Ovarian germ cell tumor history and symptoms: Difference between revisions
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{{Ovarian germ cell tumor}} | {{Ovarian germ cell tumor}} | ||
{{CMG}}; {{AE}} {{Sahar}} | {{CMG}}; {{AE}} {{Sahar}} {{MD}} | ||
==Overview== | ==Overview== | ||
The clinical manifestations of patients with ovarian germ cell tumors depend on the type of the tumor and its potential to produce hormonal materials. Usually, they present with abdominal pain or distention, menstrual irregularities, symptoms of virilization, rapidly growing abdominal/pelvic mass, acute abdominal pain from complications such as necrosis, capsular distention, rupture or torsion and or simply they can be asymptomatic. | The [[clinical]] manifestations of patients with [[ovarian]] [[germ cell]] [[tumors]] depend on the type of the [[tumor]] and its potential to produce [[hormonal]] materials. Usually, they present with [[abdominal pain]] or [[Abdominal distention|distention]], [[menstrual irregularities]], symptoms of [[virilization]], rapidly growing [[abdominal]]/[[pelvic]] [[mass]], [[acute abdominal pain]] from [[complications]] such as [[necrosis]], [[Capsule|capsular]] distention, [[rupture]] or [[torsion]] and or simply they can be [[asymptomatic]]. | ||
==History and Symptoms== | ==History and Symptoms== | ||
The clinical manifestations of patients with ovarian germ cell tumors depend on the type of the tumor and its potential to produce hormonal materials. Usually, they present with abdominal pain or distention, menstrual irregularities, symptoms of virilization, rapidly growing abdominal/pelvic mass, acute abdominal pain from complications such as necrosis, capsular distention, rupture or torsion and or simply they can be asymptomatic.<ref name="LowIlancheran2012">{{cite journal|last1=Low|first1=Jeffrey J.H.|last2=Ilancheran|first2=Arunachalam|last3=Ng|first3=Joseph S.|title=Malignant ovarian germ-cell tumours|journal=Best Practice & Research Clinical Obstetrics & Gynaecology|volume=26|issue=3|year=2012|pages=347–355|issn=15216934|doi=10.1016/j.bpobgyn.2012.01.002}}</ref> | The [[clinical]] manifestations of patients with [[ovarian]] [[germ cell]] [[tumors]] depend on the type of the [[tumor]] and its potential to produce [[hormonal]] materials. Usually, they present with [[abdominal pain]] or distention, [[menstrual irregularities]], symptoms of [[virilization]], rapidly growing [[abdominal]]/[[pelvic]] [[mass]], [[acute abdominal pain]] from [[complications]] such as [[necrosis]], [[Capsule|capsular]] distention, [[rupture]] or [[torsion]] and or simply they can be [[asymptomatic]].<ref name="LowIlancheran2012">{{cite journal|last1=Low|first1=Jeffrey J.H.|last2=Ilancheran|first2=Arunachalam|last3=Ng|first3=Joseph S.|title=Malignant ovarian germ-cell tumours|journal=Best Practice & Research Clinical Obstetrics & Gynaecology|volume=26|issue=3|year=2012|pages=347–355|issn=15216934|doi=10.1016/j.bpobgyn.2012.01.002}}</ref> | ||
===Mature teratoma=== | ===Mature teratoma=== | ||
* Approximately 20 % of patients with mature ovarian teratoma are asymptomatic.<ref name="AyhanBukulmez2000">{{cite journal|last1=Ayhan|first1=Ali|last2=Bukulmez|first2=Orhan|last3=Genc|first3=Cuneyt|last4=Karamursel|first4=Burcu S.|last5=Ayhan|first5=Ayse|title=Mature cystic teratomas of the ovary: case series from one institution over 34 years|journal=European Journal of Obstetrics & Gynecology and Reproductive Biology|volume=88|issue=2|year=2000|pages=153–157|issn=03012115|doi=10.1016/S0301-2115(99)00141-4}}</ref> | * Approximately 20 % of patients with [[Mature cystic teratoma|mature ovarian teratoma]] are [[asymptomatic]].<ref name="AyhanBukulmez2000">{{cite journal|last1=Ayhan|first1=Ali|last2=Bukulmez|first2=Orhan|last3=Genc|first3=Cuneyt|last4=Karamursel|first4=Burcu S.|last5=Ayhan|first5=Ayse|title=Mature cystic teratomas of the ovary: case series from one institution over 34 years|journal=European Journal of Obstetrics & Gynecology and Reproductive Biology|volume=88|issue=2|year=2000|pages=153–157|issn=03012115|doi=10.1016/S0301-2115(99)00141-4}}</ref> | ||
* The most common symptom in those who are symptomatic is lower abdominal pain. | * The most common symptom in those who are [[symptomatic]] is [[lower abdominal pain]]. | ||
** Acute abdominal pain may indicate the tumor is complicated by ovarian torsion or rupture that may happen in 5%-10% and 1%-3% of affected individuals, respectively. | ** [[Acute abdominal pain]] may indicate the [[tumor]] is complicated by [[ovarian torsion]] or [[rupture]] that may happen in 5%-10% and 1%-3% of affected individuals, respectively. | ||
*** Torsion usually tends to complicate at a greater extent the intermediate-sized tumors rather than the larger or smaller ones. | *** [[Torsion]] usually tends to complicate at a greater extent the intermediate-sized [[tumors]] rather than the larger or smaller ones. | ||
* Very rarely, mature teratoma can manifest with neurologic symptoms due to associated Anti-NMDA receptor encephalitis. Symptoms such as:<ref name="DalmauGleichman2008">{{cite journal|last1=Dalmau|first1=Josep|last2=Gleichman|first2=Amy J|last3=Hughes|first3=Ethan G|last4=Rossi|first4=Jeffrey E|last5=Peng|first5=Xiaoyu|last6=Lai|first6=Meizan|last7=Dessain|first7=Scott K|last8=Rosenfeld|first8=Myrna R|last9=Balice-Gordon|first9=Rita|last10=Lynch|first10=David R|title=Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies|journal=The Lancet Neurology|volume=7|issue=12|year=2008|pages=1091–1098|issn=14744422|doi=10.1016/S1474-4422(08)70224-2}}</ref> | * Very rarely, [[Mature cystic teratoma|mature teratoma]] can manifest with [[neurologic]] [[symptoms]] due to associated [[Anti-NMDA receptor encephalitis]]. [[Symptoms]] such as:<ref name="DalmauGleichman2008">{{cite journal|last1=Dalmau|first1=Josep|last2=Gleichman|first2=Amy J|last3=Hughes|first3=Ethan G|last4=Rossi|first4=Jeffrey E|last5=Peng|first5=Xiaoyu|last6=Lai|first6=Meizan|last7=Dessain|first7=Scott K|last8=Rosenfeld|first8=Myrna R|last9=Balice-Gordon|first9=Rita|last10=Lynch|first10=David R|title=Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies|journal=The Lancet Neurology|volume=7|issue=12|year=2008|pages=1091–1098|issn=14744422|doi=10.1016/S1474-4422(08)70224-2}}</ref> | ||
** Memory problems | ** [[Memory]] problems | ||
** Psychiatric problems | ** [[Psychiatric Disorders|Psychiatric]] problems | ||
** Decreased level of consciousness | ** Decreased level of [[consciousness]] | ||
** Seizure | ** [[Seizure]] | ||
** Dyskinesia | ** [[Dystonia|Dyskinesia]] | ||
===Dysgerminoma=== | ===Dysgerminoma=== | ||
*The majority of patients with dysgerminoma are symptomatic. symptoms include:<ref name="ShaabanRezvani2014">{{cite journal|last1=Shaaban|first1=Akram M.|last2=Rezvani|first2=Maryam|last3=Elsayes|first3=Khaled M.|last4=Baskin|first4=Henry|last5=Mourad|first5=Amr|last6=Foster|first6=Bryan R.|last7=Jarboe|first7=Elke A.|last8=Menias|first8=Christine O.|title=Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features|journal=RadioGraphics|volume=34|issue=3|year=2014|pages=777–801|issn=0271-5333|doi=10.1148/rg.343130067}}</ref> | *The majority of patients with [[dysgerminoma]] are [[symptomatic]]. [[symptoms]] include:<ref name="ShaabanRezvani2014">{{cite journal|last1=Shaaban|first1=Akram M.|last2=Rezvani|first2=Maryam|last3=Elsayes|first3=Khaled M.|last4=Baskin|first4=Henry|last5=Mourad|first5=Amr|last6=Foster|first6=Bryan R.|last7=Jarboe|first7=Elke A.|last8=Menias|first8=Christine O.|title=Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features|journal=RadioGraphics|volume=34|issue=3|year=2014|pages=777–801|issn=0271-5333|doi=10.1148/rg.343130067}}</ref> | ||
**Abdominal pain | **[[Abdominal pain]] | ||
** | **[[Abdominal]]/[[Pelvic masses|pelvic mass]] | ||
**Bloating | **[[Bloating]] | ||
**Menstrual irregularities | **[[Menstrual irregularities]] | ||
===Yolk sac tumor=== | ===Yolk sac tumor=== | ||
*The symptoms include abdominal pain/distention or pelvic mass.<ref name="pmid6185892">{{cite journal |vauthors=Gershenson DM, Del Junco G, Herson J, Rutledge FN |title=Endodermal sinus tumor of the ovary: the M. D. Anderson experience |journal=Obstet Gynecol |volume=61 |issue=2 |pages=194–202 |date=February 1983 |pmid=6185892 |doi= |url=}}</ref> | *The [[Symptom|symptoms]] include [[abdominal pain]]/[[Abdominal distention|distention]] or [[Pelvic masses|pelvic mass]].<ref name="pmid6185892">{{cite journal |vauthors=Gershenson DM, Del Junco G, Herson J, Rutledge FN |title=Endodermal sinus tumor of the ovary: the M. D. Anderson experience |journal=Obstet Gynecol |volume=61 |issue=2 |pages=194–202 |date=February 1983 |pmid=6185892 |doi= |url=}}</ref> | ||
*The symptoms tend to occur in a short period of time since the tumor has a rapid rate of growth. | *The [[symptoms]] tend to occur in a short period of time since the [[tumor]] has a rapid rate of growth. | ||
*Amenorrhea is a very rare symptom and is not expected.<ref name="pmid24601057">{{cite journal |vauthors=Caserta D, Ralli E, Bordi G, Moscarini M |title=An unusual clinical presentation of a pure yolk sac tumor of the ovary: case report |journal=Eur. J. Gynaecol. Oncol. |volume=34 |issue=6 |pages=577–9 |date=2013 |pmid=24601057 |doi= |url=}}</ref> | *[[Amenorrhea]] is a very rare [[symptom]] and is not expected.<ref name="pmid24601057">{{cite journal |vauthors=Caserta D, Ralli E, Bordi G, Moscarini M |title=An unusual clinical presentation of a pure yolk sac tumor of the ovary: case report |journal=Eur. J. Gynaecol. Oncol. |volume=34 |issue=6 |pages=577–9 |date=2013 |pmid=24601057 |doi= |url=}}</ref> | ||
===Embryonal carcinoma=== | ===Embryonal carcinoma=== | ||
* | *These [[tumors]] usually present with [[abdominal]]/[[pelvic]] [[mass]].<ref name="pmid1690671">{{cite journal |vauthors=Ueda G, Abe Y, Yoshida M, Fujiwara T |title=Embryonal carcinoma of the ovary: a six-year survival |journal=Int J Gynaecol Obstet |volume=31 |issue=3 |pages=287–92 |date=March 1990 |pmid=1690671 |doi= |url=}}</ref> | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 13:52, 22 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2] Monalisa Dmello, M.B,B.S., M.D. [3]
Overview
The clinical manifestations of patients with ovarian germ cell tumors depend on the type of the tumor and its potential to produce hormonal materials. Usually, they present with abdominal pain or distention, menstrual irregularities, symptoms of virilization, rapidly growing abdominal/pelvic mass, acute abdominal pain from complications such as necrosis, capsular distention, rupture or torsion and or simply they can be asymptomatic.
History and Symptoms
The clinical manifestations of patients with ovarian germ cell tumors depend on the type of the tumor and its potential to produce hormonal materials. Usually, they present with abdominal pain or distention, menstrual irregularities, symptoms of virilization, rapidly growing abdominal/pelvic mass, acute abdominal pain from complications such as necrosis, capsular distention, rupture or torsion and or simply they can be asymptomatic.[1]
Mature teratoma
- Approximately 20 % of patients with mature ovarian teratoma are asymptomatic.[2]
- The most common symptom in those who are symptomatic is lower abdominal pain.
- Acute abdominal pain may indicate the tumor is complicated by ovarian torsion or rupture that may happen in 5%-10% and 1%-3% of affected individuals, respectively.
- Very rarely, mature teratoma can manifest with neurologic symptoms due to associated Anti-NMDA receptor encephalitis. Symptoms such as:[3]
- Memory problems
- Psychiatric problems
- Decreased level of consciousness
- Seizure
- Dyskinesia
Dysgerminoma
- The majority of patients with dysgerminoma are symptomatic. symptoms include:[4]
Yolk sac tumor
- The symptoms include abdominal pain/distention or pelvic mass.[5]
- The symptoms tend to occur in a short period of time since the tumor has a rapid rate of growth.
- Amenorrhea is a very rare symptom and is not expected.[6]
Embryonal carcinoma
References
- ↑ Low, Jeffrey J.H.; Ilancheran, Arunachalam; Ng, Joseph S. (2012). "Malignant ovarian germ-cell tumours". Best Practice & Research Clinical Obstetrics & Gynaecology. 26 (3): 347–355. doi:10.1016/j.bpobgyn.2012.01.002. ISSN 1521-6934.
- ↑ Ayhan, Ali; Bukulmez, Orhan; Genc, Cuneyt; Karamursel, Burcu S.; Ayhan, Ayse (2000). "Mature cystic teratomas of the ovary: case series from one institution over 34 years". European Journal of Obstetrics & Gynecology and Reproductive Biology. 88 (2): 153–157. doi:10.1016/S0301-2115(99)00141-4. ISSN 0301-2115.
- ↑ Dalmau, Josep; Gleichman, Amy J; Hughes, Ethan G; Rossi, Jeffrey E; Peng, Xiaoyu; Lai, Meizan; Dessain, Scott K; Rosenfeld, Myrna R; Balice-Gordon, Rita; Lynch, David R (2008). "Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies". The Lancet Neurology. 7 (12): 1091–1098. doi:10.1016/S1474-4422(08)70224-2. ISSN 1474-4422.
- ↑ Shaaban, Akram M.; Rezvani, Maryam; Elsayes, Khaled M.; Baskin, Henry; Mourad, Amr; Foster, Bryan R.; Jarboe, Elke A.; Menias, Christine O. (2014). "Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features". RadioGraphics. 34 (3): 777–801. doi:10.1148/rg.343130067. ISSN 0271-5333.
- ↑ Gershenson DM, Del Junco G, Herson J, Rutledge FN (February 1983). "Endodermal sinus tumor of the ovary: the M. D. Anderson experience". Obstet Gynecol. 61 (2): 194–202. PMID 6185892.
- ↑ Caserta D, Ralli E, Bordi G, Moscarini M (2013). "An unusual clinical presentation of a pure yolk sac tumor of the ovary: case report". Eur. J. Gynaecol. Oncol. 34 (6): 577–9. PMID 24601057.
- ↑ Ueda G, Abe Y, Yoshida M, Fujiwara T (March 1990). "Embryonal carcinoma of the ovary: a six-year survival". Int J Gynaecol Obstet. 31 (3): 287–92. PMID 1690671.