ARHGAP4: Difference between revisions

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Latest revision as of 23:00, 6 November 2018

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene.^[1]^[2] It has been shown to regulate cell motility and axonal outgrowth in vitro.^[3]

References

↑ Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P (Mar 1996). "An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells". Proc Natl Acad Sci U S A. 93 (2): 695–9. doi:10.1073/pnas.93.2.695. PMC 40115. PMID 8570618.
↑ "Entrez Gene: ARHGAP4 Rho GTPase activating protein 4".
↑ Vogt, DL; Gray, CD; Young Ws, 3rd; Orellana, SA; Malouf, AT (2007). "ARHGAP4 IS A NOVEL RHOGAP THAT MEDIATES INHIBITION OF CELL MOTILITY AND AXON OUTGROWTH". Molecular and Cellular Neurosciences. 36 (3): 332–42. doi:10.1016/j.mcn.2007.07.004. PMC 2111057. PMID 17804252.

External links

Human ARHGAP4 genome location and ARHGAP4 gene details page in the UCSC Genome Browser.

Tribioli C, Mancini M, Plassart E, et al. (1995). "Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae". Hum. Mol. Genet. 3 (7): 1061–7. doi:10.1093/hmg/3.7.1061. PMID 7981673.
Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
Zuber J, Tchernitsa OI, Hinzmann B, et al. (2000). "A genome-wide survey of RAS transformation targets". Nat. Genet. 24 (2): 144–52. doi:10.1038/72799. PMID 10655059.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Demura M, Takeda Y, Yoneda T, et al. (2002). "Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus". Hum. Mutat. 19 (1): 23–9. doi:10.1002/humu.10011. PMID 11754100.
Christerson LB, Gallagher E, Vanderbilt CA, et al. (2002). "p115 Rho GTPase activating protein interacts with MEKK1". J. Cell. Physiol. 192 (2): 200–8. doi:10.1002/jcp.10125. PMID 12115726.
Foletta VC, Brown FD, Young WS (2003). "Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules". Brain Res. Mol. Brain Res. 107 (1): 65–79. doi:10.1016/S0169-328X(02)00448-5. PMID 12414125.
Soderling SH, Binns KL, Wayman GA, et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID 12447388.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[pmid8570618-1] Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P (Mar 1996). "An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells". Proc Natl Acad Sci U S A. 93 (2): 695–9. doi:10.1073/pnas.93.2.695. PMC 40115. PMID 8570618.

[entrez-2] "Entrez Gene: ARHGAP4 Rho GTPase activating protein 4".

[3] Vogt, DL; Gray, CD; Young Ws, 3rd; Orellana, SA; Malouf, AT (2007). "ARHGAP4 IS A NOVEL RHOGAP THAT MEDIATES INHIBITION OF CELL MOTILITY AND AXON OUTGROWTH". Molecular and Cellular Neurosciences. 36 (3): 332–42. doi:10.1016/j.mcn.2007.07.004. PMC 2111057. PMID 17804252.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
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+'''Rho GTPase-activating protein 4''' is an [[enzyme]] that in humans is encoded by the ''ARHGAP4'' [[gene]].<ref name="pmid8570618">{{cite journal | vauthors = Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P | title = An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 2 | pages = 695–9 |date=Mar 1996 | pmid = 8570618 | pmc = 40115 | doi =10.1073/pnas.93.2.695  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARHGAP4 Rho GTPase activating protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=393| accessdate = }}</ref> It has been shown to regulate [[cell motility]] and axonal outgrowth in vitro.<ref>{{cite journal | last1 = Vogt | first1 = DL | last2 = Gray | first2 = CD | last3 = Young Ws | first3 = 3rd | last4 = Orellana | first4 = SA | last5 = Malouf | first5 = AT | title = ARHGAP4 IS A NOVEL RHOGAP THAT MEDIATES INHIBITION OF CELL MOTILITY AND AXON OUTGROWTH | journal = Molecular and Cellular Neurosciences | volume = 36 | issue = 3 | pages = 332–42 | year = 2007 | pmid = 17804252 | pmc = 2111057 | doi = 10.1016/j.mcn.2007.07.004 }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Rho GTPase activating protein 4
- | HGNCid = 674
- | Symbol = ARHGAP4
- | AltSymbols =; C1; KIAA0131; RGC1; RhoGAP4; p115
- | OMIM = 300023
- | ECnumber =
- | Homologene = 20403
- | MGIid = 2159577
- | GeneAtlas_image1 = PBB_GE_ARHGAP4_204425_at_tn.png
-  | Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005100 |text = Rho GTPase activator activity}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 393
-    | Hs_Ensembl = ENSG00000089820
-    | Hs_RefseqProtein = NP_001657
-    | Hs_RefseqmRNA = NM_001666
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = X
-    | Hs_GenLoc_start = 152826024
-    | Hs_GenLoc_end = 152844908
-    | Hs_Uniprot = P98171
-    | Mm_EntrezGene = 171207
-    | Mm_Ensembl = ENSMUSG00000031389
-    | Mm_RefseqmRNA = NM_138630
-    | Mm_RefseqProtein = NP_619536
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = X
-    | Mm_GenLoc_start = 70147076
-    | Mm_GenLoc_end = 70163949
-    | Mm_Uniprot =
-  }}
-}}
-'''Rho GTPase activating protein 4''', also known as '''ARHGAP4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARHGAP4 Rho GTPase activating protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=393| accessdate = }}</ref>
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 {{PBB_Summary
@@ Line 53: / Line 6: @@
 | summary_text =
 }}
+==References==
+{{reflist}}
+==External links==
+* {{UCSC gene info|ARHGAP4}}
-==References==
-{{reflist|2}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Tribioli C, Mancini M, Plassart E, ''et al.'' |title=Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae. |journal=Hum. Mol. Genet. |volume=3 |issue= 7 |pages= 1061-7 |year= 1995 |pmid= 7981673 |doi=  }}
+*{{cite journal  | vauthors=Tribioli C, Mancini M, Plassart E |title=Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae |journal=Hum. Mol. Genet. |volume=3 |issue= 7 |pages= 1061–7 |year= 1995 |pmid= 7981673 |doi=10.1093/hmg/3.7.1061  |display-authors=etal}}
-*{{cite journal  | author=Tribioli C, Droetto S, Bione S, ''et al.'' |title=An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 2 |pages= 695-9 |year= 1996 |pmid= 8570618 |doi=  }}
+*{{cite journal  | vauthors=Nagase T, Seki N, Tanaka A |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=10.1093/dnares/2.4.167  |display-authors=etal}}
-*{{cite journal  | author=Nagase T, Seki N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167-74, 199-210 |year= 1996 |pmid= 8590280 |doi=  }}
+*{{cite journal  | vauthors=Brenner V, Nyakatura G, Rosenthal A, Platzer M |title=Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse |journal=Genomics |volume=44 |issue= 1 |pages= 8–14 |year= 1997 |pmid= 9286695 |doi= 10.1006/geno.1997.4822 }}
-*{{cite journal  | author=Brenner V, Nyakatura G, Rosenthal A, Platzer M |title=Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. |journal=Genomics |volume=44 |issue= 1 |pages= 8-14 |year= 1997 |pmid= 9286695 |doi= 10.1006/geno.1997.4822 }}
+*{{cite journal  | vauthors=Zuber J, Tchernitsa OI, Hinzmann B |title=A genome-wide survey of RAS transformation targets |journal=Nat. Genet. |volume=24 |issue= 2 |pages= 144–52 |year= 2000 |pmid= 10655059 |doi= 10.1038/72799 |display-authors=etal}}
-*{{cite journal  | author=Zuber J, Tchernitsa OI, Hinzmann B, ''et al.'' |title=A genome-wide survey of RAS transformation targets. |journal=Nat. Genet. |volume=24 |issue= 2 |pages= 144-52 |year= 2000 |pmid= 10655059 |doi= 10.1038/72799 }}
+*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
-*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
+*{{cite journal  | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 |display-authors=etal}}
-*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
+*{{cite journal  | vauthors=Demura M, Takeda Y, Yoneda T |title=Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus |journal=Hum. Mutat. |volume=19 |issue= 1 |pages= 23–9 |year= 2002 |pmid= 11754100 |doi= 10.1002/humu.10011 |display-authors=etal}}
-*{{cite journal  | author=Demura M, Takeda Y, Yoneda T, ''et al.'' |title=Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus. |journal=Hum. Mutat. |volume=19 |issue= 1 |pages= 23-9 |year= 2002 |pmid= 11754100 |doi= 10.1002/humu.10011 }}
+*{{cite journal  | vauthors=Christerson LB, Gallagher E, Vanderbilt CA |title=p115 Rho GTPase activating protein interacts with MEKK1 |journal=J. Cell. Physiol. |volume=192 |issue= 2 |pages= 200–8 |year= 2002 |pmid= 12115726 |doi= 10.1002/jcp.10125 |display-authors=etal}}
-*{{cite journal  | author=Christerson LB, Gallagher E, Vanderbilt CA, ''et al.'' |title=p115 Rho GTPase activating protein interacts with MEKK1. |journal=J. Cell. Physiol. |volume=192 |issue= 2 |pages= 200-8 |year= 2002 |pmid= 12115726 |doi= 10.1002/jcp.10125 }}
+*{{cite journal  | vauthors=Foletta VC, Brown FD, Young WS |title=Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules |journal=Brain Res. Mol. Brain Res. |volume=107 |issue= 1 |pages= 65–79 |year= 2003 |pmid= 12414125 |doi=10.1016/S0169-328X(02)00448-5   }}
-*{{cite journal  | author=Foletta VC, Brown FD, Young WS |title=Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules. |journal=Brain Res. Mol. Brain Res. |volume=107 |issue= 1 |pages= 65-79 |year= 2003 |pmid= 12414125 |doi=  }}
+*{{cite journal  | vauthors=Soderling SH, Binns KL, Wayman GA |title=The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling |journal=Nat. Cell Biol. |volume=4 |issue= 12 |pages= 970–5 |year= 2003 |pmid= 12447388 |doi= 10.1038/ncb886 |display-authors=etal}}
-*{{cite journal  | author=Soderling SH, Binns KL, Wayman GA, ''et al.'' |title=The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. |journal=Nat. Cell Biol. |volume=4 |issue= 12 |pages= 970-5 |year= 2003 |pmid= 12447388 |doi= 10.1038/ncb886 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Katoh M, Katoh M |title=FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 791–7 |year= 2004 |pmid= 12736724 |doi=  10.3892/ijmm.11.6.791}}
-*{{cite journal  | author=Katoh M, Katoh M |title=FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 791-7 |year= 2004 |pmid= 12736724 |doi=  }}
+*{{cite journal  | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 |display-authors=etal}}
-*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
+*{{cite journal  | vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501 |display-authors=etal}}
-*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
 }}
 {{refend}}
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ARHGAP4: Difference between revisions

Latest revision as of 23:00, 6 November 2018

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