NLGN3: Difference between revisions

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{{Infobox_gene}}
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'''Neuroligin-3''' is a [[protein]] that in humans is encoded by the ''NLGN3'' [[gene]].<ref name="pmid10767552">{{cite journal | vauthors = Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI | title = The structure and expression of the human neuroligin-3 gene | journal = Gene | volume = 246 | issue = 1–2 | pages = 303–10 |date=May 2000 | pmid = 10767552 | pmc =  | doi =10.1016/S0378-1119(00)00049-4 }}</ref><ref name="pmid10819331">{{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 2 | pages = 143–50 |date=Sep 2000 | pmid = 10819331 | pmc =  | doi =10.1093/dnares/7.2.143 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NLGN3 neuroligin 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54413| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Neuroligin 3
| HGNCid = 14289
| Symbol = NLGN3
| AltSymbols =; ASPGX1; AUTSX1; HNL3; KIAA1480
| OMIM = 300336
| ECnumber =
| Homologene = 23133
| MGIid = 2444609
  | GeneAtlas_image1 = PBB_GE_NLGN3_219726_at_tn.png
  | Function = {{GNF_GO|id=GO:0004759 |text = carboxylesterase activity}} {{GNF_GO|id=GO:0042043 |text = neurexin binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54413
    | Hs_Ensembl = ENSG00000196338
    | Hs_RefseqProtein = NP_061850
    | Hs_RefseqmRNA = NM_018977
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 70281418
    | Hs_GenLoc_end = 70307776
    | Hs_Uniprot = Q9NZ94
    | Mm_EntrezGene = 245537
    | Mm_Ensembl = ENSMUSG00000031302
    | Mm_RefseqmRNA = XM_986670
    | Mm_RefseqProtein = XP_991764
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 97476980
    | Mm_GenLoc_end = 97524067
    | Mm_Uniprot = Q69ZI4
  }}
}}
'''Neuroligin 3''', also known as '''NLGN3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NLGN3 neuroligin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54413| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: NLGN3 neuroligin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54413| accessdate = }}</ref>
| summary_text = This gene encodes a member of the [[neuroligin]] family of neuronal cell surface proteins. Neuroligins may act as splice site-specific [[Ligand (biochemistry)|ligands]] for [[Beta-neurexin|beta-neurexins]] and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with [[Autism spectrum|autism spectrum disorders]] (ASDs). Multiple [[transcript variants]] encoding distinct [[isoforms]] have been identified for this gene, but their full length sequences have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: NLGN3 neuroligin 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54413| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Missler M, Fernandez-Chacon R, Südhof TC |title=The making of neurexins. |journal=J. Neurochem. |volume=71 |issue= 4 |pages= 1339-47 |year= 1998 |pmid= 9751164 |doi=  }}
*{{cite journal  | vauthors=Missler M, Fernandez-Chacon R, Südhof TC |title=The making of neurexins |journal=J. Neurochem. |volume=71 |issue= 4 |pages= 1339–47 |year= 1998 |pmid= 9751164 |doi=10.1046/j.1471-4159.1998.71041339.x }}
*{{cite journal  | author=Cantallops I, Cline HT |title=Synapse formation: if it looks like a duck and quacks like a duck .... |journal=Curr. Biol. |volume=10 |issue= 17 |pages= R620-3 |year= 2000 |pmid= 10996085 |doi=  }}
*{{cite journal  | vauthors=Cantallops I, Cline HT |title=Synapse formation: if it looks like a duck and quacks like a duck ... |journal=Curr. Biol. |volume=10 |issue= 17 |pages= R620–3 |year= 2000 |pmid= 10996085 |doi=10.1016/S0960-9822(00)00663-1 }}
*{{cite journal  | author=Ichtchenko K, Nguyen T, Südhof TC |title=Structures, alternative splicing, and neurexin binding of multiple neuroligins. |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2676-82 |year= 1996 |pmid= 8576240 |doi=  }}
*{{cite journal  | vauthors=Ichtchenko K, Nguyen T, Südhof TC |title=Structures, alternative splicing, and neurexin binding of multiple neuroligins |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2676–82 |year= 1996 |pmid= 8576240 |doi=10.1074/jbc.271.5.2676 }}
*{{cite journal | author=Irie M, Hata Y, Takeuchi M, ''et al.'' |title=Binding of neuroligins to PSD-95. |journal=Science |volume=277 |issue= 5331 |pages= 1511-5 |year= 1997 |pmid= 9278515 |doi=  }}
*{{cite journal   |vauthors=Irie M, Hata Y, Takeuchi M, etal |title=Binding of neuroligins to PSD-95 |journal=Science |volume=277 |issue= 5331 |pages= 1511–5 |year= 1997 |pmid= 9278515 |doi=10.1126/science.277.5331.1511 }}
*{{cite journal  | author=Nguyen T, Südhof TC |title=Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 26032-9 |year= 1997 |pmid= 9325340 |doi= }}
*{{cite journal  | vauthors=Nguyen T, Südhof TC |title=Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 26032–9 |year= 1997 |pmid= 9325340 |doi=10.1074/jbc.272.41.26032 }}
*{{cite journal  | author=Philibert RA, Winfield SL, Sandhu HK, ''et al.'' |title=The structure and expression of the human neuroligin-3 gene. |journal=Gene |volume=246 |issue= 1-2 |pages= 303-10 |year= 2000 |pmid= 10767552 |doi=  }}
*{{cite journal  | vauthors=Gilbert M, Smith J, Roskams AJ, Auld VJ |title=Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia |journal=Glia |volume=34 |issue= 3 |pages= 151–64 |year= 2001 |pmid= 11329178 |doi=10.1002/glia.1050 }}
*{{cite journal  | author=Nagase T, Kikuno R, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143-50 |year= 2000 |pmid= 10819331 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Gilbert M, Smith J, Roskams AJ, Auld VJ |title=Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia. |journal=Glia |volume=34 |issue= 3 |pages= 151-64 |year= 2001 |pmid= 11329178 |doi=  }}
*{{cite journal   |vauthors=Jamain S, Quach H, Betancur C, etal |title=Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 27–9 |year= 2003 |pmid= 12669065 |doi= 10.1038/ng1136 | pmc=1925054 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Jamain S, Quach H, Betancur C, ''et al.'' |title=Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 27-9 |year= 2003 |pmid= 12669065 |doi= 10.1038/ng1136 }}
*{{cite journal   |vauthors=Vincent JB, Kolozsvari D, Roberts WS, etal |title=Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=129 |issue= 1 |pages= 82–4 |year= 2005 |pmid= 15274046 |doi= 10.1002/ajmg.b.30069 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gauthier J, Bonnel A, St-Onge J, etal |title=NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=132 |issue= 1 |pages= 74–5 |year= 2005 |pmid= 15389766 |doi= 10.1002/ajmg.b.30066 }}
*{{cite journal | author=Vincent JB, Kolozsvari D, Roberts WS, ''et al.'' |title=Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=129 |issue= 1 |pages= 82-4 |year= 2005 |pmid= 15274046 |doi= 10.1002/ajmg.b.30069 }}
*{{cite journal   |vauthors=Yan J, Oliveira G, Coutinho A, etal |title=Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients |journal=Mol. Psychiatry |volume=10 |issue= 4 |pages= 329–32 |year= 2005 |pmid= 15622415 |doi= 10.1038/sj.mp.4001629 }}
*{{cite journal | author=Gauthier J, Bonnel A, St-Onge J, ''et al.'' |title=NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=132 |issue= 1 |pages= 74-5 |year= 2005 |pmid= 15389766 |doi= 10.1002/ajmg.b.30066 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Yan J, Oliveira G, Coutinho A, ''et al.'' |title=Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients. |journal=Mol. Psychiatry |volume=10 |issue= 4 |pages= 329-32 |year= 2005 |pmid= 15622415 |doi= 10.1038/sj.mp.4001629 }}
*{{cite journal   |vauthors=Blasi F, Bacchelli E, Pesaresi G, etal |title=Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 3 |pages= 220–1 |year= 2006 |pmid= 16508939 |doi= 10.1002/ajmg.b.30287 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Talebizadeh Z, Lam DY, Theodoro MF, etal |title=Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism |journal=J. Med. Genet. |volume=43 |issue= 5 |pages= e21 |year= 2006 |pmid= 16648374 |doi= 10.1136/jmg.2005.036897 | pmc=2564526 }}
*{{cite journal | author=Blasi F, Bacchelli E, Pesaresi G, ''et al.'' |title=Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 3 |pages= 220-1 |year= 2006 |pmid= 16508939 |doi= 10.1002/ajmg.b.30287 }}
*{{cite journal   |vauthors=Yamakawa H, Oyama S, Mitsuhashi H, etal |title=Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 1 |pages= 41–6 |year= 2007 |pmid= 17292328 |doi= 10.1016/j.bbrc.2007.01.127 }}
*{{cite journal | author=Talebizadeh Z, Lam DY, Theodoro MF, ''et al.'' |title=Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism. |journal=J. Med. Genet. |volume=43 |issue= 5 |pages= e21 |year= 2006 |pmid= 16648374 |doi= 10.1136/jmg.2005.036897 }}
*{{cite journal | author=Yamakawa H, Oyama S, Mitsuhashi H, ''et al.'' |title=Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 1 |pages= 41-6 |year= 2007 |pmid= 17292328 |doi= 10.1016/j.bbrc.2007.01.127 }}
}}
}}
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Latest revision as of 15:28, 9 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuroligin-3 is a protein that in humans is encoded by the NLGN3 gene.[1][2][3]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism spectrum disorders (ASDs). Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.[3]

References

  1. ↑ Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
  2. ↑ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  3. ↑ 3.0 3.1 "Entrez Gene: NLGN3 neuroligin 3".

Further reading



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