Merkel cell cancer (patient information): Difference between revisions
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{{Merkel cell cancer (patient information)}} | {{Merkel cell cancer (patient information)}} | ||
{{CMG}} | {{CMG}} ; {{AE}} {{VKG}} | ||
==Overview== | ==Overview== | ||
[[Merkel cell carcinoma]] is a very rare and highly aggressive skin [[cancer]]. [[Merkel cell carcinoma]] is the most serious form of [[skin cancer]]. When [[merkel cell carcinoma]] spreads to the [[lymph nodes]], the average 5-year survival rate for a patient with [[merkel cell carcinoma]] is less than 50 percent. Recurrence may occur in up to half of all the patients with [[merkel cell carcinoma]]. [[Merkel cell cancer]] usually occurs on either the face, head, or neck. Patients with [[merkel cell carcinoma]] usually present with a rapid growing, firm, painless, red/violaceous skin [[lesion]]. [[Merkel cell carcinoma]] usually [[Metastasize|metastasizes]] first to regional [[lymph nodes]] and then to other organs, and spreads to other parts of the body, especially the [[liver]], [[lungs]], [[brain]] and [[Bone|bones]]. The predominant therapy for [[merkel cell carcinoma]] is surgical resection, but chemoradiation may also be required in more advanced disease. | |||
==What are the symptoms of Merkel cell cancer?== | ==What are the symptoms of Merkel cell cancer?== | ||
Rapid growing, painless and small [[mass]] that typically located on a sun exposed area of the body | |||
==What causes Merkel cell cancer?== | ==What causes Merkel cell cancer?== | ||
Common causes of [[merkel cell carcinoma]] include: | |||
* [[Merkel cell]] [[polyomavirus]] | |||
* Age | |||
* Skin tone | |||
* Exposure to [[sunlight]] and | |||
* History of [[immunosuppression]]. | |||
==Who is at highest risk?== | ==Who is at highest risk?== | ||
* Fair skin people | |||
* [[Human Immunodeficiency Virus (HIV)|HIV]] positive patients | |||
* [[Organ transplant]] patients | |||
* [[Chronic lymphocytic leukemia]] ([[Chronic lymphocytic leukemia|CLL]]) | |||
* [[Lymphoproliferative disorders]] | |||
==Diagnosis== | ==Diagnosis== | ||
* [[Lymph node]] [[biopsy]] | |||
* [[Cytogenetics|Cytogenetic]] and molecular analysis | |||
* [[Immunohistochemistry]] | |||
* [[Skin biopsy]] | |||
* | |||
==When to seek urgent medical care?== | ==When to seek urgent medical care?== | ||
when patients experience the following: | |||
* [[Seizure|Seizures]] | |||
* Bilateral radiculopathies | |||
* [[Myoclonus]] | |||
* [[Cauda equina syndrome]] and | |||
* Altered mental status | |||
==Treatment options== | ==Treatment options== | ||
* [[Radiation]] | |||
* [[Chemotherapy]] or chemoradiotherapy | |||
* Adjuvant [[immunotherapy]] | |||
==Where to find medical care for Merkel cell cancer?== | ==Where to find medical care for Merkel cell cancer?== | ||
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==Prevention of Merkel cell cancer== | ==Prevention of Merkel cell cancer== | ||
[[Primary prevention]] of [[merkel cell cancer]] includes avoidance of excessive [[sun exposure]] and use of [[sunscreen]]. | |||
==What to expect (Outlook/Prognosis)?== | ==What to expect (Outlook/Prognosis)?== | ||
* [[Merkel cell cancer]] is a highly aggressive tumor with a [[mortality]] rate that approaches 30% to 40% within 3 years of diagnosis | |||
* If diagnosed early, [[merkel cell carcinoma]] has a good prognosis with a 5-year survival rate of approximately 90% | |||
==Possible complications== | ==Possible complications== | ||
* [[Neurology|Neurologic]] [[complications]] | |||
* [[Leptomeningeal]] [[carcinomatosis]] | |||
==Source== | ==Source== | ||
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[[Category:Patient information]] | [[Category:Patient information]] | ||
[[Category:Oncology patient information]] | [[Category:Oncology patient information]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Dermatology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 18:32, 23 January 2019
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Merkel cell cancer |
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Merkel cell cancer On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Merkel cell carcinoma is a very rare and highly aggressive skin cancer. Merkel cell carcinoma is the most serious form of skin cancer. When merkel cell carcinoma spreads to the lymph nodes, the average 5-year survival rate for a patient with merkel cell carcinoma is less than 50 percent. Recurrence may occur in up to half of all the patients with merkel cell carcinoma. Merkel cell cancer usually occurs on either the face, head, or neck. Patients with merkel cell carcinoma usually present with a rapid growing, firm, painless, red/violaceous skin lesion. Merkel cell carcinoma usually metastasizes first to regional lymph nodes and then to other organs, and spreads to other parts of the body, especially the liver, lungs, brain and bones. The predominant therapy for merkel cell carcinoma is surgical resection, but chemoradiation may also be required in more advanced disease.
What are the symptoms of Merkel cell cancer?
Rapid growing, painless and small mass that typically located on a sun exposed area of the body
What causes Merkel cell cancer?
Common causes of merkel cell carcinoma include:
- Merkel cell polyomavirus
- Age
- Skin tone
- Exposure to sunlight and
- History of immunosuppression.
Who is at highest risk?
- Fair skin people
- HIV positive patients
- Organ transplant patients
- Chronic lymphocytic leukemia (CLL)
- Lymphoproliferative disorders
Diagnosis
- Lymph node biopsy
- Cytogenetic and molecular analysis
- Immunohistochemistry
- Skin biopsy
When to seek urgent medical care?
when patients experience the following:
- Seizures
- Bilateral radiculopathies
- Myoclonus
- Cauda equina syndrome and
- Altered mental status
Treatment options
- Radiation
- Chemotherapy or chemoradiotherapy
- Adjuvant immunotherapy
Where to find medical care for Merkel cell cancer?
Directions to Hospitals Treating Merkel cell cancer
Prevention of Merkel cell cancer
Primary prevention of merkel cell cancer includes avoidance of excessive sun exposure and use of sunscreen.
What to expect (Outlook/Prognosis)?
- Merkel cell cancer is a highly aggressive tumor with a mortality rate that approaches 30% to 40% within 3 years of diagnosis
- If diagnosed early, merkel cell carcinoma has a good prognosis with a 5-year survival rate of approximately 90%