Neurofibroma diagnostic criteria: Difference between revisions
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Sara Mohsin (talk | contribs) Created page with "__NOTOC__ {{Neurofibroma}} {{CMG}}; {{AE}}{{S.M.}} ==Overview== ==Diagnostic criteria== There is no established system for the staging of neurofibroma. ==References== {{Refl..." |
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==Diagnostic criteria== | ==Diagnostic criteria== | ||
Following is the '''general diagnostic criteria''' for neurofibroma: | |||
* Randomly oriented thin spindled cells with wavy, hyperchromatic nuclei | |||
** Cellularity and organization are generally insufficient to produce palisading | |||
** Thin processes with indistinct cytoplasm | |||
** Most nuclei are small and bland | |||
* Generally hypocellular | |||
** Thin and thick collagen strands (“shredded carrot collagen”) | |||
** Variable myxoid material surrounding cells and collagen | |||
** Occasional mast cells and lymphocytes, rare foam cells | |||
* Diffusely S100 immunoreactive | |||
* Entrapped axons of overrun nerve frequently scattered within lesion | |||
** Nerve frequently not grossly identifiable | |||
* May show localized hyperchromatic atypical cells (“ancient change”) | |||
** Localized cells with large, pleomorphic nuclei, cytoplasmic intranuclear inclusions, smudgy chromatin, and inconspicuous nucleoli | |||
** Often large, long standing lesions | |||
** Low mitotic index | |||
==References== | ==References== | ||
Latest revision as of 17:46, 29 March 2019
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Neurofibroma Microchapters |
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Neurofibroma diagnostic criteria On the Web |
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American Roentgen Ray Society Images of Neurofibroma diagnostic criteria |
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Risk calculators and risk factors for Neurofibroma diagnostic criteria |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
Diagnostic criteria
Following is the general diagnostic criteria for neurofibroma:
- Randomly oriented thin spindled cells with wavy, hyperchromatic nuclei
- Cellularity and organization are generally insufficient to produce palisading
- Thin processes with indistinct cytoplasm
- Most nuclei are small and bland
- Generally hypocellular
- Thin and thick collagen strands (“shredded carrot collagen”)
- Variable myxoid material surrounding cells and collagen
- Occasional mast cells and lymphocytes, rare foam cells
- Diffusely S100 immunoreactive
- Entrapped axons of overrun nerve frequently scattered within lesion
- Nerve frequently not grossly identifiable
- May show localized hyperchromatic atypical cells (“ancient change”)
- Localized cells with large, pleomorphic nuclei, cytoplasmic intranuclear inclusions, smudgy chromatin, and inconspicuous nucleoli
- Often large, long standing lesions
- Low mitotic index