Melanoma antigen family a, 8: Difference between revisions

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{{Underlinked|date=August 2014}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Melanoma antigen family A, 8''' is a [[protein]] that in humans is encoded by the MAGEA8 [[gene]].
'''Melanoma antigen family A, 8''' is a [[protein]] that in humans is encoded by the MAGEA8 [[gene]].
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==Function==
== Function ==


This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009].
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The [[Promoter (genetics)|promoters]] and first [[exon]]s of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as [[dyskeratosis congenita]]. Multiple alternatively spliced variants, encoding the same protein, have been identified.


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal
* {{cite journal | vauthors = De Plaen E, Arden K, Traversari C, Gaforio JJ, Szikora JP, De Smet C, Brasseur F, van der Bruggen P, Lethé B, Lurquin C | title = Structure, chromosomal localization, and expression of 12 genes of the MAGE family | journal = Immunogenetics | volume = 40 | issue = 5 | pages = 360–9 | year = 1994 | pmid = 7927540 | doi = 10.1007/BF01246677 }}
| pmid = 7927540
* {{cite journal | vauthors = Rogner UC, Wilke K, Steck E, Korn B, Poustka A | title = The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28 | journal = Genomics | volume = 29 | issue = 3 | pages = 725–31 | date = October 1995 | pmid = 8575766 | doi = 10.1006/geno.1995.9945 }}
| year = 1994
* {{cite journal | vauthors = Serrano A, Lethé B, Delroisse JM, Lurquin C, De Plaen E, Brasseur F, Rimoldi D, Boon T | title = Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries | journal = International Journal of Cancer | volume = 83 | issue = 5 | pages = 664–9 | date = November 1999 | pmid = 10521804 | doi = 10.1002/(SICI)1097-0215(19991126)83:5<664::AID-IJC16>3.0.CO;2-V }}
| author1 = De Plaen
| first1 = E
| title = Structure, chromosomal localization, and expression of 12 genes of the MAGE family
| journal = Immunogenetics
| volume = 40
| issue = 5
| pages = 360–9
| last2 = Arden
| first2 = K
| last3 = Traversari
| first3 = C
| last4 = Gaforio
| first4 = J. J.
| last5 = Szikora
| first5 = J. P.
| last6 = De Smet
| first6 = C
| last7 = Brasseur
| first7 = F
| last8 = Van Der Bruggen
| first8 = P
| last9 = Lethé
| first9 = B
| last10 = Lurquin
| first10 = C
| doi=10.1007/BF01246677
}}
*{{Cite journal
| pmid = 8575766
| year = 1995
| author1 = Rogner
| first1 = U. C.
| title = The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28
| journal = Genomics
| volume = 29
| issue = 3
| pages = 725–31
| last2 = Wilke
| first2 = K
| last3 = Steck
| first3 = E
| last4 = Korn
| first4 = B
| last5 = Poustka
| first5 = A
| doi = 10.1006/geno.1995.9945
}}
*{{Cite journal
| pmid = 10521804
| year = 1999
| author1 = Serrano
| first1 = A
| title = Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries
| journal = International Journal of Cancer
| volume = 83
| issue = 5
| pages = 664–9
| last2 = Lethé
| first2 = B
| last3 = Delroisse
| first3 = J. M.
| last4 = Lurquin
| first4 = C
| last5 = De Plaen
| first5 = E
| last6 = Brasseur
| first6 = F
| last7 = Rimoldi
| first7 = D
| last8 = Boon
| first8 = T
| doi = 10.1002/(SICI)1097-0215(19991126)83:5<664::AID-IJC16>3.0.CO;2-V
}}
 
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}


{{gene-X-stub}}
{{gene-X-stub}}

Latest revision as of 11:39, 20 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Melanoma antigen family A, 8 is a protein that in humans is encoded by the MAGEA8 gene. [1]

Function

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References

  1. ↑ "Entrez Gene: Melanoma antigen family A, 8". Retrieved 2014-08-25.

Further reading

  • De Plaen E, Arden K, Traversari C, Gaforio JJ, Szikora JP, De Smet C, Brasseur F, van der Bruggen P, Lethé B, Lurquin C (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540.
  • Rogner UC, Wilke K, Steck E, Korn B, Poustka A (October 1995). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
  • Serrano A, Lethé B, Delroisse JM, Lurquin C, De Plaen E, Brasseur F, Rimoldi D, Boon T (November 1999). "Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries". International Journal of Cancer. 83 (5): 664–9. doi:10.1002/(SICI)1097-0215(19991126)83:5<664::AID-IJC16>3.0.CO;2-V. PMID 10521804.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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