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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Immunoglobulin-binding protein 1''' is a [[protein]] that in humans is encoded by the ''IGBP1'' [[gene]].<ref name="pmid9441740">{{cite journal | vauthors = Onda M, Inui S, Maeda K, Suzuki M, Takahashi E, Sakaguchi N | title = Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway | journal = Genomics | volume = 46 | issue = 3 | pages = 373–8 | date = Dec 1997 | pmid = 9441740 | pmc = | doi = 10.1006/geno.1997.5048 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IGBP1 immunoglobulin (CD79A) binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3476| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Immunoglobulin (CD79A) binding protein 1
| HGNCid = 5461
| Symbol = IGBP1
| AltSymbols =; IBP1
| OMIM = 300139
| ECnumber = 
| Homologene = 44067
| MGIid = 1346500
| Function = {{GNF_GO|id=GO:0008601 |text = protein phosphatase type 2A regulator activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0009607 |text = response to biotic stimulus}} {{GNF_GO|id=GO:0009966 |text = regulation of signal transduction}} {{GNF_GO|id=GO:0042113 |text = B cell activation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3476
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_001542
    | Hs_RefseqmRNA = NM_001551
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 18518
    | Mm_Ensembl = ENSMUSG00000031221
    | Mm_RefseqmRNA = NM_008784
    | Mm_RefseqProtein = NP_032810
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 96697064
    | Mm_GenLoc_end = 96718720
    | Mm_Uniprot = Q61249
  }}
}}
'''Immunoglobulin (CD79A) binding protein 1''', also known as '''IGBP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IGBP1 immunoglobulin (CD79A) binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3476| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.<ref name="entrez">{{cite web | title = Entrez Gene: IGBP1 immunoglobulin (CD79A) binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3476| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
IGBP1 has been shown to [[Protein-protein interaction|interact]] with [[PPP4C]],<ref name=pmid18715871>{{cite journal | vauthors = Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC | title = PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 43 | pages = 29273–84 | date = Oct 2008 | pmid = 18715871 | pmc = 2662017 | doi = 10.1074/jbc.M803443200 }}</ref><ref name=pmid16085932>{{cite journal | vauthors = Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R | title = A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 11 | pages = 1725–40 | date = Nov 2005 | pmid = 16085932 | doi = 10.1074/mcp.M500231-MCP200 }}</ref><ref name=pmid9647778>{{cite journal | vauthors = Chen J, Peterson RT, Schreiber SL | title = Alpha 4 associates with protein phosphatases 2A, 4, and 6 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 827–32 | date = Jun 1998 | pmid = 9647778 | doi = 10.1006/bbrc.1998.8792 }}</ref> [[PPP6C]]<ref name=pmid16085932/><ref name=pmid9647778/> and [[PPP2CA]].<ref name=pmid16085932/><ref name=pmid9647778/><ref name=pmid18782753>{{cite journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Molecular & Cellular Proteomics | volume = 8 | issue = 1 | pages = 157–71 | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 }}</ref><ref name=pmid10441131>{{cite journal | vauthors = Chung H, Nairn AC, Murata K, Brautigan DL | title = Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2 | journal = Biochemistry | volume = 38 | issue = 32 | pages = 10371–6 | date = Aug 1999 | pmid = 10441131 | doi = 10.1021/bi990902g }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Chen J, Peterson RT, Schreiber SL | title = Alpha 4 associates with protein phosphatases 2A, 4, and 6 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 827–32 | date = Jun 1998 | pmid = 9647778 | doi = 10.1006/bbrc.1998.8792 }}
| citations =
* {{cite journal | vauthors = Chung H, Nairn AC, Murata K, Brautigan DL | title = Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2 | journal = Biochemistry | volume = 38 | issue = 32 | pages = 10371–6 | date = Aug 1999 | pmid = 10441131 | doi = 10.1021/bi990902g }}
*{{cite journal  | author=Onda M, Inui S, Maeda K, ''et al.'' |title=Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway. |journal=Genomics |volume=46 |issue= 3 |pages= 373-8 |year= 1998 |pmid= 9441740 |doi=  }}
* {{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = International Journal of Cancer | volume = 83 | issue = 4 | pages = 456–64 | date = Nov 1999 | pmid = 10508479 | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
*{{cite journal | author=Chen J, Peterson RT, Schreiber SL |title=Alpha 4 associates with protein phosphatases 2A, 4, and 6. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 3 |pages= 827-32 |year= 1998 |pmid= 9647778 |doi= 10.1006/bbrc.1998.8792 }}
* {{cite journal | vauthors = Liu J, Prickett TD, Elliott E, Meroni G, Brautigan DL | title = Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 12 | pages = 6650–5 | date = Jun 2001 | pmid = 11371618 | pmc = 34408 | doi = 10.1073/pnas.111154698 | bibcode = 2001PNAS...98.6650L }}
*{{cite journal | author=Chung H, Nairn AC, Murata K, Brautigan DL |title=Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2. |journal=Biochemistry |volume=38 |issue= 32 |pages= 10371-6 |year= 1999 |pmid= 10441131 |doi= 10.1021/bi990902g }}
* {{cite journal | vauthors = Short KM, Hopwood B, Yi Z, Cox TC | title = MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders | journal = BMC Cell Biology | volume = 3 | pages = 1 | year = 2002 | pmid = 11806752 | pmc = 64779 | doi = 10.1186/1471-2121-3-1 }}
*{{cite journal | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi= }}
* {{cite journal | vauthors = Graham JM, Wheeler P, Tackels-Horne D, Lin AE, Hall BD, May M, Short KM, Schwartz CE, Cox TC | title = A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13 | journal = American Journal of Medical Genetics Part A | volume = 123A | issue = 1 | pages = 37–44 | date = Nov 2003 | pmid = 14556245 | doi = 10.1002/ajmg.a.20504 }}
*{{cite journal | author=Liu J, Prickett TD, Elliott E, ''et al.'' |title=Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 12 |pages= 6650-5 |year= 2001 |pmid= 11371618 |doi= 10.1073/pnas.111154698 }}
* {{cite journal | vauthors = Smetana JH, Oliveira CL, Jablonka W, Aguiar Pertinhez T, Carneiro FR, Montero-Lomeli M, Torriani I, Zanchin NI | title = Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42 | journal = Biochimica et Biophysica Acta | volume = 1764 | issue = 4 | pages = 724–34 | date = Apr 2006 | pmid = 16517231 | doi = 10.1016/j.bbapap.2006.01.018 }}
*{{cite journal | author=Short KM, Hopwood B, Yi Z, Cox TC |title=MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders. |journal=BMC Cell Biol. |volume=3 |issue=  |pages= 1 |year= 2002 |pmid= 11806752 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Graham JM, Wheeler P, Tackels-Horne D, ''et al.'' |title=A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13. |journal=Am. J. Med. Genet. A |volume=123 |issue= 1 |pages= 37-44 |year= 2004 |pmid= 14556245 |doi= 10.1002/ajmg.a.20504 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Smetana JH, Oliveira CL, Jablonka W, ''et al.'' |title=Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42. |journal=Biochim. Biophys. Acta |volume=1764 |issue= 4 |pages= 724-34 |year= 2006 |pmid= 16517231 |doi= 10.1016/j.bbapap.2006.01.018 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 23:08, 3 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the IGBP1 gene.[1][2]

Function

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.[2]

Interactions

IGBP1 has been shown to interact with PPP4C,[3][4][5] PPP6C[4][5] and PPP2CA.[4][5][6][7]

References

  1. ↑ Onda M, Inui S, Maeda K, Suzuki M, Takahashi E, Sakaguchi N (Dec 1997). "Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway". Genomics. 46 (3): 373–8. doi:10.1006/geno.1997.5048. PMID 9441740.
  2. ↑ 2.0 2.1 "Entrez Gene: IGBP1 immunoglobulin (CD79A) binding protein 1".
  3. ↑ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  4. ↑ 4.0 4.1 4.2 Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
  5. ↑ 5.0 5.1 5.2 Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
  6. ↑ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
  7. ↑ Chung H, Nairn AC, Murata K, Brautigan DL (Aug 1999). "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry. 38 (32): 10371–6. doi:10.1021/bi990902g. PMID 10441131.

Further reading


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