B-cell prolymphocytic leukemia medical therapy: Difference between revisions
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{{B-cell prolymphocytic leukemia}} | {{B-cell prolymphocytic leukemia}} | ||
{{CMG}} {{CLG}} | |||
==Medical Therapy== | |||
===Overview=== | |||
[[Chemotherapy]], [[biological therapy]], and [[splenectomy]] or [[radiation therapy]] to the [[spleen]] are indicated in the treatment of [[B cell|B-cell]] [[prolymphocytic leukemia]]. | |||
===Chemotherapy=== | ===Chemotherapy=== | ||
B-cell prolymphocytic leukemia responds better when combinations of [[chemotherapy]] drugs are used. Some combinations that may be used are:<ref name=T-PLL>{{cite web | title = Canadian Cancer Society| url =http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/prolymphocytic-leukemias/?region=on }}</ref> | [[B cell|B-cell]] [[prolymphocytic leukemia]] responds better when combinations of [[chemotherapy]] drugs are used. Some [[Chemotherapy agents|combinations]] that may be used are:<ref name="T-PLL">{{cite web | title = Canadian Cancer Society| url =http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/prolymphocytic-leukemias/?region=on }}</ref> | ||
* CVP – [[Cyclophosphamide]], [[vincristine]] and [[prednisone]]. | * [[CVP regimen|CVP]] – [[Cyclophosphamide]], [[vincristine]] and [[prednisone]]. | ||
* CHOP – [[Cyclophosphamide]], [[doxorubicin]], [[vincristine]] and [[prednisone]]. | * [[CHOP]] – [[Cyclophosphamide]], [[doxorubicin]], [[vincristine]] and [[prednisone]]. | ||
Other chemotherapy drugs (purine analogues) are often used to treat T-cell prolymphocytic leukemia are: | Other [[Chemotherapy|chemotherapy drugs]] ([[Purine|purine analogues]]) are often used to treat [[T cell|T-cell]] [[prolymphocytic leukemia]] are: | ||
* [[Fludarabine]] | * [[Fludarabine]] | ||
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===Biological therapy=== | ===Biological therapy=== | ||
Monoclonal antibodies are a type of [[biological therapy]] that has been effective in treating certain types of [[leukemias]]. These drugs may be used alone or in combination with chemotherapy to treat prolymphocytic leukemia. | [[Monoclonal antibodies]] are a type of [[biological therapy]] that has been effective in treating certain types of [[leukemias]]. These [[:Category:Drugs|drugs]] may be used alone or in combination with [[chemotherapy]] to treat [[prolymphocytic leukemia]]. | ||
* [[Alemtuzumab]] seems to be particularly effective in treating T-cell prolymphocytic leukemia. It may be used in people whose [[lymphoma]] is no longer responding to chemotherapy drugs like [[fludarabine]]. | * [[Alemtuzumab]] seems to be particularly effective in treating [[T cell|T-cell]] [[prolymphocytic leukemia]]. It may be used in people whose [[lymphoma]] is no longer responding to [[Chemotherapy|chemotherapy drugs]] like [[fludarabine]]. | ||
===Splenectomy or radiation therapy to the spleen=== | ===Splenectomy or radiation therapy to the spleen=== | ||
[[Splenectomy]] and external beam radiation therapy to the spleen may be used in some people with | [[Splenectomy]] and [[external beam radiation therapy]] to the [[spleen]] may be used in some people with [[prolymphocytic leukemia]]. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Leukemia]] | |||
[[Category: Lymphocytic leukemia]] | |||
[[Category:Disease]] | |||
[[Category:Hematology]] | |||
[[Category:Types of cancer]] | |||
[[Category:Oncology]] | |||
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Latest revision as of 19:34, 8 April 2019
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B-cell prolymphocytic leukemia |
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Differentiating B-cell prolymphocytic leukemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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B-cell prolymphocytic leukemia medical therapy On the Web |
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American Roentgen Ray Society Images of B-cell prolymphocytic leukemia medical therapy |
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Directions to Hospitals Treating B-cell prolymphocytic leukemia |
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Risk calculators and risk factors for B-cell prolymphocytic leukemia medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]
Medical Therapy
Overview
Chemotherapy, biological therapy, and splenectomy or radiation therapy to the spleen are indicated in the treatment of B-cell prolymphocytic leukemia.
Chemotherapy
B-cell prolymphocytic leukemia responds better when combinations of chemotherapy drugs are used. Some combinations that may be used are:[1]
- CVP – Cyclophosphamide, vincristine and prednisone.
- CHOP – Cyclophosphamide, doxorubicin, vincristine and prednisone.
Other chemotherapy drugs (purine analogues) are often used to treat T-cell prolymphocytic leukemia are:
Biological therapy
Monoclonal antibodies are a type of biological therapy that has been effective in treating certain types of leukemias. These drugs may be used alone or in combination with chemotherapy to treat prolymphocytic leukemia.
- Alemtuzumab seems to be particularly effective in treating T-cell prolymphocytic leukemia. It may be used in people whose lymphoma is no longer responding to chemotherapy drugs like fludarabine.
Splenectomy or radiation therapy to the spleen
Splenectomy and external beam radiation therapy to the spleen may be used in some people with prolymphocytic leukemia.