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| ==Differentiating Pancytopenia from Other Diseases==
| | __NOTOC__ |
| * There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing ([[complete blood count]]).
| |
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| {| | | [[Sandbox: wdx]] |
| ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
| | |
| ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
| | [[Xyz]] |
| ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
| | |
| ! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
| | [[Abc]] |
| ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
| | # [[Sandbox:Preeti]] |
| ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
| | # [[Lymphoma]] |
| ! colspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
| | # [[Breast lumps differential diagnosis]] |
| ! colspan="8" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para−clinical findings
| | # [[Neck masses differential diagnosis]] |
| ! colspan="1" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
| | # [[Leukemia]] |
| ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
| | {| class="wikitable" |
| | |+ |
| | |- |
| | | colspan="2" |[[:Category:Risk calculator]] |
| | [[Category:Risk calculator]] |
| | |- |
| | | colspan="2" |[[Deep vein thrombosis assessment of clinical probability and risk scores]] |
| | |- |
| | | colspan="2" |[[Pulmonary embolism assessment of clinical probability and risk scores]] |
| | |- |
| | |[[Padua prediction score]] |
| | |[[widget:PaduaVTEscore]] |
| | |- |
| | |[[IMPROVE risk score calculator]] |
| | |[[Widget:IMPROVEScore]] |
| | |- |
| | |[[IMPROVEDD risk score calculator]] |
| | |[[Widget:IMPROVEDDScore]] |
| | |- |
| | |[[Caprini score calculator]] |
| | |[[Widget:CapCal]] |
| | |- |
| | |[[Wells score calculator for DVT]] |
| | |[[Widget:DVT Wells score calculator]] |
| | |- |
| | |[[Modified Wells score calculator for DVT]] |
| | |[[Widget:DVT Modified Wells score calculator]] |
| | |- |
| | |[[Pulmonary embolism Wells score calculator]] |
| | |[[widget:PE_calculator]] |
| | |- |
| | |[[Pulmonary embolism modified Wells score calculator]] |
| | |[[Widget:PE Modified Wells score calculator]] |
| | |- |
| | |[[AMUSE score calculator]] |
| | |[[Widget:AMUSE_score_calculator]] |
| | |- |
| | |[[HAMILTON score calculator]] |
| | |[[Widget:HAMILTON_score_calculator]] |
| | |- |
| | |[[Geneva score calculator]] |
| | |[[Widget:Geneva_score_calculator]] |
| | |- |
| | |[[Revised Geneva score calculator]] |
| | |[[Widget:Revised_Geneva_score_calculator]] |
| | |- |
| | |[[Simplified Geneva Score calculator]] |
| | |[[Widget:Simplified_Geneva_score_calculator]] |
| | |- |
| | |[[TIMI Risk Score for Unstable Angina or NSTEMI]] |
| | |[[Widget:TIMI_UA_NSTEMI]] |
| | |- |
| | |[[TIMI Risk Score for STEMI]] |
| | |[[Widget:TIMI_STEMI]] |
| | |- |
| | |[[Tygerberg score]] |
| | |[[widget:Tygerberg_score]] |
| | |- |
| | |[[CHA2DS2-VASc Score]] |
| | |[[Widget:CHA2DS2VASc]] |
| | |- |
| | |[[CHADS2 score]] |
| | |[[Widget:CHADS2score]] |
| | |- |
| | |[[HAS-BLED score]] |
| | |[[Widget:HASBLEDscore]] |
| | |- |
| | |[[The GRACE risk score]] |
| | |[[Widget:GRACEscore]] |
| | |- |
| | | |
| | | |
| | |- |
| | |[[Ranson criteria]] |
| | [[Acute pancreatitis diagnostic criteria]] |
| | |[[Widget:RansonScore]] |
| | |- |
| | |[[Apgar score]] |
| | |[[Widget:Apgarscore]] |
| | |- |
| | |[[Glasgow coma scale]] |
| | |[[Widget:Adult_GCS]] |
| | |- |
| | |[[Pediatric Glasgow Coma Scale]] |
| | |[[Widget:PGCS]] |
| | |- |
| | |[[Cincinnati stroke scale]] |
| | |[[Widget:Cincinnati_Stroke_Scale]] |
| |- | | |- |
| ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
| | |[[DIPSS Plus Score]] |
| ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
| | |[[Widget:DIPSS_Plus_Score]] |
| ! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
| |
| | colspan="4" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs | |
| |- | | |- |
| ! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
| | | colspan="2" |[[ICU scoring systems]] |
| |- | | |- |
| ! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
| | |[[APACHE II]] |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
| | |[[Widget:APACHEII]] |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
| |
| ! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |CBC
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
| |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
| |
| |- | | |- |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
| | |[[SAPS II]] |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
| | |[[Widget:SAPSII]] |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
| |
| sequestration/
| |
| redistribution
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
| |
| |- | | |- |
| ! rowspan="10" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic disorders
| | |[[SAPS III]] |
| ! align="center" style="background:#DCDCDC;" |[[Myelodysplastic syndrome]]<ref name="NatelsonPyatt2013">{{cite journal|last1=Natelson|first1=Ethan A.|last2=Pyatt|first2=David|title=Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog|journal=Advances in Hematology|volume=2013|year=2013|pages=1–11|issn=1687-9104|doi=10.1155/2013/309637}}</ref>
| | |[[Widget:SAPSIII]] |
| | align="left" style="background:#F5F5F5;" | | |
| * [[Bone marrow]] infiltration
| |
| * Ineffective [[hematopoiesis]]
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |−
| |
| | align="center" style="background:#F5F5F5;" | ±
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |Elderly
| |
| | align="center" style="background:#F5F5F5;" |Exposure to
| |
| * [[Chemotherapy]]
| |
| * [[Radiation therapy]]
| |
| * [[Tobacco smoking|Tobacco smoke]]
| |
| | align="center" style="background:#F5F5F5;" |
| |
| * [[Petechia|Petechiae]]
| |
| * [[Purpura]]
| |
| * Diffuse erythematous rash
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | Nl
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" | +
| |
| | align="center" style="background:#F5F5F5;" |
| |
| * [[Shortness of breath]]
| |
| * [[Fatigue]]
| |
| * [[Pallor]]
| |
| | align="center" style="background:#F5F5F5;" |↓
| |
| | align="center" style="background:#F5F5F5;" |↓
| |
| | align="center" style="background:#F5F5F5;" |↓
| |
| | align="center" style="background:#F5F5F5;" |
| |
| *Ovalomacrocytosis
| |
| *Basophilic stippling
| |
| *[[Howell-Jolly body]]
| |
| *Dysplastic [[Neutrophil|neutrophils]]
| |
| | align="center" style="background:#F5F5F5;" |
| |
| *Impaired [[myeloid]] maturation
| |
| *[[Congenital dyserythropoietic anemia|Dyserythropoiesis]]
| |
| *Dysgranulopoiesis
| |
| *Dysmegakaryocytopoiesis
| |
| *Hypercellular [[bone marrow]]
| |
| *[[Fibrosis]]
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |Nl
| |
| | align="center" style="background:#F5F5F5;" |[[Bone marrow examination]] + clinical manifestation
| |
| | align="center" style="background:#F5F5F5;" |
| |
| *Might transformed to [[acute leukemia]]
| |
| |- | | |- |
| ! align="left" style="background:#DCDCDC;" |Malignancies such as: | | |[[PIM2]] |
| * [[Acute leukemia]]
| | | |
| * [[Chronic leukemia]]
| | |} |
| * [[Multiple myeloma]]
| | ==Table== |
| * [[Metastasis|Metastatic cancer]]
| | {| |
| | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Complications |
| | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Polymyositis |
| | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Dermatomyositis |
| | |- |
| | ! align="center" style="background:#DCDCDC;" + |[[Cancer|Malignancy]] |
| | align="left" style="background:#F5F5F5;" + | | | | align="left" style="background:#F5F5F5;" + | |
| * [[Bone marrow]] infiltration | | *[[Lung]] |
| * Ineffective [[hematopoiesis]]
| |
| * Immune mediated
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |±
| |
| | align="center" style="background:#F5F5F5;" + |±
| |
| | align="center" style="background:#F5F5F5;" + |Any, more in adults
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Exposure to chemicals
| |
| *[[Radiation therapy|Radiation]]
| |
| *Pre-existent blood disorders
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Petechia|Petechiae]]
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Muscle weakness|Weakness]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Blast cells
| |
| *
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Hemoglobinuria]]
| |
| | align="center" style="background:#F5F5F5;" + |Bone marrow examination
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Tumor lysis syndrome]]
| |
| *[[Infection]]
| |
| *[[CNS]] involvement
| |
| *[[Disseminated intravascular coagulation|DIC]]
| |
| |-
| |
| ! align="center" style="background:#DCDCDC;" |[[Myelofibrosis]]
| |
| | align="left" style="background:#F5F5F5;" + | | | | align="left" style="background:#F5F5F5;" + | |
| * Bone marrow infiltration
| | *[[Lung]] |
| | align="center" style="background:#F5F5F5;" + | +
| | |} |
| | align="center" style="background:#F5F5F5;" + | +
| | <br> |
| | align="center" style="background:#F5F5F5;" + |−
| | ===Calculation of the Padua Prediction Score=== |
| | align="center" style="background:#F5F5F5;" + | +
| | Shown below is a calculator using the predictive score for VTE among hospitalized medical patients. Check all boxes that apply to your patient: |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Average 60 years old
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Exposure to chemicals
| |
| *[[Radiation therapy|Radiation]]
| |
| *Pre-existent blood disorders
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Pallor]] | |
| * Major weight loss
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Muscle weakness|Weakness]]
| |
| *[[Fatigue]]
| |
| * [[Dyspnea|Shortness of breath]]
| |
| * [[Headache]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Pancytopenia]]
| |
|
| |
|
| *Hypercellular [[bone marrow]]
| | {| style="border: 0; float: left; width: 45%; position: float; background: #104E8B; border-radius: 10px 10px 10px 10px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5); margin: 0 0 0 0; padding: 5px 5px; font-weight: bold;" |
| *[[Fibrosis]]
| | | colspan="2" style="text-align: center; color: #FFFFFF; font-size: 120%;" | IMPROVE Bleeding Risk Score |
| | align="center" style="background:#F5F5F5;" + |↑ | |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + | | |
| *[[Hemoglobinuria]]
| |
| | align="center" style="background:#F5F5F5;" + |Bone marrow examination
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Cardiac arrhythmia|Arrhythmia]]
| |
| * [[Infection]]
| |
| * [[Seizure]]
| |
| * May progress to malignancy
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Fanconi anemia]] | | ! style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Variable |
| | align="center" style="background:#F5F5F5;" + |
| | ! style=" text-align: center; color: #4479BA; background: #FFFFFF; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Score |
| * Genetic defect
| | |- |
| * Bone marrow failure
| | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Active gastric or duodenal ulcer |
| | align="center" style="background:#F5F5F5;" + |−
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |4.5 |
| | align="center" style="background:#F5F5F5;" + | + | | |- |
| | align="center" style="background:#F5F5F5;" + |− | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Prior bleeding within the last 3 months |
| | align="center" style="background:#F5F5F5;" + | + | | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |4 |
| | align="center" style="background:#F5F5F5;" + |− | | |- |
| | align="center" style="background:#F5F5F5;" + |Rare [[autosomal recessive]] genetic disorder, higher in Ashkenazi Jews and Afrikaners in South Africa | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Thrombocytopenia (<50x10<sup>9</sup>/L) |
| | align="center" style="background:#F5F5F5;" + | | | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |4 |
| * Family history of [[Fanconi anemia]]
| | |- |
| | align="center" style="background:#F5F5F5;" + | | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Age ≥ 85 years |
| * Short stature
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |3.5 |
| * Petechiae and bruises
| | |- |
| * Pallor
| | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Liver failure (INR>1.5) |
| * Skin discoloration
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2.5 |
| | align="center" style="background:#F5F5F5;" + |−
| | |- |
| | align="center" style="background:#F5F5F5;" + | + | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Severe kidney failure (GFR< 30 mL/min/m<sup>2</sup>) |
| | align="center" style="background:#F5F5F5;" + |Nl | | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2.5 |
| | align="center" style="background:#F5F5F5;" + |− | | |- |
| | align="center" style="background:#F5F5F5;" + |− | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Admission to ICU or CCU |
| | align="center" style="background:#F5F5F5;" + | | | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2.5 |
| * Skeletal defects
| | |- |
| * Deafness
| | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Central venous catheter |
| * VSD
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2 |
| * Kidney abnormalities
| | |- |
| *
| | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Rheumatic disease |
| | align="center" style="background:#F5F5F5;" + |↓
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2 |
| | align="center" style="background:#F5F5F5;" + |↓ | | |- |
| | align="center" style="background:#F5F5F5;" + |↓ | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Active malignancy |
| | align="center" style="background:#F5F5F5;" + | | | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |2 |
| *[[Pancytopenia]]
| | |- |
| | align="center" style="background:#F5F5F5;" + |
| | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Age: 40-84 years |
| * [[Pancytopenia]]
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |1.5 |
| | | |- |
| *Hypercellular [[bone marrow]]
| | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Male |
| | align="center" style="background:#F5F5F5;" + |Nl | | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |1 |
| | align="center" style="background:#F5F5F5;" + |Nl | |
| | align="center" style="background:#F5F5F5;" + |Nl | |
| | align="center" style="background:#F5F5F5;" + |Genetic studies | |
| | align="center" style="background:#F5F5F5;" + | | |
| * Progress to [[Acute myeloid leukemia|acute myelogenous leukemia]]
| |
| * [[Neoplasm|Solid tumors]]
| |
| * [[Developmental abnormality|Developmental abnormalities]]
| |
| |- | | |- |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Moderate kidney failure (GFR: 30-59 mL/min/m<sup>2</sup>) |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |1 |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
| |
| sequestration/
| |
| redistribution
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Aplastic anemia]] | | ! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Result: |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Unknown
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |±
| |
| | align="center" style="background:#F5F5F5;" + |±
| |
| | align="center" style="background:#F5F5F5;" + |Biphasic (the young and the elderly)
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Exposure to [[Radiation (medicine)|radiation]], drugs and chemicals, [[pregnancy]], [[Paroxysmal nocturnal hemoglobinuria|PNH]] and viral or [[Autoimmune disease|autoimmune]] causes
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Pallor]]
| |
| | align="center" style="background:#F5F5F5;" + |− | |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Shortness of breath]]
| |
| *[[Fatigue]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Large [[Red blood cell|RBCs]]
| |
| *Low [[Platelet|platelets]] and [[Granulocyte|granulocytes]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| *replacement of [[bone marrow]] by [[fat]]
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |[[Bone marrow examination]] +
| |
| laboratory findings
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Fanconi anemia|Fanconi Anemia]]
| |
| *[[Dyskeratosis congenita]]
| |
| *[[Shwachman-Diamond syndrome|Schwachman-Diamond syndrome]]
| |
| *[[Preleukemia]]
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Paroxysmal nocturnal hemoglobinuria]] | | ! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Interpretation: |
| | align="center" style="background:#F5F5F5;" + | | | |} |
| *Deficiency of [[complement]] regulatory proteins
| | <br style="clear:left" /> |
|
| |
|
| *Mutations
| | ===Calculation of the test Prediction Score=== |
| | align="center" style="background:#F5F5F5;" + | +
| | Shown below is a calculator using the predictive score for VTE among hospitalized medical patients. Check all boxes that apply to your patient: |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Any age
| |
| (usually younger adults)
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Sudden [[nocturnal]] [[hemoglobinuria]] with partial clearing during the day
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Normal
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Thrombosis]]
| |
| *Smooth muscle [[dystonia]]
| |
| | align="center" style="background:#F5F5F5;" + |↓/Nl
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓/Nl
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Cellular [[Bone marrow|marrow]]
| |
| *[[Erythroid]] [[hyperplasia]]
| |
| *[[dyserythropoiesis]]
| |
|
| |
|
| *Hypocellular marrow in certain stages of the disease
| | {| style="border: 0; float: left; width: 45%; position: float; background: #104E8B; border-radius: 10px 10px 10px 10px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5); margin: 0 0 0 0; padding: 5px 5px; font-weight: bold;" |
| | align="center" style="background:#F5F5F5;" + |Nl | | | colspan="2" style="text-align: center; color: #FFFFFF; font-size: 120%;" | IMPROVE Bleeding Risk Score |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + | | |
| *[[Hemoglobinuria]]
| |
| | align="center" style="background:#F5F5F5;" + |[[Flow cytometry]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Chronic renal failure]]
| |
| *[[Pulmonary hypertension]]
| |
| *[[Aplastic anemia]]
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Disseminated intravascular coagulation]] | | ! style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Variable |
| | align="center" style="background:#F5F5F5;" + |
| | ! style=" text-align: center; color: #4479BA; background: #FFFFFF; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Score |
| * Consumption
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Any
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Infection]]
| |
| * [[Physical trauma|Trauma]]
| |
| * [[Obstetrics]] complications
| |
| * [[Cancer]]
| |
| * [[Shock]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Acutely ill
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Shortness of breath]]
| |
| *[[Fatigue]]
| |
| *[[Chest pain]]
| |
| | align="center" style="background:#F5F5F5;" + |↓/Nl
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓/Nl
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |NA
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Hemoglobinuria]]
| |
| | align="center" style="background:#F5F5F5;" + |Lab findings
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * High mortality rate
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |Dyskeratosis congenital/telomere biology disorders | | ! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Gender |
| | align="center" style="background:#F5F5F5;" + |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Female |
| * Aberrant telomere biology
| |
| * Germline mutations
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Rare genetic disorder
| |
| | align="center" style="background:#F5F5F5;" + | | |
| * Family history
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Isolated congenital nail dysplasia|Nail dysplasia]]
| |
| * Abnormal skin pigmentation
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Leukoplakia|Oral leukoplakia]]
| |
| * [[Shortness of breath]]
| |
| *[[Fatigue]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Clinical findings + genetic studies
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Progress to [[Cancer|malignancy]]
| |
| * [[Idiopathic pulmonary fibrosis|Pulmonary fibrosis]]
| |
| * [[Hepato-biliary diseases|Liver disease]]
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Shwachman-Diamond syndrome]]
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Male |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Germline mutations
| |
| * Bone marrow failure
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Rare genetic disorder
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Family history
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Skeletal abnormalities
| |
| * [[Short stature]]
| |
| * [[Metaphyseal dysostosis mental retardation conductive deafness|Metaphyseal dysostosis]]
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Steatorrhea]]
| |
| * [[Delayed milestone|Growth retardation]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Clinical findings + genetic studies
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Pancreatic insufficiency|Exocrine pancreatic insufficiency]]
| |
| * [[Delayed milestone|Growth retardation]]
| |
| * Increased frequency of [[Infection|infections]]
| |
| |- | | |- |
| ! rowspan="6" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunology/ | | ! rowspan="4" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Age |
| Rheumatology
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |0-70 |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
| |
| sequestration/
| |
| redistribution
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[SLE]]
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |71-80 |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Immune mediated bone marrow failure
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |More in young females
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Family history
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Rash|Skin rash]]
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Nl to ↓
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Weight loss]]
| |
| * [[Oral ulcer|Mouth ulcers]]
| |
| * [[Chest pain]]
| |
| * [[Lymphadenopathy]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Hemoglobinuria]]
| |
| *[[Proteinuria]]
| |
| | align="center" style="background:#F5F5F5;" + |Clinical findings + laboratory studies
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Multi organ damage
| |
| * Poor prognosis
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Felty's syndrome|Felty syndrome]]
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |81-90 |
| | align="center" style="background:#F5F5F5;" + | | |
| * Immune mediated bone marrow failure
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Rare [[autoimmune disease]], more in females 50-70 years old
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * History of [[rheumatoid arthritis]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Pallor]]
| |
| * [[Hyperpigmentation|Skin hyperpigmentation]]
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Painful, stiff, and swollen [[Joint|joints]]
| |
| * [[Keratoconjunctivitis sicca]]
| |
| * [[Weight loss]]
| |
| * [[Fatigue]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Clinical findings + laboratory studies
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Rheumatoid arthritis]]
| |
| * [[Infection|Infections]]
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Wiskott-Aldrich syndrome|Wiskott Aldrich syndrome]]
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |>90 |
| | align="center" style="background:#F5F5F5;" + |
| | |- |
| * Mutation in [[GATA1|GATA-1]]
| | ! rowspan="5" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Hgb ('''g/dL)''' |
| * Immune mediated bone marrow failure
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |>17 '''g/dL''' |
| | align="center" style="background:#F5F5F5;" + |−
| | |- |
| | align="center" style="background:#F5F5F5;" + | +
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |15.5-17 '''g/dL''' |
| | align="center" style="background:#F5F5F5;" + |−
| | |- |
| | align="center" style="background:#F5F5F5;" + | +
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |12.5-15.5 '''g/dL''' |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Rare [[Sex-linked|X-linked]] [[Recessive gene|recessive]] disease
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Immunodeficiency]]
| |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" + | | |
| *[[Eczema]]
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Dysentery|Bloody diarrhea]]
| |
| | align="center" style="background:#F5F5F5;" + |↓ | |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| *Small but low [[Platelet|platelets]]
| |
| | align="center" style="background:#F5F5F5;" + |Nl | |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Genetic study
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Recurrent [[Infection|infections]]
| |
| | |
| *[[Autoimmune disease|autoimmune disorders]]
| |
| *[[Cancer|Malignancy]]
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[GATA2]] deficiency
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |12.5-11 '''g/dL''' |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Immune mediated bone marrow failure
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Rare
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Immunodeficiency]]
| |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Purpura]]
| |
| *[[Petechia|Petechiae]]
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Genetic study
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Recurrent [[Infection|infections]]
| |
| | |
| *[[Autoimmune disease|autoimmune disorders]]
| |
| *[[Cancer|Malignancy]]
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Hemophagocytic lymphohistiocytosis]]
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |<11 '''g/dL''' |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Immune mediated bone marrow failure
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Rare
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Immunodeficiency]]
| |
| * Positive family history
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Purpura]]
| |
| *[[Petechia|Petechiae]]
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Genetic study
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Recurrent [[Infection|infections]]
| |
| | |
| *[[Autoimmune disease|autoimmune disorders]]
| |
| *[[Cancer|Malignancy]]
| |
| |- | | |- |
| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |GI disorders | | ! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |CrCl (mL/min) |
| ! align="center" style="background:#DCDCDC;" |[[Portal hypertension]]/[[cirrhosis]]
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |30-60 mL/min |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Splenomegally
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Any
| |
| | align="center" style="background:#F5F5F5;" + | | |
| *[[Cirrhosis]]
| |
| *[[Alcoholism|Alcohol use]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Purpura]]
| |
| *[[Petechia|Petechiae]]
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Clinical manifestation
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Portal vein thrombosis]]
| |
| *[[Hepatorenal syndrome]]
| |
| *Variceal hemorrhage
| |
| *Hepatic [[hydrothorax]]
| |
| *[[Spontaneous bacterial peritonitis]]
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Glycogen storage disease|Storage diseases]] (eg, [[Gaucher's disease|Gaucher]])
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |15-30 mL/min |
| | align="left" style="background:#F5F5F5;" + | | |
| * Splenomegaly
| |
| * Bone marrow infiltration
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Rare in children
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Family history
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * [[Rash|Skin rash]]
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| |- | | |- |
| ! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infections | | ! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Albumin |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |>3.5 g/dL |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
| |
| sequestration/
| |
| redistribution
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Sepsis]]
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |≤3.5 g/dL |
| | align="left" style="background:#F5F5F5;" + |
| |
| *Direct [[bone marrow suppression]]
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Any
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Infection|Bacterial infection]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Petechiae]]
| |
| *[[Purpura]]
| |
| *[[Erythema]]
| |
| *[[Ulcer|Ulceration]]
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |±
| |
| | align="center" style="background:#F5F5F5;" + |Nl to ↓
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |±
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Malaise]]
| |
| *[[Lymphadenopathy]]
| |
| | align="center" style="background:#F5F5F5;" + |↓/↑
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓/↑
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |NA
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| Depends on the etiology
| |
| | align="center" style="background:#F5F5F5;" + |Clinical manifestation + culture
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Associated with ↑ mortality
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Infection|Viral infection]] such as [[Human Immunodeficiency Virus (HIV)|HIV]], [[hepatitis]], [[Epstein Barr virus|Epstein-Barr virus]] | | ! rowspan="2" style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |D-dimer |
| | align="left" style="background:#F5F5F5;" + |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |≥1 µg/mL |
| * Marrow suppression
| |
| * Splenomegaly
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Any
| |
| | align="center" style="background:#F5F5F5;" + | | |
| *High risk behaviors
| |
| *Close contact
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Petechiae]]
| |
| *[[Purpura]]
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |±
| |
| | align="center" style="background:#F5F5F5;" + |±
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Lymphadenopathy]]
| |
| *[[Muscle weakness]]
| |
| *[[Joint swelling]]
| |
| *Focal neurological deficits
| |
| *Depends on etiology
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Hematuria]]
| |
| | align="center" style="background:#F5F5F5;" + |Clinical manifestation + lab tests
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Depends on etiology
| |
| *[[Encephalomyelitis]]
| |
| |- | | |- |
| ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nutritional
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |<1 µg/mL |
| ! align="center" style="background:#DCDCDC;" |[[Macrocytic anemia|Megaloblastic anemia]]
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Ineffective hematopoiesis
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Any
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Malnutrition
| |
| *Alcohol use
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Normal
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Fatigue]]
| |
| *[[Weakness]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Laboratory findings
| |
| | align="center" style="background:#F5F5F5;" + |NA
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |Excessive [[alcohol]] | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |ICU admission |
| | align="left" style="background:#F5F5F5;" + |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" | |
| * Ineffective hematopoiesis
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Alcoholism
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *History of [[Alcoholism|alcohol use]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Normal
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Hepatomegaly]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓ | |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Clinical manifestation
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Chronic liver disease]]
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |Other nutritional deficiency such as [[copper deficiency]], [[zinc]] toxicity | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Acute stroke on hospitalization |
| | align="left" style="background:#F5F5F5;" + |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" | |
| * Ineffective hematopoiesis
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Any
| |
| | align="center" style="background:#F5F5F5;" + | | |
| *Malnutrition
| |
| *Alcohol use
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Normal
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Fatigue]]
| |
| *[[Weakness]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Laboratory findings
| |
| | align="center" style="background:#F5F5F5;" + |NA
| |
| |- | | |- |
| ! align="center" style="background:#DCDCDC;" |[[Malnutrition]] | | ! style=" text-align: left; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |History of VTE |
| | align="left" style="background:#F5F5F5;" + |
| | | style=" text-align: center; color: #FFFFFF; background: #4479BA; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" | |
| * Ineffective hematopoiesis
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Any
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Malnutrition
| |
| *Alcohol use
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| * Normal
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Fatigue]]
| |
| *[[Weakness]]
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓ | |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |Laboratory findings
| |
| | align="center" style="background:#F5F5F5;" + |NA
| |
| |- | | |- |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medications | | ! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Result: |
| ! align="left" style="background:#DCDCDC;" |Medications such as:
| |
| * [[Chemotherapy|Cytotoxic drugs]]
| |
| * Idiosyncratic reactions to medications
| |
| | align="left" style="background:#F5F5F5;" + |
| |
| * Immune destruction
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Patients with [[Cancer|malignancy]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Radiation therapy|Radiation]]
| |
| *[[Cancer]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Purpura]]
| |
| *[[Petechia|Petechiae]]
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + | +
| |
| | align="center" style="background:#F5F5F5;" + |Nl
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |−
| |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |↓ | |
| | align="center" style="background:#F5F5F5;" + |↓
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Pancytopenia]]
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *Hypocellular [[bone marrow]]
| |
| *Megakaryocytic hypoplasia or aplasia
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |↑
| |
| | align="center" style="background:#F5F5F5;" + |[[Hematuria case study one|Hematuria]]
| |
| | align="center" style="background:#F5F5F5;" + |Clinical manifestation + exclusion of the other causes
| |
| | align="center" style="background:#F5F5F5;" + |
| |
| *[[Thrombosis]]
| |
| |- | | |- |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category | | ! colspan="2" style=" text-align: left; color: #4479BA; background: #FFFFFF; padding: 2px 10px; border-radius: 5px 5px 5px 5px; text-shadow: 0 0 0 rgba(0, 0, 0, 0.2); box-shadow: 0 1px 1px rgba(0, 0, 0, 0.5);" |Interpretation: |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
| |
| sequestration/
| |
| redistribution
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
| |
| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
| |
| |} | | |} |
| | <br style="clear:left" /> |
| | |
| | ===Interpretation of the Padua Prediction Score=== |
| | The interpretation of the score is as follows: |
| | * Score ≥ 4: High risk for VTE |
| | * Score < 4: Low risk for VTE |
| | ==References== |
| <references /> | | <references /> |