Mucoepidermoid carcinoma classification: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Mucoepidermoid carcinoma}} | {{Mucoepidermoid carcinoma}} | ||
{{CMG}}{{AE}} {{Badria}} {{MV}} | |||
==Overview== | |||
Mucoepidermoid carcinoma may be classified according to location into 2 subtypes: salivary gland-confined carcinomas and other organ mucoepidermoid carcinomas. Based on histological features, it is divided into low, intermediate and high grade tumors. | |||
==Classification== | |||
Mucoepidermoid carcinoma may be classified according to location into 2 subtypes:<ref name="radiowiki">Mucoepidermoid carcinoma. Radiopedia. Dr Frank Gailliard. http://radiopaedia.org/articles/mucoepidermoid-carcinoma-of-salivary-glands Accessed on February 17, 2016 </ref> | |||
{| class="wikitable sortable" style="border: 0px; font-size: 70%; margin: 3px; width: 800px" align="left" | |||
! colspan="3" style="padding: 5px 5px; background: #4479BA; font-weight: bold; text-align:center;" |{{fontcolor|#FFF|''Classification: Mucoepidermoid Carcinomas''}} | |||
|+ | |||
|- | |||
| rowspan="2" style="padding: 0 5px; background: #DCDCDC" |{{fontcolor|#000|'''Salivary gland-confined carcinomas'''}} | |||
| style="padding: 5px 5px; background: #F5F5F5;" | | |||
*Major salivary glands (50%) | |||
| style="padding: 5px 5px; background: #F5F5F5;" | | |||
*Parotid gland (40%) | |||
*Submandibular gland (7%) | |||
*Sublingual gland (3%) | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | | |||
*Minor salivary glands (50%) | |||
| style="padding: 5px 5px; background: #F5F5F5;" | | |||
*Palate (most common) | |||
*Retromolar area | |||
*Floor of the mouth | |||
*Buccal mucosa | |||
*Lip | |||
*Tongue | |||
|- | |||
| style="padding: 0 5px; background: #DCDCDC" |{{fontcolor|#000|'''Other organ mucoepidermoid carcinomas'''}} | |||
| colspan="2" style="padding: 5px 5px; background: #F5F5F5;" | | |||
*Thyroid | |||
*Lung | |||
|} | |||
===Grading based on Histopathology:=== | |||
* Mucoepidermoid carcinoma are graded into three sub types based on [[histopathological]] features: | |||
** Low | |||
** Intermediate | |||
** High grade | |||
* The three most popular grading systems are: | |||
** The AFIP grading system <ref name="pmid9529011">{{cite journal |vauthors=Goode RK, Auclair PL, Ellis GL |title=Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria |journal=Cancer |volume=82 |issue=7 |pages=1217–24 |date=April 1998 |pmid=9529011 |doi= |url=}}</ref> | |||
** Modified Healey system<ref name="pmid2221741">{{cite journal |vauthors=Batsakis JG, Luna MA |title=Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas |journal=Ann. Otol. Rhinol. Laryngol. |volume=99 |issue=10 Pt 1 |pages=835–8 |date=October 1990 |pmid=2221741 |doi=10.1177/000348949009901015 |url=}}</ref> | |||
** The Brandwein system<ref name="pmid12484654">{{cite journal |vauthors=Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A |title=Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes |journal=Acta Otolaryngol. |volume=122 |issue=7 |pages=758–64 |date=October 2002 |pmid=12484654 |doi= |url=}}</ref> | |||
* All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion. | |||
* | |||
{| class="wikitable sortable" | |||
|+ | |||
!Category | |||
!Histopathologic findings | |||
|- | |||
|Low grade | |||
| | |||
* Macrocysts, microcysts, | |||
* Transition with [[excretory]] [[ducts]], | |||
* Differentiated [[mucin]] producing epidermoid cells, often in a 1:1 ratio, minimal to moderate intermediate [[cell]] population | |||
* Daughter [[cyst]] proliferation from large [[Cyst|cysts]] | |||
* Minimal to absent [[Pleomorphism|pleomorphism,]] rare [[mitoses]] | |||
* Broad-front, often circumscribed invasion | |||
* Pools of extravasated [[mucin]] with [[stromal]] reaction | |||
|- | |||
|Intermediated grade | |||
| | |||
* No macrocysts, few microcysts | |||
* Solid nests of [[cells]] | |||
* Large [[duct]], but not conspicuous | |||
* Slight to moderate [[pleomorphism]], few [[mitoses]], prominent [[nuclei]] and [[nucleoli]] | |||
* Invasive quality, usually well defined and uncircumscribed | |||
* Chronic [[inflammation]] at periphery | |||
* [[Fibrosis]] separates nests of [[cells]] and groups of nests | |||
|- | |||
|High grade | |||
| | |||
* No macrocysts | |||
* Predominantly solid but may be nearly all glandular | |||
* Cell constituents range from poorly differentiated to recognizable epidermoid and intermediate to [[Ductal carcinoma|ductal]] type [[adenocarcinoma]] | |||
* Considerable [[pleomorphism]], [[mitoses]] | |||
* Unquestionable soft tissue, perineural and [[intravascular]] invasion | |||
* Chronic [[inflammation]] less prominent, [[desmoplasia]] of [[stroma]] may outline [[invasive]] clusters | |||
|} | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Oral pathology]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category: | [[Category:Medicine]] | ||
[[Category:Otolaryngology]] | |||
Latest revision as of 15:38, 16 January 2019
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Mucoepidermoid carcinoma Microchapters |
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Differentiating Mucoepidermoid Carcinoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Mucoepidermoid carcinoma classification On the Web |
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American Roentgen Ray Society Images of Mucoepidermoid carcinoma classification |
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Risk calculators and risk factors for Mucoepidermoid carcinoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2] Maria Fernanda Villarreal, M.D. [3]
Overview
Mucoepidermoid carcinoma may be classified according to location into 2 subtypes: salivary gland-confined carcinomas and other organ mucoepidermoid carcinomas. Based on histological features, it is divided into low, intermediate and high grade tumors.
Classification
Mucoepidermoid carcinoma may be classified according to location into 2 subtypes:[1]
| Classification: Mucoepidermoid Carcinomas | ||
|---|---|---|
| Salivary gland-confined carcinomas |
|
|
|
| |
| Other organ mucoepidermoid carcinomas |
| |
Grading based on Histopathology:
- Mucoepidermoid carcinoma are graded into three sub types based on histopathological features:
- Low
- Intermediate
- High grade
- The three most popular grading systems are:
- All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion.
| Category | Histopathologic findings |
|---|---|
| Low grade |
|
| Intermediated grade |
|
| High grade |
|
References
- ↑ Mucoepidermoid carcinoma. Radiopedia. Dr Frank Gailliard. http://radiopaedia.org/articles/mucoepidermoid-carcinoma-of-salivary-glands Accessed on February 17, 2016
- ↑ Goode RK, Auclair PL, Ellis GL (April 1998). "Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria". Cancer. 82 (7): 1217–24. PMID 9529011.
- ↑ Batsakis JG, Luna MA (October 1990). "Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas". Ann. Otol. Rhinol. Laryngol. 99 (10 Pt 1): 835–8. doi:10.1177/000348949009901015. PMID 2221741.
- ↑ Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A (October 2002). "Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes". Acta Otolaryngol. 122 (7): 758–64. PMID 12484654.