Bladder cancer differential diagnosis: Difference between revisions

Latest revision as of 21:26, 14 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Bladder cancer must be differentiated from renal cancer, renal stones, prostate cancer, and cystitis.

Differential Diagnosis

The most common presentation of bladder cancer is hematuria; however in the advanced cases, the presentation can be bladder mass.

Bladder cancer must be differentiated from other causes of hematuria as in the below table:

		Symptoms						Physical examina			Lab Findings	Diagnosi
Diseases		Clinical manifestations									Para-clinical findings		Gold standard
		Symptoms						Physical examina			Para-clinical findings
		Low back pain	Fever	Nausea/ Vomiting	Urinary symptoms			Hypertension	Pitting edema	Other
		Low back pain	Fever	Nausea/ Vomiting	Dysuria	Frequency	Oliguria	Hypertension	Pitting edema	Other
Glomerular diseases	IgA nephropathy^[1]^[2] (Berger nephropathy)		+	-	-	-	+	+	+	-	-	Biopsy: IgA deposited in a diffuse granular pattern in the mesangium	Biopsy
	Hereditary nephritis^[3]^[4] (Alport syndrome)	-	-	-	-	-	-	+	-	Cataract Hearing loss	Pyuria Red cell casts Cylindrical casts	Biopsy: Monoclonal antibodies directed against alpha-3 (IV), alpha-4 (IV), and alpha-5 (IV) chains of typ-e IV collagen	Genetic analysis
	Post-streptococcal glomerulonephritis^[5]^[6]	+/-	+	-	-	+	+	+	+	Edema Anemia Increased Blood Pressure	Urine samples for protein and blood	Biopsy Irregularly thin and attenuated GBM Splitting of GBM Scarring Immunoglobulin G and C3 in a diffuse granular pattern Starry sky pattern	Biopsy
	Focal segmental glomerular sclerosis^[7]^[8]^[9]	-	-	-	-	-	-	+	+	Nephrotic syndrome ESRD Pleural effusion Ascites Abdominal pain	Urinalysis reveals large amounts of protein, along with hyaline and broad waxy casts Hepatitis B or C infection Anti-neutrophil cytoplasmic antibody titers, serum protein electrophoresis	Biopsy Segmental solidification in the perihilar region and peripheral areas, especially the tubular pole Coarsely granular deposits -of IgM and C3	Biopsy
	Rapidly progressive glomerulonephritis^[10]^[11]^[12]	+	+	+	-	-	-	+	-	Abdominal pain Painful cutaneous nodules Migratory poly arthropathy Sinusitis Cough Hemoptysis.	Low iron Eosinophilia Increased serum creatinine level Eleated LDH and CPK Proteinuria	Biopsy: Diffuse, proliferative, necrotizing glomerulonephritis with crescent formation	Biopsy
	Lupus nephritis^[13]^[14]	-	+	-	-	-	-	+	+	Foamy dark urine Weight gain	Hematuria Pyuria Proteinuria Cellular casts Low iron	Biopsy, Different pathologies, CLICK HERE for more information.	Biopsy
	Fabry disease	-	-	-	-	-	-	+	+	-	Hematuria Proteinuria	Biopsy	Biopsy
Disease		Low back pain	Fever	Nausea/ Vomiting	Dysuria	Frequency	Oliguria	Hypertension	Pitting edema	Other	Lab Findings	Diagnosis method	Gold standard
Tubulointerstitial diseases^[15]^[16]^[17]		+	+	+	–	–	–	–	–	Rash	Eosinophilia Eosinophiluria Isosthenuria	Biopsy: Edema and infiltration by mononuclear cells, (principally lymphocytes) Eosinophils are present, often in large numbers.	Renal biopsy
Nephrolithiasis^[18]^[19]		+	±	+	±	±	±	–	–	Radiating pain to groin	Hypercalciuria Hyperoxaluria Hypocitraturia Hyperuricemia Hyperuricosuria	Ultrasound: Hydronephrosis +/- Abdominal CT scan without contrast	Abdominal CT scan without contrast
Reflux nephropathy (hydronephrosis)		+	+	-	-	-	-	-	+	Abdomen pain Chest pain Shortness of breath	Elevated WBC count Elevated BUN Hyperkalemia	Ultrasound: Hydronephrosis +/- Biopsy: Kidney scar	–
Malignancy	Renal cell carcinoma (RCC)^[20]^[21]	-	-	-	-	-	-	±	±	Flank mass	Anemia Hematuria	Both CT and MRI may be used to detect neoplastic masses that may define renal cell carcinoma or metastasis of the primary cancer. CT scan and use of intravenous (IV) contrast is generally used for work-up and follow-up of patients with renal cell carcinoma. The histological pattern of renal cell carcinoma depends whether it is papillary, chromophobe or collecting duct renal cell carcinoma.	–
	Nephroblastoma (Wilms tumor)^[22]^[23]	-	-	-	-	-	-	-	-	Abdominal pain	Anemia Hematuria	Ultrasound is the best initial diagnostic study used in cases suspected with Wilms tumor.^[24] Doppler ultrasonography can help to detect invasion of renal vein and IVC by the tumor.^[25] Findings on CT scan:^[26] Heterogeneous soft-tissue density masses Abdominal lymph nodes and contralateral involvement Biopsy: Primitive tubules and glomeruli are often seen comprised of neoplastic cells. Spindled cell stroma surrounding abortive tubules and glomeruli is characteristic. The stroma may include: Striated muscle cartilage bone Fat tissue Fibrous tissue.	Biopsy
	Bladder cancer^[27]^[28]^[29]	-	-	-	-	±	±	-	-	Suprapubic pain	Anemia Hematuria	Ultrasound, CT scan, Biopsy	Biopsy
	Prostate cancer^[30]^[31]	±	-	-	-	±	±	-	-	-	Anemia Hematuria	Ultrasound, CT scan, Biopsy	Biopsy
Disease		Low back pain	Fever	Nausea/ Vomiting	Dysuria	Frequency	Oliguria	Hypertension	Pitting edema	Other	Lab Findings	Diagnosis method	Gold standard
Familial diseases	Polycystic kidney disease^[32]^[33]	+	-	-	-	-	-	+	+	Palpable mass in the flank Palpable abdominal mass in the lumbar quadrant Palpable nodular hepatomegaly	Hypocitraturia in 65% on patients Hyperuricemia in 20% of patients Hyperoxaluria in 20% of patients Low urine pH Hematuria (microscopic or macroscopic) Proteinuria usually less than 1 g/day	Ultrasound: Unilateral or bilateral cysts CT: Hyperdense appearance, Septations Calcifications Genetic testing demonstrates: Frame insertions/deletions Non-canonical splice site alterations Combined missense changes Biopsy: Interstitial fibrosis Tubular atrophy Thickening and lamellation of tubular basement membranes	Ultrasound
Vascular diseases	Renal vein thrombosis^[34]^[35]	+	+	+	-	-	-	-	-	Asymptomatic Abdominal pain Acute in onset	Elevation in serum lactate dehydrogenase Cholesterol levels for hyper-cholesterolemia Albumin levels for hypoalbuminemia Serum complement levels	Ultrasound Venography	Renal venography: Gold standard
	Wegner's granulomatosis polyangiitis^[36]^[37]^[38]^[39]	-	-	-	-	-	+/-	+	+	URTI CNS involvement Ophthalmic involvement	Proteinuria Microscopic hematuria RBC casts	CT chest: Multiple lung nodules Consolidation Ground-glass opacities. Biopsy: Subendothelial edema Microthrombosis, and Degranulation of neutrophils.	Biopsy
	Henoch-Schönlein purpura^[40]^[41]	-	-	-	-	-	+/-	+/-	+	Abdominal pain Rash Hematuria	Proteinuria Microscopic hematuria RBC casts	Biopsy: IgA deposited in a diffuse granular pattern in the mesangium	Renal biopsy, and clinical syndrome
Disease		Low back pain	Fever	Nausea/ Vomiting	Dysuria	Frequency	Oliguria	Hypertension	Pitting edema	Other	Lab Findings	Diagnosis method	Gold standard
Lower urinary tract diseases	Benign prostatic hyperplasia	+/-	-	-	+	+	-	-	-	Nocturia Other voiding symptoms Slow urinary stream Splitting or spraying of the urinary stream Intermittent urinary stream Hesitancy Straining to void Terminal dribbling	Urinalysis to rule out UTI Elevated BUN/Cr High PSA values	Urine cytology to screen for bladder cancer Biopsy to rule out cancer	Biopsy
Lower urinary tract diseases	Urolithiasis^[42]^[43]^[44]	+	+/-	+	+	+	+	-	-	Flank Groin pain	Urine analysis High Cr	Abdominppelvic CT scan without contrast	Abdominppelvic CT scan without contrast
Disease		Low back pain	Fever	Nausea/ Vomiting	Dysuria	Frequency	Oliguria	Hypertension	Pitting edema	Other	Lab Findings	Diagnosis method	Gold standard
Infectious diseases	Pyelonephritis^[45]^[46]	+	+	+	+	+	+	-	-	Delirium Headache	Positive leukocyte esterase test and nitrite test. Blood/urine cultures	CT and ultrasound: Enlarged kidneys Round swollen kidneys Hypodense appearance Abscesses may not be present	-
	Cystitis^[47]^[48]	-	-	-	+	+	+	-	-	Dyspareunia Supra pubic tenderness	Pyuria: > 5-10 WBC/hpf or 27 WBC/microliter Positive leukocyte esterase test and nitrite test. Positive urine/blood cultures	Ultrasound: Presence of gas in the bladder wall. Also, help to detect the presence of a tumor or a stone.	Urine culture
	Prostatitis^[49]^[50]	-	+	-	+	+	+	-	-	Body aches	Increased leukocytes (>10 per high power field) on CBC Bacteria seen on urine culture Elevated C-reactive protein Transiently elevated PSA (prostate specific antigen) levels	Ultrasound: Focal hypoechoic region located in the peripheral part of the prostate CT scan: Edema of the prostate gland with diffuse enlargement,.	-
	Urethritis^[51]^[52]	-/-	+	-	+	+	+	-	-	Urethral discharge	Mucoid, mucopurulent, or purulent discharge Gram stain of urethral secretions demonstrating ≥2 WBC per field Positive leukocyte esterase test.	CT scan: Diffuse, circumferential urothelial wall thickening and contrast-enhancement Periureteric or perinephric fat stranding.	Urine culture
Urogenital trauma	Inserted bladder or ureteral catheters	-	-	-	+	+	+	-	-	History of trauma	Hematuria	Retrograde urethrogram (RUG)	Retrograde urethrogram (RUG)

Lower abdominal mass can be classified to the gynecological and non-gynecological causes. Bladder cancer in the advanced cases can present as a bladder mass. Below table discusses lower abdominal mass causes:

References

↑ Donadio JV, Grande JP (2002). "IgA nephropathy". N Engl J Med. 347 (10): 738–48. doi:10.1056/NEJMra020109. PMID 12213946.
↑ Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB; et al. (2011). "The pathophysiology of IgA nephropathy". J Am Soc Nephrol. 22 (10): 1795–803. doi:10.1681/ASN.2011050464. PMID 21949093.
↑ McCarthy PA, Maino DM (2000). "Alport syndrome: a review". Clin Eye Vis Care. 12 (3–4): 139–150. PMID 11137428.
↑ Bodziak KA, Hammond WS, Molitoris BA (1994). "Inherited diseases of the glomerular basement membrane". Am J Kidney Dis. 23 (4): 605–18. PMID 8154501.
↑ Yoshizawa N, Yamakami K, Fujino M, Oda T, Tamura K, Matsumoto K, Sugisaki T, Boyle MD (July 2004). "Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response". J. Am. Soc. Nephrol. 15 (7): 1785–93. PMID 15213266.
↑ Oda T, Yoshizawa N, Yamakami K, Tamura K, Kuroki A, Sugisaki T, Sawanobori E, Higashida K, Ohtomo Y, Hotta O, Kumagai H, Miura S (September 2010). "Localization of nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis". Hum. Pathol. 41 (9): 1276–85. doi:10.1016/j.humpath.2010.02.006. PMID 20708459.
↑ Kwoh C, Shannon MB, Miner JH, Shaw A (2006). "Pathogenesis of nonimmune glomerulopathies". Annu Rev Pathol. 1: 349–74. doi:10.1146/annurev.pathol.1.110304.100119. PMID 18039119.
↑ Reidy K, Kaskel FJ (March 2007). "Pathophysiology of focal segmental glomerulosclerosis". Pediatr. Nephrol. 22 (3): 350–4. doi:10.1007/s00467-006-0357-2. PMC 1794138. PMID 17216262.
↑ D'Agati VD, Fogo AB, Bruijn JA, Jennette JC (2004). "Pathologic classification of focal segmental glomerulosclerosis: a working proposal". Am J Kidney Dis. 43 (2): 368–82. PMID 14750104.
↑ Couser WG (1998). "Pathogenesis of glomerular damage in glomerulonephritis". Nephrol Dial Transplant. 13 Suppl 1: 10–5. PMID 9507491.
↑ Atkins RC, Nikolic-Paterson DJ, Song Q, Lan HY (1996). "Modulators of crescentic glomerulonephritis". J Am Soc Nephrol. 7 (11): 2271–8. PMID 8959617.
↑ Jennette JC (March 2003). "Rapidly progressive crescentic glomerulonephritis". Kidney Int. 63 (3): 1164–77. doi:10.1046/j.1523-1755.2003.00843.x. PMID 12631105.
↑ Schwartz N, Goilav B, Putterman C (September 2014). "The pathogenesis, diagnosis and treatment of lupus nephritis". Curr Opin Rheumatol. 26 (5): 502–9. doi:10.1097/BOR.0000000000000089. PMC 4221732. PMID 25014039.
↑ Giannico G, Fogo AB (2013). "Lupus nephritis: is the kidney biopsy currently necessary in the management of lupus nephritis?". Clin J Am Soc Nephrol. 8 (1): 138–45. doi:10.2215/CJN.03400412. PMID 22977215.
↑ Baker, R. J.; Pusey, C. D. (2004). "The changing profile of acute tubulointerstitial nephritis". Nephrology Dialysis Transplantation. 19 (1): 8–11. doi:10.1093/ndt/gfg464. ISSN 0931-0509.
↑ Kelly C, Tomaszewski J, Neilson E. Immunopathogenic mechanisms of tubulointerstitial injury. In: Tisher C, Brenner B, eds, Renal Pathology: With Clinical and Functional Correlations, 2nd Edn., Vol. 1. J. B. Lippincott & Co, Philadelphia, PA, 1994; 699–722
↑ Dharmarajan TS, Yoo J, Russell RO, Boateng YA. Acute post streptococcal interstitial nephritis in an adult and review of the literature. Int Urol Nephrol 1999; 31:145
↑ Hochreiter W, Knoll T, Hess B (February 2003). "[Pathophysiology, diagnosis and conservative therapy of non-calcium kidney calculi]". Ther Umsch (in German). 60 (2): 89–97. doi:10.1024/0040-5930.60.2.89. PMID 12649987.
↑ Trinchieri A (February 2013). "Diet and renal stone formation". Minerva Med. 104 (1): 41–54. PMID 23392537.
↑ Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.
↑ Leveridge MJ, Bostrom PJ, Koulouris G, Finelli A, Lawrentschuk N (June 2010). "Imaging renal cell carcinoma with ultrasonography, CT and MRI". Nat Rev Urol. 7 (6): 311–25. doi:10.1038/nrurol.2010.63. PMID 20479778.
↑ Jolly RD, Stellwagen E, Babul J, Vodkaĭlo LV, Titov VL, Moldomusaev DM, Maianskiĭ AN (November 1975). "Mannosidosis of Angus Cattle: a prototype control program for some genetic diseases". Adv Vet Sci Comp Med. 19 (23): 1–21. PMID 1978.
↑ Stefanowicz J, Sierota D, Balcerska A, Stoba C (2004). "[Wilms' tumour of unfavorable histology--results of treatment with the SIOP 93-01 protocol at the Gdańsk centre. Preliminary report]". Med Wieku Rozwoj (in Polish). 8 (2 Pt 1): 197–200. PMID 15738594.
↑ Hartman DS, Sanders RC (April 1982). "Wilms' tumor versus neuroblastoma: usefulness of ultrasound in differentiation". J Ultrasound Med. 1 (3): 117–22. PMID 6152936.
↑ De Campo JF (1986). "Ultrasound of Wilms' tumor". Pediatr Radiol. 16 (1): 21–4. PMID 3003660.
↑ Cahan LD (1985). "Failure of encephalo-duro-arterio-synangiosis procedure in moyamoya disease". Pediatr Neurosci. 12 (1): 58–62. PMID 4080660.
↑ Pons F, Orsola A, Morote J, Bellmunt J (2011). "Variant forms of bladder cancer: basic considerations on treatment approaches". Curr Oncol Rep. 13 (3): 216–21. doi:10.1007/s11912-011-0161-4. PMID 21360040.
↑ Metts MC, Metts JC, Milito SJ, Thomas CR (June 2000). "Bladder cancer: a review of diagnosis and management". J Natl Med Assoc. 92 (6): 285–94. PMC 2640522. PMID 10918764.
↑ Rom M, Kuehhas FE, Djavan B (2007). "New findings in bladder and prostate cancer: highlights of the 22nd annual congress of the European association of urology, march 21-24, 2007, berlin, Germany". Rev Urol. 9 (4): 214–9. PMC 2199502. PMID 18231618.
↑ Chung SD, Liu SP, Lin HC (2013). "Association between prostate cancer and urinary calculi: a population-based study". PLoS ONE. 8 (2): e57743. doi:10.1371/journal.pone.0057743. PMC 3581486. PMID 23451265.
↑ Rom M, Kuehhas FE, Djavan B (2007). "New findings in bladder and prostate cancer: highlights of the 22nd annual congress of the European association of urology, march 21-24, 2007, berlin, Germany". Rev Urol. 9 (4): 214–9. PMC 2199502. PMID 18231618.
↑ Gabow PA (July 1993). "Autosomal dominant polycystic kidney disease". N. Engl. J. Med. 329 (5): 332–42. doi:10.1056/NEJM199307293290508. PMID 8321262.
↑ Adeva M, El-Youssef M, Rossetti S, Kamath PS, Kubly V, Consugar MB, Milliner DM, King BF, Torres VE, Harris PC (January 2006). "Clinical and molecular characterization defines a broadened spectrum of autosomal recessive polycystic kidney disease (ARPKD)". Medicine (Baltimore). 85 (1): 1–21. doi:10.1097/01.md.0000200165.90373.9a. PMID 16523049.
↑ U. Kuhlmann, J. Steurer, A. Bollinger, G. Pouliadis, J. Briner & W. Siegenthaler (1981). "[Incidence and clinical significance of thromboses and thrombo-embolic complications in nephrotic syndrome patients]". Schweizerische medizinische Wochenschrift. 111 (27–28): 1034–1040. PMID 7268357. Unknown parameter |month= ignored (help)
↑ F. Llach, S. Papper & S. G. Massry (1980). "The clinical spectrum of renal vein thrombosis: acute and chronic". The American journal of medicine. 69 (6): 819–827. PMID 7446547. Unknown parameter |month= ignored (help)
↑ Pagnoux C (2016). "Updates in ANCA-associated vasculitis". Eur J Rheumatol. 3 (3): 122–133. doi:10.5152/eurjrheum.2015.0043. PMID 27733943.
↑ Lee KS, Kim TS, Fujimoto K, Moriya H, Watanabe H, Tateishi U, Ashizawa K, Johkoh T, Kim EA, Kwon OJ (2003). "Thoracic manifestation of Wegener's granulomatosis: CT findings in 30 patients". Eur Radiol. 13 (1): 43–51. doi:10.1007/s00330-002-1422-2. PMID 12541109.
↑ Kallenberg CG, Heeringa P, Stegeman CA (2006). "Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides". Nat Clin Pract Rheumatol. 2 (12): 661–70. doi:10.1038/ncprheum0355. PMID 17133251.
↑ Jennette JC, Falk RJ (November 1997). "Small-vessel vasculitis". N. Engl. J. Med. 337 (21): 1512–23. doi:10.1056/NEJM199711203372106. PMID 9366584.
↑ Jennette JC, Falk RJ (November 1997). "Small-vessel vasculitis". N. Engl. J. Med. 337 (21): 1512–23. doi:10.1056/NEJM199711203372106. PMID 9366584.
↑ Chen JY, Mao JH (February 2015). "Henoch-Schönlein purpura nephritis in children: incidence, pathogenesis and management". World J Pediatr. 11 (1): 29–34. doi:10.1007/s12519-014-0534-5. PMID 25557596.
↑ Hochreiter W, Knoll T, Hess B (February 2003). "[Pathophysiology, diagnosis and conservative therapy of non-calcium kidney calculi]". Ther Umsch (in German). 60 (2): 89–97. doi:10.1024/0040-5930.60.2.89. PMID 12649987.
↑ Flannigan R, Choy WH, Chew B, Lange D (June 2014). "Renal struvite stones--pathogenesis, microbiology, and management strategies". Nat Rev Urol. 11 (6): 333–41. doi:10.1038/nrurol.2014.99. PMID 24818849.
↑ Pereira DJ, Schoolwerth AC, Pais VM (March 2015). "Cystinuria: current concepts and future directions". Clin. Nephrol. 83 (3): 138–46. PMID 25685869.
↑ Pereira DJ, Schoolwerth AC, Pais VM (March 2015). "Cystinuria: current concepts and future directions". Clin. Nephrol. 83 (3): 138–46. PMID 25685869.
↑ Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ (2007). "Detection of intracellular bacterial communities in human urinary tract infection". PLoS Med. 4 (12): e329. doi:10.1371/journal.pmed.0040329. PMC 2140087. PMID 18092884.
↑ Franco AV (2005). "Recurrent urinary tract infections". Best Pract Res Clin Obstet Gynaecol. 19 (6): 861–73. doi:10.1016/j.bpobgyn.2005.08.003. PMID 16298166.
↑ Franco AV (2005). "Recurrent urinary tract infections". Best Pract Res Clin Obstet Gynaecol. 19 (6): 861–73. doi:10.1016/j.bpobgyn.2005.08.003. PMID 16298166.
↑ John N. Krieger, Ulrich Dobrindt, Donald E. Riley & Eric Oswald (2011). "Acute Escherichia coli prostatitis in previously health young men: bacterial virulence factors, antimicrobial resistance, and clinical outcomes". Urology. 77 (6): 1420–1425. doi:10.1016/j.urology.2010.12.059. PMID 21459419. Unknown parameter |month= ignored (help)
↑ Sharp VJ, Takacs EB, Powell CR (2010). "Prostatitis: diagnosis and treatment". Am Fam Physician. 82 (4): 397–406. PMID 20704171.
↑ McNagny SE, Parker RM, Zenilman JM, Lewis JS (1992). "Urinary leukocyte esterase test: a screening method for the detection of asymptomatic chlamydial and gonococcal infections in men". J. Infect. Dis. 165 (3): 573–6. PMID 1538163.
↑ Brill JR (2010). "Diagnosis and treatment of urethritis in men". Am Fam Physician. 81 (7): 873–8. PMID 20353145.

Template:WH Template:WS

[pmid12213946-1] Donadio JV, Grande JP (2002). "IgA nephropathy". N Engl J Med. 347 (10): 738–48. doi:10.1056/NEJMra020109. PMID 12213946.

[pmid21949093-2] Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB; et al. (2011). "The pathophysiology of IgA nephropathy". J Am Soc Nephrol. 22 (10): 1795–803. doi:10.1681/ASN.2011050464. PMID 21949093.

[pmid11137428-3] McCarthy PA, Maino DM (2000). "Alport syndrome: a review". Clin Eye Vis Care. 12 (3–4): 139–150. PMID 11137428.

[pmid8154501-4] Bodziak KA, Hammond WS, Molitoris BA (1994). "Inherited diseases of the glomerular basement membrane". Am J Kidney Dis. 23 (4): 605–18. PMID 8154501.

[pmid15213266-5] Yoshizawa N, Yamakami K, Fujino M, Oda T, Tamura K, Matsumoto K, Sugisaki T, Boyle MD (July 2004). "Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response". J. Am. Soc. Nephrol. 15 (7): 1785–93. PMID 15213266.

[pmid20708459-6] Oda T, Yoshizawa N, Yamakami K, Tamura K, Kuroki A, Sugisaki T, Sawanobori E, Higashida K, Ohtomo Y, Hotta O, Kumagai H, Miura S (September 2010). "Localization of nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis". Hum. Pathol. 41 (9): 1276–85. doi:10.1016/j.humpath.2010.02.006. PMID 20708459.

[pmid18039119-7] Kwoh C, Shannon MB, Miner JH, Shaw A (2006). "Pathogenesis of nonimmune glomerulopathies". Annu Rev Pathol. 1: 349–74. doi:10.1146/annurev.pathol.1.110304.100119. PMID 18039119.

[pmid17216262-8] Reidy K, Kaskel FJ (March 2007). "Pathophysiology of focal segmental glomerulosclerosis". Pediatr. Nephrol. 22 (3): 350–4. doi:10.1007/s00467-006-0357-2. PMC 1794138. PMID 17216262.

[pmid14750104-9] D'Agati VD, Fogo AB, Bruijn JA, Jennette JC (2004). "Pathologic classification of focal segmental glomerulosclerosis: a working proposal". Am J Kidney Dis. 43 (2): 368–82. PMID 14750104.

[pmid9507491-10] Couser WG (1998). "Pathogenesis of glomerular damage in glomerulonephritis". Nephrol Dial Transplant. 13 Suppl 1: 10–5. PMID 9507491.

[pmid8959617-11] Atkins RC, Nikolic-Paterson DJ, Song Q, Lan HY (1996). "Modulators of crescentic glomerulonephritis". J Am Soc Nephrol. 7 (11): 2271–8. PMID 8959617.

[pmid12631105-12] Jennette JC (March 2003). "Rapidly progressive crescentic glomerulonephritis". Kidney Int. 63 (3): 1164–77. doi:10.1046/j.1523-1755.2003.00843.x. PMID 12631105.

[pmid25014039-13] Schwartz N, Goilav B, Putterman C (September 2014). "The pathogenesis, diagnosis and treatment of lupus nephritis". Curr Opin Rheumatol. 26 (5): 502–9. doi:10.1097/BOR.0000000000000089. PMC 4221732. PMID 25014039.

[pmid22977215-14] Giannico G, Fogo AB (2013). "Lupus nephritis: is the kidney biopsy currently necessary in the management of lupus nephritis?". Clin J Am Soc Nephrol. 8 (1): 138–45. doi:10.2215/CJN.03400412. PMID 22977215.

[BakerPusey2004-15] Baker, R. J.; Pusey, C. D. (2004). "The changing profile of acute tubulointerstitial nephritis". Nephrology Dialysis Transplantation. 19 (1): 8–11. doi:10.1093/ndt/gfg464. ISSN 0931-0509.

[16] Kelly C, Tomaszewski J, Neilson E. Immunopathogenic mechanisms of tubulointerstitial injury. In: Tisher C, Brenner B, eds, Renal Pathology: With Clinical and Functional Correlations, 2nd Edn., Vol. 1. J. B. Lippincott & Co, Philadelphia, PA, 1994; 699–722

[17] Dharmarajan TS, Yoo J, Russell RO, Boateng YA. Acute post streptococcal interstitial nephritis in an adult and review of the literature. Int Urol Nephrol 1999; 31:145

[pmid12649987-18] Hochreiter W, Knoll T, Hess B (February 2003). "[Pathophysiology, diagnosis and conservative therapy of non-calcium kidney calculi]". Ther Umsch (in German). 60 (2): 89–97. doi:10.1024/0040-5930.60.2.89. PMID 12649987.

[pmid23392537-19] Trinchieri A (February 2013). "Diet and renal stone formation". Minerva Med. 104 (1): 41–54. PMID 23392537.

[pmid16339096-20] Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.

[pmid20479778-21] Leveridge MJ, Bostrom PJ, Koulouris G, Finelli A, Lawrentschuk N (June 2010). "Imaging renal cell carcinoma with ultrasonography, CT and MRI". Nat Rev Urol. 7 (6): 311–25. doi:10.1038/nrurol.2010.63. PMID 20479778.

[pmid1978-22] Jolly RD, Stellwagen E, Babul J, Vodkaĭlo LV, Titov VL, Moldomusaev DM, Maianskiĭ AN (November 1975). "Mannosidosis of Angus Cattle: a prototype control program for some genetic diseases". Adv Vet Sci Comp Med. 19 (23): 1–21. PMID 1978.

[pmid157385942-23] Stefanowicz J, Sierota D, Balcerska A, Stoba C (2004). "[Wilms' tumour of unfavorable histology--results of treatment with the SIOP 93-01 protocol at the Gdańsk centre. Preliminary report]". Med Wieku Rozwoj (in Polish). 8 (2 Pt 1): 197–200. PMID 15738594.

[pmid61529362-24] Hartman DS, Sanders RC (April 1982). "Wilms' tumor versus neuroblastoma: usefulness of ultrasound in differentiation". J Ultrasound Med. 1 (3): 117–22. PMID 6152936.

[pmid30036602-25] De Campo JF (1986). "Ultrasound of Wilms' tumor". Pediatr Radiol. 16 (1): 21–4. PMID 3003660.

[pmid4080660-26] Cahan LD (1985). "Failure of encephalo-duro-arterio-synangiosis procedure in moyamoya disease". Pediatr Neurosci. 12 (1): 58–62. PMID 4080660.

[pmid21360040-27] Pons F, Orsola A, Morote J, Bellmunt J (2011). "Variant forms of bladder cancer: basic considerations on treatment approaches". Curr Oncol Rep. 13 (3): 216–21. doi:10.1007/s11912-011-0161-4. PMID 21360040.

[pmid10918764-28] Metts MC, Metts JC, Milito SJ, Thomas CR (June 2000). "Bladder cancer: a review of diagnosis and management". J Natl Med Assoc. 92 (6): 285–94. PMC 2640522. PMID 10918764.

[pmid182316182-29] Rom M, Kuehhas FE, Djavan B (2007). "New findings in bladder and prostate cancer: highlights of the 22nd annual congress of the European association of urology, march 21-24, 2007, berlin, Germany". Rev Urol. 9 (4): 214–9. PMC 2199502. PMID 18231618.

[pmid23451265-30] Chung SD, Liu SP, Lin HC (2013). "Association between prostate cancer and urinary calculi: a population-based study". PLoS ONE. 8 (2): e57743. doi:10.1371/journal.pone.0057743. PMC 3581486. PMID 23451265.

[pmid18231618-31] Rom M, Kuehhas FE, Djavan B (2007). "New findings in bladder and prostate cancer: highlights of the 22nd annual congress of the European association of urology, march 21-24, 2007, berlin, Germany". Rev Urol. 9 (4): 214–9. PMC 2199502. PMID 18231618.

[pmid8321262-32] Gabow PA (July 1993). "Autosomal dominant polycystic kidney disease". N. Engl. J. Med. 329 (5): 332–42. doi:10.1056/NEJM199307293290508. PMID 8321262.

[pmid16523049-33] Adeva M, El-Youssef M, Rossetti S, Kamath PS, Kubly V, Consugar MB, Milliner DM, King BF, Torres VE, Harris PC (January 2006). "Clinical and molecular characterization defines a broadened spectrum of autosomal recessive polycystic kidney disease (ARPKD)". Medicine (Baltimore). 85 (1): 1–21. doi:10.1097/01.md.0000200165.90373.9a. PMID 16523049.

[34] U. Kuhlmann, J. Steurer, A. Bollinger, G. Pouliadis, J. Briner & W. Siegenthaler (1981). "[Incidence and clinical significance of thromboses and thrombo-embolic complications in nephrotic syndrome patients]". Schweizerische medizinische Wochenschrift. 111 (27–28): 1034–1040. PMID 7268357. Unknown parameter |month= ignored (help)

[35] F. Llach, S. Papper & S. G. Massry (1980). "The clinical spectrum of renal vein thrombosis: acute and chronic". The American journal of medicine. 69 (6): 819–827. PMID 7446547. Unknown parameter |month= ignored (help)

[pmid27733943-36] Pagnoux C (2016). "Updates in ANCA-associated vasculitis". Eur J Rheumatol. 3 (3): 122–133. doi:10.5152/eurjrheum.2015.0043. PMID 27733943.

[pmid12541109-37] Lee KS, Kim TS, Fujimoto K, Moriya H, Watanabe H, Tateishi U, Ashizawa K, Johkoh T, Kim EA, Kwon OJ (2003). "Thoracic manifestation of Wegener's granulomatosis: CT findings in 30 patients". Eur Radiol. 13 (1): 43–51. doi:10.1007/s00330-002-1422-2. PMID 12541109.

[pmid17133251-38] Kallenberg CG, Heeringa P, Stegeman CA (2006). "Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides". Nat Clin Pract Rheumatol. 2 (12): 661–70. doi:10.1038/ncprheum0355. PMID 17133251.

[pmid93665842-39] Jennette JC, Falk RJ (November 1997). "Small-vessel vasculitis". N. Engl. J. Med. 337 (21): 1512–23. doi:10.1056/NEJM199711203372106. PMID 9366584.

[pmid9366584-40] Jennette JC, Falk RJ (November 1997). "Small-vessel vasculitis". N. Engl. J. Med. 337 (21): 1512–23. doi:10.1056/NEJM199711203372106. PMID 9366584.

[pmid25557596-41] Chen JY, Mao JH (February 2015). "Henoch-Schönlein purpura nephritis in children: incidence, pathogenesis and management". World J Pediatr. 11 (1): 29–34. doi:10.1007/s12519-014-0534-5. PMID 25557596.

[pmid126499872-42] Hochreiter W, Knoll T, Hess B (February 2003). "[Pathophysiology, diagnosis and conservative therapy of non-calcium kidney calculi]". Ther Umsch (in German). 60 (2): 89–97. doi:10.1024/0040-5930.60.2.89. PMID 12649987.

[pmid24818849-43] Flannigan R, Choy WH, Chew B, Lange D (June 2014). "Renal struvite stones--pathogenesis, microbiology, and management strategies". Nat Rev Urol. 11 (6): 333–41. doi:10.1038/nrurol.2014.99. PMID 24818849.

[pmid25685869-44] Pereira DJ, Schoolwerth AC, Pais VM (March 2015). "Cystinuria: current concepts and future directions". Clin. Nephrol. 83 (3): 138–46. PMID 25685869.

[pmid256858692-45] Pereira DJ, Schoolwerth AC, Pais VM (March 2015). "Cystinuria: current concepts and future directions". Clin. Nephrol. 83 (3): 138–46. PMID 25685869.

[pmid18092884-46] Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ (2007). "Detection of intracellular bacterial communities in human urinary tract infection". PLoS Med. 4 (12): e329. doi:10.1371/journal.pmed.0040329. PMC 2140087. PMID 18092884.

[pmid16298166-47] Franco AV (2005). "Recurrent urinary tract infections". Best Pract Res Clin Obstet Gynaecol. 19 (6): 861–73. doi:10.1016/j.bpobgyn.2005.08.003. PMID 16298166.

[pmid162981662-48] Franco AV (2005). "Recurrent urinary tract infections". Best Pract Res Clin Obstet Gynaecol. 19 (6): 861–73. doi:10.1016/j.bpobgyn.2005.08.003. PMID 16298166.

[49] John N. Krieger, Ulrich Dobrindt, Donald E. Riley & Eric Oswald (2011). "Acute Escherichia coli prostatitis in previously health young men: bacterial virulence factors, antimicrobial resistance, and clinical outcomes". Urology. 77 (6): 1420–1425. doi:10.1016/j.urology.2010.12.059. PMID 21459419. Unknown parameter |month= ignored (help)

[pmid20704171-50] Sharp VJ, Takacs EB, Powell CR (2010). "Prostatitis: diagnosis and treatment". Am Fam Physician. 82 (4): 397–406. PMID 20704171.

[pmid1538163-51] McNagny SE, Parker RM, Zenilman JM, Lewis JS (1992). "Urinary leukocyte esterase test: a screening method for the detection of asymptomatic chlamydial and gonococcal infections in men". J. Infect. Dis. 165 (3): 573–6. PMID 1538163.

[pmid20353145-52] Brill JR (2010). "Diagnosis and treatment of urethritis in men". Am Fam Physician. 81 (7): 873–8. PMID 20353145.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

[49]

[50]

[51]

[52]

@@ Line 1: / Line 1: @@
 __NOTOC__
-{{Bladder cancer}}
+[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Bladder_cancer]]
-{{CMG}}
+{{CMG}}; {{AE}} {{SC}}
 ==Overview==
-Bladder cancer must be differentiated from [[renal cancer]], [[hemorrhagic cystitis]], [[nephrolithiasis]], [[urinary tract infection]], and[[urethral]] trauma.
+Bladder cancer must be differentiated from [[renal cancer]], [[renal stones]], [[prostate cancer]], and [[cystitis]].
 ==Differential Diagnosis==
-Bladder cancer must be differentiated from:
+The most common presentation of bladder cancer is hematuria; however in the advanced cases, the presentation can be bladder mass.
-* [[Renal cancer]]
-* [[Hemorrhagic cystitis]]
+'''Bladder cancer must be differentiated from other causes of hematuria as in the below table:'''
-* [[Nephrolithiasis]]
-* [[Urinary tract infection]]
+{|
-* [[Urethral]] trauma
+|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
+! colspan="2" rowspan="5" |Diseases
+| colspan="9" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical manifestations'''
+! colspan="2" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
+! rowspan="5" |'''Gold standard'''
+|-
+| colspan="6" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Symptoms'''
+! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical examina
+|-
+! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
+! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diagnosi
+|-
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Low back pain
+! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nausea/
+Vomiting
+! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Urinary symptoms
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hypertension
+! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pitting edema
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
+|-
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Dysuria
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Frequency
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Oliguria
+|-
+| rowspan="7" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Glomerular disease|Glomerular diseases]]
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[IgA nephropathy|IgA nephropathy]]<ref name="pmid12213946">{{cite journal| author=Donadio JV, Grande JP| title=IgA nephropathy. | journal=N Engl J Med | year= 2002 | volume= 347 | issue= 10 | pages= 738-48 | pmid=12213946 | doi=10.1056/NEJMra020109 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12213946  }}</ref><ref name="pmid21949093">{{cite journal| author=Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB et al.| title=The pathophysiology of IgA nephropathy. | journal=J Am Soc Nephrol | year= 2011 | volume= 22 | issue= 10 | pages= 1795-803 | pmid=21949093 | doi=10.1681/ASN.2011050464 | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21949093 }}</ref> [[IgA nephropathy|(Berger nephropathy)]]
+| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | '''Biopsy:'''
+[[IgA]] deposited in a diffuse [[Granular cell|granular]] pattern in the [[mesangium]]
+| style="background: #F5F5F5; padding: 5px;" |Biopsy
+*
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Alport syndrome|Hereditary nephritis]]<ref name="pmid11137428">{{cite journal| author=McCarthy PA, Maino DM| title=Alport syndrome: a review. | journal=Clin Eye Vis Care | year= 2000 | volume= 12 | issue= 3-4 | pages= 139-150 | pmid=11137428 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11137428 }}</ref><ref name="pmid8154501">{{cite journal| author=Bodziak KA, Hammond WS, Molitoris BA| title=Inherited diseases of the glomerular basement membrane. | journal=Am J Kidney Dis | year= 1994 | volume= 23 | issue= 4 | pages= 605-18 | pmid=8154501 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8154501 }}</ref> [[Alport syndrome|(Alport syndrome)]]
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* Cataract
+* Hearing loss
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Pyuria]]
+* Red cell [[casts]]
+* Cylindrical [[casts]]
+| style="background: #F5F5F5; padding: 5px;" |'''Biopsy:'''
+* [[Monoclonal antibodies]] directed against alpha-3 (IV), alpha-4 (IV), and alpha-5 (IV) chains of [[Type-IV collagen|typ-e IV collage]]<nowiki/>n
+| style="background: #F5F5F5; padding: 5px;" |[[Genetics|Genetic]] analysis
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Post-streptococcal glomerulonephritis]]<ref name="pmid15213266">{{cite journal |vauthors=Yoshizawa N, Yamakami K, Fujino M, Oda T, Tamura K, Matsumoto K, Sugisaki T, Boyle MD |title=Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response |journal=J. Am. Soc. Nephrol. |volume=15 |issue=7 |pages=1785–93 |date=July 2004 |pmid=15213266 |doi= |url=}}</ref><ref name="pmid20708459">{{cite journal |vauthors=Oda T, Yoshizawa N, Yamakami K, Tamura K, Kuroki A, Sugisaki T, Sawanobori E, Higashida K, Ohtomo Y, Hotta O, Kumagai H, Miura S |title=Localization of nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis |journal=Hum. Pathol. |volume=41 |issue=9 |pages=1276–85 |date=September 2010 |pmid=20708459 |doi=10.1016/j.humpath.2010.02.006 |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | +/-
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Edema]]
+* [[Anemia]]
+* Increased [[Blood pressure|Blood Pressure]]
+| style="background: #F5F5F5; padding: 5px;" |
+* Urine samples for [[protein]] and [[blood]]
+| style="background: #F5F5F5; padding: 5px;" |
+'''Biopsy'''
+* Irregularly thin and attenuated [[GBM]]
+* Splitting of [[GBM]]
+* Scarring
+* [[Immunoglobulin G]] and [[C3 disease|C3]] in a diffuse [[Granule cell|granular]] pattern
+* Starry sky pattern
+| style="background: #F5F5F5; padding: 5px;" |Biopsy
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Focal segmental glomerulosclerosis|Focal segmental glomerular sclerosis]]<ref name="pmid18039119">{{cite journal| author=Kwoh C, Shannon MB, Miner JH, Shaw A| title=Pathogenesis of nonimmune glomerulopathies. | journal=Annu Rev Pathol | year= 2006 | volume= 1 | issue=  | pages= 349-74 | pmid=18039119 | doi=10.1146/annurev.pathol.1.110304.100119 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18039119  }}</ref><ref name="pmid17216262">{{cite journal |vauthors=Reidy K, Kaskel FJ |title=Pathophysiology of focal segmental glomerulosclerosis |journal=Pediatr. Nephrol. |volume=22 |issue=3 |pages=350–4 |date=March 2007 |pmid=17216262 |pmc=1794138 |doi=10.1007/s00467-006-0357-2 |url=}}</ref>'''<ref name="pmid14750104">{{cite journal| author=D'Agati VD, Fogo AB, Bruijn JA, Jennette JC| title=Pathologic classification of focal segmental glomerulosclerosis: a working proposal. | journal=Am J Kidney Dis | year= 2004| volume= 43 | issue= 2 | pages= 368-82 | pmid=14750104 | doi= | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14750104  }}</ref>'''
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Nephrotic syndrome]]
+* [[ESRD]]
+* [[Pleural effusion]]
+* [[Ascites]]
+* [[Abdominal pain]]
+**
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Urinalysis]] reveals large amounts of protein, along with [[hyaline]] and broad waxy casts
+* [[Hepatitis B]] or [[Hepatitis C|C]] infection
+* [[Anti-neutrophil cytoplasmic antibody]] titers, [[serum protein electrophoresis]]
+| style="background: #F5F5F5; padding: 5px;" |'''Biopsy'''
+* Segmental solidification in the perihilar region and  peripheral areas, especially the [[tubular]] pole
+* Coarsely [[Granule cell|granular]] deposits -of [[Immunoglobulin M|IgM]] and [[C3 glomerular disease|C3]]
+| style="background: #F5F5F5; padding: 5px;" |Biopsy
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Rapidly progressive glomerulonephritis]]<ref name="pmid9507491">{{cite journal| author=Couser WG| title=Pathogenesis of glomerular damage in glomerulonephritis. | journal=Nephrol Dial Transplant | year= 1998 | volume= 13 Suppl 1 | issue=  | pages= 10-5 | pmid=9507491 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9507491  }}</ref><ref name="pmid8959617">{{cite journal| author=Atkins RC, Nikolic-Paterson DJ, Song Q, Lan HY| title=Modulators of crescentic glomerulonephritis. | journal=J Am Soc Nephrol | year= 1996 | volume= 7 | issue= 11 | pages= 2271-8 | pmid=8959617 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8959617  }}</ref><ref name="pmid12631105">{{cite journal |vauthors=Jennette JC |title=Rapidly progressive crescentic glomerulonephritis |journal=Kidney Int. |volume=63 |issue=3 |pages=1164–77 |date=March 2003 |pmid=12631105 |doi=10.1046/j.1523-1755.2003.00843.x |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* Abdominal pain
+* Painful cutaneous nodules
+* Migratory poly arthropathy
+* [[Rhinosinusitis|Sinusitis]]
+* [[Cough]]
+* [[Hemoptysis]].
+| style="background: #F5F5F5; padding: 5px;" |
+* Low [[iron]]
+* [[Eosinophilia]]
+* Increased serum [[creatinine]] level
+* Eleated [[Lactate dehydrogenase|LDH]] and [[Creatine kinase|CPK]]
+* [[Proteinuria]]
+| style="background: #F5F5F5; padding: 5px;" | Biopsy:
+* Diffuse, proliferative, necrotizing [[Glomerular disease|glomerulonephritis]] with [[Glomerular disease|crescent]] formation
+| style="background: #F5F5F5; padding: 5px;" |Biopsy
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Lupus nephritis]]<ref name="pmid25014039">{{cite journal |vauthors=Schwartz N, Goilav B, Putterman C |title=The pathogenesis, diagnosis and treatment of lupus nephritis |journal=Curr Opin Rheumatol |volume=26 |issue=5 |pages=502–9 |date=September 2014 |pmid=25014039 |pmc=4221732 |doi=10.1097/BOR.0000000000000089 |url=}}</ref><ref name="pmid22977215">{{cite journal |vauthors=Giannico G, Fogo AB |title=Lupus nephritis: is the kidney biopsy currently necessary in the management of lupus nephritis? |journal=Clin J Am Soc Nephrol |volume=8 |issue=1 |pages=138–45 |year=2013 |pmid=22977215 |doi=10.2215/CJN.03400412 |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" |
+* Foamy dark urine
+* Weight gain
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Hematuria]]
+* [[Pyuria]]
+* [[Proteinuria]]
+* Cellular casts
+* Low [[iron]]
+| style="background: #F5F5F5; padding: 5px;" | Biopsy,
+* Different pathologies, [[Lupus nephritis|CLICK HERE]] for more information.
+| style="background: #F5F5F5; padding: 5px;" |Biopsy
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Fabry's disease|Fabry disease]]
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Hematuria]]
+* [[Proteinuria]]
+| style="background: #F5F5F5; padding: 5px;" | Biopsy
+| style="background: #F5F5F5; padding: 5px;" | Biopsy
+|-
+! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Low back pain
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nausea/
+Vomiting
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Dysuria
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Frequency
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Oliguria
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hypertension
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pitting edema
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diagnosis method
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
+|-
+| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Tubulointerstitial diseases of the kidney|Tubulointerstitial diseases]]<ref name="BakerPusey2004">{{cite journal|last1=Baker|first1=R. J.|last2=Pusey|first2=C. D.|title=The changing profile of acute tubulointerstitial nephritis|journal=Nephrology Dialysis Transplantation|volume=19|issue=1|year=2004|pages=8–11|issn=0931-0509|doi=10.1093/ndt/gfg464}}</ref><ref>Kelly C, Tomaszewski J, Neilson E. Immunopathogenic mechanisms of tubulointerstitial injury. In: Tisher C, Brenner B, eds, Renal Pathology: With Clinical and Functional Correlations, 2nd Edn., Vol. 1. J. B. Lippincott & Co, Philadelphia, PA, 1994; 699–722</ref><ref>Dharmarajan TS, Yoo J, Russell RO, Boateng YA. Acute post streptococcal interstitial nephritis in an adult and review of the literature. Int Urol Nephrol 1999; 31:145</ref>
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" |–
+| style="background: #F5F5F5; padding: 5px;" |–
+| style="background: #F5F5F5; padding: 5px;" |–
+| style="background: #F5F5F5; padding: 5px;" |–
+| style="background: #F5F5F5; padding: 5px;" |–
+| style="background: #F5F5F5; padding: 5px;" |Rash
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Eosinophilia]]
+* [[Eosinophiluria]]
+* [[Isosthenuria]]
+| style="background: #F5F5F5; padding: 5px;" |Biopsy:
+* [[Edema]] and infiltration by [[Monocyte|mononuclear cells]], (principally lymphocytes)
+* [[Eosinophils]] are present, often in large numbers.
+| style="background: #F5F5F5; padding: 5px;" |Renal biopsy
+|-
+| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Nephrolithiasis]]<ref name="pmid12649987">{{cite journal |vauthors=Hochreiter W, Knoll T, Hess B |title=[Pathophysiology, diagnosis and conservative therapy of non-calcium kidney calculi] |language=German |journal=Ther Umsch |volume=60 |issue=2 |pages=89–97 |date=February 2003 |pmid=12649987 |doi=10.1024/0040-5930.60.2.89 |url=}}</ref><ref name="pmid23392537">{{cite journal |vauthors=Trinchieri A |title=Diet and renal stone formation |journal=Minerva Med. |volume=104 |issue=1 |pages=41–54 |date=February 2013 |pmid=23392537 |doi= |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" |–
+| style="background: #F5F5F5; padding: 5px;" |–
+| style="background: #F5F5F5; padding: 5px;" |
+* Radiating pain to groin
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Hypercalciuria]]
+* [[Hyperoxaluria]]
+* [[Hypocitraturia]]
+* [[Hyperuricemia]]
+* [[Hyperuricosuria]]
+| style="background: #F5F5F5; padding: 5px;" |
+* Ultrasound: [[Hydronephrosis]] +/-
+* [[Computed tomography|Abdominal CT scan]] without contrast
+| style="background: #F5F5F5; padding: 5px;" |Abdominal [[Computed tomography|CT scan]] without contrast
+|-
+| colspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Reflux nephropathy|Reflux nephropathy (hydronephrosis)]]
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Abdomen]] pain
+* [[Chest pain]]
+* [[Shortness of breath]]
+| style="background: #F5F5F5; padding: 5px;" |
+* Elevated [[WBC]] count
+* Elevated [[BUN]]
+* [[Hyperkalemia]]
+| style="background: #F5F5F5; padding: 5px;" |
+* Ultrasound: [[Hydronephrosis]] +/-
+* Biopsy: [[Kidney]] scar
+| style="background: #F5F5F5; padding: 5px;" |–
+|-
+| rowspan="4" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Malignancy]]
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Renal cell carcinoma|Renal cell carcinoma (RCC)]]<ref name="pmid16339096">{{cite journal| author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 23 | pages= 2477-90 | pmid=16339096 | doi=10.1056/NEJMra043172 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096  }}</ref><ref name="pmid20479778">{{cite journal |vauthors=Leveridge MJ, Bostrom PJ, Koulouris G, Finelli A, Lawrentschuk N |title=Imaging renal cell carcinoma with ultrasonography, CT and MRI |journal=Nat Rev Urol |volume=7 |issue=6 |pages=311–25 |date=June 2010 |pmid=20479778 |doi=10.1038/nrurol.2010.63 |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Flanks|Flank]] mass
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Anemia]]
+* [[Hematuria]]
+| style="background: #F5F5F5; padding: 5px;" |
+* Both [[CT]] and [[MRI]] may be used to detect [[neoplastic]] masses that may define renal cell carcinoma or metastasis of the primary cancer. [[CT]] scan and use of intravenous (IV) contrast is generally used for work-up and follow-up of patients with [[Renal cell carcinoma|renal cell carcinom]]<nowiki/>a.
+* The histological pattern of renal cell [[carcinoma]] depends whether it is [[Papillary|papillary,]] [[chromophobe]] or [[collecting duct]] renal cell carcinoma.
+| style="background: #F5F5F5; padding: 5px;" |–
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Nephroblastoma]] ([[Wilms' tumor|Wilms tumor]])<ref name="pmid1978">{{cite journal |vauthors=Jolly RD, Stellwagen E, Babul J, Vodkaĭlo LV, Titov VL, Moldomusaev DM, Maianskiĭ AN |title=Mannosidosis of Angus Cattle: a prototype control program for some genetic diseases |journal=Adv Vet Sci Comp Med |volume=19 |issue=23 |pages=1–21 |date=November 1975 |pmid=1978 |doi= |url=}}</ref><ref name="pmid157385942">{{cite journal |vauthors=Stefanowicz J, Sierota D, Balcerska A, Stoba C |title=[Wilms' tumour of unfavorable histology--results of treatment with the SIOP 93-01 protocol at the Gdańsk centre. Preliminary report] |language=Polish |journal=Med Wieku Rozwoj |volume=8 |issue=2 Pt 1 |pages=197–200 |date=2004 |pmid=15738594 |doi= |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Abdominal pain]]
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Anemia]]
+* [[Hematuria]]
+| style="background: #F5F5F5; padding: 5px;" |
+*Ultrasound is the best initial diagnostic study used in cases suspected with [[Wilms tumor]].<ref name="pmid61529362">{{cite journal |vauthors=Hartman DS, Sanders RC |title=Wilms' tumor versus neuroblastoma: usefulness of ultrasound in differentiation |journal=J Ultrasound Med |volume=1 |issue=3 |pages=117–22 |date=April 1982 |pmid=6152936 |doi= |url=}}</ref>
+*[[Doppler ultrasonography]] can help to detect invasion of [[renal vein]] and [[Inferior vena cava|IVC]] by the tumor.<ref name="pmid30036602">{{cite journal |vauthors=De Campo JF |title=Ultrasound of Wilms' tumor |journal=Pediatr Radiol |volume=16 |issue=1 |pages=21–4 |date=1986 |pmid=3003660 |doi= |url=}}</ref>
+*Findings on [[CT scan]]:<ref name="pmid4080660">{{cite journal |vauthors=Cahan LD |title=Failure of encephalo-duro-arterio-synangiosis procedure in moyamoya disease |journal=Pediatr Neurosci |volume=12 |issue=1 |pages=58–62 |date=1985 |pmid=4080660 |doi= |url=}}</ref>
+**Heterogeneous soft-tissue density masses
+**Abdominal lymph nodes and contralateral involvement
+'''Biopsy:'''
+* Primitive tubules and [[Glomerulus|glomeruli]] are often seen comprised of [[Cancer|neoplastic]] cells.
+* Spindled cell [[stroma]] surrounding abortive tubules and [[Glomerulus|glomeruli]] is characteristic.
+*The stroma may include:
+**Striated [[muscle]] [[cartilage]]
+**[[bone]]
+**[[Adipose tissue|Fat tissue]]
+**[[Fibrous connective tissue|Fibrous tissue.]]
+| style="background: #F5F5F5; padding: 5px;" |Biopsy
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Bladder cancer]]<ref name="pmid21360040">{{cite journal| author=Pons F, Orsola A, Morote J, Bellmunt J| title=Variant forms of bladder cancer: basic considerations on treatment approaches. | journal=Curr Oncol Rep | year= 2011 | volume= 13 | issue= 3 | pages= 216-21 | pmid=21360040 | doi=10.1007/s11912-011-0161-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21360040  }}</ref><ref name="pmid10918764">{{cite journal |vauthors=Metts MC, Metts JC, Milito SJ, Thomas CR |title=Bladder cancer: a review of diagnosis and management |journal=J Natl Med Assoc |volume=92 |issue=6 |pages=285–94 |date=June 2000 |pmid=10918764 |pmc=2640522 |doi= |url=}}</ref><ref name="pmid182316182">{{cite journal |vauthors=Rom M, Kuehhas FE, Djavan B |title=New findings in bladder and prostate cancer: highlights of the 22nd annual congress of the European association of urology, march 21-24, 2007, berlin, Germany |journal=Rev Urol |volume=9 |issue=4 |pages=214–9 |date=2007 |pmid=18231618 |pmc=2199502 |doi= |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |Suprapubic pain
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Anemia]]
+* [[Hematuria]]
+| style="background: #F5F5F5; padding: 5px;" |[[Ultrasound]], [[Computed tomography|CT scan]], Biopsy
+| style="background: #F5F5F5; padding: 5px;" |Biopsy
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Prostate cancer]]<ref name="pmid23451265">{{cite journal |vauthors=Chung SD, Liu SP, Lin HC |title=Association between prostate cancer and urinary calculi: a population-based study |journal=PLoS ONE |volume=8 |issue=2 |pages=e57743 |date=2013 |pmid=23451265 |pmc=3581486 |doi=10.1371/journal.pone.0057743 |url=}}</ref><ref name="pmid18231618">{{cite journal |vauthors=Rom M, Kuehhas FE, Djavan B |title=New findings in bladder and prostate cancer: highlights of the 22nd annual congress of the European association of urology, march 21-24, 2007, berlin, Germany |journal=Rev Urol |volume=9 |issue=4 |pages=214–9 |date=2007 |pmid=18231618 |pmc=2199502 |doi= |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" |±
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Anemia]]
+* [[Hematuria]]
+| style="background: #F5F5F5; padding: 5px;" |[[Ultrasound]], [[Computed tomography|CT scan]], Biopsy
+| style="background: #F5F5F5; padding: 5px;" |Biopsy
+|-
+! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Low back pain
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nausea/
+Vomiting
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Dysuria
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Frequency
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Oliguria
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hypertension
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pitting edema
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diagnosis method
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Familial|Familial diseases]]
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Polycystic kidney disease]]'''<ref name="pmid8321262">{{cite journal |vauthors=Gabow PA |title=Autosomal dominant polycystic kidney disease |journal=N. Engl. J. Med. |volume=329 |issue=5 |pages=332–42 |date=July 1993 |pmid=8321262 |doi=10.1056/NEJM199307293290508 |url=}}</ref><ref name="pmid16523049">{{cite journal |vauthors=Adeva M, El-Youssef M, Rossetti S, Kamath PS, Kubly V, Consugar MB, Milliner DM, King BF, Torres VE, Harris PC |title=Clinical and molecular characterization defines a broadened spectrum of autosomal recessive polycystic kidney disease (ARPKD) |journal=Medicine (Baltimore) |volume=85 |issue=1 |pages=1–21 |date=January 2006 |pmid=16523049 |doi=10.1097/01.md.0000200165.90373.9a |url=}}</ref>'''
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Palpable]] [[mass]] in the [[flank]]
+* Palpable [[abdominal]] [[mass]] in the [[lumbar]] quadrant
+* [[Palpable]] [[nodular]] [[hepatomegaly]]
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Hypocitraturia]] in 65% on patients
+* [[Hyperuricemia]] in 20% of patients
+* [[Hyperoxaluria]] in 20% of patients
+* Low [[urine pH]]
+* [[Hematuria]] ([[microscopic]] or [[macroscopic]])
+* [[Proteinuria]] usually less than 1 g/day
+| style="background: #F5F5F5; padding: 5px;" |Ultrasound:
+* Unilateral or bilateral [[cysts]]
+[[CT-scans|CT]]:
+* Hyperdense appearance,
+* Septations
+* Calcifications
+[[Genetic]] testing demonstrates:
+* Frame insertions/deletions
+* Non-canonical [[splice]] site alterations
+* Combined [[missense]] changes
+Biopsy:
+* Interstitial fibrosis
+* Tubular atrophy
+* Thickening and lamellation of tubular basement membranes
+| style="background: #F5F5F5; padding: 5px;" |[[Ultrasound]]
+|-
+| rowspan="3" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Vascular anomaly|Vascular diseases]]
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Renal vein thrombosis]]<ref>{{Cite journal
+ | author = [[U. Kuhlmann]], [[J. Steurer]], [[A. Bollinger]], [[G. Pouliadis]], [[J. Briner]] & [[W. Siegenthaler]]
+ | title = &#91;Incidence and clinical significance of thromboses and thrombo-embolic complications in nephrotic syndrome patients&#93;
+ | journal = [[Schweizerische medizinische Wochenschrift]]
+ | volume = 111
+ | issue = 27-28
+ | pages = 1034–1040
+ | year = 1981
+ | month = July
+ | pmid = 7268357
+}}</ref><ref>{{Cite journal
+ | author = [[F. Llach]], [[S. Papper]] & [[S. G. Massry]]
+ | title = The clinical spectrum of renal vein thrombosis: acute and chronic
+ | journal = [[The American journal of medicine]]
+ | volume = 69
+ | issue = 6
+ | pages = 819–827
+ | year = 1980
+ | month = December
+ | pmid = 7446547
+}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* Asymptomatic
+* [[Abdominal pain]]
+* Acute in onset
+| style="background: #F5F5F5; padding: 5px;" |
+* Elevation in serum [[lactate dehydrogenase]]
+* [[Cholesterol]] levels for hyper-cholesterolemia
+* [[Albumin]] levels for hypoalbuminemia
+* Serum [[complement]] levels
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Ultrasound]]
+* [[Venography]]
+| style="background: #F5F5F5; padding: 5px;" |'''Renal venography:''' Gold standard
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Granulomatosis with polyangiitis|Wegner's granulomatosis polyangiitis]]<ref name="pmid27733943">{{cite journal| author=Pagnoux C| title=Updates in ANCA-associated vasculitis. | journal=Eur J Rheumatol | year= 2016 | volume= 3 | issue= 3 | pages= 122-133 | pmid=27733943 | doi=10.5152/eurjrheum.2015.0043 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27733943  }}</ref><ref name="pmid12541109">{{cite journal |vauthors=Lee KS, Kim TS, Fujimoto K, Moriya H, Watanabe H, Tateishi U, Ashizawa K, Johkoh T, Kim EA, Kwon OJ |title=Thoracic manifestation of Wegener's granulomatosis: CT findings in 30 patients |journal=Eur Radiol |volume=13 |issue=1 |pages=43–51 |year=2003 |pmid=12541109 |doi=10.1007/s00330-002-1422-2 |url=}}</ref><ref name="pmid17133251">{{cite journal| author=Kallenberg CG, Heeringa P, Stegeman CA| title=Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides. | journal=Nat Clin Pract Rheumatol | year= 2006 | volume= 2 | issue= 12 | pages= 661-70 | pmid=17133251 | doi=10.1038/ncprheum0355 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17133251  }}</ref><ref name="pmid93665842">{{cite journal |vauthors=Jennette JC, Falk RJ |title=Small-vessel vasculitis |journal=N. Engl. J. Med. |volume=337 |issue=21 |pages=1512–23 |date=November 1997 |pmid=9366584 |doi=10.1056/NEJM199711203372106 |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +/-
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Upper respiratory tract infection|URTI]]
+* [[CNS]] involvement
+* [[Ophthalmic]] involvement
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Proteinuria]]
+* Microscopic [[hematuria]]
+* [[RBC casts]]
+| style="background: #F5F5F5; padding: 5px;" | [[Computed tomography|CT]] chest:
+* Multiple [[Pulmonary nodule|lung nodules]]
+* [[Consolidation (medicine)|Consolidation]]
+* [[Ground glass opacification on CT|Ground-glass opacities.]]
+Biopsy:
+* Subendothelial [[edema]]
+* Microthrombosis, and
+* [[Degranulation]] of [[neutrophils]].
+| style="background: #F5F5F5; padding: 5px;" |Biopsy
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Henoch-Schönlein purpura]]<ref name="pmid9366584">{{cite journal |vauthors=Jennette JC, Falk RJ |title=Small-vessel vasculitis |journal=N. Engl. J. Med. |volume=337 |issue=21 |pages=1512–23 |date=November 1997 |pmid=9366584 |doi=10.1056/NEJM199711203372106 |url=}}</ref><ref name="pmid25557596">{{cite journal |vauthors=Chen JY, Mao JH |title=Henoch-Schönlein purpura nephritis in children: incidence, pathogenesis and management |journal=World J Pediatr |volume=11 |issue=1 |pages=29–34 |date=February 2015 |pmid=25557596 |doi=10.1007/s12519-014-0534-5 |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +/-
+| style="background: #F5F5F5; padding: 5px;" | +/-
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Abdominal pain]]
+* [[Rash]]
+* [[Hematuria]]
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Proteinuria]]
+* Microscopic [[hematuria]]
+* [[Urinary casts|RBC casts]]
+| style="background: #F5F5F5; padding: 5px;" |Biopsy:
+[[Immunoglobulin A|IgA]] deposited in a diffuse [[Granule cell|granular]] pattern in the [[mesangium]]
+| style="background: #F5F5F5; padding: 5px;" |Renal biopsy, and clinical syndrome
+|-
+! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Low back pain
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nausea/
+Vomiting
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Dysuria
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Frequency
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Oliguria
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hypertension
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pitting edema
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diagnosis method
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
+|-
+| rowspan="2" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Urinary system|Lower urinary tract diseases]]
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Benign prostatic hyperplasia]]
+| style="background: #F5F5F5; padding: 5px;" | +/-
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Nocturia]]
+* Other voiding symptoms
+** Slow urinary stream
+** Splitting or spraying of the [[Urinary system|urinary]] stream
+** Intermittent urinary stream
+** Hesitancy
+** Straining to void
+** Terminal dribbling
+| style="background: #F5F5F5; padding: 5px;" |
+* Urinalysis to rule out [[Urinary tract infection|UTI]]
+* Elevated [[Blood urea nitrogen|BUN]]/[[Creatinine|Cr]]
+* High [[Prostate specific antigen|PSA]] values
+| style="background: #F5F5F5; padding: 5px;" |
+* Urine cytology to screen for bladder cancer
+* Biopsy to rule out cancer
+| style="background: #F5F5F5; padding: 5px;" |Biopsy
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Urolithiasis]]<ref name="pmid126499872">{{cite journal |vauthors=Hochreiter W, Knoll T, Hess B |title=[Pathophysiology, diagnosis and conservative therapy of non-calcium kidney calculi] |language=German |journal=Ther Umsch |volume=60 |issue=2 |pages=89–97 |date=February 2003 |pmid=12649987 |doi=10.1024/0040-5930.60.2.89 |url=}}</ref><ref name="pmid24818849">{{cite journal |vauthors=Flannigan R, Choy WH, Chew B, Lange D |title=Renal struvite stones--pathogenesis, microbiology, and management strategies |journal=Nat Rev Urol |volume=11 |issue=6 |pages=333–41 |date=June 2014 |pmid=24818849 |doi=10.1038/nrurol.2014.99 |url=}}</ref><ref name="pmid25685869">{{cite journal |vauthors=Pereira DJ, Schoolwerth AC, Pais VM |title=Cystinuria: current concepts and future directions |journal=Clin. Nephrol. |volume=83 |issue=3 |pages=138–46 |date=March 2015 |pmid=25685869 |doi= |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +/-
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Flanks|Flank]]
+* [[Groin]] pain
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Urine|Urine analysis]]
+* High [[Creatinine|Cr]]
+| style="background: #F5F5F5; padding: 5px;" |Abdominppelvic [[Computed tomography|CT scan]] without contrast
+| style="background: #F5F5F5; padding: 5px;" |Abdominppelvic [[Computed tomography|CT scan]] without contrast
+|-
+! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Low back pain
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nausea/
+Vomiting
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Dysuria
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Frequency
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Oliguria
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hypertension
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pitting edema
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diagnosis method
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
+|-
+| rowspan="4" style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Infectious disease|Infectious diseases]]
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Pyelonephritis]]<ref name="pmid256858692">{{cite journal |vauthors=Pereira DJ, Schoolwerth AC, Pais VM |title=Cystinuria: current concepts and future directions |journal=Clin. Nephrol. |volume=83 |issue=3 |pages=138–46 |date=March 2015 |pmid=25685869 |doi= |url=}}</ref><ref name="pmid18092884">{{cite journal| author=Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ| title=Detection of intracellular bacterial communities in human urinary tract infection. | journal=PLoS Med | year= 2007 | volume= 4 | issue= 12 | pages= e329 | pmid=18092884 | doi=10.1371/journal.pmed.0040329 | pmc=2140087 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18092884  }}</ref>
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Delirium]]
+* [[Headache]]
+| style="background: #F5F5F5; padding: 5px;" |
+* Positive  [[leukocyte esterase]] test and [[nitrite test]].
+* Blood/urine cultures
+| style="background: #F5F5F5; padding: 5px;" |[[Computed tomography|CT]] and [[ultrasound]]:
+* Enlarged [[Kidney|kidneys]]
+* Round swollen [[Kidney|kidneys]]
+* Hypodense appearance
+* [[Abscess|Abscesses]] may not be present
+| style="background: #F5F5F5; padding: 5px;" | -
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Cystitis]]<ref name="pmid16298166">{{cite journal| author=Franco AV| title=Recurrent urinary tract infections. | journal=Best Pract Res Clin Obstet Gynaecol | year= 2005 | volume= 19 | issue= 6 | pages= 861-73 | pmid=16298166 | doi=10.1016/j.bpobgyn.2005.08.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16298166  }}</ref><ref name="pmid162981662">{{cite journal| author=Franco AV| title=Recurrent urinary tract infections. | journal=Best Pract Res Clin Obstet Gynaecol | year= 2005 | volume= 19 | issue= 6 | pages= 861-73 | pmid=16298166 | doi=10.1016/j.bpobgyn.2005.08.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16298166  }}</ref>
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Dyspareunia]]
+* Supra pubic tenderness
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Pyuria]]: > 5-10 [[White blood cells|WBC]]/hpf or 27 [[WBC]]/microliter
+* Positive  [[leukocyte esterase]] test and [[nitrite test]].
+* Positive urine/blood cultures
+| style="background: #F5F5F5; padding: 5px;" |[[Ultrasound|Ultrasound:]]
+* Presence of gas in the bladder wall.
+* Also, help to detect the presence of a [[tumor]] or a [[Stone massage|stone]].
+| style="background: #F5F5F5; padding: 5px;" |Urine culture
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Prostatitis]]<ref>{{Cite journal
+ | author = [[John N. Krieger]], [[Ulrich Dobrindt]], [[Donald E. Riley]] & [[Eric Oswald]]
+ | title = Acute Escherichia coli prostatitis in previously health young men: bacterial virulence factors, antimicrobial resistance, and clinical outcomes
+ | journal = [[Urology]]
+ | volume = 77
+ | issue = 6
+ | pages = 1420–1425
+ | year = 2011
+ | month = June
+ | doi = 10.1016/j.urology.2010.12.059
+ | pmid = 21459419
+}}</ref><ref name="pmid20704171">{{cite journal| author=Sharp VJ, Takacs EB, Powell CR| title=Prostatitis: diagnosis and treatment. | journal=Am Fam Physician | year= 2010 | volume= 82 | issue= 4 | pages= 397-406 | pmid=20704171 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20704171  }}</ref>
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* Body aches
+| style="background: #F5F5F5; padding: 5px;" |
+* Increased [[leukocytes]] (>10 per high power field) on [[Complete blood count|CBC]]
+* Bacteria seen on [[urine culture]]
+* Elevated [[C-reactive protein]]
+* Transiently elevated [[PSA]] ([[prostate specific antigen]]) levels
+| style="background: #F5F5F5; padding: 5px;" |[[Ultrasound|Ultrasound:]]
+* Focal hypoechoic region located in the peripheral part of the [[prostate]]
+[[Computed tomography|CT scan:]]
+* Edema of the [[prostate gland]] with diffuse enlargement,.
+| style="background: #F5F5F5; padding: 5px;" | -
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Urethritis]]<ref name="pmid1538163">{{cite journal |vauthors=McNagny SE, Parker RM, Zenilman JM, Lewis JS |title=Urinary leukocyte esterase test: a screening method for the detection of asymptomatic chlamydial and gonococcal infections in men |journal=J. Infect. Dis. |volume=165 |issue=3 |pages=573–6 |year=1992 |pmid=1538163 |doi= |url=}}</ref><ref name="pmid20353145">{{cite journal |vauthors=Brill JR |title=Diagnosis and treatment of urethritis in men |journal=Am Fam Physician |volume=81 |issue=7 |pages=873–8 |year=2010 |pmid=20353145 |doi= |url=}}</ref>
+| style="background: #F5F5F5; padding: 5px;" | -/-
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Urethral]] discharge
+| style="background: #F5F5F5; padding: 5px;" |
+* Mucoid, [[mucopurulent]], or [[purulent]] [[discharge]]
+* [[Gram staining|Gram stain]] of urethral secretions demonstrating ≥2 [[WBC]] per field
+* Positive leukocyte esterase test.
+| style="background: #F5F5F5; padding: 5px;" |
+[[Computed tomography|CT scan]]:
+* Diffuse, circumferential urothelial wall thickening and [[contrast]]-enhancement
+* Periureteric or perinephric fat stranding.
+| style="background: #F5F5F5; padding: 5px;" |[[Urine culture]]
+|-
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Urogenital|Urogenital trauma]]
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |Inserted [[bladder]] or [[Ureteral disease|ureteral catheters]]
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | +
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" | -
+| style="background: #F5F5F5; padding: 5px;" |
+* History of [[Physical trauma|trauma]]
+| style="background: #F5F5F5; padding: 5px;" |
+* [[Hematuria]]
+| style="background: #F5F5F5; padding: 5px;" |
+* Retrograde urethrogram (RUG)
+| style="background: #F5F5F5; padding: 5px;" |
+* Retrograde urethrogram (RUG)
+|}
+Lower abdominal mass can be classified to the gynecological and non-gynecological causes.
+Bladder cancer in the advanced cases can present as a bladder mass. Below table discusses lower abdominal mass causes:
 ==References==
@@ Line 21: / Line 724: @@
 [[Category:Types of cancer]]
 [[Category:Urology]]
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Nephrology]]
+[[Category:Surgery]]

Bladder cancer differential diagnosis: Difference between revisions

Latest revision as of 21:26, 14 February 2019

Overview

Differential Diagnosis

References

Navigation menu

Search