TKTL1: Difference between revisions

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{{Infobox_gene}}
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'''[[Transketolase]]-like protein 1''' is an [[enzyme]] with a catalytic function that in humans is encoded by the ''TKTL1'' [[gene]].<ref name="pmid8838793">{{cite journal |vauthors=Coy JF, Dubel S, Kioschis P, Thomas K, Micklem G, Delius H, Poustka A | title = Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes | journal = Genomics | volume = 32 | issue = 3 | pages = 309–16 |date=Feb 1997 | pmid = 8838793 | pmc =  | doi = 10.1006/geno.1996.0124 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TKTL1 transketolase-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8277| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Transketolase-like 1
| HGNCid = 11835
| Symbol = TKTL1
| AltSymbols =; TKR; TKT2
| OMIM = 300044
| ECnumber = 
| Homologene = 8169
| MGIid = 1933244
| GeneAtlas_image1 = PBB_GE_TKTL1_214183_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TKTL1_216370_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004802 |text = transketolase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
  | Process = {{GNF_GO|id=GO:0006007 |text = glucose catabolic process}} {{GNF_GO|id=GO:0006772 |text = thiamin metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8277
    | Hs_Ensembl = ENSG00000007350
    | Hs_RefseqProtein = NP_036385
    | Hs_RefseqmRNA = NM_012253
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 153177218
    | Hs_GenLoc_end = 153211894
    | Hs_Uniprot = P51854
    | Mm_EntrezGene = 83553
    | Mm_Ensembl = ENSMUSG00000031397
    | Mm_RefseqmRNA = NM_031379
    | Mm_RefseqProtein = NP_113556
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 70429979
    | Mm_GenLoc_end = 70461220
    | Mm_Uniprot = Q99MX0
  }}
}}
'''Transketolase-like 1''', also known as '''TKTL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TKTL1 transketolase-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8277| accessdate = }}</ref>
 
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Coy JF, Dübel S, Kioschis P, ''et al.'' |title=Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes. |journal=Genomics |volume=32 |issue= 3 |pages= 309-16 |year= 1997 |pmid= 8838793 |doi= 10.1006/geno.1996.0124 }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Simpson JC |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732  |name-list-format=vanc| author2=Wellenreuther R  | author3=Poustka A  | display-authors=3  | last4=Pepperkok  | first4=R  | last5=Wiemann  | first5=S }}
*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Ross MT |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286  |name-list-format=vanc| author2=Grafham DV  | author3=Coffey AJ  | display-authors=3  | last4=Scherer  | first4=Steven  | last5=McLay  | first5=Kirsten  | last6=Muzny  | first6=Donna  | last7=Platzer  | first7=Matthias  | last8=Howell  | first8=Gareth R.  | last9=Burrows  | first9=Christine }}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  |vauthors=Coy JF, Dressler D, Wilde J, Schubert P |title=Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer |journal=[[Clinical Laboratory|Clin. Lab.]] |volume=51 |issue= 5–6 |pages= 257–73 |year= 2005 |pmid= 15991799 |doi=  }}
*{{cite journal  | author=Coy JF, Dressler D, Wilde J, Schubert P |title=Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. |journal=Clin. Lab. |volume=51 |issue= 5-6 |pages= 257-73 |year= 2005 |pmid= 15991799 |doi=  }}
*{{cite journal  | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501  |name-list-format=vanc| author2=Rosenfelder H  | author3=Schupp I  | display-authors=3  | last4=Del Val  | first4=C  | last5=Arlt  | first5=D  | last6=Hahne  | first6=F  | last7=Bechtel  | first7=S  | last8=Simpson  | first8=J  | last9=Hofmann  | first9=O }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | author=Langbein S |title=Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted |journal=Br. J. Cancer |volume=94 |issue= 4 |pages= 578–85 |year= 2006 |pmid= 16465194 |doi= 10.1038/sj.bjc.6602962 | pmc=2361175  |name-list-format=vanc| author2=Zerilli M  | author3=Zur Hausen A  | display-authors=3  | last4=Staiger  | first4=W  | last5=Rensch-Boschert  | first5=K  | last6=Lukan  | first6=N  | last7=Popa  | first7=J  | last8=Ternullo  | first8=M P  | last9=Steidler  | first9=A }}
*{{cite journal  | author=Langbein S, Zerilli M, Zur Hausen A, ''et al.'' |title=Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. |journal=Br. J. Cancer |volume=94 |issue= 4 |pages= 578-85 |year= 2006 |pmid= 16465194 |doi= 10.1038/sj.bjc.6602962 }}
*{{cite journal  | author=Staiger WI |title=Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer |journal=Oncol. Rep. |volume=16 |issue= 4 |pages= 657–61 |year= 2007 |pmid= 16969476 |doi= 10.3892/or.16.4.657|name-list-format=vanc| author2=Coy JF  | author3=Grobholz R  | display-authors=3  | last4=Hofheinz  | first4=RD  | last5=Lukan  | first5=N  | last6=Post  | first6=S  | last7=Schwarzbach  | first7=MH  | last8=Willeke  | first8=F }}
*{{cite journal  | author=Staiger WI, Coy JF, Grobholz R, ''et al.'' |title=Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer. |journal=Oncol. Rep. |volume=16 |issue= 4 |pages= 657-61 |year= 2007 |pmid= 16969476 |doi=  }}
*{{cite journal  |vauthors=Zhang S, Yang JH, Guo CK, Cai PC |title=Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells |journal=Cancer Lett. |volume=253 |issue= 1 |pages= 108–14 |year= 2007 |pmid= 17321041 |doi= 10.1016/j.canlet.2007.01.010 }}
*{{cite journal  | author=Zhang S, Yang JH, Guo CK, Cai PC |title=Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. |journal=Cancer Lett. |volume=253 |issue= 1 |pages= 108-14 |year= 2007 |pmid= 17321041 |doi= 10.1016/j.canlet.2007.01.010 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:46, 15 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transketolase-like protein 1 is an enzyme with a catalytic function that in humans is encoded by the TKTL1 gene.[1][2]


References

  1. ↑ Coy JF, Dubel S, Kioschis P, Thomas K, Micklem G, Delius H, Poustka A (Feb 1997). "Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes". Genomics. 32 (3): 309–16. doi:10.1006/geno.1996.0124. PMID 8838793.
  2. ↑ "Entrez Gene: TKTL1 transketolase-like 1".

Further reading



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