Large cell carcinoma of the lung differential diagnosis: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
Ahmed Younes (talk | contribs) No edit summary |
||
| (2 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
[[Image:Home_logo1.png|right|250px|link=http://www.wikidoc.org/index.php/Large_cell_carcinoma_of_the_lung]] | |||
{{CMG}}{{AE}}{{MV}} | {{CMG}}{{AE}}{{MV}} | ||
| Line 10: | Line 10: | ||
*The table below summarizes the findings that differentiate large cell carcinoma of the lung, from other diseases that cause non-productive cough, [[weight loss]], [[fatigue]], and [[dyspnea]] among adults such as [[tuberculosis]], pulmonary fungal disease, lung abscess, and more importantly other causes of non-small cell lung cancers, such as adenocarcinoma and squamous cell lung cancer.<ref name="pmid24455507">{{cite journal| author=Bhatt M, Kant S, Bhaskar R| title=Pulmonary tuberculosis as differential diagnosis of non-small cell lung cancer | journal=South Asian J Cancer | year= 2012 | volume= 1 | issue= 1 | pages= 36-42 | pmid=24455507 | doi=10.4103/2278-330X.96507 | pmc=PMC3876596 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24455507 }}</ref><ref name="pmid19640168">{{cite journal |vauthors=Singh VK, Chandra S, Kumar S, Pangtey G, Mohan A, Guleria R |title=A common medical error: lung cancer misdiagnosed as sputum negative tuberculosis |journal=Asian Pac. J. Cancer Prev. |volume=10 |issue=3 |pages=335–8 |year=2009 |pmid=19640168 |doi= |url=}}</ref> | *The table below summarizes the findings that differentiate large cell carcinoma of the lung, from other diseases that cause non-productive cough, [[weight loss]], [[fatigue]], and [[dyspnea]] among adults such as [[tuberculosis]], pulmonary fungal disease, lung abscess, and more importantly other causes of non-small cell lung cancers, such as adenocarcinoma and squamous cell lung cancer.<ref name="pmid24455507">{{cite journal| author=Bhatt M, Kant S, Bhaskar R| title=Pulmonary tuberculosis as differential diagnosis of non-small cell lung cancer | journal=South Asian J Cancer | year= 2012 | volume= 1 | issue= 1 | pages= 36-42 | pmid=24455507 | doi=10.4103/2278-330X.96507 | pmc=PMC3876596 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24455507 }}</ref><ref name="pmid19640168">{{cite journal |vauthors=Singh VK, Chandra S, Kumar S, Pangtey G, Mohan A, Guleria R |title=A common medical error: lung cancer misdiagnosed as sputum negative tuberculosis |journal=Asian Pac. J. Cancer Prev. |volume=10 |issue=3 |pages=335–8 |year=2009 |pmid=19640168 |doi= |url=}}</ref> | ||
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px" align=center | {| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px" align="center" | ||
|valign=top| | | valign="top" | | ||
|+ | |+ | ||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Differential Diagnosis}} | ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Differential Diagnosis}} | ||
| Line 17: | Line 17: | ||
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Differentiating Features}} | ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Differentiating Features}} | ||
|- | |- | ||
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|''' [[Pulmonary tuberculosis]]''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |''' [[Pulmonary tuberculosis]]''' | ||
|style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Cough, weight loss, fatigue, and dyspnea | *Cough, weight loss, fatigue, and dyspnea | ||
|style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*In pulmonary tuberculosis, differentiating features include: size increase despite optimal medical therapy, patients age is usually younger, hemoptysis is an early feature, and CXR anatomical predilection for upper lobes | *In pulmonary tuberculosis, differentiating features include: size increase despite optimal medical therapy, patients age is usually younger, hemoptysis is an early feature, and CXR anatomical predilection for upper lobes | ||
|- | |- | ||
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|''' [[ Lung abscess]]''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |''' [[ Lung abscess]]''' | ||
|style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Non-productive cough, weight loss, and chest pain | *Non-productive cough, weight loss, and chest pain | ||
|style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*In lung abscess, differentiating features include: acute or sub-acute onset, CXR anatomical predilection for upper lobes, and usually resolve with antibiotic | *In lung abscess, differentiating features include: acute or sub-acute onset, CXR anatomical predilection for upper lobes, and usually resolve with antibiotic | ||
|- | |- | ||
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|'''[[Pneumonia]]''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |'''[[Pneumonia]]''' | ||
|style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Cough, weight loss, fatigue, and dyspnea | *Cough, weight loss, fatigue, and dyspnea | ||
|style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*In pneumonia, differentiating features include: good response to antibiotics, acute onset, predilection on CXR is consolidation, laboratory markers indicate infection | *In pneumonia, differentiating features include: good response to antibiotics, acute onset, predilection on CXR is consolidation, laboratory markers indicate infection | ||
|- | |- | ||
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"| '''[[Pulmonary fungal infection]]''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | '''[[Aspergillosis|Pulmonary fungal infection]]''' | ||
|style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Non-productive cough, weight loss, fatigue, and dyspnea | *Non-productive cough, weight loss, fatigue, and dyspnea | ||
| style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*In pulmonary fungal infection, differentiating features include: CXR findings: air-cresecent sign, no response to antibioitcs, and mimics tuberculosis | *In pulmonary fungal infection, differentiating features include: CXR findings: air-cresecent sign, no response to antibioitcs, and mimics tuberculosis | ||
|- | |- | ||
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|'''Other non-small cell lung cancers | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |'''[[Non small cell lung cancer|Other non-small cell lung cancers]]''' | ||
|style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Non-productive cough, weight loss, fatigue, and dyspnea | *Non-productive cough, weight loss, fatigue, and dyspnea | ||
|style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*In other non-small cell lung cancers , differentiating features include: histopathologica features, such as larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin | *In other non-small cell lung cancers , differentiating features include: histopathologica features, such as larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin | ||
|} | |} | ||
==References== | ==References== | ||
| Line 59: | Line 58: | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Pulmonology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 20:15, 19 February 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
Large cell carcinoma of the lung must be differentiated from other diseases that cause non-productive cough, weight loss, fatigue, and dyspnea among adults such as tuberculosis, pulmonary fungal disease, lung abscess, and more importantly from other causes of non-small cell lung cancers, such as adenocarcinoma and squamous cell lung cancer.[1][2]
Differential Diagnosis
- The table below summarizes the findings that differentiate large cell carcinoma of the lung, from other diseases that cause non-productive cough, weight loss, fatigue, and dyspnea among adults such as tuberculosis, pulmonary fungal disease, lung abscess, and more importantly other causes of non-small cell lung cancers, such as adenocarcinoma and squamous cell lung cancer.[1][2]
| Differential Diagnosis | Similar Features | Differentiating Features |
|---|---|---|
| Pulmonary tuberculosis |
|
|
| Lung abscess |
|
|
| Pneumonia |
|
|
| Pulmonary fungal infection |
|
|
| Other non-small cell lung cancers |
|
|
References
- ↑ 1.0 1.1 Bhatt M, Kant S, Bhaskar R (2012). "Pulmonary tuberculosis as differential diagnosis of non-small cell lung cancer". South Asian J Cancer. 1 (1): 36–42. doi:10.4103/2278-330X.96507. PMC 3876596. PMID 24455507.
- ↑ 2.0 2.1 Singh VK, Chandra S, Kumar S, Pangtey G, Mohan A, Guleria R (2009). "A common medical error: lung cancer misdiagnosed as sputum negative tuberculosis". Asian Pac. J. Cancer Prev. 10 (3): 335–8. PMID 19640168.