Desmoid tumor diagnostic study of choice: Difference between revisions

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{{Desmoid tumor}}
{{CMG}} {{AE}}{{S.M.}}
==Overview==
==Overview==
Definitive [[diagnosis]] of a [[desmoid tumor]] can only be established by [[Histological|histological examination]] of a [[Biopsy|biopsy specimen]]. [[Electron microscopy]] can be done which shows [[spindle cells]] of [[Desmoid tumor|desmoids]] appearing as [[myofibroblasts]].
==Diagnostic study of choice==
==Diagnostic study of choice==
*Biopsy is the most important and conclusive diagnostic procedure for desmoid tumor
*[[Biopsy]] is the most important and conclusive [[Diagnostic procedures|diagnostic procedure]] for [[desmoid tumor]]
*After biopsy, electron microscopy is performed to obtain further clarity and confirmation for the diagnosis
*After [[biopsy]], definitive [[diagnosis]] must be established on [[histopathologic]] [[analysis]]
*Spindle cells of desmoid tumors appear to be myofibroblasts on electron microscopy which represents an abnormal proliferation of myofibroblasts, which normally disappear gradually during the later stages of wound healing
*[[Electron microscopy]] is performed to obtain further clarity and confirmation for the [[diagnosis]]
*Immunohistochemical stains are done to look for nuclear accumulation of beta-catenin
*[[Spindle cells]] of [[Desmoid tumor|desmoid tumors]] appear to be [[myofibroblasts]] on [[electron microscopy]] which represents an abnormal [[proliferation]] of [[myofibroblasts]], which normally disappear gradually during the later [[Wound healing phases|stages of wound healing]]
*Regardless of the site, 90% of desmoids show nuclear reactivity (has relatively high specificity)

Latest revision as of 17:56, 13 March 2019