Carcinoma of the penis differential diagnosis: Difference between revisions

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[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Carcinoma_of_the_penis]]
[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Carcinoma_of_the_penis]]
{{CMG}}
{{CMG}}, {{Swathi}}
==Overview==
==Overview==
Carcinoma of the penis must be differentiated from [[condyloma acuminata]], penile intraepithelial [[neoplasia]] (PeIN), [[balanitis xerotica obliterans]], buschke-Lowenstein [[tumour]], [[bowenoid papulosis]], and [[leukoplakia]].
[[Carcinoma]] of the [[penis]] must be [[Differentiate|differentiated]] from [[condyloma acuminata]], [[Penis|penile]] intraepithelial [[neoplasia]] (PeIN), [[balanitis xerotica obliterans]], buschke-Lowenstein [[tumour]], [[bowenoid papulosis]], and [[leukoplakia]].


==Differential Diagnosis==
==Differential Diagnosis==
Carcinoma of the penis must be differentiated from:<ref>Precancerous conditions of the penis. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/penile/penile-cancer/precancerous-conditions/?region=ab Accessed on September, 30 2015 </ref><ref>Differential diagnoses of penile cancer. Oncology Encyclopedia 2015.http://oncolex.org/penile-cancer/background/differentialdiagnoses Accessed on September, 30 2015 </ref>
[[Carcinoma]] of the [[penis]] must be [[Differentiate|differentiated]] from:<ref>Precancerous conditions of the penis. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/penile/penile-cancer/precancerous-conditions/?region=ab Accessed on September, 30 2015 </ref><ref>Differential diagnoses of penile cancer. Oncology Encyclopedia 2015.http://oncolex.org/penile-cancer/background/differentialdiagnoses Accessed on September, 30 2015 </ref>
*Noncancerous conditions  
*[[Cancerous|Noncancerous]] conditions  
:*[[Condyloma acuminata]]
:*[[Condyloma acuminata]]
:**A common sexually transmitted disease caused by a virus belonging to the human papilloma virus (HPV) group
:**A common [[sexually transmitted disease]] caused by a [[Virus (biology)|virus]] belonging to the [[human papilloma virus]] ([[Human papillomavirus|HPV]]) group
:**Lesions normally grow as a papilloma and are usually found on the glans, prepuce, or shaft of the penis
:**[[Lesions]] normally grow as a [[papilloma]] and are usually found on the [[glans]], [[prepuce]], or [[shaft]] of the [[penis]]
:**Lesions are benign, caused by low-risk HPV 6/11
:**[[Lesions]] are [[benign]], caused by low-risk [[Human papillomavirus|HPV]] 6/11
:**Mixed infections with high-risk HPV types are relatively common
:**Mixed [[Infection|infections]] with high-risk [[Human papillomavirus|HPV]] types are relatively common
:**Progression to malignancy is rare.
:**Progression to [[malignancy]] is [[rare]].
   
   
* Precancerous conditions
* [[Precancerous]] conditions <ref>{{cite web |url=http://oncolex.org/Penile-cancer/Background/DifferentialDiagnoses |title=Differential diagnoses of penile cancer |format= |work= |accessdate=}} </ref>
:* Penile intraepithelial neoplasia (PeIN)
:* [[Penis|Penile]] intraepithelial [[neoplasia]] (PeIN)
:** most common precancerous condition of the penis
:** most common [[precancerous]] [[condition]] of the [[penis]]
:**General term used to describe precancerous conditions of the penis that may develop into invasive squamous cell carcinoma (SCC) if they are not treated
:**General term used to describe [[precancerous]] [[conditions]] of the [[penis]] that may [[Development|develop]] into [[invasive]] [[squamous cell carcinoma]] ([[Squamous cell carcinoma|SCC]]) if they are not treated
:**Refers to abnormal cell changes, called carcinoma in situ, that occur on the skin surface of the penis
:**Refers to [[abnormal]] [[cell]] changes, called [[carcinoma in situ]], that occur on the [[skin]] [[Surface area|surface]] of the [[penis]]
:**PeIN on the glans (head) or foreskin of the penis is also called erythroplasia of Queyrat
:**PeIN on the [[glans]] ([[Penis|head]]) or [[foreskin]] of the [[penis]] is also called [[erythroplasia of Queyrat]]
:**PeIN on the shaft of the penis is also called Bowen’s disease
:**PeIN on the [[shaft]] of the [[penis]] is also called [[Bowen’s disease]]
:* [[Balanitis xerotica obliterans]] (BXO) also known as lichen sclerosis
:* [[Balanitis xerotica obliterans]] ([[Balanitis xerotica obliterans|BXO]]) also known as [[Lichen sclerosus|lichen sclerosis]]
:**A precancerous skin condition localized to the glans and the prepuce
:**A [[precancerous]] [[skin]] [[condition]] localized to the [[glans]] and the [[prepuce]]
:**Presents as white atrophic patches
:**Presents as white [[atrophic]] patches
:**The secondary development of phimosis inhibits washing and prevents early diagnostics of possible malignancy development on the glans or inside of the prepuce
:**The [[secondary]] [[development]] of [[phimosis]] inhibits [[washing]] and [[Prevention|prevents]] early [[diagnostics]] of possible [[malignancy]] [[development]] on the [[glans]] or inside of the [[prepuce]]
:**A radical circumcision should therefore be performed for this disease
:**A radical [[Circumcised|circumcision]] should therefore be performed for this [[disease]]
:* Buschke-Lowenstein tumour
:* Buschke-Lowenstein tumour
:**A slow-growing, locally destructive verrucous plaque
:**A [[slow]]-[[Growth|growing]], [[Local|locally]] destructive [[Verrucous carcinoma|verrucous]] [[plaque]]
:**Cauliflower-like mass
:**Cauliflower-like [[mass]]
:**A regional variant of verrucous carcinoma, also known as giant condyloma acuminate
:**A regional variant of [[verrucous carcinoma]], also known as giant [[condyloma]] acuminate
:**Can involve the penis, vulva, scrotum, bladder, and perianal or anorectal regions
:**Can involve the [[penis]], [[vulva]], [[scrotum]], [[bladder]], and perianal or [[anorectal]] regions
:**Rare
:**[[Rare]]
:*Bowen's Disease
:*[[Bowen's disease|Bowen's Disease]]
:**Undifferentiated PeIN
:**[[Undifferentiated]] PeIN
:**Manifests as a solitary, pigmented, scaly or scab-covered area
:**Manifests as a [[solitary]], [[Pigmented lesions|pigmented]], scaly or [[scab]]-covered [[area]]
:**Affects the penis shaft, scrotum, perineum, and the suprapubic area
:**Affects the [[penis]] shaft, [[scrotum]], [[perineum]], and the suprapubic [[area]]
:* [[Bowenoid papulosis]]
:* [[Bowenoid papulosis]]
:**Multiple, slightly elevated, red to violet or brownish papules, on the penis shaft and scrotum
:**Multiple, slightly elevated, red to violet or brownish [[papules]], on the [[Penis|penis shaft]] and [[scrotum]]
:**Very rare, is preferably seen young men
:**Very [[rare]], is preferably seen young [[men]]
:**May regress without treatment  
:**May [[Regression|regress]] without treatment  
:**Caused by high-risk HPV, most commonly HPV 16
:**Caused by high-risk [[Human papillomavirus|HPV]], most commonly [[Human papillomavirus|HPV]] 16
:**Histologically cannot be separated from undifferentiated PeIN
:**[[Histologically]] cannot be separated from [[undifferentiated]] PeIN
:* [[Leukoplakia]]
:* [[Leukoplakia]]
:**Rare
:**[[Rare]]
:**Appear as a white hypertrophic or atrophic patch and usually occur secondary to chronic irritation
:**Appear as a white [[hypertrophic]] or [[atrophic]] patch and usually occur [[secondary]] to [[Chronic (medical)|chronic]] [[irritation]]
:**Develops in the meatus
:**[[Development|Develops]] in the [[meatus]]
:**Biopsy is necessary to exclude cancer and intraepithelial neoplasia (PeIN)
:**[[Biopsy]] is necessary to exclude [[cancer]] and intraepithelial [[neoplasia]] (PeIN)
:*Erythroplasia of Queyrat
:*[[Erythroplasia of Queyrat]]
:**Grows on the glans and the prepuce
:**[[Growth|Grows]] on the [[glans]] and the [[prepuce]]
:**Presents as a well-defined, red patch
:**[[Presenting symptom|Presents]] as a well-defined, red patch
:**Undifferentiated PeIN
:**[[Undifferentiated]] PeIN


==References==
==References==

Latest revision as of 12:19, 10 April 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Swathi Venkatesan, M.B.B.S.[2]

Overview

Carcinoma of the penis must be differentiated from condyloma acuminata, penile intraepithelial neoplasia (PeIN), balanitis xerotica obliterans, buschke-Lowenstein tumour, bowenoid papulosis, and leukoplakia.

Differential Diagnosis

Carcinoma of the penis must be differentiated from:[1][2]

References

  1. Precancerous conditions of the penis. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/penile/penile-cancer/precancerous-conditions/?region=ab Accessed on September, 30 2015
  2. Differential diagnoses of penile cancer. Oncology Encyclopedia 2015.http://oncolex.org/penile-cancer/background/differentialdiagnoses Accessed on September, 30 2015
  3. "Differential diagnoses of penile cancer".

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