SKAP2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Src kinase-associated phosphoprotein 2''' is an [[enzyme]] that in humans is encoded by the ''SKAP2'' [[gene]].<ref name="pmid9837776">{{cite journal | vauthors = Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T | title = RA70 is a src kinase-associated protein expressed ubiquitously | journal = Biochemical and Biophysical Research Communications | volume = 252 | issue = 3 | pages = 738–42 | date = November 1998 | pmid = 9837776 | pmc =  | doi = 10.1006/bbrc.1998.9637 }}</ref><ref name="pmid9755858">{{cite journal | vauthors = Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B | title = SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55 | journal = FEBS Letters | volume = 435 | issue = 1 | pages = 55–60 | date = September 1998 | pmid = 9755858 | pmc =  | doi = 10.1016/S0014-5793(98)01040-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SKAP2 src kinase associated phosphoprotein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8935| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SKAP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1u5e.
| PDB = {{PDB2|1u5e}}, {{PDB2|1u5g}}, {{PDB2|2otx}}
| Name = Src kinase associated phosphoprotein 2
| HGNCid = 15687
| Symbol = SKAP2
| AltSymbols =; MGC10411; MGC33304; PRAP; RA70; SAPS; SCAP2; SKAP-HOM; SKAP55R
| OMIM = 605215
| ECnumber = 
| Homologene = 2919
| MGIid = 1889206
| GeneAtlas_image1 = PBB_GE_SKAP2_204362_at_tn.png
| GeneAtlas_image2 = PBB_GE_SKAP2_204361_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SKAP2_216899_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042113 |text = B cell activation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8935
    | Hs_Ensembl = ENSG00000005020
    | Hs_RefseqProtein = NP_003921
    | Hs_RefseqmRNA = NM_003930
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 26673215
    | Hs_GenLoc_end = 26870866
    | Hs_Uniprot = O75563
    | Mm_EntrezGene = 54353
    | Mm_Ensembl = ENSMUSG00000059182
    | Mm_RefseqmRNA = NM_018773
    | Mm_RefseqProtein = NP_061243
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 51788744
    | Mm_GenLoc_end = 51942132
    | Mm_Uniprot = Q3UND0
  }}
}}
'''Src kinase associated phosphoprotein 2''', also known as '''SKAP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SKAP2 src kinase associated phosphoprotein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8935| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene belongs to the [[Src family kinase|src family kinases]]. This protein is similar to the src kinase associated [[phosphoprotein]] 1. It is an [[Signal transducing adaptor protein|adaptor protein]] that is thought to play an essential role in the src signaling pathway in various cells, but particularly specific in [[macrophages]]. It inhibits [[PTK2B|PTK2B/RAFTK]] activity and regulates [[alpha-synuclein]] phosphorylation.<ref name="entrez" />  It interacts with [[Signal-regulatory protein alpha]] and directs [[integrin]]-activated [[Cytoskeleton|cytoskeletal]] reorganization in macrophages.<ref>{{cite journal | vauthors = Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD | title = Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement | language = en | journal = Journal of Cell Science | volume = 125 | issue = Pt 22 | pages = 5535–45 | date = November 2012 | pmid = 22976304 | doi = 10.1242/jcs.111260 | url = http://jcs.biologists.org/content/125/22/5535 | pmc=3561861}}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.<ref name="entrez">{{cite web | title = Entrez Gene: SKAP2 src kinase associated phosphoprotein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8935| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE | title = FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8779–84 | date = July 1998 | pmid = 9671755 | pmc = 21153 | doi = 10.1073/pnas.95.15.8779 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Wang X, Stollar BD | title = Immunoglobulin VH gene expression in human aging | journal = Clinical Immunology | volume = 93 | issue = 2 | pages = 132–42 | date = November 1999 | pmid = 10527689 | doi = 10.1006/clim.1999.4781 }}
*{{cite journal | author=Liu J, Kang H, Raab M, ''et al.'' |title=FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8779-84 |year= 1998 |pmid= 9671755 |doi=  }}
* {{cite journal | vauthors = Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, Watson SP | title = Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin | journal = The Journal of Biological Chemistry | volume = 275 | issue = 43 | pages = 33427–34 | date = October 2000 | pmid = 10942756 | doi = 10.1074/jbc.M001439200 }}
*{{cite journal  | author=Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B |title=SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. |journal=FEBS Lett. |volume=435 |issue= 1 |pages= 55-60 |year= 1998 |pmid= 9755858 |doi=  }}
* {{cite journal | vauthors = Curtis DJ, Jane SM, Hilton DJ, Dougherty L, Bodine DM, Begley CG | title = Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest | journal = Experimental Hematology | volume = 28 | issue = 11 | pages = 1250–9 | date = November 2000 | pmid = 11063873 | doi = 10.1016/S0301-472X(00)00537-3 }}
*{{cite journal  | author=Kouroku Y, Soyama A, Fujita E, ''et al.'' |title=RA70 is a src kinase-associated protein expressed ubiquitously. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 3 |pages= 738-42 |year= 1999 |pmid= 9837776 |doi= 10.1006/bbrc.1998.9637 }}
* {{cite journal | vauthors = Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cavé-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G | title = PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 25 | pages = 22375–81 | date = June 2001 | pmid = 11301322 | doi = 10.1074/jbc.M011683200 }}
*{{cite journal | author=Wang X, Stollar BD |title=Immunoglobulin VH gene expression in human aging. |journal=Clin. Immunol. |volume=93 |issue= 2 |pages= 132-42 |year= 1999 |pmid= 10527689 |doi= 10.1006/clim.1999.4781 }}
* {{cite journal | vauthors = Kirchgessner H, Dietrich J, Scherer J, Isomäki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B | title = The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain | journal = The Journal of Experimental Medicine | volume = 193 | issue = 11 | pages = 1269–84 | date = June 2001 | pmid = 11390434 | pmc = 2193385 | doi = 10.1084/jem.193.11.1269 }}
*{{cite journal | author=Asazuma N, Wilde JI, Berlanga O, ''et al.'' |title=Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33427-34 |year= 2000 |pmid= 10942756 |doi= 10.1074/jbc.M001439200 }}
* {{cite journal | vauthors = Takahashi T, Yamashita H, Nagano Y, Nakamura T, Ohmori H, Avraham H, Avraham S, Yasuda M, Matsumoto M | title = Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 43 | pages = 42225–33 | date = October 2003 | pmid = 12893833 | doi = 10.1074/jbc.M213217200 }}
*{{cite journal | author=Curtis DJ, Jane SM, Hilton DJ, ''et al.'' |title=Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest. |journal=Exp. Hematol. |volume=28 |issue= 11 |pages= 1250-9 |year= 2001 |pmid= 11063873 |doi= }}
* {{cite journal | vauthors = Park SY, Avraham HK, Avraham S | title = RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner | journal = The Journal of Biological Chemistry | volume = 279 | issue = 32 | pages = 33315–22 | date = August 2004 | pmid = 15166227 | doi = 10.1074/jbc.M313527200 }}
*{{cite journal | author=Moog-Lutz C, Peterson EJ, Lutz PG, ''et al.'' |title=PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22375-81 |year= 2001 |pmid= 11301322 |doi= 10.1074/jbc.M011683200 }}
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | date = March 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 }}
*{{cite journal | author=Kirchgessner H, Dietrich J, Scherer J, ''et al.'' |title=The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. |journal=J. Exp. Med. |volume=193 |issue= 11 |pages= 1269-84 |year= 2001 |pmid= 11390434 |doi=  }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Takahashi T, Yamashita H, Nagano Y, ''et al.'' |title=Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42225-33 |year= 2004 |pmid= 12893833 |doi= 10.1074/jbc.M213217200 }}
*{{cite journal | author=Park SY, Avraham HK, Avraham S |title=RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33315-22 |year= 2004 |pmid= 15166227 |doi= 10.1074/jbc.M313527200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=8935}}
{{WikiDoc Sources}}
{{gene-7-stub}}

Latest revision as of 18:02, 9 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.[1][2][3]

Function

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells, but particularly specific in macrophages. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.[3] It interacts with Signal-regulatory protein alpha and directs integrin-activated cytoskeletal reorganization in macrophages.[4]

References

  1. ↑ Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T (November 1998). "RA70 is a src kinase-associated protein expressed ubiquitously". Biochemical and Biophysical Research Communications. 252 (3): 738–42. doi:10.1006/bbrc.1998.9637. PMID 9837776.
  2. ↑ Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (September 1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Letters. 435 (1): 55–60. doi:10.1016/S0014-5793(98)01040-0. PMID 9755858.
  3. ↑ 3.0 3.1 "Entrez Gene: SKAP2 src kinase associated phosphoprotein 2".
  4. ↑ Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD (November 2012). "Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement". Journal of Cell Science. 125 (Pt 22): 5535–45. doi:10.1242/jcs.111260. PMC 3561861. PMID 22976304.

Further reading

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