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{{Infobox_gene}}
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'''Heat shock 70 kDa protein 13''' is a [[protein]] that in humans is encoded by the ''HSPA13'' [[gene]].<ref name="pmid8825657">{{cite journal | vauthors = Brodsky G, Otterson GA, Parry BB, Hart I, Patterson D, Kaye FJ | title = Localization of STCH to human chromosome 21q11.1 | journal = Genomics | volume = 30 | issue = 3 | pages = 627–8 |date=Feb 1997 | pmid = 8825657 | pmc =  | doi = 10.1006/geno.1995.1291 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STCH stress 70 protein chaperone, microsome-associated, 60kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6782| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Stress 70 protein chaperone, microsome-associated, 60kDa
| HGNCid = 11375
| Symbol = STCH
| AltSymbols =;
| OMIM = 601100
| ECnumber = 
| Homologene = 5062
| MGIid = 1309463
| GeneAtlas_image1 = PBB_GE_STCH_202557_at_tn.png
| GeneAtlas_image2 = PBB_GE_STCH_202558_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}}
  | Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6782
    | Hs_Ensembl = ENSG00000155304
    | Hs_RefseqProtein = NP_008879
    | Hs_RefseqmRNA = NM_006948
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 14665310
    | Hs_GenLoc_end = 14677380
    | Hs_Uniprot = P48723
    | Mm_EntrezGene = 110920
    | Mm_Ensembl = ENSMUSG00000032932
    | Mm_RefseqmRNA = NM_030201
    | Mm_RefseqProtein = NP_084477
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 75637868
    | Mm_GenLoc_end = 75649458
    | Mm_Uniprot = Q8BM72
  }}
}}
'''Stress 70 protein chaperone, microsome-associated, 60kDa''', also known as '''STCH''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STCH stress 70 protein chaperone, microsome-associated, 60kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6782| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein.<ref name="entrez">{{cite web | title = Entrez Gene: STCH stress 70 protein chaperone, microsome-associated, 60kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6782| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the [[heat shock protein 70]] family and is found associated with [[microsome]]s. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly folded proteins. The encoded protein contains an [[ATPase]] domain and has been shown to associate with a [[ubiquitin-like protein]].<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Otterson GA, Flynn GC, Kratzke RA, ''et al.'' |title=Stch encodes the 'ATPase core' of a microsomal stress 70 protein. |journal=EMBO J. |volume=13 |issue= 5 |pages= 1216-25 |year= 1994 |pmid= 8131751 |doi= }}
*{{cite journal   |vauthors=Otterson GA, Flynn GC, Kratzke RA, etal |title=Stch encodes the 'ATPase core' of a microsomal stress 70 protein. |journal=EMBO J. |volume=13 |issue= 5 |pages= 1216–25 |year= 1994 |pmid= 8131751 |doi=  | pmc=394931  }}
*{{cite journal | author=Brodsky G, Otterson GA, Parry BB, ''et al.'' |title=Localization of STCH to human chromosome 21q11.1. |journal=Genomics |volume=30 |issue= 3 |pages= 627-8 |year= 1997 |pmid= 8825657 |doi= 10.1006/geno.1995.1291 }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal   |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Kaye FJ, Modi S, Ivanovska I, etal |title=A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. |journal=FEBS Lett. |volume=467 |issue= 2-3 |pages= 348–55 |year= 2000 |pmid= 10675567 |doi=10.1016/S0014-5793(00)01135-2 }}
*{{cite journal | author=Kaye FJ, Modi S, Ivanovska I, ''et al.'' |title=A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. |journal=FEBS Lett. |volume=467 |issue= 2-3 |pages= 348-55 |year= 2000 |pmid= 10675567 |doi=  }}
*{{cite journal   |vauthors=Hattori M, Fujiyama A, Taylor TD, etal |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal   |vauthors=Wistow G, Bernstein SL, Wyatt MK, etal |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue=  |pages= 205–20 |year= 2002 |pmid= 12107410 |doi=  }}
*{{cite journal | author=Wistow G, Bernstein SL, Wyatt MK, ''et al.'' |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue=  |pages= 205-20 |year= 2002 |pmid= 12107410 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Aoki M, Yamamoto K, Ohyama S, etal |title=A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population. |journal=Biochem. Biophys. Res. Commun. |volume=335 |issue= 2 |pages= 566–74 |year= 2005 |pmid= 16087163 |doi= 10.1016/j.bbrc.2005.07.110 }}
*{{cite journal | author=Aoki M, Yamamoto K, Ohyama S, ''et al.'' |title=A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population. |journal=Biochem. Biophys. Res. Commun. |volume=335 |issue= 2 |pages= 566-74 |year= 2005 |pmid= 16087163 |doi= 10.1016/j.bbrc.2005.07.110 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 07:12, 12 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Heat shock 70 kDa protein 13 is a protein that in humans is encoded by the HSPA13 gene.[1][2]

The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein.[2]

References

  1. ↑ Brodsky G, Otterson GA, Parry BB, Hart I, Patterson D, Kaye FJ (Feb 1997). "Localization of STCH to human chromosome 21q11.1". Genomics. 30 (3): 627–8. doi:10.1006/geno.1995.1291. PMID 8825657.
  2. ↑ 2.0 2.1 "Entrez Gene: STCH stress 70 protein chaperone, microsome-associated, 60kDa".

Further reading



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