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{{ | '''Myotrophin''' is a [[protein]] that in humans is encoded by the ''MTPN'' [[gene]].<ref name="pmid11474205">{{cite journal |vauthors=Mitra S, Timur AA, Gupta S, Wang Q, Sen S | title = Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 93 | issue = 1–2 | pages = 151–2 | date=July 2001| pmid = 11474205 | pmc = | doi =10.1159/000056974 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MTPN myotrophin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=136319| accessdate = }}</ref> | ||
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==Interactions== | |||
MTPN has been shown to [[Protein-protein interaction|interact]] with [[RELA]]<ref name=pmid11971907>{{cite journal |last=Knuefermann |first=Pascal |authorlink= |author2=Chen Peter |author3=Misra Arunima |author4=Shi Shu-Ping |author5=Abdellatif Maha |author6=Sivasubramanian Natarajan |date=June 2002|title=Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers |journal=J. Biol. Chem. |volume=277 |issue=26 |pages=23888–97 |publisher= |location = United States| issn = 0021-9258| pmid = 11971907 |doi = 10.1074/jbc.M202937200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[REL]].<ref name=pmid11971907/> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | author=Taoka M | *{{cite journal | author=Taoka M |title=A rat cerebellar protein containing the cdc10/SWI6 motif |journal=Eur. J. Biochem. |volume=207 |issue= 2 |pages= 615–20 |year= 1992 |pmid= 1633812 |doi=10.1111/j.1432-1033.1992.tb17088.x |name-list-format=vanc| author2=Yamakuni T | author3=Song SY | display-authors=3 | last4=Yamakawa | first4=Yoshio | last5=Seta | first5=Kazuo | last6=Okuyama | first6=Tsuneo | last7=Isobe | first7=Toshiaki }} | ||
*{{cite journal |vauthors=Sil P, Misono K, Sen S |title=Myotrophin in human cardiomyopathic heart |journal=Circ. Res. |volume=73 |issue= 1 |pages= 98–108 |year= 1993 |pmid= 8508536 |doi= 10.1161/01.res.73.1.98}} | |||
*{{cite journal | | *{{cite journal |vauthors=Sivasubramanian N, Adhikary G, Sil PC, Sen S |title=Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2812–6 |year= 1996 |pmid= 8576259 |doi=10.1074/jbc.271.5.2812 }} | ||
*{{cite journal | author=Anderson KM |title=cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy |journal=J. Mol. Cell. Cardiol. |volume=31 |issue= 4 |pages= 705–19 |year= 1999 |pmid= 10329199 |doi= 10.1006/jmcc.1998.0903 |name-list-format=vanc| author2=Berrebi-Bertrand I | author3=Kirkpatrick RB | display-authors=3 | last4=McQueney | first4=MS | last5=Underwood | first5=DC | last6=Rouanet | first6=S | last7=Chabot-Fletcher | first7=M }} | |||
*{{cite journal | author= | *{{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }} | ||
*{{cite journal | author=Wiemann S |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |name-list-format=vanc| author2=Weil B | author3=Wellenreuther R | display-authors=3 | last4=Gassenhuber | first4=J | last5=Glassl | first5=S | last6=Ansorge | first6=W | last7=Böcher | first7=M | last8=Blöcker | first8=H | last9=Bauersachs | first9=S }} | |||
*{{cite journal | | *{{cite journal | author=Simpson JC |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |name-list-format=vanc| author2=Wellenreuther R | author3=Poustka A | display-authors=3 | last4=Pepperkok | first4=R | last5=Wiemann | first5=S }} | ||
*{{cite journal | author= | *{{cite journal | author=Knuefermann P |title=Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23888–97 |year= 2002 |pmid= 11971907 |doi= 10.1074/jbc.M202937200 |name-list-format=vanc| author2=Chen P | author3=Misra A | display-authors=3 | last4=Shi | first4=SP | last5=Abdellatif | first5=M | last6=Sivasubramanian | first6=N }} | ||
*{{cite journal |vauthors=Gupta S, Sen S |title=Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy |journal=Biochim. Biophys. Acta |volume=1589 |issue= 3 |pages= 247–60 |year= 2002 |pmid= 12031792 |doi=10.1016/S0167-4889(02)00178-7 }} | |||
*{{cite journal | author= | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}} | ||
*{{cite journal | author=Scherer SW |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |name-list-format=vanc| author2=Cheung J | author3=MacDonald JR | display-authors=3 | last4=Osborne | first4=LR | last5=Nakabayashi | first5=K | last6=Herbrick | first6=JA | last7=Carson | first7=AR | last8=Parker-Katiraee | first8=L | last9=Skaug | first9=J |bibcode=2003Sci...300..767S}} | |||
*{{cite journal | author= | *{{cite journal | author=Hillier LW |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |name-list-format=vanc| author2=Fulton RS | author3=Fulton LA | display-authors=3 | last4=Graves | first4=Tina A. | last5=Pepin | first5=Kymberlie H. | last6=Wagner-Mcpherson | first6=Caryn | last7=Layman | first7=Dan | last8=Maas | first8=Jason | last9=Jaeger | first9=Sara |bibcode=2003Natur.424..157H}} | ||
*{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | |||
*{{cite journal | | *{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | author= | *{{cite journal | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |name-list-format=vanc| author2=Arlt D | author3=Huber W | display-authors=3 | last4=Wellenreuther | first4=R | last5=Schleeger | first5=S | last6=Mehrle | first6=A | last7=Bechtel | first7=S | last8=Sauermann | first8=M | last9=Korf | first9=U }} | ||
*{{cite journal | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |name-list-format=vanc| author2=Rosenfelder H | author3=Schupp I | display-authors=3 | last4=Del Val | first4=C | last5=Arlt | first5=D | last6=Hahne | first6=F | last7=Bechtel | first7=S | last8=Simpson | first8=J | last9=Hofmann | first9=O }} | |||
*{{cite journal | author= | *{{cite journal | author=Xiong Z |title=An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions |journal=J. Immunol. |volume=177 |issue= 7 |pages= 4907–16 |year= 2006 |pmid= 16982933 |doi= 10.4049/jimmunol.177.7.4907|name-list-format=vanc| author2=Liu E | author3=Yan Y | display-authors=3 | last4=Silver | first4=RT | last5=Yang | first5=F | last6=Chen | first6=IH | last7=Chen | first7=Y | last8=Verstovsek | first8=S | last9=Wang | first9=H |pmc=3902139}} | ||
*{{cite journal | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |name-list-format=vanc| author2=Chu P | author3=Elisma F | display-authors=3 | last4=Li | first4=Hongyan | last5=Taylor | first5=Paul | last6=Climie | first6=Shane | last7=McBroom-Cerajewski | first7=Linda | last8=Robinson | first8=Mark D | last9=O'Connor | first9=Liam }} | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=136319}} | |||
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{{ | {{gene-7-stub}} | ||
Latest revision as of 03:44, 25 June 2018
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| UniProt |
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| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
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Myotrophin is a protein that in humans is encoded by the MTPN gene.[1][2]
Interactions
MTPN has been shown to interact with RELA[3] and REL.[3]
References
- ↑ Mitra S, Timur AA, Gupta S, Wang Q, Sen S (July 2001). "Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization". Cytogenet Cell Genet. 93 (1–2): 151–2. doi:10.1159/000056974. PMID 11474205.
- ↑ "Entrez Gene: MTPN myotrophin".
- ↑ 3.0 3.1 Knuefermann, Pascal; Chen Peter; Misra Arunima; Shi Shu-Ping; Abdellatif Maha; Sivasubramanian Natarajan (June 2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. United States. 277 (26): 23888–97. doi:10.1074/jbc.M202937200. ISSN 0021-9258. PMID 11971907.
Further reading
- Taoka M, Yamakuni T, Song SY, et al. (1992). "A rat cerebellar protein containing the cdc10/SWI6 motif". Eur. J. Biochem. 207 (2): 615–20. doi:10.1111/j.1432-1033.1992.tb17088.x. PMID 1633812.
- Sil P, Misono K, Sen S (1993). "Myotrophin in human cardiomyopathic heart". Circ. Res. 73 (1): 98–108. doi:10.1161/01.res.73.1.98. PMID 8508536.
- Sivasubramanian N, Adhikary G, Sil PC, Sen S (1996). "Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro". J. Biol. Chem. 271 (5): 2812–6. doi:10.1074/jbc.271.5.2812. PMID 8576259.
- Anderson KM, Berrebi-Bertrand I, Kirkpatrick RB, et al. (1999). "cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy". J. Mol. Cell. Cardiol. 31 (4): 705–19. doi:10.1006/jmcc.1998.0903. PMID 10329199.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Knuefermann P, Chen P, Misra A, et al. (2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26): 23888–97. doi:10.1074/jbc.M202937200. PMID 11971907.
- Gupta S, Sen S (2002). "Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy". Biochim. Biophys. Acta. 1589 (3): 247–60. doi:10.1016/S0167-4889(02)00178-7. PMID 12031792.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Xiong Z, Liu E, Yan Y, et al. (2006). "An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions". J. Immunol. 177 (7): 4907–16. doi:10.4049/jimmunol.177.7.4907. PMC 3902139. PMID 16982933.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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