ref name="pmid7651391">{{cite journal | vauthors = Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E | title = The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE | journal = Molecular and Cellular Biology | volume = 15 | issue = 9 | pages = 4735–44 | date = Sep 1995 | pmid = 7651391 | pmc = 230717 | doi =  10.1128/mcb.15.9.4735}}</ref><ref name="pmid9003410">{{cite journal | vauthors = Callebaut I, Mornon JP | title = The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development | journal = The Biochemical Journal | volume = 321 | issue = 1 | pages = 125–32 | date = Jan 1997 | pmid = 9003410 | pmc = 1218045 | doi =  10.1042/bj3210125}}</ref><ref name="pmid12819296">{{cite journal | vauthors = Paukku K, Yang J, Silvennoinen O | title = Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5 | journal = Molecular Endocrinology | volume = 17 | issue = 9 | pages = 1805–14 | date = Sep 2003 | pmid = 12819296 | pmc =  | doi = 10.1210/me.2002-0256 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SND1 staphylococcal nuclease and tudor domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27044| accessdate = }}</ref> SND1 is a main component of [[RNA-induced silencing complex|RISC complex]]<ref name="pmid17909068">{{cite journal | vauthors = Tsuchiya N, Ochiai M, Nakashima K, Ubagai T, Sugimura T, Nakagama H | title = SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis | journal = Cancer Research | volume = 67 | issue = 19 | pages = 9568–76 | date = Oct 2007 | pmid = 17909068 | doi = 10.1158/0008-5472.CAN-06-2707 }}</ref> and plays an important role in [[MicroRNA|miRNA]] function.<ref name=Yoo_2011>{{cite journal | vauthors = Yoo BK, Santhekadur PK, Gredler R, Chen D, Emdad L, Bhutia S, Pannell L, Fisher PB, Sarkar D | title = Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma | journal = Hepatology | volume = 53 | issue = 5 | pages = 1538–48 | date = May 2011 | pmid = 21520169 | pmc = 3081619 | doi = 10.1002/hep.24216 }}</ref><ref name="pmid21256156">{{cite journal | vauthors = Yoo BK, Emdad L, Lee SG, Su ZZ, Santhekadur P, Chen D, Gredler R, Fisher PB, Sarkar D | title = Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology | journal = Pharmacology & Therapeutics | volume = 130 | issue = 1 | pages = 1–8 | date = Apr 2011 | pmid = 21256156 | pmc = 3043119 | doi = 10.1016/j.pharmthera.2011.01.008 }}</ref> SND1 is Tudor Domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster.<ref>{{cite journal|last=Ying|first=Muying|author2=Chen, Dahua |title=Tudor domain-containing proteins of Drosophila melanogaster|journal=Development, Growth & Differentiation|date=1 January 2012|volume=54|issue=1|pages=32–43|doi=10.1111/j.1440-169X.2011.01308.x}}</ref> SND1 is also involved in Autism.<ref>{{cite journal | vauthors = Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantojärvi K, Järvelä I, Klauck SM, Poustka F, Bailey AJ, Monaco AP | title = Linkage and candidate gene studies of autism spectrum disorders in European populations | journal = European Journal of Human Genetics | volume = 18 | issue = 9 | pages = 1013–9 | date = Sep 2010 | pmid = 20442744 | pmc = 2987412 | doi = 10.1038/ejhg.2010.69 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{GNF_Protein_box
| image = PBB_Protein_SND1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hqx.
| PDB = {{PDB2|2hqx}}, {{PDB2|2o4x}}
| Name = Staphylococcal nuclease and tudor domain containing 1
| HGNCid = 30646
| Symbol = SND1
| AltSymbols =; p100; TDRD11
| OMIM = 602181
| ECnumber = 
| Homologene = 8665
| MGIid = 1929266
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0004518 |text = nuclease activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27044
    | Hs_Ensembl = ENSG00000197157
    | Hs_RefseqProtein = NP_055205
    | Hs_RefseqmRNA = NM_014390
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 127079438
    | Hs_GenLoc_end = 127519894
    | Hs_Uniprot = Q7KZF4
    | Mm_EntrezGene = 56463
    | Mm_Ensembl = ENSMUSG00000001424
    | Mm_RefseqmRNA = NM_019776
    | Mm_RefseqProtein = NP_062750
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 28430358
    | Mm_GenLoc_end = 28838842
    | Mm_Uniprot = Q3TJ56
  }}
}}
'''Staphylococcal nuclease and tudor domain containing 1''', also known as '''SND1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SND1 staphylococcal nuclease and tudor domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27044| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SND1 acts as [[oncogene]] in many cancers<ref name="pmid20883704">{{cite journal | vauthors = Tsuchiya N, Nakagama H | title = MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis | journal = Mutation Research | volume = 693 | issue = 1–2 | pages = 94–100 | date = Nov 2010 | pmid = 20883704 | doi = 10.1016/j.mrfmmm.2010.09.001 }}</ref><ref name="pmid19435788">{{cite journal | vauthors = Kuruma H, Kamata Y, Takahashi H, Igarashi K, Kimura T, Miki K, Miki J, Sasaki H, Hayashi N, Egawa S | title = Staphylococcal nuclease domain-containing protein 1 as a potential tissue marker for prostate cancer | journal = The American Journal of Pathology | volume = 174 | issue = 6 | pages = 2044–50 | date = Jun 2009 | pmid = 19435788 | pmc = 2684170 | doi = 10.2353/ajpath.2009.080776 }}</ref><ref name="pmid19086899">{{cite journal | vauthors = Ho J, Kong JW, Choong LY, Loh MC, Toy W, Chong PK, Wong CH, Wong CY, Shah N, Lim YP | title = Novel breast cancer metastasis-associated proteins | journal = Journal of Proteome Research | volume = 8 | issue = 2 | pages = 583–94 | date = Feb 2009 | pmid = 19086899 | doi = 10.1021/pr8007368 }}</ref> and in [[hepatocellular carcinoma]] progression.<ref name="Yoo_2011"/><ref name="pmid21256156"/> SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves [[NF-kappaB]] and [[mir-221 microRNA|miR-221]].<ref name="pmid22396537">{{cite journal | vauthors = Santhekadur PK, Das SK, Gredler R, Chen D, Srivastava J, Robertson C, Baldwin AS, Fisher PB, Sarkar D | title = Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221 | journal = The Journal of Biological Chemistry | volume = 287 | issue = 17 | pages = 13952–8 | date = Apr 2012 | pmid = 22396537 | pmc = 3340184 | doi = 10.1074/jbc.M111.321646 }}</ref> SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGFβ signaling.<ref name=Santhekadur_2014>{{cite journal | vauthors = Santhekadur PK, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson CL, Mukhopadhyay ND, Fisher PB, Sarkar D | title = Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling | journal = FEBS Open Bio | volume = 4 | pages = 353–61 | year = 2014 | pmid = 24918049 | doi = 10.1016/j.fob.2014.03.012 | pmc=4050181}}</ref> SND1 expression is regulated by [[Mir-184]] in [[glioma]]s.<ref>{{cite journal | vauthors = Emdad L, Janjic A, Alzubi MA, Hu B, Santhekadur PK, Menezes ME, Shen XN, Das SK, Sarkar D, Fisher PB | title = Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness | journal = Neuro-Oncology | volume = 17 | issue = 3 | pages = 419–29 | date = Mar 2015 | pmid = 25216670 | doi = 10.1093/neuonc/nou220 | pmc=4483100}}</ref>
{{PBB_Summary
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| summary_text =  
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SND1 has been shown to [[Protein-protein interaction|interact]] with [[MYB (gene)|MYB]],<ref name = "pmid8756344">{{cite journal | vauthors = Dash AB, Orrico FC, Ness SA | title = The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb | journal = Genes & Development | volume = 10 | issue = 15 | pages = 1858–69 | date = Aug 1996 | pmid = 8756344 | doi = 10.1101/gad.10.15.1858 }}</ref>
* [[PIM1]],<ref name = "pmid9809063">{{cite journal | vauthors = Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA | title = Pim-1 kinase and p100 cooperate to enhance c-Myb activity | journal = Molecular Cell | volume = 2 | issue = 4 | pages = 417–25 | date = Oct 1998 | pmid = 9809063 | doi = 10.1016/S1097-2765(00)80141-0 }}</ref> [[POLR2A]],<ref name = pmid12234934/> [[RBPJ]],<ref name = "pmid10644367">{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD | title = A role for SKIP in EBNA2 activation of CBF1-repressed promoters | journal = Journal of Virology | volume = 74 | issue = 4 | pages = 1939–47 | date = Feb 2000 | pmid = 10644367 | pmc = 111672 | doi = 10.1128/jvi.74.4.1939-1947.2000 }}</ref><ref name = "pmid9874765">{{cite journal | vauthors = Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD | title = CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 1 | pages = 23–8 | date = Jan 1999 | pmid = 9874765 | pmc = 15086 | doi = 10.1073/pnas.96.1.23 }}</ref>  and [[STAT6]].<ref name = "pmid12234934">{{cite journal | vauthors = Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O | title = Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II | journal = The EMBO Journal | volume = 21 | issue = 18 | pages = 4950–8 | date = Sep 2002 | pmid = 12234934 | pmc = 126276 | doi = 10.1093/emboj/cdf463 }}</ref>
 
SND1 also interacts with [[G3BP1|G3BP]] (stress granule protein)<ref name="pmid20643132">{{cite journal | vauthors = Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J | title = Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions | journal = FEBS Letters | volume = 584 | issue = 16 | pages = 3525–32 | date = Aug 2010 | pmid = 20643132 | doi = 10.1016/j.febslet.2010.07.022 }}</ref> and [[MTDH|AEG-1]].<ref name="Yoo_2011"/><ref name="pmid21256156"/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Dash AB, Orrico FC, Ness SA | title = The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb | journal = Genes & Development | volume = 10 | issue = 15 | pages = 1858–69 | date = Aug 1996 | pmid = 8756344 | doi = 10.1101/gad.10.15.1858 }}
| citations =
* {{cite journal | vauthors = Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA | title = Pim-1 kinase and p100 cooperate to enhance c-Myb activity | journal = Molecular Cell | volume = 2 | issue = 4 | pages = 417–25 | date = Oct 1998 | pmid = 9809063 | doi = 10.1016/S1097-2765(00)80141-0 }}
*{{cite journal | author=Tong X, Drapkin R, Yalamanchili R, ''et al.'' |title=The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 4735-44 |year= 1995 |pmid= 7651391 |doi=  }}
* {{cite journal | vauthors = Liénard P, Rivière M, Van Vooren P, Szpirer C, Szpirer J | title = Assignment of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 90 | issue = 3–4 | pages = 253–4 | year = 2001 | pmid = 11124528 | doi = 10.1159/000056783 }}
*{{cite journal  | author=Dash AB, Orrico FC, Ness SA |title=The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb. |journal=Genes Dev. |volume=10 |issue= 15 |pages= 1858-69 |year= 1996 |pmid= 8756344 |doi= }}
* {{cite journal | vauthors = Rushton JJ, Ness SA | title = The conserved DNA binding domain mediates similar regulatory interactions for A-Myb, B-Myb, and c-Myb transcription factors | journal = Blood Cells, Molecules & Diseases | volume = 27 | issue = 2 | pages = 459–63 | year = 2001 | pmid = 11259168 | doi = 10.1006/bcmd.2001.0405 }}
*{{cite journal  | author=Callebaut I, Mornon JP |title=The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development. |journal=Biochem. J. |volume=321 ( Pt 1) |issue=  |pages= 125-32 |year= 1997 |pmid= 9003410 |doi=  }}
* {{cite journal | vauthors = Broadhurst MK, Wheeler TT | title = The p100 coactivator is present in the nuclei of mammary epithelial cells and its abundance is increased in response to prolactin in culture and in mammary tissue during lactation | journal = The Journal of Endocrinology | volume = 171 | issue = 2 | pages = 329–37 | date = Nov 2001 | pmid = 11691653 | doi = 10.1677/joe.0.1710329 }}
*{{cite journal | author=Leverson JD, Koskinen PJ, Orrico FC, ''et al.'' |title=Pim-1 kinase and p100 cooperate to enhance c-Myb activity. |journal=Mol. Cell |volume=2 |issue= 4 |pages= 417-25 |year= 1998 |pmid= 9809063 |doi= }}
* {{cite journal | vauthors = Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O | title = Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II | journal = The EMBO Journal | volume = 21 | issue = 18 | pages = 4950–8 | date = Sep 2002 | pmid = 12234934 | pmc = 126276 | doi = 10.1093/emboj/cdf463 }}
*{{cite journal | author=Liénard P, Rivière M, Van Vooren P, ''et al.'' |title=Assignment of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 3-4 |pages= 253-4 |year= 2001 |pmid= 11124528 |doi= }}
* {{cite journal | vauthors = Tijms MA, Snijder EJ | title = Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100 | journal = The Journal of General Virology | volume = 84 | issue = Pt 9 | pages = 2317–22 | date = Sep 2003 | pmid = 12917451 | doi = 10.1099/vir.0.19297-0 }}
*{{cite journal | author=Rushton JJ, Ness SA |title=The conserved DNA binding domain mediates similar regulatory interactions for A-Myb, B-Myb, and c-Myb transcription factors. |journal=Blood Cells Mol. Dis. |volume=27 |issue= 2 |pages= 459-63 |year= 2001 |pmid= 11259168 |doi= 10.1006/bcmd.2001.0405 }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = Jan 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal | author=Broadhurst MK, Wheeler TT |title=The p100 coactivator is present in the nuclei of mammary epithelial cells and its abundance is increased in response to prolactin in culture and in mammary tissue during lactation. |journal=J. Endocrinol. |volume=171 |issue= 2 |pages= 329-37 |year= 2001 |pmid= 11691653 |doi= }}
* {{cite journal | vauthors = Broadhurst MK, Lee RS, Hawkins S, Wheeler TT | title = The p100 EBNA-2 coactivator: a highly conserved protein found in a range of exocrine and endocrine cells and tissues in cattle | journal = Biochimica et Biophysica Acta | volume = 1681 | issue = 2–3 | pages = 126–33 | date = Jan 2005 | pmid = 15627504 | doi = 10.1016/j.bbaexp.2004.10.009 }}
*{{cite journal | author=Yang J, Aittomäki S, Pesu M, ''et al.'' |title=Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. |journal=EMBO J. |volume=21 |issue= 18 |pages= 4950-8 |year= 2002 |pmid= 12234934 |doi=  }}
* {{cite journal | vauthors = Välineva T, Yang J, Palovuori R, Silvennoinen O | title = The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6 | journal = The Journal of Biological Chemistry | volume = 280 | issue = 15 | pages = 14989–96 | date = Apr 2005 | pmid = 15695802 | doi = 10.1074/jbc.M410465200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF | title = Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes | journal = Journal of Proteome Research | volume = 5 | issue = 11 | pages = 3135–44 | date = Nov 2006 | pmid = 17081065 | doi = 10.1021/pr060363j }}
*{{cite journal  | author=Paukku K, Yang J, Silvennoinen O |title=Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5. |journal=Mol. Endocrinol. |volume=17 |issue= 9 |pages= 1805-14 |year= 2004 |pmid= 12819296 |doi= 10.1210/me.2002-0256 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Tijms MA, Snijder EJ |title=Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100. |journal=J. Gen. Virol. |volume=84 |issue= Pt 9 |pages= 2317-22 |year= 2003 |pmid= 12917451 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Broadhurst MK, Lee RS, Hawkins S, Wheeler TT |title=The p100 EBNA-2 coactivator: a highly conserved protein found in a range of exocrine and endocrine cells and tissues in cattle. |journal=Biochim. Biophys. Acta |volume=1681 |issue= 2-3 |pages= 126-33 |year= 2005 |pmid= 15627504 |doi= 10.1016/j.bbaexp.2004.10.009 }}
*{{cite journal | author=Välineva T, Yang J, Palovuori R, Silvennoinen O |title=The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 14989-96 |year= 2005 |pmid= 15695802 |doi= 10.1074/jbc.M410465200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Chi A, Valencia JC, Hu ZZ, ''et al.'' |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135-44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 13:54, 7 November 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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Wikidata
View/Edit Human

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene.[1][2][3][4] SND1 is a main component of RISC complex[5] and plays an important role in miRNA function.[6][7] SND1 is Tudor Domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster.[8] SND1 is also involved in Autism.[9]

Clinical significance

SND1 acts as oncogene in many cancers[10][11][12] and in hepatocellular carcinoma progression.[6][7] SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221.[13] SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGFβ signaling.[14] SND1 expression is regulated by Mir-184 in gliomas.[15]

Interactions

SND1 has been shown to interact with MYB,[16]

SND1 also interacts with G3BP (stress granule protein)[21] and AEG-1.[6][7]

References

  1. ↑ Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (Sep 1995). "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Molecular and Cellular Biology. 15 (9): 4735–44. doi:10.1128/mcb.15.9.4735. PMC 230717. PMID 7651391.
  2. ↑ Callebaut I, Mornon JP (Jan 1997). "The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development". The Biochemical Journal. 321 (1): 125–32. doi:10.1042/bj3210125. PMC 1218045. PMID 9003410.
  3. ↑ Paukku K, Yang J, Silvennoinen O (Sep 2003). "Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5". Molecular Endocrinology. 17 (9): 1805–14. doi:10.1210/me.2002-0256. PMID 12819296.
  4. ↑ "Entrez Gene: SND1 staphylococcal nuclease and tudor domain containing 1".
  5. ↑ Tsuchiya N, Ochiai M, Nakashima K, Ubagai T, Sugimura T, Nakagama H (Oct 2007). "SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis". Cancer Research. 67 (19): 9568–76. doi:10.1158/0008-5472.CAN-06-2707. PMID 17909068.
  6. ↑ 6.0 6.1 6.2 Yoo BK, Santhekadur PK, Gredler R, Chen D, Emdad L, Bhutia S, Pannell L, Fisher PB, Sarkar D (May 2011). "Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma". Hepatology. 53 (5): 1538–48. doi:10.1002/hep.24216. PMC 3081619. PMID 21520169.
  7. ↑ 7.0 7.1 7.2 Yoo BK, Emdad L, Lee SG, Su ZZ, Santhekadur P, Chen D, Gredler R, Fisher PB, Sarkar D (Apr 2011). "Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology". Pharmacology & Therapeutics. 130 (1): 1–8. doi:10.1016/j.pharmthera.2011.01.008. PMC 3043119. PMID 21256156.
  8. ↑ Ying, Muying; Chen, Dahua (1 January 2012). "Tudor domain-containing proteins of Drosophila melanogaster". Development, Growth & Differentiation. 54 (1): 32–43. doi:10.1111/j.1440-169X.2011.01308.x.
  9. ↑ Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantojärvi K, Järvelä I, Klauck SM, Poustka F, Bailey AJ, Monaco AP (Sep 2010). "Linkage and candidate gene studies of autism spectrum disorders in European populations". European Journal of Human Genetics. 18 (9): 1013–9. doi:10.1038/ejhg.2010.69. PMC 2987412. PMID 20442744.
  10. ↑ Tsuchiya N, Nakagama H (Nov 2010). "MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis". Mutation Research. 693 (1–2): 94–100. doi:10.1016/j.mrfmmm.2010.09.001. PMID 20883704.
  11. ↑ Kuruma H, Kamata Y, Takahashi H, Igarashi K, Kimura T, Miki K, Miki J, Sasaki H, Hayashi N, Egawa S (Jun 2009). "Staphylococcal nuclease domain-containing protein 1 as a potential tissue marker for prostate cancer". The American Journal of Pathology. 174 (6): 2044–50. doi:10.2353/ajpath.2009.080776. PMC 2684170. PMID 19435788.
  12. ↑ Ho J, Kong JW, Choong LY, Loh MC, Toy W, Chong PK, Wong CH, Wong CY, Shah N, Lim YP (Feb 2009). "Novel breast cancer metastasis-associated proteins". Journal of Proteome Research. 8 (2): 583–94. doi:10.1021/pr8007368. PMID 19086899.
  13. ↑ Santhekadur PK, Das SK, Gredler R, Chen D, Srivastava J, Robertson C, Baldwin AS, Fisher PB, Sarkar D (Apr 2012). "Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221". The Journal of Biological Chemistry. 287 (17): 13952–8. doi:10.1074/jbc.M111.321646. PMC 3340184. PMID 22396537.
  14. ↑ Santhekadur PK, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson CL, Mukhopadhyay ND, Fisher PB, Sarkar D (2014). "Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling". FEBS Open Bio. 4: 353–61. doi:10.1016/j.fob.2014.03.012. PMC 4050181. PMID 24918049.
  15. ↑ Emdad L, Janjic A, Alzubi MA, Hu B, Santhekadur PK, Menezes ME, Shen XN, Das SK, Sarkar D, Fisher PB (Mar 2015). "Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness". Neuro-Oncology. 17 (3): 419–29. doi:10.1093/neuonc/nou220. PMC 4483100. PMID 25216670.
  16. ↑ Dash AB, Orrico FC, Ness SA (Aug 1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb". Genes & Development. 10 (15): 1858–69. doi:10.1101/gad.10.15.1858. PMID 8756344.
  17. ↑ Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA (Oct 1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity". Molecular Cell. 2 (4): 417–25. doi:10.1016/S1097-2765(00)80141-0. PMID 9809063.
  18. ↑ 18.0 18.1 Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O (Sep 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". The EMBO Journal. 21 (18): 4950–8. doi:10.1093/emboj/cdf463. PMC 126276. PMID 12234934.
  19. ↑ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
  20. ↑ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
  21. ↑ Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J (Aug 2010). "Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions". FEBS Letters. 584 (16): 3525–32. doi:10.1016/j.febslet.2010.07.022. PMID 20643132.

Further reading

  • Dash AB, Orrico FC, Ness SA (Aug 1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb". Genes & Development. 10 (15): 1858–69. doi:10.1101/gad.10.15.1858. PMID 8756344.
  • Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA (Oct 1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity". Molecular Cell. 2 (4): 417–25. doi:10.1016/S1097-2765(00)80141-0. PMID 9809063.
  • Liénard P, Rivière M, Van Vooren P, Szpirer C, Szpirer J (2001). "Assignment of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization". Cytogenetics and Cell Genetics. 90 (3–4): 253–4. doi:10.1159/000056783. PMID 11124528.
  • Rushton JJ, Ness SA (2001). "The conserved DNA binding domain mediates similar regulatory interactions for A-Myb, B-Myb, and c-Myb transcription factors". Blood Cells, Molecules & Diseases. 27 (2): 459–63. doi:10.1006/bcmd.2001.0405. PMID 11259168.
  • Broadhurst MK, Wheeler TT (Nov 2001). "The p100 coactivator is present in the nuclei of mammary epithelial cells and its abundance is increased in response to prolactin in culture and in mammary tissue during lactation". The Journal of Endocrinology. 171 (2): 329–37. doi:10.1677/joe.0.1710329. PMID 11691653.
  • Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O (Sep 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". The EMBO Journal. 21 (18): 4950–8. doi:10.1093/emboj/cdf463. PMC 126276. PMID 12234934.
  • Tijms MA, Snijder EJ (Sep 2003). "Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100". The Journal of General Virology. 84 (Pt 9): 2317–22. doi:10.1099/vir.0.19297-0. PMID 12917451.
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (Jan 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
  • Broadhurst MK, Lee RS, Hawkins S, Wheeler TT (Jan 2005). "The p100 EBNA-2 coactivator: a highly conserved protein found in a range of exocrine and endocrine cells and tissues in cattle". Biochimica et Biophysica Acta. 1681 (2–3): 126–33. doi:10.1016/j.bbaexp.2004.10.009. PMID 15627504.
  • Välineva T, Yang J, Palovuori R, Silvennoinen O (Apr 2005). "The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6". The Journal of Biological Chemistry. 280 (15): 14989–96. doi:10.1074/jbc.M410465200. PMID 15695802.
  • Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (Nov 2006). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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