TMED10: Difference between revisions

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{{Infobox_gene}}
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'''Transmembrane emp24 domain-containing protein 10''' is a [[protein]] that in humans is encoded by the ''TMED10'' [[gene]].<ref name="pmid7596406">{{cite journal |vauthors=Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, etal | title = Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | journal = Nature | volume = 375 | issue = 6534 | pages = 754–60 |date=Aug 1995 | pmid = 7596406 | pmc =  | doi = 10.1038/375754a0 }}</ref><ref name="pmid8663407">{{cite journal | vauthors = Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I | title = Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking | journal = J Biol Chem | volume = 271 | issue = 29 | pages = 17183–9 |date=Sep 1996 | pmid = 8663407 | pmc =  | doi =10.1074/jbc.271.29.17183 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10972| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
  | image =
| image_source =
| PDB =
| Name = Transmembrane emp24-like trafficking protein 10 (yeast)
| HGNCid = 16998
| Symbol = TMED10
| AltSymbols =; P24(DELTA); S31I125; S31III125; TMP21; Tmp-21-I
| OMIM = 605406
| ECnumber =
| Homologene = 4972
| MGIid = 1915831
  | GeneAtlas_image1 = PBB_GE_TMED10_200929_at_tn.png
| GeneAtlas_image2 = PBB_GE_TMED10_212352_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005793 |text = ER-Golgi intermediate compartment}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0042589 |text = zymogen granule membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0006903 |text = vesicle targeting}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10972
    | Hs_Ensembl = ENSG00000170348
    | Hs_RefseqProtein = NP_006818
    | Hs_RefseqmRNA = NM_006827
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 74667926
    | Hs_GenLoc_end = 74713045
    | Hs_Uniprot = P49755
    | Mm_EntrezGene = 68581
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_026775
    | Mm_RefseqProtein = NP_081051
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot =   
  }}
}}
'''Transmembrane emp24-like trafficking protein 10 (yeast)''', also known as '''TMED10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10972| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.<ref name="entrez">{{cite web | title = Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10972| accessdate = }}</ref>
| summary_text = This gene is a member of the [[EMP24/GP25L/p24 family]] and encodes a protein with a GOLD domain. This type I membrane protein is localized to the [[plasma membrane]] and [[golgi cisternae]] and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial [[Alzheimer's]] disease. This gene has a [[pseudogene]] on [[chromosome 8]].<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Sherrington R, Rogaev EI, Liang Y, ''et al.'' |title=Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. |journal=Nature |volume=375 |issue= 6534 |pages= 754-60 |year= 1995 |pmid= 7596406 |doi= 10.1038/375754a0 }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Blum R, Feick P, Puype M, ''et al.'' |title=Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. |journal=J. Biol. Chem. |volume=271 |issue= 29 |pages= 17183-9 |year= 1996 |pmid= 8663407 |doi= }}
*{{cite journal   |vauthors=Gommel D, Orci L, Emig EM, etal |title=p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway |journal=FEBS Lett. |volume=447 |issue= 2–3 |pages= 179–85 |year= 1999 |pmid= 10214941 |doi=10.1016/S0014-5793(99)00246-X }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Hörer J, Blum R, Feick P, etal |title=A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II |journal=DNA Seq. |volume=10 |issue= 2 |pages= 121–6 |year= 1999 |pmid= 10376215 |doi=10.3109/10425179909008429 }}
*{{cite journal | author=Gommel D, Orci L, Emig EM, ''et al.'' |title=p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. |journal=FEBS Lett. |volume=447 |issue= 2-3 |pages= 179-85 |year= 1999 |pmid= 10214941 |doi=  }}
*{{cite journal  | vauthors=Wang H, Kazanietz MG |title=Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4541–50 |year= 2002 |pmid= 11689559 |doi= 10.1074/jbc.M107150200 }}
*{{cite journal | author=Hörer J, Blum R, Feick P, ''et al.'' |title=A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II. |journal=DNA Seq. |volume=10 |issue= 2 |pages= 121-6 |year= 1999 |pmid= 10376215 |doi=  }}
*{{cite journal   |vauthors=Majoul I, Straub M, Hell SW, etal |title=KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET |journal=Dev. Cell |volume=1 |issue= 1 |pages= 139–53 |year= 2001 |pmid= 11703931 |doi=10.1016/S1534-5807(01)00004-1 }}
*{{cite journal  | author=Wang H, Kazanietz MG |title=Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4541-50 |year= 2002 |pmid= 11689559 |doi= 10.1074/jbc.M107150200 }}
*{{cite journal   |vauthors=Gommel DU, Memon AR, Heiss A, etal |title=Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23 |journal=EMBO J. |volume=20 |issue= 23 |pages= 6751–60 |year= 2002 |pmid= 11726511 |doi= 10.1093/emboj/20.23.6751 | pmc=125325 }}
*{{cite journal | author=Majoul I, Straub M, Hell SW, ''et al.'' |title=KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET. |journal=Dev. Cell |volume=1 |issue= 1 |pages= 139-53 |year= 2001 |pmid= 11703931 |doi=  }}
*{{cite journal  | vauthors=Barr FA, Preisinger C, Kopajtich R, Körner R |title=Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus |journal=J. Cell Biol. |volume=155 |issue= 6 |pages= 885–91 |year= 2002 |pmid= 11739402 |doi= 10.1083/jcb.200108102 | pmc=2150891 }}
*{{cite journal | author=Gommel DU, Memon AR, Heiss A, ''et al.'' |title=Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23. |journal=EMBO J. |volume=20 |issue= 23 |pages= 6751-60 |year= 2002 |pmid= 11726511 |doi= 10.1093/emboj/20.23.6751 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Barr FA, Preisinger C, Kopajtich R, Körner R |title=Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus. |journal=J. Cell Biol. |volume=155 |issue= 6 |pages= 885-91 |year= 2002 |pmid= 11739402 |doi= 10.1083/jcb.200108102 }}
*{{cite journal   |vauthors=Heilig R, Eckenberg R, Petit JL, etal |title=The DNA sequence and analysis of human chromosome 14 |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Heilig R, Eckenberg R, Petit JL, ''et al.'' |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601-7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Breuza L, Halbeisen R, Jenö P, etal |title=Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46 |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47242–53 |year= 2004 |pmid= 15308636 |doi= 10.1074/jbc.M406644200 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Breuza L, Halbeisen R, Jenö P, ''et al.'' |title=Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47242-53 |year= 2004 |pmid= 15308636 |doi= 10.1074/jbc.M406644200 }}
*{{cite journal   |vauthors=Chen F, Hasegawa H, Schmitt-Ulms G, etal |title=TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity |journal=Nature |volume=440 |issue= 7088 |pages= 1208–12 |year= 2006 |pmid= 16641999 |doi= 10.1038/nature04667 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Chi A, Valencia JC, Hu ZZ, etal |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135–44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
*{{cite journal | author=Chen F, Hasegawa H, Schmitt-Ulms G, ''et al.'' |title=TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. |journal=Nature |volume=440 |issue= 7088 |pages= 1208-12 |year= 2006 |pmid= 16641999 |doi= 10.1038/nature04667 }}
*{{cite journal | author=Chi A, Valencia JC, Hu ZZ, ''et al.'' |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135-44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
}}
}}
{{refend}}
{{refend}}


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{{gene-14-stub}}

Latest revision as of 15:53, 18 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transmembrane emp24 domain-containing protein 10 is a protein that in humans is encoded by the TMED10 gene.[1][2][3]

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.[3]

References

  1. ↑ Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al. (Aug 1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–60. doi:10.1038/375754a0. PMID 7596406.
  2. ↑ Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (Sep 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". J Biol Chem. 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.
  3. ↑ 3.0 3.1 "Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast)".

Further reading



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