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{{Infobox_gene}}
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'''Protein unc-84 homolog A''' is a [[protein]] that in humans is encoded by the ''UNC84A'' [[gene]].<ref name="pmid11593002">{{cite journal | vauthors = Dreger M, Bengtsson L, Schoneberg T, Otto H, Hucho F | title = Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 21 | pages = 11943–8 |date=Oct 2001 | pmid = 11593002 | pmc = 59747 | doi = 10.1073/pnas.211201898 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UNC84A unc-84 homolog A (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23353| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Unc-84 homolog A (C. elegans)
| HGNCid = 18587
| Symbol = UNC84A
| AltSymbols =; FLJ12407; KIAA0810; SUN1
| OMIM = 607723
| ECnumber = 
| Homologene = 11544
| MGIid = 1924303
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23353
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_079430
    | Hs_RefseqmRNA = NM_025154
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 77053
    | Mm_Ensembl = ENSMUSG00000036817
    | Mm_RefseqmRNA = NM_024451
    | Mm_RefseqProtein = NP_077771
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 139454285
    | Mm_GenLoc_end = 139503437
    | Mm_Uniprot = Q3TIW3
  }}
}}
'''Unc-84 homolog A (C. elegans)''', also known as '''UNC84A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UNC84A unc-84 homolog A (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23353| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: UNC84A unc-84 homolog A (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23353| accessdate = }}</ref>
| summary_text = This gene is a member of the unc-84 [[homolog]] family and encodes a nuclear [[nuclear envelope]] protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Several alternatively spliced [[transcript variants]] of this gene have been described; however, the full-length nature of some of these variants has not been determined.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=10.1093/dnares/5.5.277 }}
*{{cite journal  | author=Malone CJ, Fixsen WD, Horvitz HR, Han M |title=UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. |journal=Development |volume=126 |issue= 14 |pages= 3171-81 |year= 1999 |pmid= 10375507 |doi=  }}
*{{cite journal  | vauthors=Malone CJ, Fixsen WD, Horvitz HR, Han M |title=UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development |journal=Development |volume=126 |issue= 14 |pages= 3171–81 |year= 1999 |pmid= 10375507 |doi=  }}
*{{cite journal  | author=Dreger M, Bengtsson L, Schöneberg T, ''et al.'' |title=Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 21 |pages= 11943-8 |year= 2001 |pmid= 11593002 |doi= 10.1073/pnas.211201898 }}
*{{cite journal  | vauthors=Bray JD, Chennathukuzhi VM, Hecht NB |title=Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X |journal=Genomics |volume=79 |issue= 6 |pages= 799–808 |year= 2002 |pmid= 12036294 |doi= 10.1006/geno.2002.6779 }}
*{{cite journal  | author=Bray JD, Chennathukuzhi VM, Hecht NB |title=Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X. |journal=Genomics |volume=79 |issue= 6 |pages= 799-808 |year= 2002 |pmid= 12036294 |doi= 10.1006/geno.2002.6779 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Schirmer EC, Florens L, Guan T, etal |title=Nuclear membrane proteins with potential disease links found by subtractive proteomics |journal=Science |volume=301 |issue= 5638 |pages= 1380–2 |year= 2003 |pmid= 12958361 |doi= 10.1126/science.1088176 }}
*{{cite journal | author=Schirmer EC, Florens L, Guan T, ''et al.'' |title=Nuclear membrane proteins with potential disease links found by subtractive proteomics. |journal=Science |volume=301 |issue= 5638 |pages= 1380-2 |year= 2003 |pmid= 12958361 |doi= 10.1126/science.1088176 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Padmakumar VC, Libotte T, Lu W, etal |title=The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope |journal=J. Cell Sci. |volume=118 |issue= Pt 15 |pages= 3419–30 |year= 2005 |pmid= 16079285 |doi= 10.1242/jcs.02471 }}
*{{cite journal | author=Padmakumar VC, Libotte T, Lu W, ''et al.'' |title=The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. |journal=J. Cell. Sci. |volume=118 |issue= Pt 15 |pages= 3419-30 |year= 2005 |pmid= 16079285 |doi= 10.1242/jcs.02471 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Hasan S, Güttinger S, Mühlhäusser P, etal |title=Nuclear envelope localization of human UNC84A does not require nuclear lamins |journal=FEBS Lett. |volume=580 |issue= 5 |pages= 1263–8 |year= 2006 |pmid= 16445915 |doi= 10.1016/j.febslet.2006.01.039 }}
*{{cite journal | author=Hasan S, Güttinger S, Mühlhäusser P, ''et al.'' |title=Nuclear envelope localization of human UNC84A does not require nuclear lamins. |journal=FEBS Lett. |volume=580 |issue= 5 |pages= 1263-8 |year= 2006 |pmid= 16445915 |doi= 10.1016/j.febslet.2006.01.039 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Wang Q, Du X, Cai Z, Greene MI |title=Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome |journal=DNA Cell Biol. |volume=25 |issue= 10 |pages= 554–62 |year= 2006 |pmid= 17132086 |doi= 10.1089/dna.2006.25.554 }}
*{{cite journal  | author=Wang Q, Du X, Cai Z, Greene MI |title=Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome. |journal=DNA Cell Biol. |volume=25 |issue= 10 |pages= 554-62 |year= 2006 |pmid= 17132086 |doi= 10.1089/dna.2006.25.554 }}
*{{cite journal  | vauthors=Chi YH, Haller K, Peloponese JM, Jeang KT |title=Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes |journal=J. Biol. Chem. |volume=282 |issue= 37 |pages= 27447–58 |year= 2007 |pmid= 17631499 |doi= 10.1074/jbc.M703098200 }}
*{{cite journal  | author=Chi YH, Haller K, Peloponese JM, Jeang KT |title=Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. |journal=J. Biol. Chem. |volume=282 |issue= 37 |pages= 27447-58 |year= 2007 |pmid= 17631499 |doi= 10.1074/jbc.M703098200 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 19:00, 15 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein unc-84 homolog A is a protein that in humans is encoded by the UNC84A gene.[1][2]

This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.[2]

References

  1. ↑ Dreger M, Bengtsson L, Schoneberg T, Otto H, Hucho F (Oct 2001). "Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane". Proc Natl Acad Sci U S A. 98 (21): 11943–8. doi:10.1073/pnas.211201898. PMC 59747. PMID 11593002.
  2. ↑ 2.0 2.1 "Entrez Gene: UNC84A unc-84 homolog A (C. elegans)".

Further reading



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