Mycosis fungoides history and symptoms: Difference between revisions

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__NOTOC__
__NOTOC__
{{Cutaneous T cell lymphoma}}
{{Mycosis fungoides}}
History{{CMG}}; {{AE}}, {{AS}}
{{CMG}}; {{AE}} {{S.G.}}
 
==Overview==
==Overview==
The most common symptoms of cutaneous T cell lymphoma include [[fever]], [[weight loss]], [[skin]] [[rash]], [[night sweats]], [[itching]], [[chest pain]], [[abdominal pain]], and [[bone pain]].<ref name="seer.cancer">Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016</ref>
The most common [[Symptom|symptoms]] of mycosis fungoides include [[fever]], [[weight loss]], [[skin]] [[rash]], [[night sweats]], [[itching]], [[chest pain]], [[abdominal pain]], and [[bone pain]].<ref name="seer.cancer">Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016</ref>


==History and Symptoms==
==History and Symptoms==
===History===
===History===
*The majority of patients with mycosis fungoides and Sezary syndrome are present with:<ref name="FossGirardi2017">{{cite journal|last1=Foss|first1=Francine M.|last2=Girardi|first2=Michael|title=Mycosis Fungoides and Sezary Syndrome|journal=Hematology/Oncology Clinics of North America|volume=31|issue=2|year=2017|pages=297–315|issn=08898588|doi=10.1016/j.hoc.2016.11.008}}</ref>
*The majority of [[Patient|patients]] with mycosis fungoides is present with:<ref name="FossGirardi2017">{{cite journal|last1=Foss|first1=Francine M.|last2=Girardi|first2=Michael|title=Mycosis Fungoides and Sezary Syndrome|journal=Hematology/Oncology Clinics of North America|volume=31|issue=2|year=2017|pages=297–315|issn=08898588|doi=10.1016/j.hoc.2016.11.008}}</ref>
**Skin patches and plaques  
**[[Skin]] patches and [[Plaque|plaques]]
**Eczema
**[[Skin]] [[erythema]] with or without [[exfoliation]]
**Psoriasis
***[[Erythroderma]] observed patchy or [[diffuse]]<ref name="VonderheidBernengo2002" />
**Other benign skin disorders
***[[Erythroderma]] observed with cracking or fissuring of the palms and soles.<ref name="VonderheidBernengo2002">{{cite journal|last1=Vonderheid|first1=Eric C.|last2=Bernengo|first2=Maria Grazia|last3=Burg|first3=Günter|last4=Duvic|first4=Madeleine|last5=Heald|first5=Peter|last6=Laroche|first6=Liliane|last7=Olsen|first7=Elise|last8=Pittelkow|first8=Mark|last9=Russell-Jones|first9=Robin|last10=Takigawa|first10=Masahiro|last11=Willemze|first11=Rein|title=Update on erythrodermic cutaneous T-cell lymphoma: Report of the international society for cutaneous lymphomas|journal=Journal of the American Academy of Dermatology|volume=46|issue=1|year=2002|pages=95–106|issn=01909622|doi=10.1067/mjd.2002.118538}}</ref>
*Patients with advanced disease may be present with cutaneous tumors or nodules or diffuse skin erythema with or without exfoliation
**[[Eczema]]
*Skin lesions in the disease obserevedc in non–sunexposed areas (bathing trunk distribution) and lesions may be hyperpigmented or hypopigmented, or may ulcerate.
**[[Psoriasis]]
**Other [[benign]] [[skin]] [[Disorder (medicine)|disorders]]
*[[Patient|Patients]] with advanced [[disease]] may have a positive history of with cutaneous tumors or nodules or diffuse skin erythema with or without exfoliation.
*[[Skin]] [[Lesion|lesions]] in the [[disease]] obserevedc in non–sunexposed areas (bathing trunk distribution) and lesions may be hyperpigmented or hypopigmented, or may ulcerate.
*[[Tumor|Tumors]]
**> 1 cm in size (depth or vertical growth)
Diagnosis criteria from the International Society for Cutaneous Lymphoma is:<ref name="FossGirardi2017" /><ref name="PimpinelliOlsen2005">{{cite journal|last1=Pimpinelli|first1=Nicola|last2=Olsen|first2=Elise A.|last3=Santucci|first3=Marco|last4=Vonderheid|first4=Eric|last5=Haeffner|first5=Andreas C.|last6=Stevens|first6=Seth|last7=Burg|first7=Guenter|last8=Cerroni|first8=Lorenzo|last9=Dreno|first9=Brigitte|last10=Glusac|first10=Earl|last11=Guitart|first11=Joan|last12=Heald|first12=Peter W.|last13=Kempf|first13=Werner|last14=Knobler|first14=Robert|last15=Lessin|first15=Stuart|last16=Sander|first16=Christian|last17=Smoller|first17=Bruce S.|last18=Telang|first18=Gladys|last19=Whittaker|first19=Sean|last20=Iwatsuki|first20=Keiji|last21=Obitz|first21=Erik|last22=Takigawa|first22=Masahiro|last23=Turner|first23=Maria L.|last24=Wood|first24=Gary S.|title=Defining early mycosis fungoides|journal=Journal of the American Academy of Dermatology|volume=53|issue=6|year=2005|pages=1053–1063|issn=01909622|doi=10.1016/j.jaad.2005.08.057}}</ref>
 
{| class="wikitable"
|+
! style="background: #4479BA; color:#FFF;" |Criteria
! style="background: #4479BA; color:#FFF;" |Major( 2pinots)
! style="background: #4479BA; color:#FFF;" |Minor(1point)
|-
|'''Persistent and/or progressive patches and plaques plus'''
|Any 2
|Any 1
|-
| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |Clinical
|-
|1. Non–sun-exposed location
|
|
|-
|2.Size/shape variation
|
|
|-
|3.Poikiloderma
|
|
|-
| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |'''Histopathologic'''
|-
|Superficial lymphoid infiltrate plus
|Both
|Either
|-
|1. Epidermotropism
|
|
|-
|2. Atypia
|
|
|-
| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |'''Molecular/biological'''
|-
|Clonal TCR gene rearrangement
|
|Present
|-
| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |'''Immunopathologic'''
|-
|1. CD2, CD3, CD5 in <59% of T cells
|
|Any 1
|-
|2. CD7 in <10% of T cells
|
|
|-
| colspan="3" |3. Epidermal discordance from expression of CD2, CD3, CD5, and CD7 on dermal T cells
|}


Symptoms of cutaneous T cell lymphoma include:<ref name="seer.cancer">Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016</ref>
===Common Symptoms===
Symptoms of cutaneous T cell lymphoma include:<ref name="seer.cancer" />
* [[Fever]]
* [[Fever]]
* [[Weight loss]]
* [[Weight loss]]
Line 24: Line 89:
* [[Abdominal pain]]  
* [[Abdominal pain]]  
* [[Bone pain]]
* [[Bone pain]]
*The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
*Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. 
Patients with [disease name]] may have a positive history of:
*[History finding 1]
*[History finding 2]
*[History finding 3]
===Common Symptoms===
Common symptoms of [disease] include:
*[Symptom 1]
*[Symptom 2]
*[Symptom 3]
===Less Common Symptoms===
Less common symptoms of [disease name] include
*[Symptom 1]
*[Symptom 2]
*[Symptom 3]


==References==
==References==

Latest revision as of 17:54, 12 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

The most common symptoms of mycosis fungoides include fever, weight loss, skin rash, night sweats, itching, chest pain, abdominal pain, and bone pain.[1]

History and Symptoms

History

Diagnosis criteria from the International Society for Cutaneous Lymphoma is:[2][4]

Criteria Major( 2pinots) Minor(1point)
Persistent and/or progressive patches and plaques plus Any 2 Any 1
Clinical
1. Non–sun-exposed location
2.Size/shape variation
3.Poikiloderma
Histopathologic
Superficial lymphoid infiltrate plus Both Either
1. Epidermotropism
2. Atypia
Molecular/biological
Clonal TCR gene rearrangement Present
Immunopathologic
1. CD2, CD3, CD5 in <59% of T cells Any 1
2. CD7 in <10% of T cells
3. Epidermal discordance from expression of CD2, CD3, CD5, and CD7 on dermal T cells

Common Symptoms

Symptoms of cutaneous T cell lymphoma include:[1]

References

  1. ↑ 1.0 1.1 Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016
  2. ↑ 2.0 2.1 Foss, Francine M.; Girardi, Michael (2017). "Mycosis Fungoides and Sezary Syndrome". Hematology/Oncology Clinics of North America. 31 (2): 297–315. doi:10.1016/j.hoc.2016.11.008. ISSN 0889-8588.
  3. ↑ 3.0 3.1 Vonderheid, Eric C.; Bernengo, Maria Grazia; Burg, Günter; Duvic, Madeleine; Heald, Peter; Laroche, Liliane; Olsen, Elise; Pittelkow, Mark; Russell-Jones, Robin; Takigawa, Masahiro; Willemze, Rein (2002). "Update on erythrodermic cutaneous T-cell lymphoma: Report of the international society for cutaneous lymphomas". Journal of the American Academy of Dermatology. 46 (1): 95–106. doi:10.1067/mjd.2002.118538. ISSN 0190-9622.
  4. ↑ Pimpinelli, Nicola; Olsen, Elise A.; Santucci, Marco; Vonderheid, Eric; Haeffner, Andreas C.; Stevens, Seth; Burg, Guenter; Cerroni, Lorenzo; Dreno, Brigitte; Glusac, Earl; Guitart, Joan; Heald, Peter W.; Kempf, Werner; Knobler, Robert; Lessin, Stuart; Sander, Christian; Smoller, Bruce S.; Telang, Gladys; Whittaker, Sean; Iwatsuki, Keiji; Obitz, Erik; Takigawa, Masahiro; Turner, Maria L.; Wood, Gary S. (2005). "Defining early mycosis fungoides". Journal of the American Academy of Dermatology. 53 (6): 1053–1063. doi:10.1016/j.jaad.2005.08.057. ISSN 0190-9622.


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