Chronic lymphocytic leukemia differential diagnosis: Difference between revisions

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__NOTOC__
__NOTOC__
{{Chronic lymphocytic leukemia}}
[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Chronic_lymphocytic_leukemia]]
{{CMG}} {{AE}}{{HL}}
{{CMG}} {{AE}}{{HL}} {{HK}}
==Overview==
==Overview==
* Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], [[Prolymphocytic leukemia|prolymphocytic leukaemia]], [[follicular lymphoma]], and [[mantle cell lymphoma]].


==Differenting Chronic lymphocytic leukemia from other Diseases==
==Differenting Chronic lymphocytic leukemia from other Diseases==
* Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].
Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], [[Prolymphocytic leukemia|prolymphocytic leukaemia]], [[follicular lymphoma]], and [[mantle cell lymphoma]].
* The table below summarizes how to differentiate chronic lymphocytic leukemia from other conditions that cause a similar clinical presentation:<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
<br>
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
|valign=top|
|+
! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''Surface Immunoglobulin'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD5'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD22/FMC7'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD23'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD79b'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD103'''}}
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Chronic lymphocytic leukaemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
'''Weakly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive/Negative'''
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Prolymphocytic leukaemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Hairy cell leukaemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive/Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Mantle cell lymphoma'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Follicular lymphoma'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
|}
<br>
* Chronic lymphocytic leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:<ref name="wiki">Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015</ref>
:* [[Splenic marginal zone lymphoma]]
:* Nodal marginal zone [[lymphoma]]
:* [[Lymphoplasmacytic lymphoma]]
:* [[Sézary syndrome]]
:* Smoldering adult [[T cell]] leukemia


==References==
==References==
{{reflist|2}}
{{reflist|2}}
[[Category:Disease]]
[[Category:Hematology]]
[[Category:Mature chapter]]
{{Hematology}}
{{Hematological malignancy histology}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}

Latest revision as of 20:33, 27 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Syed Hassan A. Kazmi BSc, MD [3]

Overview

Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.

Differenting Chronic lymphocytic leukemia from other Diseases

Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.

References

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