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__NOTOC__
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''.
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''.


{{Infobox_Disease |
{{CMG}}; {{AE}}{{Anmol}}  
  Name          = {{PAGENAME}} |
  Image          = |
  Caption        = |
  DiseasesDB    = |
  ICD10          = |
  ICD9          = |
  ICDO          = |
  OMIM          = |
  MedlinePlus    = |
  MeshID        = D016399 |
}}
{{CMG}}
{{T cell lymphoma}}
{{T cell lymphoma}}


==[[T-cell lymphoma overview|Overview]]==
==Overview==
 
T-cell lymphoma describes several different types of [[Non-Hodgkin lymphoma]] affecting [[T cell]]s or [[Natural killer cell]]s ([[NK-cells]]), also known as a NK/T-cell lymphoma. Any organ that has [[lymphatic tissue]] may develop a lymphoma, including the [[spleen]], [[thymus]], [[adenoids]], [[tonsils]], [[digestive tract]] and [[bone marrow]]. Characteristically, they may present as fast (aggressive) or slow (indolent) growing lymphomas.
==[[T-cell lymphoma historical perspective|Historical Perspective]]==
 
==[[T-cell lymphoma pathophysiology|Pathophysiology]]==
 
==[[T-cell lymphoma epidemiology and demographics|Epidemiology & Demographics]]==
 
==[[T-cell lymphoma risk factors|Risk Factors]]==
 
==[[T-cell lymphoma screening|Screening]]==
 
==[[T-cell lymphoma causes|Causes]]==
 
==[[T-cell lymphoma differential diagnosis|Differentiating T-cell lymphoma]]==
 
==[[T-cell lymphoma natural history|Complications & Prognosis]]==
 
==Diagnosis==
[[T-cell lymphoma history and symptoms|History and Symptoms]] | [[T-cell lymphoma physical examination|Physical Examination]] | [[T-cell lymphoma staging|Staging]] | [[T-cell lymphoma laboratory tests|Laboratory tests]] | [[T-cell lymphoma electrocardiogram|Electrocardiogram]] | [[T-cell lymphoma x ray|X Rays]] | [[T-cell lymphoma CT|CT]] | [[T-cell lymphoma MRI|MRI]] [[T-cell lymphoma echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[T-cell lymphoma other imaging findings|Other images]] | [[T-cell lymphoma other diagnostic studies|Alternative diagnostics]]


==Treatment==
Lymphomas are named after the [[precursor]] cell from which it developed. A [[peripheral T-cell lymphomas]] include lymphomas which arise from mature T-cells (after [[maturation]] in the [[thymus]]), in contrast with immature T-cell lymphomas, the [[lymphoblastic lymphoma]].
[[T-cell lymphoma medical therapy|Medical therapy]] | [[T-cell lymphoma surgery|Surgical options]] | [[T-cell lymphoma primary prevention|Primary prevention]]  | [[T-cell lymphoma secondary prevention|Secondary prevention]] | [[T-cell lymphoma cost-effectiveness of therapy|Financial costs]] | [[T-cell lymphoma future or investigational therapies|Future therapies]]
==See also==
* [[B-cell lymphoma]]
* [[T-cell leukemia]]


{{Hematological malignancy histology}}
==Classification==
T-cell lymphomas may be classified according to updated WHO classification into 2 subtypes:<ref name="pmid26980727">{{cite journal |vauthors=Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES |title=The 2016 revision of the World Health Organization classification of lymphoid neoplasms |journal=Blood |volume=127 |issue=20 |pages=2375–90 |date=May 2016 |pmid=26980727 |pmc=4874220 |doi=10.1182/blood-2016-01-643569 |url=}}</ref>


[[Category:Hematology]]
{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
[[Category:Types of cancer]]
|+'''Updated WHO classification of Non-Hodgkin lymphoma'''
[[Category:Oncology]]
! style="background: #4479BA; color:#FFF; text-align: center; font-weight: bold;" |T-cell and putative NK-cell neoplasms
|-
| style="padding: 5px 5px; background: #DCDCDC; text-align: center;" |'''Precursor T-cell neoplasm'''
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Precursor T-acute lymphoblastic leukemia / [[lymphoblastic lymphoma]] (LBL)
|-
| style="padding: 5px 5px; background: #DCDCDC; text-align: center; font-weight: bold;" |Peripheral T-cell and NK-cell neoplasms
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[T-cell prolymphocytic leukemia]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[T-cell granular lymphocytic leukemia]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Chronic lymphoproliferative disorder of NK cells]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Aggressive NK-cell leukemia]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Systemic EBV positive T-cell lymphoma of childhood
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Hydroa vacciniforme like lymphoproliferative disorder
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Adult T-cell leukemia/lymphoma]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Extranodal T/NK-cell lymphoma, nasal type
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Enteropathy-type intestinal T-cell lymphoma|Enteropathy associated intestinal T-cell lymphoma]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Monomorphic epitheliotropic intestinal T-cell lymphoma
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Indolent T-cell lymphoproliferative disorder of the GI tract
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Hepatosplenic T cell lymphoma|Hepatosplenic T-cell lymphoma]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Subcutaneous panniculitis-like T-cell lymphoma]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Mycosis fungoides]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Sézary syndrome]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Primary cutaneous CD30 T-cell [[lymphoproliferative disorders]]
*Lymphomatoid papulosis
*Primary cutaneous anaplastic large cell lymphoma
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Primary cutaneous gamma delta T-cell lymphoma
Primary cutaneous CD8 aggressive epidermotropic cytotoxic T-cell lymphoma


{{WikiDoc Help Menu}}
Primary cutaneous acral CD8 T-cell lymphoma


Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Peripheral T-cell lymphoma, NOS  *
[[Peripheral T-cell lymphoma]], not otherwise characterized
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Angioimmunoblastic T-cell lymphoma]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Follicular lymphoma|Follicular T-cell lymphoma]]
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Nodal peripheral T-cell lymphoma with TFH phenotype
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Anaplastic large cell lymphoma]]
*ALK positive
*ALK negitive
|-
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Breast implant associated anaplastic large-cell lymphoma
|}


{{WikiDoc Sources}}
==References==
{{Reflist|2}}

Latest revision as of 15:06, 6 March 2019


For patient information click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]

T-cell lymphoma Microchapters

Home

Patient Information

Overview

Classification

Lymphoblastic lymphoma
T-cell prolymphocytic leukemia
T-cell granular lymphocytic leukemia
Chronic lymphoproliferative disorder of NK cells
Aggressive NK-cell leukemia
Adult T-cell leukemia/lymphoma
Enteropathy-type intestinal T-cell lymphoma
Hepatosplenic T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Mycosis fungoides
Sézary syndrome
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphoma

Overview

T-cell lymphoma describes several different types of Non-Hodgkin lymphoma affecting T cells or Natural killer cells (NK-cells), also known as a NK/T-cell lymphoma. Any organ that has lymphatic tissue may develop a lymphoma, including the spleen, thymus, adenoids, tonsils, digestive tract and bone marrow. Characteristically, they may present as fast (aggressive) or slow (indolent) growing lymphomas.

Lymphomas are named after the precursor cell from which it developed. A peripheral T-cell lymphomas include lymphomas which arise from mature T-cells (after maturation in the thymus), in contrast with immature T-cell lymphomas, the lymphoblastic lymphoma.

Classification

T-cell lymphomas may be classified according to updated WHO classification into 2 subtypes:[1]

Updated WHO classification of Non-Hodgkin lymphoma
T-cell and putative NK-cell neoplasms
Precursor T-cell neoplasm
Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL)
Peripheral T-cell and NK-cell neoplasms
T-cell prolymphocytic leukemia
T-cell granular lymphocytic leukemia
Chronic lymphoproliferative disorder of NK cells
Aggressive NK-cell leukemia
Systemic EBV positive T-cell lymphoma of childhood
Hydroa vacciniforme like lymphoproliferative disorder
Adult T-cell leukemia/lymphoma
Extranodal T/NK-cell lymphoma, nasal type
Enteropathy associated intestinal T-cell lymphoma
Monomorphic epitheliotropic intestinal T-cell lymphoma
Indolent T-cell lymphoproliferative disorder of the GI tract
Hepatosplenic T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Mycosis fungoides
Sézary syndrome
Primary cutaneous CD30 T-cell lymphoproliferative disorders
  • Lymphomatoid papulosis
  • Primary cutaneous anaplastic large cell lymphoma
Primary cutaneous gamma delta T-cell lymphoma

Primary cutaneous CD8 aggressive epidermotropic cytotoxic T-cell lymphoma

Primary cutaneous acral CD8 T-cell lymphoma

Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder

Peripheral T-cell lymphoma, NOS *

Peripheral T-cell lymphoma, not otherwise characterized

Angioimmunoblastic T-cell lymphoma
Follicular T-cell lymphoma
Nodal peripheral T-cell lymphoma with TFH phenotype
Anaplastic large cell lymphoma
  • ALK positive
  • ALK negitive
Breast implant associated anaplastic large-cell lymphoma

References

  1. ↑ Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (May 2016). "The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375–90. doi:10.1182/blood-2016-01-643569. PMC 4874220. PMID 26980727.
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