PIR (gene): Difference between revisions
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*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }} | ||
*{{cite journal |vauthors=Adams M, Jia Z |title=Structural and biochemical analysis reveal pirins to possess quercetinase activity. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28675–82 |year= 2005 |pmid= 15951572 |doi= 10.1074/jbc.M501034200 }} | *{{cite journal |vauthors=Adams M, Jia Z |title=Structural and biochemical analysis reveal pirins to possess quercetinase activity. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28675–82 |year= 2005 |pmid= 15951572 |doi= 10.1074/jbc.M501034200 }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
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*{{cite journal |vauthors=Pang H, Bartlam M, Zeng Q, etal |title=Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1491–8 |year= 2004 |pmid= 14573596 |doi= 10.1074/jbc.M310022200 }} | *{{cite journal |vauthors=Pang H, Bartlam M, Zeng Q, etal |title=Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1491–8 |year= 2004 |pmid= 14573596 |doi= 10.1074/jbc.M310022200 }} | ||
*{{cite journal |vauthors=Zeng Q, Li X, Bartlam M, etal |title=Purification, crystallization and preliminary X-ray analysis of human pirin. |journal=Acta Crystallogr. D |volume=59 |issue= Pt 8 |pages= 1496–8 |year= 2004 |pmid= 12876364 |doi=10.1107/S0907444903012289 }} | *{{cite journal |vauthors=Zeng Q, Li X, Bartlam M, etal |title=Purification, crystallization and preliminary X-ray analysis of human pirin. |journal=Acta Crystallogr. D |volume=59 |issue= Pt 8 |pages= 1496–8 |year= 2004 |pmid= 12876364 |doi=10.1107/S0907444903012289 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Dechend R, Hirano F, Lehmann K, etal |title=The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. |journal=Oncogene |volume=18 |issue= 22 |pages= 3316–23 |year= 1999 |pmid= 10362352 |doi= 10.1038/sj.onc.1202717 }} | *{{cite journal |vauthors=Dechend R, Hirano F, Lehmann K, etal |title=The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. |journal=Oncogene |volume=18 |issue= 22 |pages= 3316–23 |year= 1999 |pmid= 10362352 |doi= 10.1038/sj.onc.1202717 }} | ||
}} | }} | ||
Latest revision as of 19:44, 25 June 2018
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Pirin is a protein that in humans is encoded by the PIR gene.[1][2]
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.[2]
Interactions
PIR (gene) has been shown to interact with BCL3.[3]
References
- ↑ Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.
- ↑ 2.0 2.1 "Entrez Gene: PIR pirin (iron-binding nuclear protein)".
- ↑ Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. ENGLAND. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352.
Further reading
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- Adams M, Jia Z (2005). "Structural and biochemical analysis reveal pirins to possess quercetinase activity". J. Biol. Chem. 280 (31): 28675–82. doi:10.1074/jbc.M501034200. PMID 15951572.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Pang H, Bartlam M, Zeng Q, et al. (2004). "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor". J. Biol. Chem. 279 (2): 1491–8. doi:10.1074/jbc.M310022200. PMID 14573596.
- Zeng Q, Li X, Bartlam M, et al. (2004). "Purification, crystallization and preliminary X-ray analysis of human pirin". Acta Crystallogr. D. 59 (Pt 8): 1496–8. doi:10.1107/S0907444903012289. PMID 12876364.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Dechend R, Hirano F, Lehmann K, et al. (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.
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