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{{Thrombotic thrombocytopenic purpura}}
{{Thrombotic thrombocytopenic purpura}}
{{CMG}}; {{AE}} {{S.G.}}
{{CMG}}; {{AE}} {{S.G.}}
==Overview==
==Overview==
 
TTP may be classified according to ''[[ADAMTS13]]'' [[gene]] [[Mutation|mutations]] and [[autoantibody]]  against  [[ADAMTS13]] into two subtypes: herditary [[Syndrome|syndromes]], aquired [[Syndrome|syndromes]].


==Classification==
==Classification==
TTP may be classified into several subtypes based on:
TTP may be classified into several subtypes based on ''[[ADAMTS13]]'' [[gene]] [[Mutation|mutations]](herditary [[Syndrome|syndromes]]) and [[autoantibody]] against [[ADAMTS13]](aquired [[Syndrome|syndromes]]):<ref name="pmid26581428">{{cite journal |vauthors=Tersteeg C, Verhenne S, Roose E, Schelpe AS, Deckmyn H, De Meyer SF, Vanhoorelbeke K |title=ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies |journal=Expert Rev Hematol |volume=9 |issue=2 |pages=209–21 |date=2016 |pmid=26581428 |doi=10.1586/17474086.2016.1122515 |url=}}</ref><ref>{{Cite journal
#autoantibody against ADAMTS13
Congenital TTP
Inherited TTP
familial TTP
Upshaw-Schulman syndrome (USS) is an autosomal recessive disease of ADAMTS13 gene on chromosome 9q34
#gene mutations of  ADAMTS13
 
* '''Hereditary:''' 
* Congenital TTP
* Inherited TTP
* familial TTP
* Upshaw-Schulman syndrome (USS) is an autosomal recessive disease of ADAMTS13 gene on chromosome 9q34 <ref>{{Cite journal
  | author = [[Yoshihiro Fujimura]], [[Masanori Matsumoto]], [[Hideo Yagi]], [[Akira Yoshioka]], [[Taei Matsui]] & [[Koiti Titani]]
  | author = [[Yoshihiro Fujimura]], [[Masanori Matsumoto]], [[Hideo Yagi]], [[Akira Yoshioka]], [[Taei Matsui]] & [[Koiti Titani]]
  | title = Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome
  | title = Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome
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  | month = January
  | month = January
  | pmid = 11843286
  | pmid = 11843286
}}</ref>.
}}</ref>
 
'''1.Hereditary:''' 
* [[Congenital disorder|Congenital]] TTP
* [[Inherited]] TTP
* [[Familial]] TTP
* Upshaw-Schulman syndrome (USS) is an [[autosomal]] recessive [[disease]] of [[ADAMTS13]] [[gene]] on [[chromosome]] 9q34 .


* '''Acquired:''' Existence of an inhibitory antibody against ADAMS13 due to the variety of conditions.
'''2.Acquired'''
* Existence of an [[inhibitory]] [[antibody]] against [[ADAMTS13]] due to the variety of [[Condition|conditions.]]


==References==
==References==

Latest revision as of 12:02, 14 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

TTP may be classified according to ADAMTS13 gene mutations and autoantibody against ADAMTS13 into two subtypes: herditary syndromes, aquired syndromes.

Classification

TTP may be classified into several subtypes based on ADAMTS13 gene mutations(herditary syndromes) and autoantibody against ADAMTS13(aquired syndromes):[1][2]

1.Hereditary:

2.Acquired

References

  1. Tersteeg C, Verhenne S, Roose E, Schelpe AS, Deckmyn H, De Meyer SF, Vanhoorelbeke K (2016). "ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies". Expert Rev Hematol. 9 (2): 209–21. doi:10.1586/17474086.2016.1122515. PMID 26581428.
  2. Yoshihiro Fujimura, Masanori Matsumoto, Hideo Yagi, Akira Yoshioka, Taei Matsui & Koiti Titani (2002). "Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome". International journal of hematology. 75 (1): 25–34. PMID 11843286. Unknown parameter |month= ignored (help)

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