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| {{Carcinoma of the penis}} | | {{Carcinoma of the penis}} |
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| '''Editor(s)-in-Chief:''' [[C. Michael Gibson, M.S., M.D.]] [mailto:mgibson@perfuse.org] Phone:617-632-7753; Joel Gelman, M.D. [mailto:jgelman@uci.edu], ''Director of the Center for Reconstructive Urology and Associate Clinical Professor in the Department of Urology at the University of California,Irvine'' | | '''Editor(s)-in-Chief:''' [[C. Michael Gibson, M.S., M.D.]] [mailto:charlesmichaelgibson@gmail.com] Phone:617-632-7753; {{Swathi}} |
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| ==Overview== | | ==Overview== |
| | Common risk factors in the development of carcinoma of the penis are [[human papillomavirus]], [[phimosis]], poor [[genital]] hygiene, uncircumcised males, weakened [[immune system]], smoking, and PUVA treatment for [[psoriasis]]. |
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| ==Risk factors== | | ==Risk factors== |
| The [[American Cancer Society]] <ref>http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_penile_cancer_35.asp?sitearea= provides</ref> the following as risk factors for penile cancer: [[human papillomavirus]] (HPV) infection, [[tobacco smoking|smoking]], [[smegma]], [[phimosis]], treatment of [[psoriasis]], age, and [[AIDS]]. The other etiologic factor most commonly associated with penile carcinoma is poor hygiene. There is some evidence that lichen sclerosus (also known as [[balanitis xerotica obliterans]]) may also be a risk factor.<ref>http://bmj.bmjjournals.com/cgi/eletters/321/7264/792#110919</ref>
| | Common risk factors in the development of carcinoma of the penis include:<ref>Risk factors for penile cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/penile/risks/?region=ab</ref> |
| | | * [[Human papillomavirus]] |
| ==Risk==
| | * Multiple sex partners |
| | | * [[Phimosis]] |
| The lifetime risk of a man developing invasive penile cancer (IPC) in the United States is 1 in 600 if he is uncircumcised <ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7377156&dopt=Abstract</ref>, and more than 3 times lower if he was circumcised neonatally.<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11144896&dopt=Abstract</ref><<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8380060&dopt=Abstract</ref><ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8260177&dopt=Abstract</ref>
| | * Poor [[genital]] hygiene |
| | | * Uncircumcised males |
| This and other evidence suggests that childhood [[circumcision]] reduces the incidence of penile cancer.<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11196386&dopt=Abstract</ref><ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11144896&dopt=Abstract</ref><ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7377156&dopt=Abstract</ref><ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11405332&dopt=Abstract</ref><ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10643514&dopt=Abstract</ref><ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10699138&dopt=Abstract</ref> <ref>http://216.180.250.186/~circsec/library/kochen/index.html</ref><ref>http://www.cirp.org/library/disease/cancer/boczko/ Full text</ref>Studies have found that circumcision decreases the risk of HPV infection in males and thereby the risk of developing penile cancer.<ref>http://content.nejm.org/cgi/pmidlookup?view=short&pmid=11948269</ref><ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15388997</ref><ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12238658</ref>
| | * Weakened [[immune system]] |
| | | * Smoking |
| But Wallerstein found that the risk of penile cancer in Finland, Norway, and Denmark (all noncircumcising countries) is about the same (1 in 100,000 per year) as in the US. The [[American Medical Association]] and the [[Royal Australasian College of Physicians]] say the use of infant circumcision in hope of preventing penile cancer in adulthood is not justified.<ref>http://www.ama-assn.org/ama/pub/category/13585.html</ref><ref>http://www.racp.edu.au/hpu/paed/circumcision/print.htm</ref> The [[American Cancer Society]] stated in 1998:
| | * PUVA treatment for [[psoriasis]] |
| : "... penile cancer risk is low in some uncircumcised populations, and circumcision is strongly associated with other socioethnic practices that are associated with lessened risk. The consensus among studies that have taken these other factors into account is that circumcision alone is not the major factor preventing cancer of the penis. It is important that the issue of circumcision not distract the public's attention from avoiding known penile cancer risk factors -- having unprotected sexual relations with multiple partners (increasing the likelihood of human papillomavirus infection) and cigarette smoking."<ref>http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_penile_cancer_35.asp?sitearea=</ref>
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| ==References== | | ==References== |
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| [[Category:Disease]] | | [[Category:Disease]] |
| [[Category:Types of cancer]] | | [[Category:Types of cancer]] |
| [[Category:Oncology]]
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| [[Category:Andrology]] | | [[Category:Andrology]] |
| [[Category:Penis]] | | [[Category:Penis]] |