Anaplastic large cell lymphoma diagnostic study of choice: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Anaplastic large cell lymphoma}} | {{Anaplastic large cell lymphoma}} | ||
{{CMG}}; {{AE}} {{AS}}, {{kakbar}}; {{GRR}} {{Nat}} | |||
==Overview== | |||
Lymph node or extranodal tissue biopsy is diagnostic of anaplastic large cell lymphoma. According to the Lugano classification, there are four stages of anaplastic large cell lymphoma based on the number of nodes and extranodal involvement. | |||
==Diagnostic Study of Choice== | |||
===Biopsy=== | |||
*Lymph node or extranodal tissue biopsy is diagnostic of anaplastic large cell lymphoma.<ref name="pmid28093529">{{cite journal| author=Li CY, Chien ST, Liao CY| title=Anaplastic large cell lymphoma of the spinal cord. | journal=QJM | year= 2017 | volume= 110 | issue= 3 | pages= 185-186 | pmid=28093529 | doi=10.1093/qjmed/hcw200 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28093529 }} </ref> | |||
*To view findings on biopsy characteristic of each morphological variant of anaplastic large cell lymphoma, click [[anaplastic large cell lymphoma pathophysiology #Microscopic Pathology|'''here''']]. | |||
===Staging=== | |||
Staging for anaplastic large cell lymphoma is provided in the following table:<ref>{{Cite journal| doi = 10.1200/JCO.2013.54.8800| issn = 1527-7755| volume = 32| issue = 27| pages = 3059–3068| last1 = Cheson| first1 = Bruce D.| last2 = Fisher| first2 = Richard I.| last3 = Barrington| first3 = Sally F.| last4 = Cavalli| first4 = Franco| last5 = Schwartz| first5 = Lawrence H.| last6 = Zucca| first6 = Emanuele| last7 = Lister| first7 = T. Andrew| last8 = Alliance, Australasian Leukaemia and Lymphoma Group| last9 = Eastern Cooperative Oncology Group| last10 = European Mantle Cell Lymphoma Consortium| last11 = Italian Lymphoma Foundation| last12 = European Organisation for Research| last13 = Treatment of Cancer/Dutch Hemato-Oncology Group| last14 = Grupo Español de Médula Ósea| last15 = German High-Grade Lymphoma Study Group| last16 = German Hodgkin's Study Group| last17 = Japanese Lymphorra Study Group| last18 = Lymphoma Study Association| last19 = NCIC Clinical Trials Group| last20 = Nordic Lymphoma Study Group| last21 = Southwest Oncology Group| last22 = United Kingdom National Cancer Research Institute| title = Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification| journal = Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology| date = 2014-09-20| pmid = 25113753}}</ref> | |||
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center | |||
|+ '''Revised staging system for primary nodal lymphomas (Lugano classification)''' | |||
! style="background: #4479BA; color:#FFF;" | Stage | |||
! style="background: #4479BA; color:#FFF;" | Involvement | |||
! style="background: #4479BA; color:#FFF;" | Extranodal (E) status | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC;" colspan=3 | '''Limited''' | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | I | |||
| style="padding: 5px 5px; background: #F5F5F5;" | One node or a group of adjacent nodes | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Single extranodal lesions without nodal involvement | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | II | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Two or more nodal groups on the same side of the diaphragm | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Stage I or II by nodal extent with limited contiguous extranodal involvement | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | II bulky* | |||
| style="padding: 5px 5px; background: #F5F5F5;" | II as above with "bulky" disease | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Not applicable | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC;" colspan=3 | '''Advanced''' | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | III | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Nodes on both sides of the diaphragm; nodes above the diaphragm with spleen involvement | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Not applicable | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | IV | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Additional noncontiguous extralymphatic involvement | |||
| style="padding: 5px 5px; background: #F5F5F5;" | Not applicable | |||
|} | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Pathology]] | [[Category:Pathology]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Hematology]] | |||
[[Category:Immunology]] | |||
Latest revision as of 12:44, 11 April 2019
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Anaplastic large cell lymphoma Microchapters |
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Differentiating Anaplastic large cell lymphoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2], Kamal Akbar, M.D.[3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]
Overview
Lymph node or extranodal tissue biopsy is diagnostic of anaplastic large cell lymphoma. According to the Lugano classification, there are four stages of anaplastic large cell lymphoma based on the number of nodes and extranodal involvement.
Diagnostic Study of Choice
Biopsy
- Lymph node or extranodal tissue biopsy is diagnostic of anaplastic large cell lymphoma.[1]
- To view findings on biopsy characteristic of each morphological variant of anaplastic large cell lymphoma, click here.
Staging
Staging for anaplastic large cell lymphoma is provided in the following table:[2]
| Stage | Involvement | Extranodal (E) status |
|---|---|---|
| Limited | ||
| I | One node or a group of adjacent nodes | Single extranodal lesions without nodal involvement |
| II | Two or more nodal groups on the same side of the diaphragm | Stage I or II by nodal extent with limited contiguous extranodal involvement |
| II bulky* | II as above with "bulky" disease | Not applicable |
| Advanced | ||
| III | Nodes on both sides of the diaphragm; nodes above the diaphragm with spleen involvement | Not applicable |
| IV | Additional noncontiguous extralymphatic involvement | Not applicable |
References
- ↑ Li CY, Chien ST, Liao CY (2017). "Anaplastic large cell lymphoma of the spinal cord". QJM. 110 (3): 185–186. doi:10.1093/qjmed/hcw200. PMID 28093529.
- ↑ Cheson, Bruce D.; Fisher, Richard I.; Barrington, Sally F.; Cavalli, Franco; Schwartz, Lawrence H.; Zucca, Emanuele; Lister, T. Andrew; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute (2014-09-20). "Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification". Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 32 (27): 3059–3068. doi:10.1200/JCO.2013.54.8800. ISSN 1527-7755. PMID 25113753.