NLGN4X: Difference between revisions

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{{Infobox_gene}}
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'''Neuroligin-4, X-linked''' is a [[protein]] that in humans is encoded by the ''NLGN4X'' [[gene]].<ref name="pmid10574462">{{cite journal | vauthors = Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 6 | issue = 5 | pages = 337–45 |date=Jan 2000 | pmid = 10574462 | pmc =  | doi =10.1093/dnares/6.5.337 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NLGN4X neuroligin 4, X-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57502| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Neuroligin 4, X-linked
| HGNCid = 14287
| Symbol = NLGN4X
| AltSymbols =; ASPGX2; AUTSX2; HLNX; HNLX; KIAA1260; MGC22376; NLGN; NLGN4
| OMIM = 300427
| ECnumber = 
| Homologene = 84460
| MGIid = 
| GeneAtlas_image1 = PBB_GE_NLGN4X_221933_at_tn.png
| Function = {{GNF_GO|id=GO:0004759 |text = carboxylesterase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57502
    | Hs_Ensembl = ENSG00000146938
    | Hs_RefseqProtein = NP_065793
    | Hs_RefseqmRNA = NM_020742
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 5818067
    | Hs_GenLoc_end = 6156904
    | Hs_Uniprot = Q8N0W4
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Neuroligin 4, X-linked''', also known as '''NLGN4X''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NLGN4X neuroligin 4, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57502| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: NLGN4X neuroligin 4, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57502| accessdate = }}</ref>
| summary_text = This gene encodes a member of the [[neuroligin]] family of neuronal cell surface proteins. Neuroligins may act as splice site-specific [[Ligand (biochemistry)|ligands]] for [[Beta-neurexin|beta-neurexins]] and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with [[DLG4|discs, large (Drosophila) homolog 4]] (DLG4). Mutations in this gene have been associated with [[autism]] and [[Asperger syndrome]]. Two [[transcript variants]] encoding the same protein have been identified for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal  | author=Cantallops I, Cline HT |title=Synapse formation: if it looks like a duck and quacks like a duck .... |journal=Curr. Biol. |volume=10 |issue= 17 |pages= R620-3 |year= 2000 |pmid= 10996085 |doi=  }}
*{{cite journal  | vauthors=Cantallops I, Cline HT |title=Synapse formation: if it looks like a duck and quacks like a duck ... |journal=Curr. Biol. |volume=10 |issue= 17 |pages= R620–3 |year= 2000 |pmid= 10996085 |doi=10.1016/S0960-9822(00)00663-1 }}
*{{cite journal | author=Irie M, Hata Y, Takeuchi M, ''et al.'' |title=Binding of neuroligins to PSD-95. |journal=Science |volume=277 |issue= 5331 |pages= 1511-5 |year= 1997 |pmid= 9278515 |doi= }}
*{{cite journal   |vauthors=Irie M, Hata Y, Takeuchi M, etal |title=Binding of neuroligins to PSD-95 |journal=Science |volume=277 |issue= 5331 |pages= 1511–5 |year= 1997 |pmid= 9278515 |doi=10.1126/science.277.5331.1511 }}
*{{cite journal  | author=Nagase T, Ishikawa K, Kikuno R, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337-45 |year= 2000 |pmid= 10574462 |doi= }}
*{{cite journal  | vauthors=Bolliger MF, Frei K, Winterhalter KH, Gloor SM |title=Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression |journal=Biochem. J. |volume=356 |issue= Pt 2 |pages= 581–8 |year= 2001 |pmid= 11368788 |doi=10.1042/0264-6021:3560581  | pmc=1221872 }}
*{{cite journal  | author=Bolliger MF, Frei K, Winterhalter KH, Gloor SM |title=Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression. |journal=Biochem. J. |volume=356 |issue= Pt 2 |pages= 581-8 |year= 2001 |pmid= 11368788 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Jamain S, Quach H, Betancur C, etal |title=Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 27–9 |year= 2003 |pmid= 12669065 |doi= 10.1038/ng1136 | pmc=1925054 }}
*{{cite journal | author=Jamain S, Quach H, Betancur C, ''et al.'' |title=Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 27-9 |year= 2003 |pmid= 12669065 |doi= 10.1038/ng1136 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Laumonnier F, Bonnet-Brilhault F, Gomot M, etal |title=X-Linked Mental Retardation and Autism Are Associated with a Mutation in the NLGN4 Gene, a Member of the Neuroligin Family |journal=Am. J. Hum. Genet. |volume=74 |issue= 3 |pages= 552–7 |year= 2004 |pmid= 14963808 |doi= 10.1086/382137 | pmc=1182268 }}
*{{cite journal | author=Laumonnier F, Bonnet-Brilhault F, Gomot M, ''et al.'' |title=X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. |journal=Am. J. Hum. Genet. |volume=74 |issue= 3 |pages= 552-7 |year= 2004 |pmid= 14963808 |doi= 10.1086/382137 }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Yan J, Oliveira G, Coutinho A, etal |title=Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients |journal=Mol. Psychiatry |volume=10 |issue= 4 |pages= 329–32 |year= 2005 |pmid= 15622415 |doi= 10.1038/sj.mp.4001629 }}
*{{cite journal | author=Yan J, Oliveira G, Coutinho A, ''et al.'' |title=Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients. |journal=Mol. Psychiatry |volume=10 |issue= 4 |pages= 329-32 |year= 2005 |pmid= 15622415 |doi= 10.1038/sj.mp.4001629 }}
*{{cite journal   |vauthors=Blasi F, Bacchelli E, Pesaresi G, etal |title=Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 3 |pages= 220–1 |year= 2006 |pmid= 16508939 |doi= 10.1002/ajmg.b.30287 }}
*{{cite journal | author=Blasi F, Bacchelli E, Pesaresi G, ''et al.'' |title=Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 3 |pages= 220-1 |year= 2006 |pmid= 16508939 |doi= 10.1002/ajmg.b.30287 }}
*{{cite journal   |vauthors=Talebizadeh Z, Lam DY, Theodoro MF, etal |title=Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism |journal=J. Med. Genet. |volume=43 |issue= 5 |pages= e21 |year= 2006 |pmid= 16648374 |doi= 10.1136/jmg.2005.036897 | pmc=2564526 }}
*{{cite journal | author=Talebizadeh Z, Lam DY, Theodoro MF, ''et al.'' |title=Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism. |journal=J. Med. Genet. |volume=43 |issue= 5 |pages= e21 |year= 2006 |pmid= 16648374 |doi= 10.1136/jmg.2005.036897 }}
*{{cite journal   |vauthors=Yamakawa H, Oyama S, Mitsuhashi H, etal |title=Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 1 |pages= 41–6 |year= 2007 |pmid= 17292328 |doi= 10.1016/j.bbrc.2007.01.127 }}
*{{cite journal | author=Yamakawa H, Oyama S, Mitsuhashi H, ''et al.'' |title=Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 1 |pages= 41-6 |year= 2007 |pmid= 17292328 |doi= 10.1016/j.bbrc.2007.01.127 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 15:31, 9 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Neuroligin-4, X-linked is a protein that in humans is encoded by the NLGN4X gene.[1][2]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.[2]

References

  1. ↑ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  2. ↑ 2.0 2.1 "Entrez Gene: NLGN4X neuroligin 4, X-linked".

Further reading



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