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{{Infobox_gene}}
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'''Tax1-binding protein 1''' is a [[protein]] that in humans is encoded by the ''TAX1BP1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8887| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Tax1 (human T-cell leukemia virus type I) binding protein 1
| HGNCid = 11575
| Symbol = TAX1BP1
| AltSymbols =; CALCOCO3; T6BP; TXBP151
| OMIM = 605326
| ECnumber = 
| Homologene = 4395
| MGIid = 1289308
| GeneAtlas_image1 = PBB_GE_TAX1BP1_200976_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TAX1BP1_200977_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TAX1BP1_213786_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8887
    | Hs_Ensembl = ENSG00000106052
    | Hs_RefseqProtein = NP_001073333
    | Hs_RefseqmRNA = NM_001079864
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 27746333
    | Hs_GenLoc_end = 27835399
    | Hs_Uniprot = Q86VP1
    | Mm_EntrezGene = 52440
    | Mm_Ensembl = ENSMUSG00000004535
    | Mm_RefseqmRNA = NM_025816
    | Mm_RefseqProtein = NP_080092
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 52643326
    | Mm_GenLoc_end = 52695652
    | Mm_Uniprot = Q3UKC1
  }}
}}
'''Tax1 (human T-cell leukemia virus type I) binding protein 1''', also known as '''TAX1BP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8887| accessdate = }}</ref>


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==Interactions==
TAX1BP1 has been shown to [[Protein-protein interaction|interact]] with [[TNFAIP3]]<ref name=pmid10435631>{{cite journal |last=De Valck |first=D |authorlink= |author2=Jin D Y |author3=Heyninck K |author4=Van de Craen M |author5=Contreras R |author6=Fiers W |author7=Jeang K T |author8=Beyaert R  |date=July 1999  |title=The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases |journal=Oncogene |volume=18 |issue=29 |pages=4182–90 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10435631 |doi = 10.1038/sj.onc.1202787 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[TRAF6]].<ref name=pmid10920205>{{cite journal |last=Ling |first=L |authorlink= |author2=Goeddel D V  |date=August 2000  |title=T6BP, a TRAF6-interacting protein involved in IL-1 signaling |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=17 |pages=9567–72 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10920205 |doi = 10.1073/pnas.170279097 | bibcode =2000PNAS...97.9567L | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16905 }}</ref> TAX1BP1 binds to [[TNFAIP3]] or [[TRAF6]] and suppresses NF-kappaB transcriptional activation.


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal  |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal | author=De Valck D, Jin DY, Heyninck K, ''et al.'' |title=The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. |journal=Oncogene |volume=18 |issue= 29 |pages= 4182-90 |year= 1999 |pmid= 10435631 |doi= 10.1038/sj.onc.1202787 }}
*{{cite journal   |vauthors=De Valck D, Jin DY, Heyninck K, etal |title=The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases |journal=Oncogene |volume=18 |issue= 29 |pages= 4182–90 |year= 1999 |pmid= 10435631 |doi= 10.1038/sj.onc.1202787 }}
*{{cite journal  | author=Ling L, Goeddel DV |title=T6BP, a TRAF6-interacting protein involved in IL-1 signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9567-72 |year= 2000 |pmid= 10920205 |doi= 10.1073/pnas.170279097 }}
*{{cite journal  |vauthors=Ling L, Goeddel DV |title=T6BP, a TRAF6-interacting protein involved in IL-1 signaling |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9567–72 |year= 2000 |pmid= 10920205 |doi= 10.1073/pnas.170279097 | pmc=16905 |bibcode=2000PNAS...97.9567L }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072}}
*{{cite journal  | author=Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R |title=Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions. |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 93-7 |year= 2001 |pmid= 11389905 |doi=  }}
*{{cite journal  |vauthors=Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R |title=Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 93–7 |year= 2001 |pmid= 11389905 |doi=10.1016/S0014-5793(01)02504-2 }}
*{{cite journal  | author=Dodon MD, Hamaia S, Martin J, Gazzolo L |title=Heterogeneous nuclear ribonucleoprotein A1 interferes with the binding of the human T cell leukemia virus type 1 rex regulatory protein to its response element. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18744-52 |year= 2002 |pmid= 11893730 |doi= 10.1074/jbc.M109087200 }}
*{{cite journal  |vauthors=Dodon MD, Hamaia S, Martin J, Gazzolo L |title=Heterogeneous nuclear ribonucleoprotein A1 interferes with the binding of the human T cell leukemia virus type 1 rex regulatory protein to its response element |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18744–52 |year= 2002 |pmid= 11893730 |doi= 10.1074/jbc.M109087200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal   |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |bibcode=2003Sci...300..767S }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H }}
*{{cite journal | author=Wu K, Bottazzi ME, de la Fuente C, ''et al.'' |title=Protein profile of tax-associated complexes. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 495-508 |year= 2004 |pmid= 14530271 |doi= 10.1074/jbc.M310069200 }}
*{{cite journal   |vauthors=Wu K, Bottazzi ME, de la Fuente C, etal |title=Protein profile of tax-associated complexes |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 495–508 |year= 2004 |pmid= 14530271 |doi= 10.1074/jbc.M310069200 }}
*{{cite journal  | author=Nagaraja GM, Kandpal RP |title=Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 654-65 |year= 2004 |pmid= 14697242 |doi=  }}
*{{cite journal  |vauthors=Nagaraja GM, Kandpal RP |title=Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 654–65 |year= 2004 |pmid= 14697242 |doi=10.1016/j.bbrc.2003.12.001 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Morriswood B, Ryzhakov G, Puri C, ''et al.'' |title=T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion. |journal=J. Cell. Sci. |volume=120 |issue= Pt 15 |pages= 2574-85 |year= 2007 |pmid= 17635994 |doi= 10.1242/jcs.007005 }}
*{{cite journal   |vauthors=Morriswood B, Ryzhakov G, Puri C, etal |title=T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion |journal=J. Cell Sci. |volume=120 |issue= Pt 15 |pages= 2574–85 |year= 2007 |pmid= 17635994 |doi= 10.1242/jcs.007005 | pmc=2621013 }}
}}
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Latest revision as of 19:10, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tax1-binding protein 1 is a protein that in humans is encoded by the TAX1BP1 gene.[1]


Interactions

TAX1BP1 has been shown to interact with TNFAIP3[2] and TRAF6.[3] TAX1BP1 binds to TNFAIP3 or TRAF6 and suppresses NF-kappaB transcriptional activation.

References

  1. ↑ "Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1".
  2. ↑ De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R (July 1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. ENGLAND. 18 (29): 4182–90. doi:10.1038/sj.onc.1202787. ISSN 0950-9232. PMID 10435631.
  3. ↑ Ling, L; Goeddel D V (August 2000). "T6BP, a TRAF6-interacting protein involved in IL-1 signaling". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. doi:10.1073/pnas.170279097. ISSN 0027-8424. PMC 16905. PMID 10920205.

Further reading



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