KIAA0895: Difference between revisions
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'''KIAA0895''' is a human [[gene]] that encodes a [[protein]] known as ''KIAA0895 protein'' or ''hypothetical protein LOC23366''.<ref name="entrez">{{cite web | title = Entrez Gene: KIAA0895| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=23366| accessdate = 2011-04-24}}</ref><ref name="pmid10048485">{{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 6 | pages = 355–64 |date=December 1998 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355| url = }}</ref> Other known aliases are ''OTTHUMP00000206979'' and ''OTTHUMP00000206980.''<ref name="genecards">{{cite web | title = GeneCards: KIAA0895 Gene| url = | '''KIAA0895''' is a human [[gene]] that encodes a [[protein]] known as ''KIAA0895 protein'' or ''hypothetical protein LOC23366''.<ref name="entrez">{{cite web | title = Entrez Gene: KIAA0895| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=23366| accessdate = 2011-04-24}}</ref><ref name="pmid10048485">{{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 6 | pages = 355–64 |date=December 1998 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355| url = }}</ref> Other known aliases are ''OTTHUMP00000206979'' and ''OTTHUMP00000206980.''<ref name="genecards">{{cite web | title = GeneCards: KIAA0895 Gene| url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=KIAA0895&search=kiaa0895| accessdate = 2011-04-24}}</ref> | ||
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}} LOC23366 contains a protein [[domain of unknown function]] called DUF1704.<ref name="Pfam Sanger">{{cite web|title=Wellcome Trust Sanger Institute, Pfam |url=http://pfam.sanger.ac.uk/ |archive-url=http://webarchive.nationalarchives.gov.uk/20140617135541/http://pfam.sanger.ac.uk/ |dead-url=yes |archive-date=2014-06-17 |accessdate=2011-05-09 }}</ref> | }} LOC23366 contains a protein [[domain of unknown function]] called DUF1704.<ref name="Pfam Sanger">{{cite web|title=Wellcome Trust Sanger Institute, Pfam |url=http://pfam.sanger.ac.uk/ |archive-url=http://webarchive.nationalarchives.gov.uk/20140617135541/http://pfam.sanger.ac.uk/ |dead-url=yes |archive-date=2014-06-17 |accessdate=2011-05-09 }}</ref> | ||
It also contains a region of low complexity from position 120 to position 150 in the protein,<ref name = "Dotlet">{{cite web | title =MyHits Dotlet| url = http://myhits.isb-sib.ch/cgi-bin/dotlet| accessdate = 2011-05-09}}</ref> and an [[arginine]]-rich area from position 12 to position 51.<ref name = "Uniprot">{{cite web | title =Uniprot| url = | It also contains a region of low complexity from position 120 to position 150 in the protein,<ref name = "Dotlet">{{cite web | title =MyHits Dotlet| url = http://myhits.isb-sib.ch/cgi-bin/dotlet| accessdate = 2011-05-09}}</ref> and an [[arginine]]-rich area from position 12 to position 51.<ref name = "Uniprot">{{cite web | title =Uniprot| url = https://www.uniprot.org/uniprot/Q8NCT3| accessdate = 2011-05-09}}</ref> | ||
===Post-translational Modification=== | ===Post-translational Modification=== | ||
Latest revision as of 08:04, 23 March 2018
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
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KIAA0895 is a human gene that encodes a protein known as KIAA0895 protein or hypothetical protein LOC23366.[1][2] Other known aliases are OTTHUMP00000206979 and OTTHUMP00000206980.[3]
Gene
The KIAA0895 gene is located at p14.2 on chromosome 7.
It can be transcribed into 15 transcript variants, which in turn can produce 13 different isoforms of the protein.[4]
The genomic DNA is 65,976 [base pair]s long,[1] while the longest mRNA that it produces is 4463 bases long.
Gene Neighborhood
KIAA0895 is surrounded by the following genes on chromosome 7:[1]
Protein
The longest protein isoform that is produced by the KIAA0895 gene is termed LOC23366 isoform 1 and is 520 amino acids long.[5]
Regions
| Domain of unknown function 1704 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DUF1704 | ||||||||
| Pfam | PF08014 | ||||||||
| InterPro | IPR012548 | ||||||||
| |||||||||
LOC23366 contains a protein domain of unknown function called DUF1704.[6]
It also contains a region of low complexity from position 120 to position 150 in the protein,[7] and an arginine-rich area from position 12 to position 51.[8]
Post-translational Modification
The KIAA0895 protein is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout its structure, particularly in the first half of the protein[9] The predicted phosphorylation sites are shown on the accompanying graph. There are also predicted to be three N-linked glycosylation sites.[10]
Expression
KIAA0895 is shown to be expressed at low levels in various tissues throughout the body. It is expressed most highly in the adrenal gland, the bone marrow, and the testis.[11] It is also found in cancerous tissues, most highly in cervical tumors and bladder carcinoma.
Conservation
KIAA0895 has one paralog in humans known as KIAA0895L.[12] Orthologs have been found in all mammals, and eukaryotes through T. thermophila.[13] The full list of organisms in which orthologs have been found is given below.
- Pan troglodytes
- Pongo abelii
- Macaca mulatta
- Callithrix jacchus
- Sus scrofa
- Canis familiaris
- Ailuropoda melanoleuca
- Equus caballus
- Oryctolagus cuniculus
- Mus musculus
- Rattus norvegicus
- Monodelphis domestica
- Ornithorhynchus anatinus
- Taeniopygia guttata
- Meleagris gallopavo
- Gallus gallus
- Xenopus (Silurana) tropicalis
- Danio rerio
- Ciona intestinalis
- Strongylocentrotus purpuratus
- Branchiostoma floridae
- Tetrahymena thermophila
References
- ↑ 1.0 1.1 1.2 "Entrez Gene: KIAA0895". Retrieved 2011-04-24.
- ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
- ↑ "GeneCards: KIAA0895 Gene". Retrieved 2011-04-24.
- ↑ "NCBI AceView: KIAA0895". Retrieved 2011-04-24.
- ↑ "NCBI Protein: LOC23366 isoform 1". Retrieved 2011-05-09.
- ↑ "Wellcome Trust Sanger Institute, Pfam". Archived from the original on 2014-06-17. Retrieved 2011-05-09.
- ↑ "MyHits Dotlet". Retrieved 2011-05-09.
- ↑ "Uniprot". Retrieved 2011-05-09.
- ↑ "DTU Center for Biological Sciences, NetPhos". Retrieved 2011-05-09.
- ↑ "DTU Center for Biological Sciences, NetNGlyc". Retrieved 2011-05-09.
- ↑ "NCBI Unigene EST Profile: KIAA0895". Retrieved 2011-05-09.
- ↑ "KEGG: KIAA0895". Retrieved 2011-05-09.
- ↑ "NCBI BLAST". Retrieved 2011-05-09.