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==Differentiating Pancytopenia from Other Diseases==
__NOTOC__
* There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing ([[complete blood count]]).


{|
[[Sandbox: wdx]]
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
 
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
[[Xyz]]
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
 
! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
[[Abc]]
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
# [[Sandbox:Preeti]]
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
# [[Lymphoma]]
! colspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
# [[Breast lumps differential diagnosis]]
! colspan="8" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para−clinical findings
# [[Neck masses differential diagnosis]]
! colspan="1" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
# [[Leukemia]]
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
{| class="wikitable"
|+
|-
| colspan="2" |[[:Category:Risk calculator]]
[[Category:Risk calculator]]
|-
| colspan="2" |[[Deep vein thrombosis assessment of clinical probability and risk scores]]
|-
| colspan="2" |[[Pulmonary embolism assessment of clinical probability and risk scores]]
|-
|[[Padua prediction score]]
|[[widget:PaduaVTEscore]]
|-
|[[IMPROVE risk score calculator]]
|[[Widget:IMPROVEScore]]
|-
|[[IMPROVEDD risk score calculator]]
|[[Widget:IMPROVEDDScore]]
|-
|[[Caprini score calculator]]
|[[Widget:CapCal]]
|-
|[[Wells score calculator for DVT]]
|[[Widget:DVT Wells score calculator]]
|-
|[[Modified Wells score calculator for DVT]]
|[[Widget:DVT Modified Wells score calculator]]
|-
|[[Pulmonary embolism Wells score calculator]]
|[[widget:PE_calculator]]
|-
|[[Pulmonary embolism modified Wells score calculator]]
|[[Widget:PE Modified Wells score calculator]]
|-
|[[AMUSE score calculator]]
|[[Widget:AMUSE_score_calculator]]
|-
|[[HAMILTON score calculator]]
|[[Widget:HAMILTON_score_calculator]]
|-
|[[Geneva score calculator]]
|[[Widget:Geneva_score_calculator]]
|-
|[[Revised Geneva score calculator]]
|[[Widget:Revised_Geneva_score_calculator]]
|-
|[[Simplified Geneva Score calculator]]
|[[Widget:Simplified_Geneva_score_calculator]]
|-
|[[TIMI Risk Score for Unstable Angina or NSTEMI]]
|[[Widget:TIMI_UA_NSTEMI]]
|-
|[[TIMI Risk Score for STEMI]]
|[[Widget:TIMI_STEMI]]
|-
|[[Tygerberg score]]
|[[widget:Tygerberg_score]]
|-
|[[CHA2DS2-VASc Score]]
|[[Widget:CHA2DS2VASc]]
|-
|[[CHADS2 score]]
|[[Widget:CHADS2score]]
|-
|[[HAS-BLED score]]
|[[Widget:HASBLEDscore]]
|-
|[[The GRACE risk score]]
|[[Widget:GRACEscore]]
|-
|
|
|-
|[[Ranson criteria]]
[[Acute pancreatitis diagnostic criteria]]
|[[Widget:RansonScore]]
|-
|[[Apgar score]]
|[[Widget:Apgarscore]]
|-
|[[Glasgow coma scale]]
|[[Widget:Adult_GCS]]
|-
|[[Pediatric Glasgow Coma Scale]]
|[[Widget:PGCS]]
|-
|[[Cincinnati stroke scale]]
|[[Widget:Cincinnati_Stroke_Scale]]
|-
|[[DIPSS Plus Score]]
|[[Widget:DIPSS_Plus_Score]]
|-
|-
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
| colspan="2" |[[ICU scoring systems]]
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
| colspan="4" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
|-
|-
! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
|[[APACHE II]]
|[[Widget:APACHEII]]
|-
|-
! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
|[[SAPS II]]
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
|[[Widget:SAPSII]]
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |CBC
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
|-
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
|[[SAPS III]]
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
|[[Widget:SAPSIII]]
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
sequestration/
redistribution
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
|-
|-
! rowspan="10" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic disorders
|[[PIM2]]
! align="center" style="background:#DCDCDC;" |[[Myelodysplastic syndrome (patient information)|Myelodysplastic syndrome]]<ref name="NatelsonPyatt2013">{{cite journal|last1=Natelson|first1=Ethan A.|last2=Pyatt|first2=David|title=Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog|journal=Advances in Hematology|volume=2013|year=2013|pages=1–11|issn=1687-9104|doi=10.1155/2013/309637}}</ref>
|
| align="left" style="background:#F5F5F5;" |
|}
* [[Bone marrow]] infiltration
==Table==
* Ineffective [[hematopoiesis]]
{|
| align="center" style="background:#F5F5F5;" | +
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Complications
| align="center" style="background:#F5F5F5;" | +
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Polymyositis
| align="center" style="background:#F5F5F5;" |−
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Dermatomyositis
| align="center" style="background:#F5F5F5;" | ±
| align="center" style="background:#F5F5F5;" | +
| align="center" style="background:#F5F5F5;" |Elderly
| align="center" style="background:#F5F5F5;" |Exposure to
* [[Chemotherapy]]
* [[Radiation therapy]]
* [[Tobacco smoking|Tobacco smoke]]
| align="center" style="background:#F5F5F5;" |
* [[Petechia|Petechiae]]
* [[Purpura]]
* Diffuse erythematous rash
| align="center" style="background:#F5F5F5;" | +
| align="center" style="background:#F5F5F5;" | +
| align="center" style="background:#F5F5F5;" | Nl
| align="center" style="background:#F5F5F5;" | +
| align="center" style="background:#F5F5F5;" | +
| align="center" style="background:#F5F5F5;" |
* [[Shortness of breath]]
* [[Fatigue]]
* [[Pallor]]
| align="center" style="background:#F5F5F5;" |↓
| align="center" style="background:#F5F5F5;" |↓
| align="center" style="background:#F5F5F5;" |↓
| align="center" style="background:#F5F5F5;" |
*Ovalomacrocytosis
*Basophilic stippling
*[[Howell-Jolly body]]
*Dysplastic [[Neutrophil|neutrophils]]
| align="center" style="background:#F5F5F5;" |
*Impaired [[myeloid]] maturation
*[[Congenital dyserythropoietic anemia|Dyserythropoiesis]]
*Dysgranulopoiesis
*Dysmegakaryocytopoiesis
*Hypercellular [[bone marrow]]
*[[Fibrosis]]
| align="center" style="background:#F5F5F5;" |Nl
| align="center" style="background:#F5F5F5;" |Nl
| align="center" style="background:#F5F5F5;" |Nl
| align="center" style="background:#F5F5F5;" |[[Bone marrow examination]] + clinical manifestation
| align="center" style="background:#F5F5F5;" |
*Might transformed to [[acute leukemia]]
|-
|-
! align="left" style="background:#DCDCDC;" |Malignancies such as:<ref name="OshimaYuji2013">{{cite journal|last1=Oshima|first1=Yasuo|last2=Yuji|first2=Koichiro|last3=Tanimoto|first3=Tetsuya|last4=Hinomura|first4=Yasushi|last5=Tojo|first5=Arinobu|title=Association between Acute Myelogenous Leukemia and Thrombopoietin Receptor Agonists in Patients with Immune Thrombocytopenia|journal=Internal Medicine|volume=52|issue=19|year=2013|pages=2193–2201|issn=0918-2918|doi=10.2169/internalmedicine.52.0324}}</ref><ref name="pmid24088751">{{cite journal |vauthors=Oshima Y, Yuji K, Tanimoto T, Hinomura Y, Tojo A |title=Association between acute myelogenous leukemia and thrombopoietin receptor agonists in patients with immune thrombocytopenia |journal=Intern. Med. |volume=52 |issue=19 |pages=2193–201 |date=2013 |pmid=24088751 |doi= |url=}}</ref>
! align="center" style="background:#DCDCDC;" + |[[Cancer|Malignancy]]
* [[Acute leukemia]]
* [[Chronic leukemia]]
* [[Multiple myeloma]]
* [[Metastasis|Metastatic cancer]]
| align="left" style="background:#F5F5F5;" + |
| align="left" style="background:#F5F5F5;" + |
* [[Bone marrow]] infiltration
*[[Lung]]
* Ineffective [[hematopoiesis]]
* Immune mediated
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |±
| align="center" style="background:#F5F5F5;" + |±
| align="center" style="background:#F5F5F5;" + |Any, more in adults
| align="center" style="background:#F5F5F5;" + |
*Exposure to chemicals
*[[Radiation therapy|Radiation]]
*Pre-existent blood disorders
| align="center" style="background:#F5F5F5;" + |
* [[Petechia|Petechiae]]
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + |
*[[Muscle weakness|Weakness]]
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |
*[[Pancytopenia]]
| align="center" style="background:#F5F5F5;" + |
*Blast cells
*
| align="center" style="background:#F5F5F5;" + |↑
| align="center" style="background:#F5F5F5;" + |↑
| align="center" style="background:#F5F5F5;" + |
*[[Hemoglobinuria]]
| align="center" style="background:#F5F5F5;" + |Bone marrow examination
| align="center" style="background:#F5F5F5;" + |
*[[Tumor lysis syndrome]]
*[[Infection]]
*[[CNS]] involvement
*[[Disseminated intravascular coagulation|DIC]]
|-
! align="center" style="background:#DCDCDC;" |[[Myelofibrosis]]<ref name="BaePark2013">{{cite journal|last1=Bae|first1=E.|last2=Park|first2=C.-J.|last3=Cho|first3=Y.-U.|last4=Seo|first4=E.-J.|last5=Chi|first5=H.-S.|last6=Jang|first6=S.|last7=Lee|first7=K.-H.|last8=Lee|first8=J.-H.|last9=Lee|first9=J.-H.|last10=Suh|first10=J.-J.|last11=Im|first11=H.-J.|title=Differential diagnosis of myelofibrosis based on WHO 2008 criteria: Acute panmyelosis with myelofibrosis, acute megakaryoblastic leukemia with myelofibrosis, primary myelofibrosis and myelodysplastic syndrome with myelofibrosis|journal=International Journal of Laboratory Hematology|volume=35|issue=6|year=2013|pages=629–636|issn=17515521|doi=10.1111/ijlh.12101}}</ref>
| align="left" style="background:#F5F5F5;" + |
| align="left" style="background:#F5F5F5;" + |
* Bone marrow infiltration
*[[Lung]]
| align="center" style="background:#F5F5F5;" + | +
|}
| align="center" style="background:#F5F5F5;" + | +
<br>
| align="center" style="background:#F5F5F5;" + |−
===Calculation of the Padua Prediction Score===
| align="center" style="background:#F5F5F5;" + | +
Shown below is a calculator using the predictive score for VTE among hospitalized medical patients. Check all boxes that apply to your patient:
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |Average 60 years old
| align="center" style="background:#F5F5F5;" + |
*Exposure to chemicals
*[[Radiation therapy|Radiation]]
*Pre-existent blood disorders
| align="center" style="background:#F5F5F5;" + |
* [[Pallor]]
* Major weight loss
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | -
| align="center" style="background:#F5F5F5;" + |
*[[Muscle weakness|Weakness]]
*[[Fatigue]]
* [[Dyspnea|Shortness of breath]]
* [[Headache]]
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |
*[[Pancytopenia]]
| align="center" style="background:#F5F5F5;" + |
* [[Pancytopenia]]


*Hypercellular [[bone marrow]]
{| style="border: 0; float: left; width: 45%; position: float; background: #104E8B; border-radius: 10px 10px 10px 10px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5); margin: 0 0 0 0; padding: 5px 5px; font-weight: bold;"
*[[Fibrosis]]
| colspan="2" style="text-align: center; color: #FFFFFF; font-size: 120%;" | IMPROVE Bleeding Risk Score
| align="center" style="background:#F5F5F5;" + |↑
|-
| align="center" style="background:#F5F5F5;" + |↑
! style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Variable
| align="center" style="background:#F5F5F5;" + |
! style=" text-align: center; color: #4479BA; background: #FFFFFF; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Score
*[[Hemoglobinuria]]
|-
| align="center" style="background:#F5F5F5;" + |Bone marrow examination
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Active gastric or duodenal ulcer
| align="center" style="background:#F5F5F5;" + |
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |4.5
* [[Cardiac arrhythmia|Arrhythmia]]
|-
* [[Infection]]
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Prior bleeding within the last 3 months
* [[Seizure]]
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |4
* May progress to malignancy
|-
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Thrombocytopenia (<50x10<sup>9</sup>/L)
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |4
|-
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Age ≥ 85 years
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |3.5
|-
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Liver failure (INR>1.5)
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2.5
|-
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Severe kidney failure (GFR< 30 mL/min/m<sup>2</sup>)
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2.5
|-
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Admission to ICU or CCU
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2.5
|-
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Central venous catheter
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2
|-
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Rheumatic disease
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2
|-
|-
! align="center" style="background:#DCDCDC;" |[[Fanconi anemia]]<ref name="ZhangBenedetti2015">{{cite journal|last1=Zhang|first1=Qing-Shuo|last2=Benedetti|first2=Eric|last3=Deater|first3=Matthew|last4=Schubert|first4=Kathryn|last5=Major|first5=Angela|last6=Pelz|first6=Carl|last7=Impey|first7=Soren|last8=Marquez-Loza|first8=Laura|last9=Rathbun|first9=R. Keaney|last10=Kato|first10=Shigeaki|last11=Bagby|first11=Grover C.|last12=Grompe|first12=Markus|title=Oxymetholone Therapy of Fanconi Anemia Suppresses Osteopontin Transcription and Induces Hematopoietic Stem Cell Cycling|journal=Stem Cell Reports|volume=4|issue=1|year=2015|pages=90–102|issn=22136711|doi=10.1016/j.stemcr.2014.10.014}}</ref>
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Active malignancy
| align="center" style="background:#F5F5F5;" + |
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Age: 40-84 years
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |1.5
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
sequestration/
redistribution
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|-
|-
! align="center" style="background:#DCDCDC;" |[[Aplastic anemia]]<ref name="DolbergLevy2014">{{cite journal|last1=Dolberg|first1=Osnat Jarchowsky|last2=Levy|first2=Yair|title=Idiopathic aplastic anemia: Diagnosis and classification|journal=Autoimmunity Reviews|volume=13|issue=4-5|year=2014|pages=569–573|issn=15689972|doi=10.1016/j.autrev.2014.01.014}}</ref>
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Male
| align="center" style="background:#F5F5F5;" + |
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |1
*Unknown
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + |±
| align="center" style="background:#F5F5F5;" + |±
| align="center" style="background:#F5F5F5;" + |Biphasic (the young and the elderly)
| align="center" style="background:#F5F5F5;" + |
* Exposure to [[Radiation (medicine)|radiation]], drugs and chemicals, [[pregnancy]], [[Paroxysmal nocturnal hemoglobinuria|PNH]] and viral or [[Autoimmune disease|autoimmune]] causes
| align="center" style="background:#F5F5F5;" + |
* [[Pallor]]
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + |
*[[Shortness of breath]]
*[[Fatigue]]
*[[Pallor]]
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |
*Large [[Red blood cell|RBCs]]
*Low [[Platelet|platelets]] and [[Granulocyte|granulocytes]]
| align="center" style="background:#F5F5F5;" + |
*Hypocellular [[bone marrow]]
*replacement of [[bone marrow]] by [[fat]]
| align="center" style="background:#F5F5F5;" + |↑
| align="center" style="background:#F5F5F5;" + |↑
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |[[Bone marrow examination]] +
laboratory findings
| align="center" style="background:#F5F5F5;" + |
*[[Fanconi anemia|Fanconi Anemia]]
*[[Dyskeratosis congenita]]
*[[Shwachman-Diamond syndrome|Schwachman-Diamond syndrome]]
*[[Preleukemia]]
|-
|-
! align="center" style="background:#DCDCDC;" |[[Paroxysmal nocturnal hemoglobinuria]]<ref name="BoyerGrardel2015">{{cite journal|last1=Boyer|first1=Thomas|last2=Grardel|first2=Nathalie|last3=Copin|first3=Marie-Christine|last4=Roumier|first4=Christophe|last5=Touzart|first5=Aurore|last6=Buchdahl|first6=Anne-Laure|last7=Corm|first7=Sélim|last8=de Latour|first8=Régis Peffault|last9=Preudhomme|first9=Claude|last10=Terriou|first10=Louis|title=Paroxysmal nocturnal hemoglobinuria (PNH) and T cell large granular lymphocyte (LGL) leukemia—an unusual association: another cause of cytopenia in PNH|journal=Annals of Hematology|volume=94|issue=10|year=2015|pages=1759–1760|issn=0939-5555|doi=10.1007/s00277-015-2439-3}}</ref>
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Moderate kidney failure (GFR: 30-59 mL/min/m<sup>2</sup>)
| align="center" style="background:#F5F5F5;" + |
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |1
*Deficiency of [[complement]] regulatory proteins
|-
! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Result:
|-
! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Interpretation:
|}
<br style="clear:left" />


*Mutations
===Calculation of the test Prediction Score===
| align="center" style="background:#F5F5F5;" + | +
Shown below is a calculator using the predictive score for VTE among hospitalized medical patients. Check all boxes that apply to your patient:
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |Any age
(usually younger adults)
| align="center" style="background:#F5F5F5;" + |
*Sudden [[nocturnal]] [[hemoglobinuria]] with partial clearing during the day
| align="center" style="background:#F5F5F5;" + |
* Normal
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + |−
| align="center" style="background:#F5F5F5;" + |
*[[Thrombosis]]
*Smooth muscle [[dystonia]]
| align="center" style="background:#F5F5F5;" + |↓/Nl
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓/Nl
| align="center" style="background:#F5F5F5;" + |
*[[Pancytopenia]]
| align="center" style="background:#F5F5F5;" + |
*Cellular [[Bone marrow|marrow]]
*[[Erythroid]] [[hyperplasia]]
*[[dyserythropoiesis]]


*Hypocellular marrow in certain stages of the disease
{| style="border: 0; float: left; width: 45%; position: float; background: #104E8B; border-radius: 10px 10px 10px 10px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5); margin: 0 0 0 0; padding: 5px 5px; font-weight: bold;"
| align="center" style="background:#F5F5F5;" + |Nl
| colspan="2" style="text-align: center; color: #FFFFFF; font-size: 120%;" | IMPROVE Bleeding Risk Score
| align="center" style="background:#F5F5F5;" + |Nl
|-
| align="center" style="background:#F5F5F5;" + |
! style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Variable
*[[Hemoglobinuria]]
! style=" text-align: center; color: #4479BA; background: #FFFFFF; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Score
| align="center" style="background:#F5F5F5;" + |[[Flow cytometry]]
|-
| align="center" style="background:#F5F5F5;" + |
! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Gender
*[[Chronic renal failure]]
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Female
*[[Pulmonary hypertension]]
|-
*[[Aplastic anemia]]
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Male
|-
|-
! align="center" style="background:#DCDCDC;" |[[Disseminated intravascular coagulation]]<ref name="HossainPaidas2013">{{cite journal|last1=Hossain|first1=Nazli|last2=Paidas|first2=Michael J.|title=Disseminated intravascular coagulation|journal=Seminars in Perinatology|volume=37|issue=4|year=2013|pages=257–266|issn=01460005|doi=10.1053/j.semperi.2013.04.008}}</ref>
! rowspan="4" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Age
| align="center" style="background:#F5F5F5;" + |Consumption
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |0-70
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! align="center" style="background:#DCDCDC;" |Dyskeratosis congenital/telomere biology disorders<ref name="PaivaCalado2014">{{cite journal|last1=Paiva|first1=Raquel M.A.|last2=Calado|first2=Rodrigo T.|title=Telomere Dysfunction and Hematologic Disorders|volume=125|year=2014|pages=133–157|issn=18771173|doi=10.1016/B978-0-12-397898-1.00006-2}}</ref>
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |71-80
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! align="center" style="background:#DCDCDC;" |[[Shwachman-Diamond syndrome]]<ref name="GokceTuncer2012">{{cite journal|last1=Gokce|first1=Muge|last2=Tuncer|first2=Murat|last3=Cetin|first3=Mualla|last4=Gumruk|first4=Fatma|title=Molecular Diagnosis of Shwachman-Diamond Syndrome Presenting with Pancytopenia at an Early Age: The First Report from Turkey|journal=Indian Journal of Hematology and Blood Transfusion|volume=29|issue=3|year=2012|pages=161–163|issn=0971-4502|doi=10.1007/s12288-012-0163-x}}</ref>
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |81-90
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! rowspan="6" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunology/
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |>90
Rheumatology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
sequestration/
redistribution
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|-
|-
! align="center" style="background:#DCDCDC;" |[[SLE]]<ref name="NewmanOwlia2013">{{cite journal|last1=Newman|first1=Kam|last2=Owlia|first2=Mohammad Bagher|last3=El-Hemaidi|first3=Ihab|last4=Akhtari|first4=Mojtaba|title=Management of immune cytopenias in patients with systemic lupus erythematosus — Old and new|journal=Autoimmunity Reviews|volume=12|issue=7|year=2013|pages=784–791|issn=15689972|doi=10.1016/j.autrev.2013.02.001}}</ref>
! rowspan="5" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Hgb ('''g/dL)'''
| align="center" style="background:#F5F5F5;" + |
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |>17 '''g/dL'''
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
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|-
|-
! align="center" style="background:#DCDCDC;" |[[Felty's syndrome|Felty syndrome]]<ref name="LiatsosTsironi2018">{{cite journal|last1=Liatsos|first1=George D.|last2=Tsironi|first2=Ioanna|last3=Vassilopoulos|first3=Dimitrios|last4=Dourakis|first4=Spyridon|title=Severe pancytopenia and splenomegaly associated with felty's syndrome, both fully responsive solely to corticosteroids|journal=Clinical Case Reports|volume=6|issue=3|year=2018|pages=509–512|issn=20500904|doi=10.1002/ccr3.1396}}</ref>
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |15.5-17 '''g/dL'''
| align="center" style="background:#F5F5F5;" + |
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|-
|-
! align="center" style="background:#DCDCDC;" |[[Wiskott-Aldrich syndrome|Wiskott Aldrich syndrome]]<ref name="pmid1960605">{{cite journal |vauthors=Brochstein JA, Gillio AP, Ruggiero M, Kernan NA, Emanuel D, Laver J, Small T, O'Reilly RJ |title=Marrow transplantation from human leukocyte antigen-identical or haploidentical donors for correction of Wiskott-Aldrich syndrome |journal=J. Pediatr. |volume=119 |issue=6 |pages=907–12 |date=December 1991 |pmid=1960605 |doi= |url=}}</ref>
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |12.5-15.5 '''g/dL'''
| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + | +
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|-
|-
! align="center" style="background:#DCDCDC;" |[[GATA2]] deficiency<ref name="SanyiJaye2018">{{cite journal|last1=Sanyi|first1=Allen|last2=Jaye|first2=David L.|last3=Rosand|first3=Cecilia B.|last4=Box|first4=Amanda|last5=Shanmuganathan|first5=Chandrakasan|last6=Waller|first6=Edmund K.|title=Diagnosis of GATA2 haplo-insufficiency in a young woman prompted by pancytopenia with deficiencies of B-cell and dendritic cell development|journal=Biomarker Research|volume=6|issue=1|year=2018|issn=2050-7771|doi=10.1186/s40364-018-0127-x}}</ref>
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |12.5-11 '''g/dL'''
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| align="center" style="background:#F5F5F5;" + | +
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|-
|-
! align="center" style="background:#DCDCDC;" |[[Hemophagocytic lymphohistiocytosis]]<ref name="Larroche2012">{{cite journal|last1=Larroche|first1=Claire|title=Hemophagocytic lymphohistiocytosis in adults: Diagnosis and treatment|journal=Joint Bone Spine|volume=79|issue=4|year=2012|pages=356–361|issn=1297319X|doi=10.1016/j.jbspin.2011.10.015}}</ref>
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |<11 '''g/dL'''
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| align="center" style="background:#F5F5F5;" + | +
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|-
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! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |GI disorders
! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |CrCl (mL/min)
! align="center" style="background:#DCDCDC;" |[[Portal hypertension]]/[[cirrhosis]]<ref name="SarinKhanna2014">{{cite journal|last1=Sarin|first1=Shiv K.|last2=Khanna|first2=Rajeev|title=Non-cirrhotic Portal Hypertension|journal=Clinics in Liver Disease|volume=18|issue=2|year=2014|pages=451–476|issn=10893261|doi=10.1016/j.cld.2014.01.009}}</ref><ref name="AksoyKoklu2015">{{cite journal|last1=Aksoy|first1=Evrim K.|last2=Koklu|first2=Seyfettin|title=Albendazole-Induced Cirrhosis Decompensation and Pancytopenia|journal=Annals of Pharmacotherapy|volume=49|issue=8|year=2015|pages=945–946|issn=1060-0280|doi=10.1177/1060028015590178}}</ref>
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |30-60 mL/min
| align="left" style="background:#F5F5F5;" + |
* Splenomegally
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
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! align="center" style="background:#DCDCDC;" |[[Glycogen storage disease|Storage diseases]] (eg, [[Gaucher's disease|Gaucher]])<ref name="Düzenli KarÖzdemir2018">{{cite journal|last1=Düzenli Kar|first1=Yeter|last2=Özdemir|first2=Zeynep C.|last3=Kiral|first3=Eylem|last4=Kiliç Yildirim|first4=Gonca|last5=Dinleyici|first5=Ener Ç.|last6=Bör|first6=Özcan|title=Hemophagocytic Lymphohystiocytosis Associated With Type Ia Glycogen Storage Disease|journal=Journal of Pediatric Hematology/Oncology|year=2018|pages=1|issn=1077-4114|doi=10.1097/MPH.0000000000001208}}</ref>
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |15-30 mL/min
| align="left" style="background:#F5F5F5;" + |
* Splenomegaly
* Bone marrow infiltration
| align="center" style="background:#F5F5F5;" + | +
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! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infections
! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Albumin
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |>3.5 g/dL
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
sequestration/
redistribution
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
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! align="center" style="background:#DCDCDC;" |[[Sepsis]]<ref name="TendasNiscola2010">{{cite journal|last1=Tendas|first1=Andrea|last2=Niscola|first2=Pasquale|last3=Dentamaro|first3=Teresa|last4=Cupelli|first4=Luca|last5=Di Matteo|first5=Gigliola|last6=Finocchi|first6=Andrea|last7=Siniscalchi|first7=Agostina|last8=Fratoni|first8=Stefano|last9=Scimò|first9=Teresa|last10=Scaramucci|first10=Laura|last11=Giovannini|first11=Marco|last12=Ales|first12=Micaela|last13=Pio Perrotti|first13=Alessio|last14=de Fabritiis|first14=Paolo|title=Pancytopenia and severe sepsis in an adult case of congenital X-linked agammaglobulinemia (XLA)|journal=Annals of Hematology|volume=89|issue=9|year=2010|pages=949–951|issn=0939-5555|doi=10.1007/s00277-009-0891-7}}</ref>
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |≤3.5 g/dL
| align="left" style="background:#F5F5F5;" + |
* Bone marrow infiltration
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
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! align="center" style="background:#DCDCDC;" |[[Infection|Viral infection]] such as [[Human Immunodeficiency Virus (HIV)|HIV]], [[hepatitis]], [[Epstein Barr virus|Epstein-Barr virus]]<ref name="Santiago-RodríguezMayor2015">{{cite journal|last1=Santiago-Rodríguez|first1=Eduardo|last2=Mayor|first2=Angel|last3=Fernández-Santos|first3=Diana|last4=Hunter-Mellado|first4=Robert|title=Profile of HIV-Infected Hispanics with Pancytopenia|journal=International Journal of Environmental Research and Public Health|volume=13|issue=1|year=2015|pages=38|issn=1660-4601|doi=10.3390/ijerph13010038}}</ref>
! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |D-dimer
| align="left" style="background:#F5F5F5;" + |
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |≥1 µg/mL
* Marrow suppression
* Splenomegaly
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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|-
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! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nutritional
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |<1 µg/mL
! align="center" style="background:#DCDCDC;" |[[Macrocytic anemia|Megaloblastic anemia]]<ref name="pmid24669609">{{cite journal |vauthors=Khattak MB, Ismail M, Marwat ZI, Khan F |title=Frequency and characterisation of pancytopenia in megaloblastic anaemia |journal=J Ayub Med Coll Abbottabad |volume=24 |issue=3-4 |pages=53–5 |date=2012 |pmid=24669609 |doi= |url=}}</ref>
| align="left" style="background:#F5F5F5;" + |
* Ineffective hematopoiesis
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + | +
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|-
|-
! align="center" style="background:#DCDCDC;" |Excessive [[alcohol]]<ref name="pmid3671238">{{cite journal |vauthors=Weston CF, Hall MJ |title=Pancytopenia and folate deficiency in alcoholics |journal=Postgrad Med J |volume=63 |issue=736 |pages=117–20 |date=February 1987 |pmid=3671238 |pmc=2428237 |doi= |url=}}</ref>
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |ICU admission
| align="left" style="background:#F5F5F5;" + |
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |
* Ineffective hematopoiesis
| align="center" style="background:#F5F5F5;" + |
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|-
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! align="center" style="background:#DCDCDC;" |Other nutritional deficiency such as [[copper deficiency]], [[zinc]] toxicity<ref name="pmid23652881">{{cite journal |vauthors=Hudspeth M, Turner A, Miller N, Lazarchick J |title=Pancytopenia after allogeneic bone marrow transplant due to copper deficiency |journal=J. Pediatr. Hematol. Oncol. |volume=36 |issue=4 |pages=316–8 |date=May 2014 |pmid=23652881 |doi=10.1097/MPH.0b013e318290c644 |url=}}</ref><ref name="pmid24082414">{{cite journal |vauthors=Robinson SD, Cooper B, Leday TV |title=Copper deficiency (hypocupremia) and pancytopenia late after gastric bypass surgery |journal=Proc (Bayl Univ Med Cent) |volume=26 |issue=4 |pages=382–6 |date=October 2013 |pmid=24082414 |pmc=3777101 |doi= |url=}}</ref>
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Acute stroke on hospitalization
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| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |
* Ineffective hematopoiesis
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|-
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! align="center" style="background:#DCDCDC;" |[[Malnutrition]]<ref name="DragusinMurray2015">{{cite journal|last1=Dragusin|first1=Roxana C.|last2=Murray|first2=Jean-Michel|last3=Mallet|first3=Dominique|last4=Gonzalez|first4=Hugo|last5=Markou|first5=Georges A.|title=Pancytopenia related to malnutrition during pregnancy|journal=International Journal of Gynecology & Obstetrics|volume=130|issue=1|year=2015|pages=86–87|issn=00207292|doi=10.1016/j.ijgo.2015.02.020}}</ref>
! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |History of VTE
| align="left" style="background:#F5F5F5;" + |
| style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |
* Ineffective hematopoiesis
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|-
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medications
! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Result:
! align="left" style="background:#DCDCDC;" |Medications such as:<ref name="pmid22862866">{{cite journal |vauthors=Kelm DJ, Torres KM, Sohail MR |title=46-year-old man with fevers, chills, and pancytopenia |journal=Mayo Clin. Proc. |volume=87 |issue=8 |pages=799–802 |date=August 2012 |pmid=22862866 |pmc=3498402 |doi=10.1016/j.mayocp.2012.03.012 |url=}}</ref><ref name="pmid24937727">{{cite journal |vauthors=Davis SA, Krowchuk DP, Feldman SR |title=Prescriptions for a toxic combination: use of methotrexate plus trimethoprim-sulfamethoxazole in the United States |journal=South. Med. J. |volume=107 |issue=5 |pages=292–3 |date=May 2014 |pmid=24937727 |doi=10.1097/SMJ.0000000000000098 |url=}}</ref>
* [[Chemotherapy|Cytotoxic drugs]]
* Idiosyncratic reactions to medications
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* Immune destruction
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|-
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Interpretation:  
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
sequestration/
redistribution
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|}
|}
<br style="clear:left" />
===Interpretation of the Padua Prediction Score===
The interpretation of the score is as follows:
* Score ≥ 4: High risk for VTE
* Score < 4: Low risk for VTE
==References==
<references />
<references />

Latest revision as of 18:11, 14 January 2019


Sandbox: wdx

Xyz

Abc

  1. Sandbox:Preeti
  2. Lymphoma
  3. Breast lumps differential diagnosis
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Category:Risk calculator
Deep vein thrombosis assessment of clinical probability and risk scores
Pulmonary embolism assessment of clinical probability and risk scores
Padua prediction score widget:PaduaVTEscore
IMPROVE risk score calculator Widget:IMPROVEScore
IMPROVEDD risk score calculator Widget:IMPROVEDDScore
Caprini score calculator Widget:CapCal
Wells score calculator for DVT Widget:DVT Wells score calculator
Modified Wells score calculator for DVT Widget:DVT Modified Wells score calculator
Pulmonary embolism Wells score calculator widget:PE_calculator
Pulmonary embolism modified Wells score calculator Widget:PE Modified Wells score calculator
AMUSE score calculator Widget:AMUSE_score_calculator
HAMILTON score calculator Widget:HAMILTON_score_calculator
Geneva score calculator Widget:Geneva_score_calculator
Revised Geneva score calculator Widget:Revised_Geneva_score_calculator
Simplified Geneva Score calculator Widget:Simplified_Geneva_score_calculator
TIMI Risk Score for Unstable Angina or NSTEMI Widget:TIMI_UA_NSTEMI
TIMI Risk Score for STEMI Widget:TIMI_STEMI
Tygerberg score widget:Tygerberg_score
CHA2DS2-VASc Score Widget:CHA2DS2VASc
CHADS2 score Widget:CHADS2score
HAS-BLED score Widget:HASBLEDscore
The GRACE risk score Widget:GRACEscore
Ranson criteria

Acute pancreatitis diagnostic criteria

Widget:RansonScore
Apgar score Widget:Apgarscore
Glasgow coma scale Widget:Adult_GCS
Pediatric Glasgow Coma Scale Widget:PGCS
Cincinnati stroke scale Widget:Cincinnati_Stroke_Scale
DIPSS Plus Score Widget:DIPSS_Plus_Score
ICU scoring systems
APACHE II Widget:APACHEII
SAPS II Widget:SAPSII
SAPS III Widget:SAPSIII
PIM2

Table

Complications Polymyositis Dermatomyositis
Malignancy


Calculation of the Padua Prediction Score

Shown below is a calculator using the predictive score for VTE among hospitalized medical patients. Check all boxes that apply to your patient:

IMPROVE Bleeding Risk Score
Variable Score
Active gastric or duodenal ulcer 4.5
Prior bleeding within the last 3 months 4
Thrombocytopenia (<50x109/L) 4
Age ≥ 85 years 3.5
Liver failure (INR>1.5) 2.5
Severe kidney failure (GFR< 30 mL/min/m2) 2.5
Admission to ICU or CCU 2.5
Central venous catheter 2
Rheumatic disease 2
Active malignancy 2
Age: 40-84 years 1.5
Male 1
Moderate kidney failure (GFR: 30-59 mL/min/m2) 1
Result:
Interpretation:


Calculation of the test Prediction Score

Shown below is a calculator using the predictive score for VTE among hospitalized medical patients. Check all boxes that apply to your patient:

IMPROVE Bleeding Risk Score
Variable Score
Gender Female
Male
Age 0-70
71-80
81-90
>90
Hgb (g/dL) >17 g/dL
15.5-17 g/dL
12.5-15.5 g/dL
12.5-11 g/dL
<11 g/dL
CrCl (mL/min) 30-60 mL/min
15-30 mL/min
Albumin >3.5 g/dL
≤3.5 g/dL
D-dimer ≥1 µg/mL
<1 µg/mL
ICU admission
Acute stroke on hospitalization
History of VTE
Result:
Interpretation:


Interpretation of the Padua Prediction Score

The interpretation of the score is as follows:

  • Score ≥ 4: High risk for VTE
  • Score < 4: Low risk for VTE

References

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