Ovarian germ cell tumor surgery: Difference between revisions
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{{Ovarian germ cell tumor}} | {{Ovarian germ cell tumor}} | ||
{{CMG}}; {{AE}} {{Sahar}} | {{CMG}}; {{AE}} {{MD}} {{Sahar}} | ||
==Overview== | ==Overview== | ||
[[Surgical]] [[intervention]] is the mainstay of management of [[ovarian]] [[germ cell]] [[tumors]]. [[Surgery]] | [[Surgical]] [[intervention]] is the mainstay of management of [[ovarian]] [[germ cell]] [[tumors]]. [[Surgery]] is recommended both for [[Cancer staging|staging]] and choosing appropriate treatment approaches. accordingly. | ||
[[Surgical]] management of the [[ovarian]] [[germ cell]] [[tumors]], for the purpose of treatment, classified to two categories according to the preference of the patient to preserve the [[ovary]] or not | [[Surgical]] management of the [[ovarian]] [[germ cell]] [[tumors]], for the purpose of treatment, classified to two categories according to the preference of the patient to preserve the [[ovary]] or not. | ||
==Surgery== | ==Surgery== | ||
* [[Surgery]] is the mainstay of management of [[ | * [[Surgery]] is the mainstay of management of [[ovarian]] [[germ cell]] [[tumors]].<ref name="xxx">Stage I Ovarian Germ Cell Tumors | ||
. http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_33. URL Accessed on Nov 5, 2015</ref><ref name="abc">Stage II Ovarian Germ Cell Tumors | . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_33. URL Accessed on Nov 5, 2015</ref><ref name="abc">Stage II Ovarian Germ Cell Tumors | ||
. http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_43. URL Accessed on Nov 5, 2015</ref><ref name="aaa">Stage III Ovarian Germ Cell Tumors | . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_43. URL Accessed on Nov 5, 2015</ref><ref name="aaa">Stage III Ovarian Germ Cell Tumors | ||
. http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_54. URL Accessed on Nov 5, 2015</ref><ref name="ccc">Stage IV Ovarian Germ Cell Tumors | . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_54. URL Accessed on Nov 5, 2015</ref><ref name="ccc">Stage IV Ovarian Germ Cell Tumors | ||
. http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_65. URL Accessed on Nov 5, 2015</ref> | . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_65. URL Accessed on Nov 5, 2015</ref> | ||
* [[Surgery]] is | * [[Surgery]] is recommended both for [[Cancer staging|staging]] and choosing appropriate treatment approaches. accordingly.<ref name="Gershenson2007">{{cite journal|last1=Gershenson|first1=David M.|title=Management of Ovarian Germ Cell Tumors|journal=Journal of Clinical Oncology|volume=25|issue=20|year=2007|pages=2938–2943|issn=0732-183X|doi=10.1200/JCO.2007.10.8738}}</ref> | ||
* [[Surgical]] | * [[Surgical]] options depends upon the choice of preserving fertility. | ||
== | {| class="wikitable" | ||
|+ | |||
! colspan="2" |Management of Mature Teratoma | |||
|- | |||
|Mature Teratoma | |||
| | |||
*[[Surgery]] is the mainstay of [[treatment]] for [[Mature cystic teratoma|mature teratoma]].<ref name="Yayla AbideBostancı Ergen2018">{{cite journal|last1=Yayla Abide|first1=Çiğdem|last2=Bostancı Ergen|first2=Evrim|title=Retrospective analysis of mature cystic teratomas in a single center and review of the literature|journal=Journal of Turkish Society of Obstetric and Gynecology|volume=15|issue=2|year=2018|pages=95–98|issn=1307699X|doi=10.4274/tjod.86244}}</ref> | *[[Surgery]] is the mainstay of [[treatment]] for [[Mature cystic teratoma|mature teratoma]].<ref name="Yayla AbideBostancı Ergen2018">{{cite journal|last1=Yayla Abide|first1=Çiğdem|last2=Bostancı Ergen|first2=Evrim|title=Retrospective analysis of mature cystic teratomas in a single center and review of the literature|journal=Journal of Turkish Society of Obstetric and Gynecology|volume=15|issue=2|year=2018|pages=95–98|issn=1307699X|doi=10.4274/tjod.86244}}</ref> | ||
*Nonsurgical management may be considered in those with [[tumors]] smaller than 6 cm, especially those who is planning to get [[pregnant]].<ref name="CaspiAppelman1997">{{cite journal|last1=Caspi|first1=Benjamin|last2=Appelman|first2=Zvi|last3=Rabinerson|first3=David|last4=Zalel|first4=Yaron|last5=Tulandi|first5=Togas|last6=Shoham|first6=Zeev|title=The growth pattern of ovarian dermoid cysts: a prospective study in premenopausal and postmenopausal women|journal=Fertility and Sterility|volume=68|issue=3|year=1997|pages=501–505|issn=00150282|doi=10.1016/S0015-0282(97)00228-8}}</ref> | *Nonsurgical management may be considered in those with [[tumors]] smaller than 6 cm, especially those who is planning to get [[pregnant]].<ref name="CaspiAppelman1997">{{cite journal|last1=Caspi|first1=Benjamin|last2=Appelman|first2=Zvi|last3=Rabinerson|first3=David|last4=Zalel|first4=Yaron|last5=Tulandi|first5=Togas|last6=Shoham|first6=Zeev|title=The growth pattern of ovarian dermoid cysts: a prospective study in premenopausal and postmenopausal women|journal=Fertility and Sterility|volume=68|issue=3|year=1997|pages=501–505|issn=00150282|doi=10.1016/S0015-0282(97)00228-8}}</ref> | ||
*[[Surgery]] | *[[Surgery]] increases the risk of [[Adhesions|band adhesion]] formation that may be associated with future [[fertility|infertility]] in women. | ||
*[[Surgery]] is usually reserved for patients with either:<ref name="CaspiAppelman1997" | *[[Surgery]] is usually reserved for patients with either:<ref name="CaspiAppelman1997" /> | ||
**[[Tumor]] size larger than 6 cm | **[[Tumor]] size larger than 6 cm | ||
**No plans for future [[pregnancy]] | **No plans for future [[pregnancy]] | ||
**[[Menopausal|Post-menopausal]] women | **[[Menopausal|Post-menopausal]] women | ||
|- | |||
! colspan="2" |Management of [[Dysgerminoma|Dysgerminomas]]<ref name="xxx" /><ref name="abc" /><ref name="aaa" /><ref name="ccc" /> | |||
|- | |||
|Stage I ovarian germ cell tumors | |||
| | |||
* Unilateral [[salpingo-oophorectomy]] with or without [[lymphangiography ]]or [[computed tomography]] ([[CT]]) | |||
* Unilateral [[salpingo-oophorectomy]] followed by [[observation]] | |||
* Unilateral [[salpingo-oophorectomy]] with [[adjuvant]] [[radiation therapy]] or [[chemotherapy]] | |||
* Unilateral [[salpingo-oophorectomy]] with conservation of [[uterus]] and contralateral [[ovar]] is [[Indication (medicine)|indicated]] in those who plan for future [[pregnancies]]. | |||
* Postoperative [[lymphangiography]] or [[CT]] is [[Indication (medicine)|indicated]] for those who have not had the careful [[surgical]] and [[pathological]] examination of [[pelvic]] and [[Paraaortic lymph nodes|para-aortic lymph nodes]] during [[surgery]]. | |||
* Patients with [[Surgery|surgically]] staged stage IA [[tumors]] may be observed carefully after [[surgery]] without the need for [[adjuvant treatment]]. | |||
* Patients with incompletely staged [[tumor]] through [[surgery]] or those with higher stages may need [[adjuvant treatment]]. | |||
|- | |||
|Stage II ovarian germ cell tumors | |||
| | |||
* Total [[abdominal]] [[hysterectomy]] and [[bilateral]] [[salpingo-oophorectomy]] with [[adjuvant]] [[radiation]] therapy or [[chemotherapy]] | |||
* Unilateral [[salpingo-oophorectomy]] with [[adjuvant]] [[chemotherapy]] | |||
** This option is considered for younger patients and those who desire to preserve their [[fertility]] for future [[pregnancies]]. | |||
** [[Radiotherapy]] has been associated with [[ovarian failure]]. | |||
** [[Adjuvant]] [[chemotherapy]] with the [[platinum]]-based regimen has replaced [[radiation therapy]] except in the rare patient in whom [[chemotherapy]] is not considered appropriate. | |||
|- | |||
|Stage III ovarian germ cell tumors | |||
| | |||
:* Unilateral [[salpingo-oophorectomy]] with [[adjuvant chemotherapy]] | :* Unilateral [[salpingo-oophorectomy]] with [[adjuvant chemotherapy]] | ||
:* Second-look [[laparotomy]] | :* Second-look [[laparotomy]] | ||
:** This strategy is not beneficial in patients with completely resected [[tumors]] who receive [[cisplatin]]-based [[adjuvant treatment]]. | :** This strategy is not beneficial in patients with completely resected [[tumors]] who receive [[cisplatin]]-based [[adjuvant treatment]]. | ||
:** Second-look [[surgery]] may be beneficial in those whose [[tumor]] was not completely resected at the initial [[surgical]] procedure and who had teratomatous elements in their primary [[tumor]]. | :** Second-look [[surgery]] may be beneficial in those whose [[tumor]] was not completely resected at the initial [[surgical]] procedure and who had teratomatous elements in their primary [[tumor]]. | ||
|- | |||
|Stage IV ovarian germ cell tumors | |||
| | |||
:* Total [[abdominal]] [[hysterectomy]] and [[bilateral]] [[salpingo-oophorectomy]] | :* Total [[abdominal]] [[hysterectomy]] and [[bilateral]] [[salpingo-oophorectomy]] | ||
:* Unilateral [[salpingo-oophorectomy]] with [[adjuvant]] [[chemotherapy]] | :* Unilateral [[salpingo-oophorectomy]] with [[adjuvant]] [[chemotherapy]] | ||
:** [[Chemotherapy]] is the preferred treatment in the patient who wants to preserve [[fertility]]. | :** [[Chemotherapy]] is the preferred treatment in the patient who wants to preserve [[fertility]]. | ||
|} | |||
===Management options of Other Ovarian Tumors=== | |||
:* | |||
{| class="wikitable" | |||
|+ | |||
! colspan="2" |Surgical options for other ovarian tumors | |||
|- | |||
|Stage I ovarian germ cell tumors | |||
| | |||
* Unilateral [[salpingo-oophorectomy]] with [[adjuvant chemotherapy]] | |||
* Unilateral [[salpingo-oophorectomy]] followed by [[observation]] | |||
* Unilateral [[salpingo-oophorectomy]] with conservation of [[uterus]] and contralateral [[ovar]] is [[Indication (medicine)|indicated]] in those who plan for future [[pregnancies]]. | |||
* [[Chemotherapy agent|Chemotherapy]] is usually done postoperatively in those with [[ovarian]] [[germ cell]] [[tumors]] other than pure [[dysgerminoma]] and low grade (grade 1) immature [[teratoma]], but it can also preserved for those whose [[tumors]] [[relapse]] after the [[surgery]]. | |||
|- | |||
|Stage II ovarian germ cell tumors | |||
| | |||
* Total [[abdominal]] [[hysterectomy]] and [[bilateral]] [[salpingo-oophorectomy]] with [[adjuvant]] [[chemotherapy]], with or without [[neoadjuvant chemotherapy]] | |||
* Unilateral [[salpingo-oophorectomy]] with [[adjuvant]] [[chemotherapy]], with or without [[neoadjuvant chemotherapy]] | |||
* Second-look [[laparotomy]] | |||
|- | |||
|Stage III ovarian germ cell tumors | |||
| | |||
* Total [[abdominal]] [[hysterectomy]] and [[bilateral]] [[salpingo-oophorectomy]] with [[adjuvant]] [[chemotherapy]] | |||
* Unilateral [[salpingo-oophorectomy]] with [[adjuvant]] [[chemotherapy]] | |||
|- | |||
|Stage IV ovarian germ cell tumors | |||
| | |||
* Total [[abdominal]] [[hysterectomy]] and [[bilateral]] [[salpingo-oophorectomy]] with [[adjuvant]] [[chemotherapy]] with or without [[neoadjuvant chemotherapy]] | |||
* Unilateral [[salpingo-oophorectomy]] with [[adjuvant]] [[chemotherapy]] with or without [[neoadjuvant chemotherapy]] | |||
|} | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} |
Latest revision as of 14:00, 22 April 2019
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Ovarian germ cell tumor surgery On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2] Sahar Memar Montazerin, M.D.[3]
Overview
Surgical intervention is the mainstay of management of ovarian germ cell tumors. Surgery is recommended both for staging and choosing appropriate treatment approaches. accordingly. Surgical management of the ovarian germ cell tumors, for the purpose of treatment, classified to two categories according to the preference of the patient to preserve the ovary or not.
Surgery
- Surgery is the mainstay of management of ovarian germ cell tumors.[1][2][3][4]
- Surgery is recommended both for staging and choosing appropriate treatment approaches. accordingly.[5]
- Surgical options depends upon the choice of preserving fertility.
Management of Mature Teratoma | |
---|---|
Mature Teratoma |
|
Management of Dysgerminomas[1][2][3][4] | |
Stage I ovarian germ cell tumors |
|
Stage II ovarian germ cell tumors |
|
Stage III ovarian germ cell tumors |
|
Stage IV ovarian germ cell tumors |
|
Management options of Other Ovarian Tumors
Surgical options for other ovarian tumors | |
---|---|
Stage I ovarian germ cell tumors |
|
Stage II ovarian germ cell tumors |
|
Stage III ovarian germ cell tumors |
|
Stage IV ovarian germ cell tumors |
|
References
- ↑ 1.0 1.1 Stage I Ovarian Germ Cell Tumors . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_33. URL Accessed on Nov 5, 2015
- ↑ 2.0 2.1 Stage II Ovarian Germ Cell Tumors . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_43. URL Accessed on Nov 5, 2015
- ↑ 3.0 3.1 Stage III Ovarian Germ Cell Tumors . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_54. URL Accessed on Nov 5, 2015
- ↑ 4.0 4.1 Stage IV Ovarian Germ Cell Tumors . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_65. URL Accessed on Nov 5, 2015
- ↑ Gershenson, David M. (2007). "Management of Ovarian Germ Cell Tumors". Journal of Clinical Oncology. 25 (20): 2938–2943. doi:10.1200/JCO.2007.10.8738. ISSN 0732-183X.
- ↑ Yayla Abide, Çiğdem; Bostancı Ergen, Evrim (2018). "Retrospective analysis of mature cystic teratomas in a single center and review of the literature". Journal of Turkish Society of Obstetric and Gynecology. 15 (2): 95–98. doi:10.4274/tjod.86244. ISSN 1307-699X.
- ↑ 7.0 7.1 Caspi, Benjamin; Appelman, Zvi; Rabinerson, David; Zalel, Yaron; Tulandi, Togas; Shoham, Zeev (1997). "The growth pattern of ovarian dermoid cysts: a prospective study in premenopausal and postmenopausal women". Fertility and Sterility. 68 (3): 501–505. doi:10.1016/S0015-0282(97)00228-8. ISSN 0015-0282.
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